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301篇 您的检索式：作者名="Califano"

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	题名	作者	年代	出处	被引量
1	肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.	Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone	2010	中华神经外科疾病研究杂志2010，9，1：	16
2	High frequency of p16 (CDKN2/MTS - 1/INK4A) inactivation in head and neck squamous cell carcinoma 显示文摘	REED A L CALIFANO J CAIRNS P	1996	Cancer Res1996，56，16：	1
3	Effect of freezing conditions on functional properties of low moisture Mozzarella cheese 显示文摘	Bertola N C Califano A N Bevilacqua A E	1996	J Dairy Sci1996，79，2：	1
4	Anterior cranial base reconstruction using free tissue transfer:changing trends显示文摘	Califano J Cordeiro PG Disa JJ	2003	Head Neck2003，25，2：	1
5	Laparo-endoscopic single site cholecystectomy versus standard laparoscopic cholecysteetomy: results of a pilot randomized trial 显示文摘	Liriei MM Califano AD Angelini P	2011	Am J Surg2011，202，1：	1
6	Tumor growth dependent on kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate显示文摘	Wellstein A Zugmaier G Califano JA	1991	J Natl Cancerlnst1991，83，10：	1
7	High frequency of p16 ( CD- KN2/MTS - 1/INK4A ) inactivation in head and neck squamous cell carcinoma显示文摘	Reed AL Califano J Calms P ct al	1996	Cancer Res1996，56，16：	1
8	Effect of freezing conditions on functional properties of low moisture Mozzarella cheese显示文摘	BERTOLA N C CALIFANO A N BEVILACQUA A E	1996	J Dairy Sci1996，79，2：	1
9	Multidimensional indexing for recognizing visual shapes显示文摘	Califano A Mohan R	1991	IEEE transactions on Pattern Analysis and Machine Intelligence1991，16，4：	1
10	Fingerprint matching using transformation parameter clustering 显示文摘	Germain R S Califano A Colville S	1997	IEEE Computational Science & Engineering1997，4，4：	1
11	Management of small cell lung cancer: recent developments for optimal care显示文摘	Califano R Abidin AZ Peck R	2012	Drugs2012，，：	1
12	Effect of freezing conditions on functional properties of low moisture Mozzarella cheese显示文摘	BERTOLA N C CALIFANO A N BEVILACQUA A E	1996	J Dairy Sci1996，79，2：	1
13	Clinical impor- tance of thrombomodulin serum levels 显示文摘	Califano F Giovanniello T Pantone P	2000	Eur Rev Med Pharmacol Sci2000，4，3：	1
14	The current and future role of the medical oncologist in the professional care for cancer patients: a position paper by the European Society for Medical Oncology (ESMO)显示文摘	Popeseu RA Schifer R Califano R	2014	Ann Oncol2014，25，1：	1
15	Implantedadipose progenitor cells as physicochemicalregulators of breast cancer显示文摘	Chandler EM Seo BR Califano JP	2012	Proc Natl Acad SciUSA2012，109，25：	1
16	Trends in incidence and prognosis for head and neck cancer in the United States:a site-specific analysis of the SEER database显示文摘	CARVALHO A I NISHIMOTO I N CALIFANO J A	2005	Int J Cancer2005，114，：	1
17	Diffusion of sodium chloride in pork tissue显示文摘	GRAIVER N PINOTTI A CALIFANO A	2006	Journal of Food Engineering2006，77，4：	1
18	Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma显示文摘	Challa-Malladi M Lieu YK Califano O	2011	Cancer Cell2011，20，6：	1
19	Treatment of benign paroxysmal positional ver tigo of posterior semicircular canal by 'Quick Libera- tory Rotation Manoeuvre'显示文摘	CALIFANO L CAPPARUCCIA P G DI MARIA D	2003	Acta Otorhinolaryngol Ital2003，23，：	1
20	Partial dehydration and cryopreservation of eitrus seeds 显示文摘	Graiver N Califano A Zaritzky N	2011	Journal of the Seienee of Food and Agrieuhure2011，91，14：	1

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