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| 1 | Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type显示文摘AIM To report 3 of 120 patients on the German MALT lymphoma trial with H. pYlori-associated gastric MALT Iymphoma who developed early gastric cancer 4 and 5 years, after complete Iymphoma remission following cure of H. pylori infection.PATIENTS AND RESULTS Three patients (two men, 74 and 70 years; one women, 77 years)with H. pylori -associated low-grade MALTlymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years aftercomplete lymphoma remission in two patients,and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type Ⅱ a and type Ⅱ c, respectively, was detetcted,which were completely removed by endoscopic mucosa resection. in one patient, the gastric cancer was diagnosed at the same location as the previous. MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time.CONCLUSION These findings strengthen the importance of regular long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H.pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori. | Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer Birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 28 |
| 2 | Cyclin基因在胃癌患者及其第一代亲属中的表达(英文)显示文摘目的 CyclinD和CyclinE的异常表达常引起细胞周期调节异常而导致肿瘤。为阐明这些Cyclin基因在人体胃癌发生、发展过程中的作用 ,本文对 38例胃癌患者、2 9例胃癌的第一代亲属及 18例健康对照者进行了研究。方法 本研究对上述不同组别及相应的病理组织学表现 ,包括肠化生、萎缩、HP感染及胃炎的状况进行了Cyclin基因表达的研究 ,采取逆转录聚合酶链反应 (RT PCR)的方法。结果 胃癌组织中CyclinD2、D3和E的表达相对于癌旁正常组织明显增高 ,并且CyclinD2和D3的增高表达也发现于胃癌的第一代亲属中 (P <0 0 5 )。不同病理组织学改变 ,肠化生组织CyclinD2、D3和E的表达明显增高 ,胃粘膜萎缩仅CyclinD3表达增高 ,HP感染较未感染组CyclinD2、D3表达增高。但CyclinD1的表达状况与病理组织学改变无关。结论 本研究提示增高的CyclinD2、D3和E是胃癌变过程中的一个常见和早期事件 ,并且基因的异常表达可出现于胃癌患者的第一代亲属中。CyclinD1的表达与胃癌变过程中的临床及病理学变化无明显关系。 | 于君 Stephan Miehlke Matthias P.A.Ebert Daniel Szokodi B.Wehvnignh Peter Malfertheiner G Ehninger Ekkehard Bayerdoerfer | 2002 | Chinese Medical Journal2002，，5： | 2 |
| 3 | The bone marrow stem cell niche grows up : mesenchymal stem cells and macmphages move in 显示文摘 | Ehninger A Trumpp A | 2011 | J Exp Med2011，208，3： | 1 |
| 4 | On Systems of Rhetoric显示文摘 | Ehninger D | | 0，，03： | 1 |
| 5 | Allogeneic stem cell transplantation after a fludarabine/busulfan - based reduced-intensity conditioning in patients with myelodysplastic syndrome or secondary acute myeloid leukemia显示文摘 | Kroger N Bomhauser M Ehninger G | 2003 | Ann Hematol2003，82，： | 1 |
| 6 | Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice 显示文摘 | Fabel K Wolf SA Ehninger D | 2009 | Frontier in neuroscience2009，3，10： | 1 |
| 7 | CMV prophylaxis in hemato- poietic-cell transplantation显示文摘 | Chemaly RF Ullmann A J Ehninger G | 2014 | N Engl J Med2014，371，6： | 1 |
| 8 | Plasma vitamin E and (-carotene concertrations during radiochemotherapy preceding bone Marrow Transplantation显示文摘 | Clemens MR Ladner C Ehninger G | 1990 | Am J Clin Nutr1990，51，2： | 1 |
| 9 | Paradoxical effects of learning the Morris water maze on adult hippocampal neurogenesis in mice may be explained by a combination of stress and physical activity显示文摘 | EHNINGER D KEMPERMANN G | 2006 | Genes Brain Behav2006，5，1： | 1 |
| 10 | Regional effects of wheel running and environmental enrichment on cell genesis and microglia proliferation in the adult murine neocortex 显示文摘 | Ehninger D Kempernmnn G | 2003 | Cereb Cortex2003，13，8： | 1 |
| 11 | Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice显示文摘 | FabelK Wolf SA Ehninger D | 2009 | Front Neurosci2009，，3： | 1 |
| 12 | Additive effects of physical exercise and environmental enrichment on adult hippocampal neuro- genesis in miee 显示文摘 | Fabel K Wolf SA Ehninger D | 2009 | Front Neurosci2009，3，： | 1 |
| 13 | Fluconazole in the prophylaxis of fungal infection after bone marrow transplantation显示文摘 | Ehninger G Schuler HK Sarnow E | 1996 | Mycoses1996，39，78： | 1 |
| 14 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 15 | Safety and cost effectiveness of a 10 X109/L trigger for prophylactic platelet transfusions compared with the traditional 20 X109/L trigger: a prospective comparative trial_ in 105 patients with acute myeloid leukemia显示文摘 | Wandt H Frank M Ehninger G | 1998 | Blood1998，91，： | 1 |
| 16 | Allogeneic trans, plantation of CD34^+ selected hematopoietic cells-clinical problems and current challenges 显示文摘 | Platzbecker U Ehninger G Bomhauser M | 2004 | Leuk Lymphoma2004，45，3： | 1 |
| 17 | The clinical,quality of life,and economic consequences of chronic anemia and transfusion support in patients with myelodysplastic syndromes显示文摘 | Platzbecker U Hofbauer LC Ehninger G | | 0，，05： | 1 |
| 18 | Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies显示文摘 | Frank Kroschinsky Matthias Weise Thomas Illmer Mathias Haenel Martin Bornhaeuser Gert Hoeffken Gerhard Ehninger Ulrich Schuler | 2002 | Intensive Care Medicine2002，，9： | 1 |
| 19 | The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in显示文摘 | EHNINGER A TRUMPP A | 2011 | J Exp Med2011，208，3： | 1 |
| 20 | Gene and haplotype frequencies for the loci HLA-A,HLA-B,and HLA-DR based on over 13000 German blood donors显示文摘 | Müller CR Ehninger G Goldmann SF | 2003 | Hum Immunol2003，64，2： | 1 |
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