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| 1 | Effects of Jianpi Jiedu Recipe (健脾解毒方)on Reversion of P-Glycoprotein-Mediated Multidrug Resistance through COX-2 Pathway in Colorectal Cancer显示文摘Objective:To evaluate the underlying mechanism of Jianpi Jiedu Recipe(健脾解毒方,JJR)in the reversion of multidrug resistance concerning colorectal cancer in vitro and in vivo.Methods:Mice were treated orally with JJR at a daily 4.25 g/(kg-day)or injected with vinblastine(VCR)2.5 mg/(kg·day)for 3 weeks after having been inoculated with HCT8/V cells;tumor tissues were assayed by hematoxylin and eosin staining.Firstly,the effects of JJR on the expression of cyclooxygenase-2(COX-2)were tested by real-time polymerase chain reaction(PCR)technique and COX-2 gene silenced by siRNA.Secondly,the variation of intracellular concentration of oxaliplatin(L-OHP)was evaluated by the inductively coupled plasma mass spectroscopy(ICPMS)in HCT8/V and its COX-2 siRNA cells;the concentration of JJR combined with chemotherapeutic drugs and the reverse effect of multidrug resistance(MDR)in HCT8/V cells was evaluated by the MTT assay.Thirdly,real-time quantitative PCR and Western blot analysis were used to detect the multidrug resistance gene 1(MDR1)mRNA and P-gp expression.Results:JJR had an inhibitory effect on the growth of tumors in vivo,and it,in combination with chemotherapeutic drugs,could reverse the drug-resistance of HCT8/V cells and increase the sensitivity of HCT8/V cells to VCR,DDP,5-Fu,and THP.ICP-MS results showed that JJR could increase the concentration of drugs in HCT8/V cells(P<0.01).Furthermore,it was shown that JJR could reverse drug resistance of colorectal cancer cells by decreasing MDR1 expression and P-gp level via downregulation of COX-2,which has been represented as one of the major mechanisms that contributes to the MDR phenotype(P<0.01).Conclusion:JJR reversed multidrug resistance and enhanced the sensitivity to chemotherapy,which could be attributed to the down-regulation of COX-2 in MDR1/P-gp-mediated MDR colorectal cancer after chemotherapy. | 隋华 朱惠蓉 吴杰 NIKITIN Alexander Yu 蔡健锋 范忠泽 李琦 | 2014 | Chinese Journal of Integrative Medicine2014，20，8： | 15 |
| 2 | 铝基细化剂和变质剂的遗传性对A356.2合金组织和性能的影响显示文摘对我国工业上常用的细化剂和变质剂Al Ti、Al Ti B和Al Sr等中间合金与俄罗斯萨马拉国立工业大学开发生产的细结晶体 (Fine crystalline)晶粒细化剂和变质剂的组织形貌进行了比较 ,并研究了它们的组织遗传效应对A3 5 6 2合金组织和性能的影响。研究表明 ,Al Ti中间合金中的金属间化合物的形状由传统的粗针状转变为细结晶体中的块状。细结晶体添加剂比传统的效果更好 ,它们的高效性依赖于本身细结晶体组织的遗传性。添加小于 0 5 %的细结晶体中间合金即可使得A3 5 6 2合金的伸长率提高 8%~ 2 0 %。 | 熊玉华 张燕飞 李培杰 曾大本 Nikitin V.I. Kandalova E.G. | 2002 | 铸造2002，51，10： | 2 |
| 3 | New generation 3-dimensional echocardiography for left ventricular volumetric and functional measurements:comparison with cardiac magnetic resonance显示文摘 | Nikitin NP Constantin C Loh PH | 2006 | Eur J Echocardiogr2006，7，5： | 1 |
| 4 | The prevalence of heart failure and asymptomatic left ventricular dysfunction in a typical gional pacemaker population显示文摘 | Thackray SDR Witte KKA Nikitin NP | 2003 | Eur Heart J2003，24，： | 1 |
| 5 | The effect of heat and pressure on certain physical properties of diamonds显示文摘 | Nikitin A V Samoilovich M I Bezrukov G N | 1969 | Soviet Physics Doklady1969，13，9： | 1 |
| 6 | Effect of Al powder content on SHS Al Ti grain refiner 显示文摘 | KANDALOVA E G NIKITIN V I WANQI Jie | 2002 | Materials Letters2002，54，： | 1 |
| 7 | Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice显示文摘 | Utomo ARH Nikitin AY Lee WH | 1999 | Nature Biotech1999，17，： | 1 |
| 8 | The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population显示文摘 | Thackray S D Witte K K Nikitin N P | 2003 | Eur Heart J2003，24，12： | 1 |
| 9 | Power reflection coefficient analysis for complex impedances in RFID tag design显示文摘 | Nikitin P Rao K Lam S | 2005 | IEEE Transactions on Microwave Theory and Techniques2005，53，9： | 1 |
| 10 | Antenna design for UHF RFID tags: a review and a practical application显示文摘 | RAO K V S NIKITIN P V LAM S F | 2005 | IEEE Transactions on Antennas and Propagation2005，53，12： | 1 |
| 11 | Oscillations of the inertia moment of a finite Fermi system in the cranking model framework显示文摘 | KHAMZIN A A NIKITIN A S SITDIKOV A S | 2013 | Theoretical and Mathematical Physics2013，176，3： | 1 |
| 12 | New type of biosensor based on magnetic nanoparticle detection显示文摘 | Nikitin P I Vetoshko P M Ksenevicha T I | 2007 | Journal of Magnetism and Magnetic Materials2007，311，： | 1 |
| 13 | Pathway studio - the analysis and nav- igation of molecular networks 显示文摘 | Nikitin A Egorov S Daraselia N | 2003 | Bioinformatics2003，19，16： | 1 |
| 14 | The role of social approach and avoidance motives for subjective well- being and the successful transition to adulthood 显示文摘 | Jana Nikitin Alexandra M Freund | 2008 | Applied Psychology2008，57，1： | 1 |
| 15 | Control of locomotor activity in humans and animals in the absence of supraspinal influences 显示文摘 | Gerasimenko Y P Makarovskii A N Nikitin O A | 2002 | Neurosci Behav Physiol2002，32，4： | 1 |
| 16 | Antenna design for UHF RFID tags: A review and a practical application 显示文摘 | Seshagiri K V Nikitin P V Sander F L | 2005 | IEEE Transactions on Antennas and Propagation2005，53，12： | 1 |
| 17 | Prognostic value of systolic mitral annular velocity measured with Doppler tissue imaging in patients with chronic heart failure caused by left ventricular systolic dysfunction显示文摘 | Nikitin NP Loh PH Silva R | 2006 | Heart2006，92，6： | 1 |
| 18 | Low Cost Silver Ink RFID Tag Antennas显示文摘 | NIKITIN P V LAM S RAO K V S | 2005 | Proceedings of IEEE Antennas and Propagation Society International Symposium2005，2，： | 1 |
| 19 | Surface plasmon resonance bio- and chemical sensors with phase-polarisation contrast显示文摘 | KABASHIN A V KOCHERGIN V E NIKITIN P I | 1999 | Sensors & Actuators: B Chemical1999，54，1： | 1 |
| 20 | Heat transfer and pressure drop correlations of microchannel heat exchangers with S-shaped and zigzag fins for carbon dioxide cycles显示文摘 | Tri Lam Ngo Yasuyoshi Kato Konstantin Nikitin Takao Ishizuka | 2007 | Experimental Thermal and Fluid Science2007，，2： | 1 |
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