|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Female hepatology:Favorable role of estrogen in chronic liver disease with hepatitis B virus infection显示文摘Chronic hepatitis B virus (HBV) infection is the most common cause of hepatic fibrosis and hepatocellular carcinoma (HCC),mainly as a result of chronic necroinflammatory liver disease. A characteristic feature of chronic hepatitis B infection,alcoholic liver disease and nonalcoholic fatty liver disease (NAFLD) is hepatic steatosis. Hepatic steatosis leads to an increase in lipid peroxidation in hepatocytes,which,in turn,activates hepatic stellate cells (HSCs). HSCs are the primary target cells for inflammatory and oxidative stimuli,and these cells produce extracellular matrix components. Chronic hepatitis B appears to progress more rapidly in males than in females,and NAFLD,cirrhosis and HCC are predominately diseases that tend to occur in men and postmenopausal women. Premenopausal women have lower hepatic iron stores and a decreased production of proinflammatory cytokines. Hepatic steatosis has been observed in aromatase-deficient mice,and has been shown to decrease in animals after estradiol treatment. Estradiol is a potent endogenous antioxidant which suppresses hepatic fibrosis in animal models,and attenuates induction of redox sensitive transcription factors,hepatocyte apoptosis and HSC activation by inhibiting a generation of reactive oxygen species in primary cultures. Variant estrogen receptors are expressed to a greater extent in male patients with chronic liver disease than in females. These lines of evidence suggest that the greater progression of hepatic fibrosis and HCC in men and postmenopausal women may be due,at least in part,to lower production of estradiol and a reduced response to the action of estradiol. A better understanding of the basic mechanisms underlying the sex-associated differences in hepatic fibrogenesis and carciogenesis may open up new avenues for the prevention and treatment of chronic liver disease. | Ichiro Shimizu Nao Kohno Katsuyoshi Tamaki Masayuki Shono Hui-Wei Huang Jiang-Hong He Deng-Fu Yao | 2007 | World Journal of Gastroenterology2007，13，32： | 49 |
| 2 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 3 | High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection显示文摘AIM: Human β-defensin (HBD)-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice duringH pylori infection.METHODS: HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 H pylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in 13 patients with H pylori-associated gastritis. Interleukin (IL)-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay (ELISA). Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography (RP-HPLC)was used to identify HBD-2.RESULTS: HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in H pylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in H pylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1concentrations were similar in H pylori-infected and uninfected subjects.CONCLUSION: Our results place the β-defensins, especially HBD-2, in the front line of innate immune defence.Moreover, HBD-2 may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator. | Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto Yoshito Nishi Chun-Yang Wen Akihiro Wad Ken Ohnita Toshiya Hirayama Masamitsu Nakazato Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，31： | 10 |
| 4 | 基本参数法X-射线荧光光谱同时分析镍、钴和铁基合金显示文摘用基本参数法分析了镍、钴和铁基合金,对每种元素在整个含量范围内用单一校准进行了测定,并获得了满意的结果。研究显示,本方法可以采用多通道光谱仪对主次元素进行分析测定。例如,对镍元素来说,在质量分数0%到100%的浓度范围内,准确度达到质量分数0.14%。我们还发现,在铬的分析中,三级激发很显著,对整体强度的贡献率达到2.4%。通过将三级激发考虑进理论强度计算,方法的准确度可由质量分数0.14%提高到0.10%。对灵敏度进行了最小二乘拟合法校准,研究显示二次拟合多项式用单一校准曲线在整个浓度范围内都能给出很好的结果。在多通道光谱仪中,当通道不再适合谱线重叠时,理论强度重叠校正法是有效的手段。 | KATAOKA Yoshiyukki FURUSAWA Eiichi KOHNO Hisayuki ARAI Tomoya MARTIN Al INOUE Hisashi MANTLER Michael | 2009 | 冶金分析2009，29，5： | 9 |
| 5 | X射线荧光分析法测定铁矿石中全铁显示文摘铁矿石中全铁的含量范围通常较宽,因此需要高的分析精确度。尽管熔融制样法已经被普遍用于铁矿石的X射线荧光光谱分析,但作为样品制备的另一种方法,压片法由于简便、快捷的特点,其应用需求同样较大。康普顿散射比法已经被普遍用于岩石等样品中的重金属元素测定,其中荧光X射线与X射线管线发射的康普顿散射X射线的强度比被用作校正。不过,这种方法不能为矿石和精矿中高含量重金属元素的测定提供足够的准确度。本研究建立了一种新的方法,在元素间校正项中,将基本参数法获取的理论α系数用于康普顿散射比校正。本方法可以将铁矿石中全铁含量的测定准确度提高到0.14%(质量分数)。 | KATAOKA Y HOMMA H KOHNO H | 2011 | 冶金分析2011，31，7： | 8 |
| 6 | Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife显示文摘AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped device.METHODS Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also assessed.RESULTS Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, respectively.CONCLUSION ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes. | Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 7 | Three-dimensional imaging identified the accessory bile duct in a patient with cholangiocarcinoma显示文摘The development of diagnostic imaging technology, such as multidetector computed tomography(MDCT) and magnetic resonance cholangiopancreatography(MRCP), has made it possible to obtain detailed images of the bile duct. Recent reports have indicated that a 3-dimensional(3D) reconstructed imaging system would be useful for understanding the liver anatomy before surgery. We have investigated a novel method that fuses MDCT and MRCP images. This novel system easily made it possible to detect the anatomical relationship between the vessels and bile duct in the portal hepatis. In this report, we describe a very rare case of extrahepatic cholangiocarcinoma associated with an accessory bile duct from the caudate lobe connecting with the intrapancreatic bile duct. We were unable to preoperatively detect this accessory bile duct using MDCT and MRCP. However, prior to the second operation, we were able to clearly visualise the injured accessory bile duct using our novel 3D imaging modality. In thisreport, we suggest that this imaging technique can be considered a novel and useful modality for understanding the anatomy of the portal hepatis, including the hilar bile duct. | Ryoichi Miyamoto Yukio Oshiro Shinji Hashimoto Keisuke Kohno Kiyoshi Fukunaga Tatsuya Oda Nobuhiro Ohkohchi | 2014 | World Journal of Gastroenterology2014，20，32： | 6 |
| 8 | Enzyme inhibition assay for pyruvate dehydrogenase complex: Clinical utility for the diagnosis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis (PBC) is usually diagnosed by the presence of characteristic histopathological features of the liver and/or antimitochondrial antibodies (AMA) in the serum traditionally detected by immunofluorescence. Recently, new and more accurate serological assays for the detection of AMA, such as enzyme-linked immunosorbent assay (ELISA), immunoblotting, and enzyme inhibition assay, have been developed. Of these, the enzyme inhibition assay for the detection of anti-pyruvate dehydrogenase complex (PDC) antibodies offers certain advantages such as objectivity, rapidity, simplicity, and low cost. Since this assay has almost 100% specificity, it may have particular applicability in screening the at-risk segment of the population in developing countries. Moreover, this assay could be also used for monitoring the disease course in PBC. Almost all sera of PBC-suspected patients can be confirmed for PBC or non-PBC by the combination results of immunoblotting and enzyme inhibition assay without histopathological examination. For the development of a 'complete' or 'gold standard' diagnostic assay for PBC, similar assays of the enzyme inhibition for anti-2-oxoglutarate dehydrogenase complex (OGDC) and anti-branched chain oxo-acid dehydrogenase complex (BCOADC) antibodies will be needed in future. | Katsuhisa Omagari Hiroaki Hazama Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 9 | Effects of estradiol and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C显示文摘AIM:To investigate the effects of estradiol (E2) and progesterone on the unstimulated and oxidative stressstimulated production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, and macrophage chemotactic protein (MCP)-1 by peripheral blood mononuclear cells (PBMCs) from patients with chronic hepatitis C and healthy controls. METHODS:The PBMCs were separated from agematched 72 males and 71 females with and without chronic hepatitis C, who were divided into two groups based on a mean menopausal age of 50 years. Oxidative stress was induced by hydrogen peroxide in the cells incubated in serum-free media. Cytokines in the culture supernatant were measured by an enzyme-linked immunosorbent assay. RESULTS:The highest levels of the spontaneous production of TNF-α, IL-1β, IL-8, and MCP-1 by the unstimulated PBMCs were in the older male patients with chronic hepatitis C and the lowest levels were in the premenopausal female healthy controls. E2 inhibited the cytokine production by the unstimulated PBMCs from the older male and post-menopausal female patients, which was further stimulated by progesterone. The exposure to hydrogen peroxide in the PBMCs from the younger male and pre-menopausal female healthy subjects induced the production of cytokines. The change rates of the hydrogen peroxide-stimulated cytokine production were suppressed by E2 and enhanced by progesterone. CONCLUSION:These findings suggest that E2 may play a favorable role in the course of persistent liver injury by preventing the accumulation of monocytes-macrophages and by inhibiting proinflammatory cytokine production, whereas progesterone may counteract the favorable E2 effects. | Ying Yuan Ichiro Shimizu Mi Shen Eriko Aoyagi Hidetaka Takenaka Tatuzo Itagaki Mari Urata Katsutaka Sannomiya Nao Kohno Katsuyoshi Tamaki Masayuki Shono Tetsuji Takayama | 2008 | World Journal of Gastroenterology2008，14，14： | 5 |
| 10 | RECENT PROGRESS IN STORM SURGE FORECASTING显示文摘This report briefly summarizes recent progress in storm surge forecasts, one of topics discussed during the fourth International Workshop on Tropical Cyclone Landfall Process(IWTCLP 4) held during 5-8 December, 2017. In the workshop, improvement of storm surge forecasting system was mainly discussed with relevance to the problem of estimating the impacts of tropical cyclone landfall.To deal with storm surges, accurate TC condition(predictions and forecasts) as input, reasonable storm surge predictions(with forecasting systems), and effective advisories/warnings(i.e. useful information products) are necessary. Therefore, we need to improve storm surge related matters systematically: input, prediction system, and ef fective information.This report tries to highlight recent progress in the field of storm surges in relation to three key points: improvement in storm surge forecasting models/system, TC conditions as input for storm surge predictions, and informative products for end users. | NADAO KOHNO SHISHIR K.DUBE MIKHAIL ENTEL S.H.M.FAKHRUDDIN DIANA GREENSLADE MARIE-DOMINIQUE LEROUX JAMIE RHOME NGUYEN BA THUY | 2018 | Tropical Cyclone Research and Review2018，7，2： | 4 |
| 11 | Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese显示文摘AIM: To examine an association between the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene that plays a role in downregulation of T-cell activation and inflammatory bowel disease consisting of ulcerative colitis (UC) and Crohn's disease (CD) in the Japanese.METHODS: We studied 108 patients with UC, 79 patients with CD, and 200 sex-matched healthy controls, with respect to three single nucleotide polymorphisms (SNPs)in CTLA4, such as C-318T in the promoter region, A+49G in exon 1 and G+6230A in the 3' untranslated region (3'-UTR) by a PCR-restriction fragment length polymorphism method, and to an (AT)n repeat polymorphism in 3'-UTR by fragment analysis with fluorescence-labeling on denaturing sequence gels. Frequency of alleles and genotypes and their distribution were compared statistically between patients and controls and among subgroups of patients, using χ2 and Fisher exact tests.RESULTS: The frequency of 'A/A' genotype at the G+6230A SNP site was statistically lower in UC patients than in controls (3.7% vs 11.0%, P= 0.047, odds ratio (OR) = 0.311). Moreover, the frequency of'G/G' genotype at the A+49G SNP site was significantly higher in CD patients with fistula (48.6%) than those without it (26.2%)(P = 0.0388, OR=2.67).CONCLUSION: The results suggest that CTLA4 located at 2q33 is a determinant of UC and responsible for fistula formation in CD in the Japanese. | Haruhisa Machida Kazuhiro Tsukamoto Chun-Yang Wen Yukiko Narumi Saburou Shikuwa Hajime Isomoto Fuminao Takeshima Yohei Mizuta Norio Niikawa Ikuo Murata Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，27： | 4 |
| 12 | Enlarged accessory spleen presenting stomach submucosal tumor显示文摘A 62-year-old man presented with upper abdominal discomfort underwent upper gastrointestinal endoscopy. Gastroscopy and endoscopic ultrasonography revealed a submucosal tumor (SMT) with homogenous echogenicity originated from extragastric organs. An abdominal contrast-enhanced computed tomography (CT) showed that the well-marginated ovoid mass, approximately 6 cm in diameter, enhanced homogenously to a similar degree as splenic parenchyma. 99mTechnetium sulfur colloid scintigraphy revealed the splenic nature of the mass. A diagnosis of accessory spleen mimicking gastric SMT was made. Subsequent follow-up was uneventful without performing splenectomy. | Shunzen Chin Hajime Isomoto Yohei Mizuta Chun-Yang Wen Saburo Shikuwa Shigeru Kohno | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 13 | 脊髓小胶质细胞群参与神经病理性疼痛的缓解和复发显示文摘神经病理性疼痛通常由损伤和影响躯体感觉系统的疾病所致。虽然疼痛的发展已经得到了很好地研究,但疼痛恢复机制仍不清楚。在该研究中,研究者发现表达 CD11c 的脊髓小胶质细胞出现在神经损伤引起的疼痛超敏反应行为的发展之后。脊髓 CD11c^(+)小胶质细胞缺失的神经损伤小鼠不能从这种超敏反应中自发恢复。脊髓 CD11c^(+)小胶质细胞表达胰岛素样生长因子-1 (IGF1),IGF1 信号的干扰会再现疼痛恢复的障碍。在疼痛恢复的小鼠中,CD11c^(+)小胶质细胞的缺失或 IGF1 信号的中断均会导致疼痛超敏反应的复发。该研究揭示了神经病理性疼痛缓解和复发的一种新机制,为神经病理性疼痛治疗策略提供了潜在的靶标。 | 张晴(译) 吉海旺(译) 唐宗湘(校) Kohno K Shirasaka R Yoshihara K | 2022 | 中国疼痛医学杂志2022，28，8： | 4 |
| 14 | Evaluation of a strawberry-harvesting robot in a field test显示文摘 | Shigehiko Hayashi Kenta Shigematsu Satoshi Yamamoto Ken Kobayashi Yasushi Kohno Junzo Kamata Mitsutaka Kurita | 2009 | Biosystems Engineering2009，，2： | 4 |
| 15 | Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca^(2+) signaling in neuropeptide Y neurons of the arcuate nucleus显示文摘AIM: To explore the mechanism for interactions of leptin with ghrelin and orexin in the arcuate nucleus (ARC) activating neuropeptide Y (NPY) neurons during physiological regulation of feeding. METHODS: Single neurons from ARC of adult rats with matured feeding function were isolated. [Ca2+]i was measured to monitore their activities. The time course of leptin effects on ghrelin-induced versus orexin-induced [Ca2+]i increases in NPY neurons was studied. RESULTS: Administration of ghrelin or orexin-A at 10-10 mol/L increased cytosolic Ca2+ concentration ([Ca2+]i) in NPY neurons isolated from the ARC of adult rats. Upon administration of leptin at 10-14-10-12 mol/L, ghrelin-induced [Ca2+]i increases were initially (< 10 min) inhibited but later restored, exhibiting a transient pattern of inhibition. In contrast, orexin-induced [Ca2+]i increases were inhibited by leptin in a longlasting manner. Furthermore, a prior administration of leptin inhibited orexin action but not ghrelin action to increase [Ca2+]i. CONCLUSION: Leptin counteracted ghrelin effects transiently and orexin effects long-lastingly in NPY neurons. The transient property with which leptin counteracts ghrelin action in NPY neurons may allow the fasting-associated increase in ghrelin levels to activate NPY neurons in the presence of physiological leptin and to stimulate feeding. | Daisuke Kohno Shigetomo Suyama Toshihiko Yada | 2008 | World Journal of Gastroenterology2008，14，41： | 4 |
| 16 | Body mass index correlated with forced expiratory volume in 1 second/forced vital capacity in a population with a relatively low prevalence of obesity显示文摘背景肥胖是在世界上的最普通的新陈代谢的疾病。然而,在肥胖之间的关系和肺功能充分没被理解。尽管几纵的研究证明了那在身体增加,重量能在肺的功能导致减小,这是否并且是否高是有日本人口的盒子身体团索引( BMI )地位独自代表现在的学习的 unclear.The 目的是在日本病人的呼吸量测定法在一般诊所测量的肺功能上估计 BMI 的效果的妨碍的肺机能障碍遗体的一个适当预言者。我们屏蔽请教了一般 clinics.Methods 题目的病人上的测量 BMI 和执行呼吸量测定法包括了 1231 个病人 40 岁(吝啬的年龄(65. | Susumu Fukahori Hiroto Matsuse Nobom Takamura Tomoko Tsuchida Tetsuya Kawano Chizu Fukushima Senjyu Hideaki Shigeru Kohno | 2010 | Chinese Medical Journal2010，，20： | 3 |
| 17 | Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene显示文摘AIM: To investigate the frequency and distribution of N-acetyltransferase 2 (NAT2) and uridine 5′-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD).METHODS: Frequencies and distributions of NAT2 and UGT1A7SNPs as well as their haplotypes were investigated in 95 patients with UC, 60 patients with CD, and 200gender-matched, unrelated, healthy, control volunteers by PCR-restriction fragment length polymorphism (RFLP),PCR-denaturing high-performance liquid chromatography (DHPLC), and direct DNA sequencing.RESULTS: Multiple logistic regression analysis revealed that the frequency of haplotype, NAT2*7B, significantly increased in CD patients, compared to that in controls (P= 0.0130, OR = 2.802, 95%CI = 1.243-6.316). However,there was no association between NAT2 haplotypes and UC, or between any UGT1A7haplotypes and inflammatory bowel disease (IBD).CONCLUSION: It is likely that the NAT2 gene is one of the determinants for CD in Japanese. Alternatively, a new CD determinant may exist in the 8p22 region, whereNAT2is located. | Haruhisa Machida Kazuhiro Tsukamoto Chun-Yang Wen Saburou Shikuwa Hajime Isomoto Yohei Mizuta Fuminao Takeshima Kunihiko Murase Naomichi Matsumoto Ikuo Murata Shigeru Kohno Chen-Yang Wen | 2005 | World Journal of Gastroenterology2005，11，31： | 3 |
| 18 | The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma显示文摘 | Tadahiro Nozoe Mayuko Kohno Tomohiro Iguchi Emiko Mori Takashi Maeda Akito Matsukuma Takahiro Ezaki | 2012 | Surgery Today2012，，6： | 3 |
| 19 | Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer显示文摘We herein report a case of bronchial bleeding afterradical esophagectomy that was treated with lobectomy.A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis.After the esophagectomy,bilateral vocal cord paralysis was observed,and the patient suffered from repeated episodes of aspiration pneumonia.Bronchoscopy revealed hemosputum in the right middle lobe bronchus,and contrast-enhanced computed tomography showed tortuous arteries arising from the right inferior phrenic artery and left subclavian artery toward the right middle lobe bronchus.Although bronchial arterial embolization was performed twice to control the recurrent hemoptysis,the procedures were unsuccessful.Right middle lobectomy was therefore performed via video-assisted thoracic surgery.Engorged bronchial arterys with medial hypertrophy and overgrowth of the small branches were noted near the bronchus in the resected specimen.The patient recovered uneventfully and was discharged on postoperative day 14. | Toshihiro Kitajima Kota Momose Seigi Lee Shusuke Haruta Masaki Ueno Hisashi Shinohara Sakashi Fujimori Takeshi Fujii Ryoji Takei Tadasu Kohno Harushi Udagawa | 2015 | World Journal of Gastroenterology2015，21，11： | 3 |
| 20 | An iterative test for H - matrix显示文摘 | KOHNO T NIKI H SAWAMI H | 2000 | Journal of Computational and Applied Mathematics2000，115，： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员