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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | 计算机辅助测试技术及其应用显示文摘计算机辅助测试 (CAT )技术是测量领域的前沿技术。文章阐述了CAT技术的发展对机械参数在线测量的影响。并运用德国的专用测量软件 ,用CAT技术对机械参数进行在线测量的例子 。 | 高晓康 Walter Stuetz Juergen Zech Karlheinz Schuler | 2001 | 计算机自动测量与控制2001，9，5： | 13 |
| 3 | Renal sympathetic denervation in therapy resistant hypertension-pathophysiological aspects and predictors for treatment success显示文摘Many forms of human hypertension are associated with an increased systemic sympathetic activity. Especially the renal sympathetic nervous system has been found to play a prominent role in this context. Therefore, catheterinterventional renal sympathetic denervation(RDN) has been established as a treatment for patients suffering from therapy resistant hypertension in the past decade. The initial enthusiasm for this treatment was markedly dampened by the results of the Symplicity-HTN-3 trial, although the transferability of the results into clinical practice to date appears to be questionable. In contrast to the extensive use of RDN in treating hypertensive patients within or without clinical trial settings over the past years, its effects on the complex pathophysiological mechanisms underlying therapy resistant hypertension are only partly understood and are part of ongoing research. Effects of RDN have been described on many levels in human trials: From altered systemic sympathetic activity across cardiac and metabolic alterations down to changes in renal function. Most of these changes could sustainably change long-term morbidity and mortality of the treated patients, even if blood pressure remains unchanged. Furthermore, a number of promising predictors for a successful treatment with RDN have been identified recently and further trials are ongoing. This will certainly help to improve the preselection of potential candidates for RDN and thereby optimize treatment outcomes. This review summarizes important pathophysiologic effects of renal denervation and illustrates the currently known predictors for therapy success. | Karl Fengler Karl Philipp Rommel Thomas Okon Gerhard Schuler Philipp Lurz | 2016 | World Journal of Cardiology2016，8，8： | 5 |
| 4 | 高龄老年心绞痛患者的介入治疗和外科手术治疗显示文摘目的 评价介入治疗(PCI)和外科手术(CABG)治疗老年(≥80岁)心绞痛患者的有效性和安全性。方法 回顾性分析4年间在莱比锡心脏中心连续就诊的老年心绞痛,接受PCI和CAN3治疗患者。观察终点为住院期间死亡、再次心肌梗死、再次血运重建。结果 共482例患者,分为PCI组281例,CABG组201例。糖尿病、高血压、肥胖症、既往心肌梗死史等在两组间无显著性差异。既往PCI、CABG史者在PCI组更多(20.6% vs 8.0%,P<0.05:10.096 vs 2.0%,P<0.05);而手术组左主干、3支病变比例较高(1.1% vs 7.5%,P<0.05;17.4% vs 62.2%,P<0.05)。住院期间两组复合终点事件无差异(9.6% vs 7.5%,P>0.05)。但外科手术死亡率稍高(3.2% vs7.5%),有一定比例的手术并发症。结论 老年心绞痛病人,接受PCI或CABG治疗是可行的,住院期间两组终点事件无差异。 | 张福春 J Niebauer 郭静萱 G Schuler 毛节明 | 2003 | 中华老年多器官疾病杂志2003，2，3： | 3 |
| 5 | WATCHMAN左心耳封闭系统用于房颤患者卒中预防的全球初步经验 | Sick P.B. Schuler G. Hauptmann K.E. 朱冰坡 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，0，8： | 3 |
| 6 | 骨骼肌诱导型一氧化氮合成酶基因表达和细胞凋亡在心力衰竭进展中的作用显示文摘目的 :探讨慢性充血性心力衰竭 ( CHF)患者骨骼肌中诱导型一氧化氮合成酶 ( i NOS)基因表达与反映 CHF进展指标及细胞凋亡的关系 ,进一步了解可能影响 CHF进展的因素 ,为临床 CHF的治疗提供理论依据。方法 :用反转录多聚酶链式反应 ( RT- PCR)以及脱氧核糖核酸转化酶分析方法分别测定 2 1例 CHF患者 (扩张型心肌病 14例 ,缺血性心肌病 7例 ) ,其中 NYHA分级 级 14例 , 级 7例及 8例健康人骨骼肌标本中 i NOS基因表达和细胞凋亡 ,用心肺功能测定仪对症状限制性最大氧耗 ( VO2 max)进行连续测定。结果 :健康人骨骼肌中无i NOS基因表达及细胞凋亡 ,而 2 1例 CHF患者中有 18例 ( 85 .7% )显示 i NOS表达。 NYHA 级者 i NOS基因表达较健康者有增高趋势 ,但差异无显著性意义 ( P >0 .0 5 ) ,而 NYHA 级者 i NOS基因表达显著高于 NYHA 级 ( P <0 .0 1)。 i NOS基因表达与 VO2 max呈显著负相关 ( r =- 0 .6,P <0 .0 1)。 i NOS基因高表达 ( i NOS/GAPDH率≥ 0 .3 )患者骨骼肌细胞凋亡率高于 i NOS基因中度表达 ( i NOS/ GAPDH率 <0 .3 )患者的骨骼肌细胞凋亡率 ,P <0 .0 1。结论 :i NOS基因表达与 NYHA分级和 VO2 max显著相关 ,i NOS基因表达可反映 CHF疾病进展 ,i NOS在 | 姜红 姜波 李裕舒 Adams V Hambrecht R Schuler G | 2001 | 临床心血管病杂志2001，17，10： | 3 |
| 7 | Modelling growing space of four valuable broadleaved tree species in southern China显示文摘We present management tools for growing four valuable broadleaved tree species,indigenous to subtropical southern China.Crown diameter(CD)of the species studied can be predicted very well by using a model that is solely a linear function of diameter at breast height(DBH).The addition of tree age(AGE)and yield class(YC)to this model did not significantly improve its predictive capacity.We used species-specific crown diameter models to calculate the amount of growing space and subsequently stand density that each species needs to achieve desired stem radial growth rates.Furthermore we used this information to calculate a'distance factor',a rule of thumb that roughly estimates the distance between two neighboring trees needed to achieve a desired future target diameter.These tools facilitate the planning of thinning regimes by using crown diameter models combined with annual radial growth rates to calculate the number of crop trees per hectare required to reach a desired target stem diameter. | Johanna SCHULER Josephine CUENI Heinrich SPIECKER Wen-Fu GUO | 2013 | Forestry Studies in China2013，15，3： | 3 |
| 8 | Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction显示文摘 | Ingo Eitel Volker Adams Patrick Dieterich Georg Fuernau Suzanne de Waha Steffen Desch Gerhard Schuler Holger Thiele | 2012 | American Heart Journal2012，，： | 2 |
| 9 | 人工全膝关节置换术截骨测量(英文)显示文摘[目的]作者对人工全膝关节置换术中股骨截骨方法进行了改良,增加了股骨后髁截骨厚度,本项研究通过截骨厚度的测量对改良截骨方法的手术效果进行了验证。[方法]对81例人工全膝关节置换术中的各向截骨骨块的厚度进行了测量,分为膝内翻和膝外翻两组,采用Student's t-test对截骨厚度和假体厚度进行了比较。[结果]总体截骨厚度在膝间隙和伸膝间隙均小于假体厚度。膝内翻组,外侧屈膝间隙存在微量的过度截骨;膝外翻组,内侧屈膝间隙存在微量的过度截骨。[结论]采用改良的股骨截骨方法,手术效果良好。 | 孙水 Udo Malzer Peter Schuler | 2008 | 中国矫形外科杂志2008，16，2： | 2 |
| 10 | Kontrastverst?rkte Sonografie (CEUS) zur Charakterisierung fokaler Leberl?sionen in der klinischen Routine (DEGUM-Multicenterstudie): CEUS vs. MRI – ein prospektiver Vergleich bei 269 Patienten显示文摘 | K. Seitz T. Bernatik D. Strobel W. Blank M. Friedrich-Rust H. Strunk C. Greis W. Kratzer A. Schuler | 2010 | Ultraschall in Med2010，，05： | 2 |
| 11 | 准分子激光与旋磨术在冠状动脉支架再狭窄治疗中的作用显示文摘目的比较准分子激光与旋磨及常规球囊对冠状动脉支架内再狭窄治疗的效果。方法将461例单支冠状动脉病变支架内再狭窄患者分别用准分子激光、旋磨术与常规球囊进行扩张治疗,并在治疗后即刻及6个月时再次行冠状动脉造影并进行定量分析。结果介入治疗前各组间支架内再狭窄情况无明显区别;准分子激光和旋磨后加PTCA即刻所获得的冠状动脉支架内最小血管直径(MLD)显著高于常规球囊治疗组(P<0.05),且旋磨与准分子激光组间无明显差异(P>0.05);6个月后准分子激光及旋磨组治疗组冠状动脉支架内血管直径明显低于常规球囊治疗组(P<0.05),且旋磨及准分子激光组无显著性差异(P>0.05)。旋磨与准分子激光及常规球囊治疗组支架内血管直径狭窄率分别为57.17%、54.78%及38.31%;准分子激光及旋磨组后期血管丢失量高于常规球囊治疗组(P<0.05)。结论准分子激光及旋磨对冠状动脉支架内再狭窄即刻疗效明显优于常规球囊治疗组,但6个月后支架内再狭窄率高于常规球囊治疗组,因而不宜首选用作支架内再狭窄的治疗。 | 祝宝华 Josef Niebauer Gerhard Schuler | 2007 | 实用临床医药杂志2007，11，1： | 2 |
| 12 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 13 | 旋磨术与切割球囊在冠状动脉支架再狭窄治疗中的作用显示文摘目的比较旋磨术与切割球囊及常规球囊对冠状动脉支架内再狭窄的疗效。方法将416例单支冠状动脉病变支架内再狭窄患者分别用旋磨术、切割球囊与常规球囊进行扩张治疗,在治疗即刻及6个月时再次行冠状动脉造影并进行定量分析。结果(1)介入治疗前各组间支架内再狭窄情况无明显区别。(2)旋磨后即刻所获得的冠状动脉支架内最小血管直径(MLD)最大(2.67±0.55mm,P<0.05),切割球囊与常规球囊治疗组差异无统计学意义(2.51±0.65mm比2.53±0.65mm,P>0.05)。(3)6个月后旋磨治疗组的冠状动脉支架内MLD最小(1.52±0.91mm,P<0.05),切割球囊组大于常规球囊治疗组,但差异无统计学意义(1.96±0.74mm比1.75±0.83mm,P>0.05)。旋磨术与切割球囊及常规球囊治疗组支架内血管直径狭窄率分别为54.78%,38.31%及46.50%。(4)旋磨治疗组后期血管丢失量最大(P<0.05),切割球囊组明显低于常规球囊治疗组(P<0.05)。结论旋磨术对冠状动脉支架内再狭窄即刻疗效显著,但远期疗效仍以经皮腔内冠状动脉成形术(PTCA)最佳。 | 祝宝华 Josef Niebauer Gerhard Schuler | 2006 | 中国介入心脏病学杂志2006，14，2： | 2 |
| 14 | Targeted therapies in gastroesophageal cancer显示文摘 | Stefan Kasper Martin Schuler | 2014 | European Journal of Cancer2014，，： | 2 |
| 15 | 新型洗涤助剂简述——适应环保要求的层状硅酸钠——多功能的漂白活化剂(英文)显示文摘4A沸石作为STPP的替代品 ,功能上有一些缺点 ,并在废水处理中有欠缺。层状硅酸盐与洗衣粉中的其他成分相容性很好 ,并显示出杰出的有效性。层状硅酸钠可以在下水道中水解 ,释放出硅酸和钠离子而不会造成固体沉积。主要用于粉状洗涤剂的层状硅酸钠有望扩大其应用领域。基于它能够使玻璃免受腐蚀的杰出能力 ,它还可以用做自动洗碗机洗涤粉中的多功能原料。过硼酸钠的有效性和合理的价格使其成为粉状洗涤剂中一广为应用的原料。由于过硼酸钠在低温下活性较低 ,而现代的许多纤维要求较低的洗涤温度。一些研究者试图用其他活性氧化物如过碳酸钠代替过硼酸钠 ,而另一些研究者则建议用金属螯合剂作为过硼酸钠的催化剂。这两种方法都未能真正有效。第三种方法 ,是通过使用第二种化学物质与过硼酸钠形成中间体 ,而降低其分解所需的较高的活化能 ,已被证明是有效的。在各种化合物中 ,TAED (四乙酰基乙二胺 )赢得了最大的市场。TAED在 1999年的消费量已达至 75 0 0 0t。TAED不仅被用于纺织品洗涤剂中 ,也用于自动洗碗机洗涤剂、清洁剂以及其他产品中。TAED的主要作用是作漂白活化剂 。 | Wilfried Schuler Bauer | 2000 | 日用化学品科学2000，23，S2： | 2 |
| 16 | Space durable polymeric films: Advanced materials for inflatable struc tures and thermal control Applications 显示文摘 | SCHULER P HAGHIGHAT R | 1999 | SAMPEJournal1999，5，35： | 2 |
| 17 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 18 | Genetic marker study ofdentinogenesis imperfecta 显示文摘 | Crall M G Schuler C F Buetow K H | 1992 | Proe Finn Dent Soc1992，88，1： | 1 |
| 19 | ST-segment resolution and prognosis after facilitated versus primary percutaneous coronary intervention in acute myocardial infarction:a meta-analysis显示文摘 | Eitel I Franke A Schuler G | 2010 | Clin Res Cardiol2010，99，1： | 1 |
| 20 | Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumours显示文摘 | Langer C Gunawan B Schuler P | 2003 | Br J Surg2003，90，3： | 1 |
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