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| 1 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 2 | Targeted therapies in gastroesophageal cancer显示文摘 | Stefan Kasper Martin Schuler | 2014 | European Journal of Cancer2014，，： | 2 |
| 3 | Crystallization-induced reactions of copolymers: I , Ring-sized isomerization of poly(ester acetals)显示文摘 | Lenz R W Martin E Schuler A N | 1973 | J Polym Sci Polym Chem1973，11，： | 1 |
| 4 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 5 | A Stiglerian View on Banking Supervision显示文摘 | HEINEMANN FRIEDRICH MARTIN SCHULER | 2004 | Public Choice2004，121，1： | 1 |
| 6 | Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies显示文摘 | Frank Kroschinsky Matthias Weise Thomas Illmer Mathias Haenel Martin Bornhaeuser Gert Hoeffken Gerhard Ehninger Ulrich Schuler | 2002 | Intensive Care Medicine2002，，9： | 1 |
| 7 | Identification of the Fanconi anemia complementation group I gene, FANCI显示文摘 | Josephine C. Dorsman Marieke Levitus Davy Rockx Martin A. Rooimans Anneke B. Oostra Anneke Haitjema Sietske T. Bakker J?rgen Steltenpool Dezs? Schuler Sheila Mohan Detlev Schindler Fré Arwert Gerard Pals Christopher G. Mathew Quinten Waisfisz Johan P. de | 2007 | Cellular Oncology2007，，3： | 1 |
| 8 | Transcatheter Aortic Valve Implantation显示文摘 | Jean-Bernard Masson Jan Kovac Gerhard Schuler Jian Ye Anson Cheung Samir Kapadia Murat E. Tuzcu Susheel Kodali Martin B. Leon John G. Webb | 2009 | JACC: Cardiovascular Interventions2009，，9： | 1 |
| 9 | Biomimetic modification of titanium dental implant model surfaces using the RGDSP-peptide sequence: A cell morphology study显示文摘 | Martin Schuler Gethin Rh. Owen Douglas W. Hamilton Michael de Wild Marcus Textor Donald M. Brunette Samuele G.P. Tosatti | 2006 | Biomaterials2006，，21： | 1 |
| 10 | LUX-Lung 3 : A randomized, open-la- bel,phase III study of afatinib versus pemetrexed and cis- platin as first-line treatment for patients with advanced ad- enocarcinoma of the lung harboring EGFR-activating mu- tations 显示文摘 | James Chih-Hsin Yang Martin H Schuler Nobuyuki Yamamoto | 2012 | J Clin Oncol2012，，： | 1 |
| 11 | Transcription,apoptosis and p53:catch-22显示文摘 | Martin Schuler Douglas R Green | 2005 | Trends in Genetics2005，21，3： | 1 |
| 12 | MDR1 and ERCC1 Expression Predict Outcome of Patients with Locally Advanced Bladder Cancer Receiving Adjuvant Chemotherapy显示文摘 | Andreas-Claudius Hoffmann Peter Wild Christina Leicht Simone Bertz Kathleen D. Danenberg Peter V. Danenberg Robert St?hr Michael St?ckle Jan Lehmann Martin Schuler Arndt Hartmann | 2010 | Neoplasia2010，，： | 1 |
| 13 | Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients显示文摘 | Tobias P. Kunzler Tanja Drobek Martin Schuler Nicholas D. Spencer | 2007 | Biomaterials2007，，： | 1 |
| 14 | Interimanalysis of afa-tinib monotherapy in patients with metastatic NSCLC progressingafter chemotherapy and erlotinib/gefitinib ( E/G) in a trial ofafatinib pluspaclitaxel versus investigator’s choice chemotherapyfollowing progression onafatinib monotherapy 显示文摘 | MARTIN H SCHULER DP YANG JCH | 2012 | J Clin Oncol2012，，： | 1 |
| 15 | LUX-Lung 3: A randomized, open-label, phase Ⅲ study of afatinib versus peme- trexed and cisplatin as first-line treatment for patients with ad- vanced adenoearcinoma of the lung harboring EGFR-activating mutations显示文摘 | JAMES CY MARTIN H SCHULER | 2012 | J Clin Oncol2012，，： | 1 |
| 16 | Transcription, apoptosis and p53: catch-22 显示文摘 | Martin Schuler Green DR | 2005 | Trends In Genetics2005，21，3： | 1 |
| 17 | Symptom Control and Quality of Life in LUX-Lung 3: A Phase III Study of Afatinib or Cisplatin/Pemetrexed in Patients With Advanced Lung Adenocarcinoma With EGFR Mutations显示文摘 | James Chih-Hsin Yang Vera Hirsh Martin Schuler Nobuyuki Yamamoto Kenneth J. O’Byrne Tony S.K. Mok Victoria Zazulina Mehdi Shahidi Juliane Lungershausen Dan Massey Michael Palmer Lecia V. Sequist | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 18 | Regular Physical Exercise and Low-Fat Diet: Effects on Progression of Coronary Artery Disease显示文摘 | Gerhard Schuler Rainer Hambrecht Günter Schlierf Josef Niebauer Klaus Hauer Josef Neumann Eike Hoberg Arno Drinkmann Frank Bacher Martin Grunze Wolfgang Küibler | 1992 | Circulation1992，，1： | 1 |
| 19 | Randomized Sham-Controlled Trial of Renal Sympathetic Denervation in Mild Resistant Hypertension显示文摘 | Steffen Desch Thomas Okon Diana Heinemann Konrad Kulle Karoline R?hnert Melanie Sonnabend Martin Petzold Ulrike Müller Gerhard Schuler Ingo Eitel Holger Thiele Philipp Lurz | 2015 | Hypertension2015，，6： | 1 |
| 20 | TACCOS-A Thermography-assisted Combustion Control System for Waste Incinerators 显示文摘 | Schuler F Rampp F Martin J Wolfrum J | 1994 | Combustion and flame1994，99，： | 1 |
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