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| 1 | Breeding wheat for drought tolerance: Progress and technologies显示文摘Recurrent drought associated with climate change is among the principal constraints to global productivity of wheat(Triticum aestivum(L.) and T. turgidum(L.)). Numerous efforts to mitigate drought through breeding resilient varieties are underway across the world. Progress is, however, hampered because drought tolerance is a complex trait that is controlled by many genes and its full expression is affected by the environment. Furthermore, wheat has a structurally intricate and large genome. Consequently, breeding for drought tolerance requires the integration of various knowledge systems and methodologies from multiple disciplines in plant sciences. This review summarizes the progress made in dry land wheat improvement, advances in knowledge, complementary methodologies, and perspectives towards breeding for drought tolerance in the crop to create a coherent overview. Phenotypic, biochemical and genomics-assisted selection methodologies are discussed as leading research components used to exploit genetic variation. Advances in phenomic and genomic technologies are highlighted as options to circumvent existing bottlenecks in phenotypic and genomic selection, and gene transfer. The prospects of further integration of these technologies with other omics technologies are also provided. | Learnmore Mwadzingeni Hussein Shimelis Ernest Dube Mark D Laing Toi J Tsilo | 2016 | Journal of Integrative Agriculture2016，15，5： | 6 |
| 2 | Unreliability of aortic size index to predict risk of aortic dissection in a patient with Turner syndrome显示文摘Aortic size index(ASI) has been proposed as a reliable criterion to predict risk for aortic dissection in Turner syndrome with significant thresholds of 20-25 mm/m2. We report a case of aortic arch dissection in a patient with Turner syndrome who, from the ASI thresholds proposed, was deemed to be at low risk of aortic dis-section or rupture and was not eligible for prophylactic surgery. This case report strongly supports careful monitoring and surgical evaluation even when the ASI is < 20 mm/m2 if other significant risk factors are present. | Jan Nijs Sandro Gelsomino Fabiana Lucà Orlando Parise Jos G Maessen Mark La Meir | 2014 | World Journal of Cardiology2014，6，5： | 3 |
| 3 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 4 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat显示文摘 | Ramesh V. Kantety Mauricio La Rota David E. Matthews Mark E. Sorrells | 2002 | Plant Molecular Biology2002，，5： | 2 |
| 5 | Significance of the balance between intracellular glutathione and polyethylene glycol for successful release of small interfering RNA from gold nanoparticles显示文摘为特定的基因 silencing 的小介入 RNA (siRNAs ) 的治疗学的诺言依赖于到细胞质的功能的 siRNAs 的成功的交货。他们到一个确定的交货平台的变化形式例如金 nanoparticles,为治疗疾病并且推进我们细胞的过程的理解提供巨大的潜力。他们的成功或失败依赖于两个进房间和功能的 siRNA 的随后的细胞内部的版本的 nanoparticles 的举起。在这研究,利用金 nanoparticle 对 C-MYC 的 调停siRNA 的交货,我们试图决定我们是否能完成在一个癌症房间击倒与细胞内部的谷胱甘肽的底层排队,并且如果有的话,聚乙烯乙二醇(木钉)决定影响 ligand 密度在上击倒,考虑到决定最佳的 nanoparticle 设计完成 C-MYC 击倒。我们表明那,不管木钉密度,在有相对低的谷胱甘肽层次的房间击倒能被完成,以及为在细胞内部的环境的劈开的 siRNA 的可获得性上的木钉的位的阻碍者的可能的效果。当击倒时,金 nanoparticle 举起经由传播电子显微镜学和集体光谱学被表明被在里面房间 westerns 和 BrdU 加入分别地在蛋白质和生理的层次(在 S 阶段的房间) 决定。 | Mark McCully Yulan Hernandez Joao Conde Pedro V. Baptista Jesus M. de la Fuente Andrew Hursthouse David Stirling Catherine C. Berry | 2015 | Nano Research2015，8，10： | 2 |
| 6 | Utilisation du fluor chez les enfants:recoendations de 1 European Academy for Paediatric Dentistry显示文摘 | Martens LC | 1998 | Rev Belg Med Dent1998，，： | 1 |
| 7 | Serotonin and central nervous system fatigue: nutritional considerations 显示文摘 | Mark D Nathan LA Ralph SW | 2000 | Am J Clin Nutr2000，72，2： | 1 |
| 8 | Increased cyclooxygenase -2 expression in juvenile polyposis syndrome 显示文摘 | van Hattem WA Brosens LA Marks SY | 2009 | Clin Gastroenterol Hepatol2009，7，1： | 1 |
| 9 | Respiratory syncytial virus puzzle : clinical features, pathophysiology, treatment, andprevention显示文摘 | La Via WV Marks MI Stutman HR | 1992 | J pediatr1992，121，4： | 1 |
| 10 | Excess costs of medical care 1 and 8 years after diagnosis of diabetes: estimates from young and middle-aged incidence cohorts in Sweden 显示文摘 | Jonsson PM Marke LA Nystrom L | 2000 | Diabetes Research and Clinical Practice2000，50，： | 1 |
| 11 | EAU 2004 Guidelines on Assessment, Therapy and Follow-Up of Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction (BPH Guidelines)显示文摘 | Stephan Madersbacher Gerasimos Alivizatos Jorgen Nordling Carlos Rioja Sanz Mark Emberton Jean J.M.C.H. de la Rosette | 2004 | European Urology2004，，5： | 1 |
| 12 | Aptamer: toxin conjugates that specifically target prostate tumor cells 显示文摘 | Chu TC Marks JW Lavery LA | 2006 | Cancer Res2006，66，： | 1 |
| 13 | Staged repair of pentalogy of Cantrell with tetralogy of Faltot 显示文摘 | Abdallab HI Marks LA Balsara RK | 1993 | Ann Thorac Surg1993，56，4： | 1 |
| 14 | Inhibition of nitric oxide synthase reduces renal ischemia/reperfusion injury 显示文摘 | Mark LA Robinson AV Schlak JA | 2005 | J Surg Res2005，129，2： | 1 |
| 15 | Asymptomatic primary hyperparathyroidism: a surgical perspective显示文摘 | MARK LA PASIEKA JL | 2004 | Surg Clin North Am2004，84，3： | 1 |
| 16 | The Limitations of Spatial Land Use Data in Environmental Analysis显示文摘 | Christian Schmit Mark DA Rounsevell Isidore La jeunesse | 2006 | Environmental Science & Policy2006，9，2： | 1 |
| 17 | Conservative interproximal boxonly polyacid modified composite reslorations in pfimary molars,twelve-month clinical results显示文摘 | Marks LA Ameongen WE Kreulen CM | 1999 | J Dent Child1999，66，1： | 1 |
| 18 | Aptamer:toxin conjugates that specifically target prostate tumor cells显示文摘 | Chu TC Marks JW Lavery LA | 2006 | Cancer Res2006，66，12： | 1 |
| 19 | Comparison of patient- centered outcomes after laparoscopic Nissen fundoplication for gastroesophageal reflux disease or paraesophageal hernia 显示文摘 | Mark LA Okrainec A Ferri LE | 2008 | Surg Endosc2008，22，2： | 1 |
| 20 | Discrepant and congruent high self-esteem:Behavior self-handicapping as a preemptive defensive strategy显示文摘 | SHANNON PL MARK DS JESSICA LA | 2010 | J Exper Soc Psychol2010，46，1： | 1 |
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