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| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | Potential antibacterial activity of berberine against multi drug resistant enterovirulent Escherichia coli isolated from yaks(Poephagus grunniens) with haemorrhagic diarrhoea显示文摘Objective:To evaluate the antimicrobial efficacy of berberine,a plant alkaloid.Methods:Five multi-drug resistant(MDR) STEC/EPEC and five MDR ETEC isolates from yaks with haemorrhagic diarrhoea were selected for the study.Antibacterial activity of berberine was evaluated by broth dilution and disc diffusion methods.The binding kinetics of berberine to DNA and protein was also enumerated.Results:For both categories of enterovirulent Escherichia coli(E.roli) isolates, berberine displayed the antibaclerial effect in a dose dependent manner.The MIC50 of berberine chloride for STEC/EPEC isolates varied from 2.07μM to 3.6μM with a mean of(2.95±0.33)μM where as for ETEC strains it varied from 1.75 to 1.96μM with a mean of(1.87±0.03)μM. Berberine bind more tightly with double helix DNA with Bmax and Kd of(24.68±2.62) and(357.8±57.8),respectively.Berberine reacted with protein in comparatively loose manner with Bmax and Kd of(18.9±3.83) and <286.2±113.6),respectively.Conclusions:The results indicate clearly that berberine may serve as a good antibacterial against multi drug resistant E.coli. | Samiran Bandyopadhyay Pabitra H Patra Achintya Mahanti Dipak K Mondal Premanshu Dandapat Subhasis Bandyopadhyay Indranil Samanta Chandan Lodh Asit K Bera Debasish Bhattacharyya Mihir Sarkar Kishore K Baruah | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 11 |
| 3 | Burden of care in caregivers of patients with alcohol use disorder and schizophrenia and its association with anxiety, depression and quality of life显示文摘Background Caregivers play a pivotal role in providing care for mentally ill patients.Increase in caregiver burden can make them vulnerable to mental illness themselves.Aims We assessed the severity of burden of care and its association with depression,anxiety and quality of life among caregivers of patients with alcohol use disorder(AUD)and schizophrenia.Methods This was an observational,cross-sectional,single-centred study of 50 consecutive caregivers of patients with AUD and schizophrenia.Participants were recruited from the psychiatry outpatient department of a tertiary care hospital between January and June 2017.The caregivers were further assessed by demographic details,Hospital Anxiety Depression Scale for assessment of depression and anxiety,Zarit Burden Interview for assessment of caregiver burden and WHO Quality Of Life-BREF for assessment of quality of life.Statistical data were analysed using GraphPad InStat V.3.06(California).Multiple linear regression analysis was applied to identify the predictors of caregiver burden.Results Burden of care experienced by caregivers of patients with AUD is as high as that of caregivers of patients with schizophrenia(U=1142.5,p=0.46).Caregivers experiencing high burden of care are likely to have symptoms of anxiety(U=22,p<0.001),depression(U=32,p<0.001)and poor quality of life(U=84.5,p<0.001).Female caregivers are likely to experience higher burden of care(U=819.5,p=0.006).For caregivers of patients with schizophrenia,anxiety,environmental health,socioeconomic status and patients,occupation can predict burden of care,while for caregivers of patients with AUD,depression and environmental health can predict burden of care.Conclusion Our study suggests that caregivers of patients with AUD experience burden of care as high as that of caregivers of patients with schizophrenia.Caregivers with high burden of care are more likely to have depression,anxiety and poor quality of life.Trial registration number CTRI/2017/03/008224. | Sneha Vadher Rishi Desai Bharat Pancha Ashok Vala Imran Jahangirali Ratnani Mihir P Rupani Kinjal Vasava | 2020 | General Psychiatry2020，33，4： | 7 |
| 4 | Corporate tax avoidance and high-powered incentives显示文摘 | Mihir A. Desai Dhammika Dharmapala | 2005 | Journal of Financial Economics2005，，1： | 7 |
| 5 | Safety and Efficacy of Radiofrequency Ablation in the Management of Unresectable Bile Duct and Pancreatic Cancer: A Novel Palliation Technique显示文摘 | Paola Figueroa-Barojas Mihir R. Bakhru Nagy A. Habib Kristi Ellen Jennifer Millman Armeen Jamal-Kabani Monica Gaidhane Michel Kahaleh Jose G. de la Mora-Levy | 2013 | Journal of Oncology2013，，： | 5 |
| 6 | Utility of arthroscopic guided synovial biopsy in understanding synovial tissue pathology in health and disease states显示文摘The synovium is the soft tissue lining diarthrodial joints, tendon sheaths and bursae and is composed of intimal and subintimal layers. The intimal layer is composed of type A cells(macrophages) and type B cells(fibroblasts); in health, the subintima has few inflammatory cells. The synovium performs several homeostatic functions and is the primary target in several inflammatory arthritides. Inflammatory states are characterised by thickening of the synovial lining, macrophage recruitment and fibroblast proliferation, and an influx of inflammatory cells including lymphocytes, monocytes and plasma cells. Of the various methods employed to perform synovial biopsies arthroscopic techniques are considered the 'gold standard', and have an established safety record. Synovial biopsy has been of critical importance in understanding disease pathogenesis and has provided insight into mechanisms of action of targeted therapies by way of direct evidence about eventsin the synovial tissue in various arthritides. It has been very useful as a research tool for proof of concept studies to assess efficacy and mechanisms of new therapies, provide tissue for in vitro studies, proteomics and microarrays and allow evaluation for biomarkers that may help predict response to therapy and identify new targets for drug development. It also has diagnostic value in the evaluation of neoplastic or granulomatous disease or infection when synovial fluid analysis is noncontributory. | Mihir D Wechalekar Malcolm D Smith | 2014 | World Journal of Orthopedics2014，5，5： | 4 |
| 7 | “Zero Ischemia” Partial Nephrectomy: Novel Laparoscopic and Robotic Technique显示文摘 | Inderbir S. Gill Manuel S. Eisenberg Monish Aron Andre Berger Osamu Ukimura Mukul B. Patil Vito Campese Duraiyah Thangathurai Mihir M. Desai | 2010 | European Urology2010，，1： | 3 |
| 8 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 9 | LAPAROSCOPIC PARTIAL NEPHRECTOMY FOR HILAR TUMORS显示文摘 | INDERBIR S. GILL JOSE R. COLOMBO IGOR FRANK ALIREZA MOINZADEH JIHAD KAOUK MIHIR DESAI | 2005 | The Journal of Urology2005，，3： | 3 |
| 10 | Safety and Efficacy of Flexible Ureterorenoscopy and Holmium:YAG Lithotripsy for Intrarenal Stones in Anticoagulated Cases显示文摘 | Burak Turna Robert J. Stein Marc C. Smaldone Bruno R. Santos John C. Kefer Stephen V. Jackman Timothy D. Averch Mihir M. Desai | 2008 | The Journal of Urology2008，，4： | 2 |
| 11 | Integration of silicon nanowires in solar cell structure for efficiencyenhancement: A review显示文摘Silicon nanowires (SiNWs) are a one-dimensional semiconductor, which shows promising applications indistinct areas such as photocatalysis, lithium-ion batteries, gas sensors, medical diagnostics, drug delivery,and solar cell. From an implementation point of view, SiNWs are fabricated using either a topdownor bottom-up approach, and SiNWs are both optically and electronically active. SiNWs enhancesthe efficiency of the solar cell due to better electronic, optical, and physical properties that can becontrolled by tuning the physical dimensions of SiNWs. The SiNWs shows an inherent capability to beutilized in radial or coaxial p-n junction solar cells, to stipulate orthogonal photon absorption, antireflection,and enhanced carrier collection. This paper reviews property-control of SiNWs, theirvarious types of incorporation in a solar cell, and the reasons behind enhanced efficiency. | Mihir Kumar Sahoo Paresh Kale | 2019 | Journal of Materiomics2019，5，1： | 2 |
| 12 | Randomized, controlled trial of standard, large-capacity versus jumbo biopsy forceps for polypectomy of small, sessile, colorectal polyps显示文摘 | Peter V. Draganov Myron N. Chang Ahmad Alkhasawneh Lisa R. Dixon John Lieb Baharak Moshiree Steven Polyak Shahnaz Sultan Dennis Collins Amitabh Suman John F. Valentine Mihir S. Wagh Samir L. Habashi Chris E. Forsmark | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 13 | Prospective evaluation of the long-term outcomes after deep small-bowel spiral enteroscopy in patients with obscure GI bleeding显示文摘 | J. Blair Williamson Joel R. Judah Jill K.J. Gaidos Dennis P. Collins Mihir S. Wagh Shailendra S. Chauhan Shabnam Zoeb Jonathan M. Buscaglia Hui Yan Wei Hou Peter V. Draganov | 2012 | Gastrointestinal Endoscopy2012，，4： | 2 |
| 14 | Searchable Encryption Revisited: Consistency Properties, Relation to Anonymous IBE, and Extensions显示文摘 | Michel Abdalla Mihir Bellare Dario Catalano Eike Kiltz Tadayoshi Kohno Tanja Lange John Malone-Lee Gregory Neven Pascal Paillier Haixia Shi | 2008 | Journal of Cryptology2008，，3： | 2 |
| 15 | Theft and taxes显示文摘 | Mihir A. Desai Alexander Dyck Luigi Zingales | 2007 | Journal of Financial Economics2007，，3： | 2 |
| 16 | COMPLICATIONS OF LAPAROSCOPIC PARTIAL NEPHRECTOMY IN 200 CASES显示文摘 | ANUP P. RAMANI MIHIR M. DESAI ANDREW P. STEINBERG CHRISTOPHER S. NG SIDNEY C. ABREU JIHAD H. KAOUK ANTONIO FINELLI ANDREW C. NOVICK INDERBIR S. GILL | 2005 | The Journal of Urology2005，，： | 2 |
| 17 | TRANSPERITONEAL VERSUS RETROPERITONEAL LAPAROSCOPIC PARTIAL NEPHRECTOMY: PATIENT SELECTION AND PERIOPERATIVE OUTCOMES显示文摘 | CHRISTOPHER S. NG INDERBIR S. GILL ANUP P. RAMANI ANDREW P. STEINBERG MASSIMILIANO SPALIVIERO SIDNEY C. ABREU JIHAD H. KAOUK MIHIR M. DESAI | 2005 | The Journal of Urology2005，，： | 2 |
| 18 | Design, Implementation and Deploying of the iKP Secure Electronic Payment System显示文摘 | Mihir Bellare | 2000 | IEEE Journal on Selected Areas in Communications2000，18，4： | 2 |
| 19 | Prospective evaluation of the use of fully covered self-expanding metal stents for EUS-guided transmural drainage of pancreatic pseudocysts显示文摘 | D. Eli Penn Peter V. Draganov Mihir S. Wagh Chris E. Forsmark Anand R. Gupte Shailendra S. Chauhan | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 20 | Single-Port Transvesical Simple Prostatectomy: Initial Clinical Report显示文摘 | Mihir M. Desai Monish Aron David Canes Khaled Fareed Oswaldo Carmona Georges-Pascal Haber Sebastien Crouzet Juan Carlos Astigueta Roy Lopez Robert de Andrade Robert J. Stein James Ulchaker Rene Sotelo Inderbir S. Gill | 2008 | Urology2008，，5： | 1 |
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