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| 1 | Long-term alpha interferon and lamivudine combination therapy in non-responder patients with anti-HBe-positive chronic hepatitis B:Results of an open,controlled trial显示文摘AIM: To investigate the safety and efficacy of long-term combination therapy with alpha interferon and lamivudine in non-responsive patients with anti-HBe-positive chronic hepatitis B.METHODS: 34 patients received combination treatment (1 month lamivudine, 12 month lamivudine+interferon, 6month lamivudine), 24 received lamivudine (12 months),24 received interferon (12 months). Interferon was administered at 6 MU tiw and lamivudine at 100 mg orally once daily. Patients were followed up for 6 months after treatment.RESULTS: At the end of treatment, HBV DNA negativity rates were 88 % with lamivudine+interferon, 99 % with lamivudine and 55 % with interferon, (P=0.004, combination therapy vs. interferon, and P=0.001 lamivudine vs.interferon), and serum transaminase normalization rates were 84 %, 91% and 53 % (P=0.01 combination therapy vs. interferon, and P=0.012 lamivudine vs. interferon). Six months later, HBV DNA negativity rates were 44 % with lamivudine+interferon, 33 % with lamivudine and 25 % with interferon, and serum transaminase normalization rates were 61%, 42 % and 45 %, respectively, without statistical significance. No YMDD variants were observed with lamivudine+interferon (vs. 12 % with lamivudine). The combination therapy appeared to be safe. CONCLUSION: Although viral clearance and transaminase normalization are slower with long-term lamivudine+interferon than that with lamivudine alone, the combination regimen seems to provide more lasting benefits and to protect against the appearance of YMDD variants. Studies with other regimens regarding sequence and duration are needed. | M. Francesca Jaboli Carlo Fabbri Stefania Liva Francesco Azzaroli Giovanni Nigro Silvia Giovanelli Francesco Ferrara Anna Miracolo Sabrina Marchetto Marco Montagnani Antonio Colecchia Davide Festi Letizia Bacchi Reggiani Enrico Roda Giuseppe Mazzella | 2003 | World Journal of Gastroenterology2003，9，7： | 10 |
| 2 | Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery?显示文摘AIM To clarify which factors may influence pathological tumor response and affect clinical outcomes in patients with locally advanced rectal carcinoma treated with neo-adjuvant chemoradiotherapy and surgery.METHODS Tumor regression grade(TRG) according to the Dworak system and yT NM stage were assessed and correlated with pre-treatment clinico-pathological variables in 215 clinically locally advanced(c TNM stage Ⅱ and Ⅲ) rectal carcinomas. Prognostic value of all pathological and clinical factors on disease free survival(DFS) and cancer specific survival(CSS) was analyzed by Kaplan Meier and Cox-regression analyses.RESULTS cN + status, mucinous histotype or poor differentiation in the pre-treatment biopsy were significantly associated with lower pathological response(low Dworak grade and TNM remaining unchanged/upstaging). Cases showing acellular mucin pools in surgical specimens all had unremarkable clinical courses with no deaths or recurrences during follow-up. Dworak grade had prognostic significance for DFS and CSS. However, compared to the 5-tiered system, a simplified twotiered grading system, in which grades 0, 1 and 2 were grouped as absent/partial regression and grades 3 and 4 were grouped as total/subtotal regression, was more reproducible and prognostically informative. The twotiered Dworak system, yN stage, craniocaudal extension of the tumor and radial margin status were significant independent prognostic variables. CONCLUSION Our data suggest that caution should be applied in using a conservative approach in rectal carcinomas with c N+ status, extensive/lower involvement of the rectum and mucinous histotype or poor differentiation. Although Dworak TRG is prognostically significant, a simplified two-tiered system could be preferable. Finally, cases with acellular mucin pools should be carefully evaluated to definitely exclude residual mucinous carcinoma. | Luca Reggiani Bonetti Simona Lionti Federica Domati Valeria Barresi | 2017 | World Journal of Gastroenterology2017，23，8： | 7 |
| 3 | Review article: the diagnosis of non‐alcoholic fatty liver disease – availability and accuracy of non‐invasive methods显示文摘 | D. Festi R. Schiumerini L. Marzi A. R. Di Biase D. Mandolesi L. Montrone E. Scaioli G. Bonato G. Marchesini‐Reggiani A. Colecchia | 2012 | Aliment Pharmacol Ther2012，，4： | 6 |
| 4 | How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center显示文摘Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC.Methods: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors.Results: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality risk.Conclusion: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients. | Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni Maria Letizia Bacchi Reggiani Daniele Parlanti Isacco Montroni | 2015 | Cancer Biology & Medicine2015，12，4： | 4 |
| 5 | Effect of a triage course on quality of rating triage codes in a group of university nursing students:a before-after observational study显示文摘BACKGROUND:Most current triage tools have been tested among hospital nurses groups but there are not similar studies in university setting.In this study we analyzed if a course on a new fourlevel triage model,triage emergency method(TEM),could improve the quality of rating in a group of nursing students.METHODS:This observational study was conducted with paper scenarios at the University of Parma,Italy.Fifty students were assigned a triage level to 105 paper scenarios before and after a course on triage and TEM.We used weighted kappa statistics to measure the inter-rater reliability of TEM and assessed its validity by comparing the students' predictions with the triage code rating of a reference standard(a panel of five experts in the new triage method).RESULTS:Inter-rater reliability was K=0.42(95%Cl:0.37-0.46) before the course on TEM,and K=0.61(95%CI:0.56-0.67) after.The accuracy of students' triage rating for the reference standard triage code was good:81%(95%Cl:71-90).After the TEM course,the proportion of cases assigned to each acuity triage level was similar for the student group and the panel of experts.CONCLUSION:Among the group of nursing students,a brief course on triage and on a new inhospital triage method seems to improve the quality of rating codes.The new triage method shows good inter-rater reliability for rating triage acuity and good accuracy in predicting the triage code rating of the reference standard. | Nicola Parenti Maria Letizia Bacchi Reggiani Diego Sangiorgi Vito Serventi Leopoldo Sarli | 2013 | World Journal of Emergency Medicine2013，4，1： | 3 |
| 6 | Measurement of Spleen Stiffness to Evaluate Portal Hypertension and the Presence of Esophageal Varices in Patients With HCV-Related Cirrhosis显示文摘 | Antonio Colecchia Lucia Montrone Eleonora Scaioli Maria Letizia Bacchi–Reggiani Agostino Colli Giovanni Casazza Ramona Schiumerini Laura Turco Anna Rita Di Biase Giuseppe Mazzella Luca Marzi Umberto Arena Massimo Pinzani Davide Festi | 2012 | Gastroenterology2012，，3： | 3 |
| 7 | Heavily calcified gastrointestinal stromal tumors:Pathophysiology and implications of a rare clinicopathologic entity显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended andthe patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis(longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature. | Massimiliano Salati Giulia Orsi Luca Reggiani Bonetti Fabrizio Di Benedetto Giuseppe Longo Stefano Cascinu | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
| 8 | Clinical outcome of low- and high-risk malignant colorectal polyps: results of a population-based study and meta-analysis of the available literature显示文摘 | Carmela Di Gregorio Luca Reggiani Bonetti Carmela Gaetani Monica Pedroni Shaniko Kaleci Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，2： | 2 |
| 9 | Use of Electrophoretic Mobility and Streaming Potential Measurements to Characterize Electrokinetic Properties of Ultrafiltration and Microfiltration Membranes显示文摘 | Ricq Laurence Pierre Andre Reggiani Jean-Claude | 1998 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1998，138，4： | 1 |
| 10 | A compact double-gate MOSFET model comprising quantum-mechanical and nonstatic effects显示文摘 | Baccarani G Reggiani S | 1999 | IEEE Trans Electron Devices1999，46，： | 1 |
| 11 | Risk of stroke in patients with high on-clopidogrel platelet reactivity to adenosine diphosphate after percutaneous coronary intervention显示文摘 | Taglieri N Bacchi Reggiani ML Palmerini T | 2014 | Am J Cardiol2014，113，11： | 1 |
| 12 | Deforma- tion Behaviour of a Ferritic Hot-work Tool Steel with Respect to the Microstructure显示文摘 | Krumphals F Reggiani B Donati L | 2012 | Computa- tional Materials Science2012，52，1： | 1 |
| 13 | Pseudo-chaotic time hopping for UWB impulse radio 显示文摘 | Maggio G Rulkov N Reggiani L | 2001 | IEEE Trans on Circuit and System2001，48，12： | 1 |
| 14 | A unifying framework for watershed Thermodynamics:constitutive relationships显示文摘 | Reggiani P Hassanizadeh S M Sivapalan M | 1999 | Advance in Water Resource1999，23，： | 1 |
| 15 | A simple model for the photocurrent density of a graded band gap CIGS thin film solar cell显示文摘 | Nima E. Gorji Ugo Reggiani Leonardo Sandrolini | 2011 | Solar Energy2011，，3： | 1 |
| 16 | Streaming Potential and Ion Transmission During Ultra- and Micrefiltration on Inorganic Membranes 显示文摘 | Ricq Laurence Pierre Andre Reggiani Jean-Claude | 1997 | Desalination1997，114，2： | 1 |
| 17 | In silico research in drug discovery显示文摘 | Terstappen GC Reggiani A | | 0，，01： | 1 |
| 18 | A bayesian approach to decision- making under uncertainty: an application to real time Fore casting in the river rhine显示文摘 | Reggiani P Weerts A H | 2008 | Journal of Hydrology2008，356，12： | 1 |
| 19 | Prognostic significance of mean platelet volume on admission in an unselected cohort of patients with non ST-segment elevation acute coronary syndrome显示文摘 | Marrozzini C Bacchi Reggiani ML Palmeri T | 2011 | Thromb Haemost2011，106，1： | 1 |
| 20 | SSJD14101300034250显示文摘 | Federica Domati Stefania Maffei Shaniko Kaleci Carmela Gregorio Monica Pedroni Luca Roncucci Piero Benatti Giulia Magnani Luigi Marcheselli Luca Reggiani Bonetti Francesco Mariani Antonio Maria Alberti Valerio Rossi Maurizio Ponz de Leon | 2014 | Internal and Emergency Medicine2014，，6： | 1 |
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