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| 1 | Pathophysiology of chronic pancreatitis显示文摘Chronic pancreatitis(CP)is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory parenchyma.Despite the heterogeneity in pathogenesis and involved risk factors,processes such as necrosis/apoptosis,inflammation or duct obstruction are involved.This fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas,deformation of the large ducts and severe changes in the arrangement and composition of the islets.These conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine functions.The prevalence of the disease is largely dependent on culture and geography.The etiological risk-factors associated with CP are multiple and involve both genetic and environmental factors.Throughout this review the M-ANNHEIM classification system will be used,comprising a detailed description of risk factors such as:alcohol-consumption,nicotineconsumption,nutritional factors,hereditary factors,efferent duct factors,immunological factors and miscellaneous and rare metabolic factors.Increased knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools,which potentially will help clinicians to diagnose CP at an earlier stage.However,in view of the multi factorial disease and the complex clinical picture,it is not surprising that treatment of patients with CP is challenging and often unsuccessful. | Christina Brock Lecia Mφller Nielsen Dina Lelic Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 11 |
| 2 | Isolation of rare circulating tumor cells in cancer patients by microchip technology 显示文摘 | Sunitha N Lecia V Shyamala M | 2007 | Nature2007，450，： | 1 |
| 3 | Efficacy of rociletinib (CO-1686) in plasma-genotyped T790M-positive non-small cell lung cancer (NSCLC) patients (pts)显示文摘 | Lecia S Jonathan W G Heather A W | 2015 | ASCO Annual Meet- ing Proceedings2015，，： | 1 |
| 4 | Phase I/II Study of AT-101 with Topotecan in Relapsed and Refractory Small Cell Lung Cancer显示文摘 | Rebecca Suk Heist Jerry Fain Bernard Chinnasami Waseem Khan Julian R. Molina Lecia V. Sequist Jennifer S. Temel Panos Fidias Valari Brainerd Lance Leopold Thomas J. Lynch | 2010 | Journal of Thoracic Oncology2010，，10： | 1 |
| 5 | Isolation of rare circulating tumor cells in cancer patients by microchip technology 显示文摘 | Sunitha N Lecia V Shyamala M | 2007 | Nature2007，450，7196： | 1 |
| 6 | Differences between opioids: pharmacological, experimental, clinical and economical perspectives显示文摘 | Asbj?rn M. Drewes Rasmus D. Jensen Lecia M. Nielsen Joanne Droney Lona L. Christrup Lars Arendt‐Nielsen Julia Riley Albert Dahan | 2012 | British Journal of Clinical Pharmacology2012，，1： | 1 |
| 7 | Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations显示文摘 | Lecia V. Sequist James Chih-Hsin Yang Nobuyuki Yamamoto Kenneth O’Byrne Vera Hirsh Tony Mok Sarayut Lucien Geater Sergey Orlov Chun-Ming Tsai Michael Boyer Wu-Chou Su Jaafar Bennouna Terufumi Kato Vera Gorbunova Ki Hyeong Lee Riyaz Shah Dan Massey Victori | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 8 | Genotypic and histological evolution of lung cancer acquiring resistance to egfr inhibitors显示文摘 | Lecia V Sequist | 2011 | Sci Transl Med2011，3，： | 1 |
| 9 | Pathogenic Role for Virus-Specific CD4 T Cells in Mice with Coronavirus-Induced Acute Encephalitis显示文摘 | Daniela Anghelina Lecia Pewe Stanley Perlman | 2006 | The American Journal of Pathology2006，，1： | 1 |
| 10 | Symptom Control and Quality of Life in LUX-Lung 3: A Phase III Study of Afatinib or Cisplatin/Pemetrexed in Patients With Advanced Lung Adenocarcinoma With EGFR Mutations显示文摘 | James Chih-Hsin Yang Vera Hirsh Martin Schuler Nobuyuki Yamamoto Kenneth J. O’Byrne Tony S.K. Mok Victoria Zazulina Mehdi Shahidi Juliane Lungershausen Dan Massey Michael Palmer Lecia V. Sequist | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 11 | Anti-inflammatory, antinociceptive, and sedating effects of lafoensia paeari aqueous extract 显示文摘 | De Matos Lecia G Santos Lucio da R Ferreira Reginaldo N | 2008 | Pharm Biol2008，46，5： | 1 |
| 12 | First-line gefitinib in patients with advanced non small cell lung cancer harboring somatic EGFR mutations显示文摘 | Lecia VS Renato GM | 2008 | J Clin Oncol2008，26，15： | 1 |
| 13 | First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations显示文摘 | Lecia VS Renato GM Spigel D | 2008 | J Clin Oncol2008，26，： | 1 |
| 14 | Isolation of rare circulating tumor cells in cancer patients by microchip technology显示文摘 | Sunitha N Lecia V Shyamala M | 2007 | Nature2007，450，7173： | 1 |
| 15 | Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations显示文摘 | Lecia V. Sequist James Chih-Hsin Yang Nobuyuki Yamamoto Kenneth O’Byrne Vera Hirsh Tony Mok Sarayut Lucien Geater Sergey Orlov Chun-Ming Tsai Michael Boyer Wu-Chou Su Jaafar Bennouna Terufumi Kato Vera Gorbunova Ki Hyeong Lee Riyaz Shah Dan Massey Victori | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 16 | Breast-Conserving Surgery for Breast Cancer显示文摘 | Lecia M | 2002 | Am Faro Physician2002，66，12： | 1 |
| 17 | The CTC-Chip: An Exciting New Tool to Detect Circulating Tumor Cells in Lung Cancer Patients显示文摘 | Lecia V. Sequist Sunitha Nagrath Mehmet Toner Daniel A. Haber Thomas J. Lynch | 2009 | Journal of Thoracic Oncology2009，，3： | 1 |
| 18 | Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With EGFR Mutations显示文摘 | Lecia V. Sequist James Chih-Hsin Yang Nobuyuki Yamamoto Kenneth O’Byrne Vera Hirsh Tony Mok Sarayut Lucien Geater Sergey Orlov Chun-Ming Tsai Michael Boyer Wu-Chou Su Jaafar Bennouna Terufumi Kato Vera Gorbunova Ki Hyeong Lee Riyaz Shah Dan Massey Victori | 2013 | Journal of Clinical Oncology2013，，27： | 1 |
| 19 | 机器人外科医生在没有人类医生的帮助下成功完成手术显示文摘人都会犯错。即使是经过多年强化训练、谨遵严苛治疗方案的医生也做不到万无一失。但是如果这些医生可以汇集他们的知识和经验,制定一套最佳的外科治疗标准,然后南机器来执行,又当如何? | Lecia Bushak 涂颀 | 2016 | 英语文摘2016，0，10： | 0 |
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