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| 1 | Population-level economic burden of lung cancer in China:Provisional prevalence-based estimations,2017-2030显示文摘Objective:Population-level economic burden is essential for prioritizing healthcare resources and healthcare budget making in the future.However,little is known about the economic burden of lung cancer in China.Methods:A prevalence-based approach was adopted to estimate the economic burden of lung cancer,including direct expenditure(medical and non-medical)and indirect cost(disability and premature death).Data on direct expenditure and work-loss days per patient in each year post-diagnosis were obtained from two primary surveys.Other parameters were obtained from literatures and official reports.Projections were conducted based on varying parameters.All expenditure data were reported in United States dollars(USD)using 2017 value(exchange rate:1 USD=6.760 CNY),with the discount rate of 3%.Results:The total economic burden of lung cancer was estimated to be 25,069 million USD in China in 2017(0.121%of gross domestic productivity,GDP).The estimated direct expenditure was 11,098 million USD,up to1.43%of total healthcare expenditure for China,covering 10,303 million USD and 795 million USD for medical and non-medical expenditure,respectively.The estimated indirect cost was 13,971 million,including 1,517 million USD due to disability and 12,454 million USD due to premature death.Under current assumptions,the projected total economic burden would increase to 30.1 billion USD,40.4 billion USD,and 53.4 billion USD in 2020,2025,and 2030,accounting for 0.121%,0.131%,and 0.146%of China's GDP,respectively.However,if China meets the United Nation sustainable development goal of reducing premature death from non-communicable diseases by one-third by 2030,the total economic burden in 2030 would be 31.9 billion USD,0.087%of China's GDP.Conclusions:The economic burden of lung cancer in China in 2017 is substantial and more likely to increase significantly in the future.Policy makers need to take urgent actions in budget making for health systems.The economic burden could be alleviated by reducing the disease burden of lung cancer via effective control and prevention actions. | Chengcheng Liu Jufang Shi Hong Wang Xinxin Yan Le Wang Jiansong Ren Mark Parascandola Wanqing Chen Alin Dai | 2021 | Chinese Journal of Cancer Research2021，33，1： | 6 |
| 2 | Targeted prostate biopsy: value of multiparametric magnetic resonance imaging in detection of localized cancer显示文摘前列腺癌症是在人的第二很普通的癌症,与一最近的年里的世界健康组织全球报导的 110 万个新案例。指导活体检视被用于的 Transrectal 超声(TRUS ) 为超过 2 十年的前列腺癌症的诊断,而是这种技术对癌症通常盲目地点。而且, TRUS 活体检视的假否定的率被报导了象 47% 一样高。Multiparametric 磁性的回声成像(mp-MRI ) 包括 T1 加权、 T2 加权的成像象一样动态提高对比(数据通信设备) 并且散开加权的成像(DWI ) 。mp-MRI 是在前列腺癌症的成像的主要进展,启用可疑损害的指向的活体检视。演变指向的活体检视 techniques—包括的直接在里面厌烦活体检视,认知熔化和基于软件的 MRI 超声(MRI 美国) fusion—与更早的方法相比在癌症察觉导致了好几倍的改进。重要地,临床上重要的癌症的察觉被指向极大地便于,与系统的活体检视相比独自一个。经由 MRI 美国熔化的指向的活体检视可以戏剧性地改变前列腺癌症被诊断并且设法的方法。 | Jesse D Le Jiaoti Huang Leonard S Marks | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 3 | Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects显示文摘 | MyPhuong T. Le Reginald F. Frye Christopher J. Rivard Jing Cheng Kim K. McFann Mark S. Segal Richard J. Johnson Julie A. Johnson | 2012 | Metabolism2012，，5： | 1 |
| 4 | Distribution and Generation of the Overpressure System, Eastern Delaware Basin, Western Texas and Southern New Mexico 显示文摘 | Ming Luo Mark R Baker David V Le Mon | 1994 | AAPG Bulletin1994，78，9： | 1 |
| 5 | Immunocamouflage of latex surfaces by grafted methoxypoly(ethylene glycol)(mPEG):Proteomic analysis of plasma protein adsorption显示文摘Grafting of methoxypoly(ethylene glycol)(mPEG) to cells and biomaterials is a promising non-pharmacological immunomodulation technology.However,due to the labile nature of cells,surface-plasma interactions are poorly understood;hence,a latex bead model was studied.PEGylation of beads resulted in a density and molecular weight dependent decrease in total adsorbed protein with a net reduction from(159.9±6.4) ng cm-2 on bare latex to(18.4±0.8) and(52.3±5.3) ng cm-2 on PEGylated beads(1 mmol L-1 of 2 or 20 kD SCmPEG,respectively).SDS-PAGE and iTRAQ-MS analysis revealed differential compositions of the adsorbed protein layer on the PEGylated latex with a significant reduction in the compositional abundance of proteins involved in immune system activation.Thus,the biological efficacy of immunocamouflaged cells and materials is mediated by both biophysical obfuscation of antigens and reduced surface-macromolecule interactions. | LE Yevgeniya LI Li WANG DunCheng SCOTT Mark D | 2012 | Science China(Life Sciences)2012，55，3： | 1 |
| 6 | Visualization of the distal intra temporal facial nerve with MR imaging:use of an oblique plane显示文摘 | Mark LP Yetkin FZ Hendrix LE | 1992 | Radiology1992，18，2： | 1 |
| 7 | Brighter noise: sensory enhance- ment of perceived loudness by concurrent visual stimulation显示文摘 | Odgaard EC Arieh Y Marks LE | 2004 | Cogn Affect Behav Neurosci2004，4，2： | 1 |
| 8 | Investigation of the effect of three sprue designs on the porosity and the completeness of titanium cast removable partial denture frameworks显示文摘 | Al-Mesmar HS Morgano SM Mark LE | 1999 | J Prosthet Dent1999，82，1： | 1 |
| 9 | Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy显示文摘 | Susan F. Plummer Iveta Garaiova Tinnu Sarvotham Simon L. Cottrell Stephanie Le Scouiller Mark A. Weaver James Tang Philippa Dee John Hunter | 2005 | International Journal of Antimicrobial Agents2005，，1： | 1 |
| 10 | The inflammatory response in myocardial infarction显示文摘 | Nikolaos GF Smith CW Mark LE | 2002 | Cardiovasc Res2002，53，1： | 1 |
| 11 | Efficacy and complications of covered Wallstents in malignant distal biliary obstruction <ce:link locator='fx1'/>显示文摘 | Michel Kahaleh Jeffrey Tokar Mark R. Conaway Andrew Brock Tri Le Reid B. Adams Paul Yeaton | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 12 | Comparison of patient- centered outcomes after laparoscopic Nissen fundoplication for gastroesophageal reflux disease or paraesophageal hernia 显示文摘 | Mark LA Okrainec A Ferri LE | 2008 | Surg Endosc2008，22，2： | 1 |
| 13 | The inflammatory response in myocardial infarction显示文摘 | Rangogiannis NG Smith CW Mark LE | 2002 | Cardiovasc Res2002，53，： | 1 |
| 14 | Investigation of the effect of three sprue designs on the porosity and the completeness of titanium cast removable partial denture frameworks显示文摘 | Al-Mesmar HS Morgano SM Mark LE | 1999 | J Prosthet Dent1999，82，1： | 1 |
| 15 | Repeated expo-sure to corticosterone increases depression-like behavior in two different versions of the forced swim test without ahe- ring nonspecific locomotor activity or muscle strength 显示文摘 | Marks W Fournier NM Kalynchuk LE | 2009 | Physiol Behav2009，98，12： | 1 |
| 16 | The Moderating Effects ofExtemal Monitors on the Relationship between R&D Spending and Firm Performance 显示文摘 | Son Anh Le Bruce Waiters Mark Kroll | 2006 | Journal of Business Research2006，，59： | 1 |
| 17 | Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model显示文摘 | Vincent E. de Meijer Hau D. Le Jonathan A. Meisel M. Reza Akhavan Sharif Amy Pan Vania Nosé Mark Puder | 2010 | Metabolism2010，，8： | 1 |
| 18 | Implanted adipose progenitor cells as physicochemical regulators of breast cancer显示文摘 | Emily M. Chandler Bo Ri Seo Joseph P. Califano Roberto C. Andresen Eguiluz Jason S. Lee Christine J. Yoon David T. Tims James X. Wang Le Cheng Sunish Mohanan Mark R. Buckley Itai Cohen Alexander Yu Nikitin Rebecca M. Williams Delphine Gourdon Cynthia A. R | 2012 | Proceedings of the National Academy of Sciences2012，，25： | 1 |
| 19 | Brighter noise: sensory enhancement of perceived loudness by concurrent visual stimulation 显示文摘 | Odgaard EC Arieh Y Marks LE | 2004 | Cogn Affect Behav Neurosci2004，4，： | 1 |
| 20 | Cancer Risks for MLH 1 and MSH 2 Mutation Carriers显示文摘 | James G. Dowty Aung K. Win Daniel D. Buchanan Noralane M. Lindor Finlay A. Macrae Mark Clendenning Yoland C. Antill Stephen N. Thibodeau Graham Casey Steve Gallinger Loic Le Marchand Polly A. Newcomb Robert W. Haile Graeme P. Young Paul A. James Graham G. | 2013 | Human Mutation2013，，3： | 1 |
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