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| 1 | 长期施肥下我国南方典型农田土壤的酸化特征显示文摘【目的】阐明长期施肥下我国南方典型农田土壤的酸化特征,为合理施肥缓解农田土壤酸化提供科学依据。【方法】对湖南省典型农田土壤一水稻土和红壤上设置的32个长期监测点10年间的土壤pH及相关数据进行统计分析。【结果】从整体上看水稻土在长期施肥下未呈现明显酸化;在水旱轮作模式下的水稻土出现显著酸化,其pH平均下降速率为每年0.076是持续种稻模式的10倍。化学氮肥施用量的增加是水旱轮作下土壤酸化的重要因素之一,有机肥的施用对水稻土酸化无显著影响。红壤在常规施肥10 a期间pH呈明显的阶段性变化特征,施肥4-6 a与1-3a相比土壤pH下降了0.19个单位显著酸化;持续施肥至7-10 a红壤pH保持相对稳定。起始pH相对较高(pH〉6)的红壤长期施肥下出现极显著酸化,pH平均下降速率为每年0.075,与化肥氮施用量呈显著正相关;pH相对较低(pH 4-5)的红壤长期施肥下未显著酸化。【结论】我国南方地区长期施肥下,与持续种稻模式相比水旱轮作模式加速了水稻土的酸化,化学氮肥施用量的增加是导致其酸化的重要原因;起始pH相对较高(pH〉6)的红壤显著酸化化学氮肥用量增加导致其显著酸化。因此,控制和减少化学氮肥的用量是防止水旱轮作模式下土壤及红壤旱地进一步酸化的重要措施。 | 周晓阳 徐明岗 周世伟 Colinet Gilles | 2015 | 植物营养与肥料学报2015，21，6： | 85 |
| 2 | 美国腹腔镜内镜手术协会有关单孔腹腔镜手术的共识显示文摘 | Gill IS Advincula AP Aron M 谢晓峰 朱江帆 | 2010 | 中国微创外科杂志2010，10，11： | 51 |
| 3 | 中国南方水稻土酸化演变特征及影响因素显示文摘【目的】明确中国南方水稻土酸化特征及主要影响因素,为防控水稻土酸化提供理论依据。【方法】选择中国南方江苏、湖南、广东、广西、四川和云南6个省份(自治区)的20个水稻土长期定位监测点,统计分析水稻土pH演变特征及阶段性变化规律,并探讨施肥量及土壤氮素含量对水稻土酸化的影响。【结果】1988—2013年25年间中国南方水稻土显著酸化,土壤pH下降0.59个单位,平均每年下降0.023个单位。水稻土酸化具有明显的阶段性特征,起始的14年中水稻土pH急速下降,平均每年可下降0.051个单位;近10年间,土壤pH趋于平稳。增施化肥特别是化学氮肥可导致水稻土酸化,二者与土壤pH均呈显著负相关关系(P<0.01),由此推算出化学氮肥每增施100 kg·hm-2,水稻土pH可下降0.65个单位。减少有机肥的施用也可引起水稻土酸化,有机肥施用量与土壤pH之间呈显著正相关关系,有机肥每减少100 kg·hm-2,水稻土pH下降0.51个单位。土壤全氮及碱解氮含量与pH间均呈极显著负相关关系,土壤全氮和碱解氮含量每增加100 mg·kg-1,水稻土pH约下降0.1个单位。【结论】在过去25年间,中国南方水稻土显著酸化,酸化具有明显的阶段性特征,施肥初期土壤pH显著降低。减少化学氮肥的施用和增施有机肥是控制水稻土酸化的重要措施。 | 周晓阳 周世伟 徐明岗 Colinet Gilles | 2015 | 中国农业科学2015，48，23： | 52 |
| 4 | 复杂介质下保真振幅Kirchhoff深度偏移显示文摘本文详细讨论地下复杂介质地震成像问题.当速度模型含有强横向变化时,射线场会折叠形成多次走时,在这种情况下,文中证明在保真振幅叠前深度偏移时,应当考虑所有的到时才能得到定量的像.通过实例证明,在多次走时情况下,常规的共炮集、共检波器集都存在强的假像;由此提出共角度偏移的概念.最后,在多次走时下,讨论多次偏移算子(走时、相移、振幅等)的高效重构,给出了三维叠前深度偏移的快速算法. | 徐升 Gilles Lambaré | 2006 | 地球物理学报2006，49，5： | 44 |
| 5 | 长期不同施肥处理黑土磷的吸附-解吸特征及对土壤性质的响应显示文摘【目的】长期不同施肥处理影响土壤磷库和土壤性质的变化。研究不同施肥处理下黑土磷的吸附解析特征及其与土壤性质的响应关系,为黑土合理施用磷肥,提高磷有效性提供理论依据。【方法】本研究依托于公主岭黑土肥力长期定位试验,供试作物为玉米。选取不施肥(CK)、施氮、钾肥(NK)、氮磷钾平衡施肥(NPK)、氮磷钾+有机肥(NPKM)4个处理。取1990、2000和2010年的0—20 cm土层的土壤样品,分析土壤性质,测定磷的吸附解吸值,并用Langmuir方程拟合了磷的吸附曲线,计算磷最大吸附量(Qmax)、磷吸附常数(K)、最大缓冲容量(MBC)、磷吸附饱和度(DPS)以及土壤易解吸磷(RDP)。【结果】Langmuir吸附等温线方程能很好的拟合土壤吸附磷和相应的平衡溶液磷浓度曲线(R2=0.93—0.99)。不同施肥处理磷吸附解吸特征参数具有明显的差异。随试验年限的增加,不同处理各特征参数变化不尽相同,与1990年相比,2010年不施磷处理(CK和NK),Qmax值分别增加了1.83和1.61倍,MBC值分别增加了0.80%和49.40%,DPS值分别降低了92.04%和87.50%,RDP值分别降低了20.00%和82.83%;NPK处理Qmax和DPS值分别增加了81.39%和90.74%,MBC和RDP值分别降低了79.37%和48.57%;NPKM处理Qmax和MBC值分别降低了33.35%和78.52%,DPS和RDP值分别增加了11.36倍和1.48倍。施肥21年后,与CK和NPK处理相比,NPKM处理的Qmax值降低了64.66%和49.52%,MBC值降低了81.87%和79.56%,DPS值增加了110和3.81倍,RDP值增加了4.36倍和78.57%。NPKM处理显著增加了土壤全磷(Total-P)、有效磷(Olsen-P)、有机质(SOM)和CaCO3含量,降低了比表面积,维持pH、游离铁铝氧化物值不变。冗余分析结果表明:SOM和Total-P是造成磷吸附解吸特征参数差异的主要因素,分别解释了全部变异的49.5%和18.7%(P<0.05)。【结论】长期有机无机配施可显著增加SOM和土壤中磷素累积,降低土壤对磷的吸附能力,增加土壤对磷的解吸,提高土壤磷的有效性,但同时显著提高了土壤磷吸附饱和度,易引起磷素流失的风险,对于NPKM处理应考虑有机肥与无机肥的投入量。 | 王琼 展晓莹 张淑香 彭畅 高洪军 张秀芝 朱平 GILLES Colinet | 2019 | 中国农业科学2019，52，21： | 27 |
| 6 | Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit显示文摘在附睾运输期间,精子获得新蛋白质。一些这些最新获得的蛋白质作为不可分的膜蛋白质表现,包括 glycosylphosphatidylinositol (GPI ) 抛锚的蛋白质。这建议分泌附睾蛋白质被不平常的机制转移到精子。在附睾腔以内,精子与小膜的泡交往命名 epididymosomes。许多蛋白质与 epididymosomes 被联系,这些泡的蛋白质作文沿着流出的管变化并且不同于 solubleintraluminal 蛋白质。一些联系 epididymosome 的蛋白质被识别了,他们在精子成熟的功能假设了。这些包括 P25b,带像素明星绑定蛋白质,巨噬细胞迁居抑制因子, polyol 小径的酶, HE5/CD52,类型 5 glutathioneperoxidase,和 SPAM1 或 PH-20。蛋白质的电泳模式联系了 toepididymosomes 是复杂的,一些这些蛋白质被转移到定义表面领域 ofepididymal 精子。从不同附睾片断收集的 Epididymosomes 与精子不同地交往。从 epididymosomes 的这蛋白质转移到精子 istime 依赖,温度依赖者并且 pH 依赖,并且面对锌是更有效的。一些蛋白质被分离到 epididymosomes 的类脂化合物木排领域并且有选择地被转移到精子血浆膜的木排领域。一些证据被介绍证明 thatepididymosomes 被附睾上皮细胞以一种泌离的方式分泌。在结论, epididymosomes 是在附睾的 intraluminalcompartment 以一种泌离的方式分泌的小膜的泡并且由成熟精子在新蛋白质的获得起一个主要作用。 | Robert Sullivan Gilles Frenette Julie Girouard | 2007 | Asian Journal of Andrology2007，9，4： | 26 |
| 7 | 长期有机无机肥配施提高黑土磷含量和活化系数显示文摘【目的】长期不同施肥模式影响着耕层土壤磷库以及各形态磷的变化。研究不同施肥模式下黑土各磷素形态含量及有效性的变化,为黑土的肥力培育和合理施用磷肥提供理论依据。【方法】黑土长期定位施肥试验位于吉林省公主岭市,始于1990年,供试作物是连作玉米。肥料试验包括不施肥对照(CK)、施氮、钾肥(NK)、氮磷钾平衡施肥(NPK)、氮磷钾+有机肥(NPKM)共4个处理。化肥处理施氮肥(N) 165 kg/hm^2、磷肥(P) 36 kg/hm^2、钾肥(K) 68 kg/hm^2、猪粪21 t/hm^2,NPKM处理的最终N-P-K养分投入量为165-75-145kg/hm^2。选取了1990、1995、2000、2005和2010年的土样,采用Hedley连续浸提法,分析了土壤全磷、有效磷及各有效磷形态含量,计算了土壤磷活化系数(PAC)。【结果】与初始年份相比,NPKM处理土壤全磷、有效磷和磷活化系数,分别显著提高了88.47%、12.98倍和6.42倍。NPK处理对全磷含量影响较小,土壤有效磷含量和PAC值分别增加了1.65倍和2.67倍。CK和NK处理全磷含量降低了15.12%和32.67%,有效磷含量降低了33.47%和12.57%,土壤磷活化系数(PAC)分别降低了52.49%和2.55%。所有处理黑土磷库均以无机磷为主,占全磷的80.53%~90.43%。施磷肥处理的无机磷含量占全磷的比值显著高于不施磷处理,对有机磷含量影响不显著。不同处理均以中活性态磷含量最多,占全磷的50.37%~55.06%,活性态磷含量最少,占全磷的7.61%~19.02%。与不施磷处理相比,施磷处理显著提高了土壤活性态磷的比值,尤其是无机磷中的活性态磷的比值。CK、NK处理中Resin-P、NaHCO_3-Pi、NaOH-Pi、Conc.HCl-Pi、Residual-P无机磷形态均呈减少趋势;NPK处理中Resin-P、NaHCO_3-Pi、NaOH-Pi、Dil.HCl-Pi呈增加趋势,Conc.HCl-Pi和Residual-P呈减少趋势;NPKM处理中,各无机态磷含量均随施肥年限的增加呈增加趋势。相关分析结果表明有效磷含量的变化值与Resin-P、NaHCO_3-Pi、NaOH-Pi、Conc.HCl-Po变化值之间存在显著的相关性,其相关系数为0.972、0.665、0.860和0.605,说明活性较高的无机磷对有效磷效率的贡献最大。【结论】与施氮钾肥和氮磷钾肥相比,氮磷钾配合有机肥可显著提高土壤全磷、有效磷含量,显著提高土壤活性态无机磷的比例,进而提高土壤磷活化系数,提高磷素利用率。 | 王琼 展晓莹 张淑香 彭畅 高洪军 张秀芝 朱平 Colinet Gilles | 2018 | 植物营养与肥料学报2018，24，6： | 20 |
| 8 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 9 | Conceptual integration networks显示文摘 | Gilles Fauconnier | 1998 | Cognitive Science1998，，2： | 17 |
| 10 | Large balloon dilation post endoscopic sphincterotomy in removal of difficult common bile duct stones:A literature review显示文摘Endoscopic sphincterotomy(ES)is the standard therapy in common bile duct(CBD)stones extraction.Large stones(≥12 mm)or multiple stones extraction may be challenging after ES alone.Endoscopic sphincterotomy followed by large balloon dilation(ESLBD)has been described as an alternative to ES in these indications.Efficacy,safety,cost-effectiveness and technical aspects of the procedure have been here reviewed.PubMed and Google Scholar search resulted in fortyone articles dealing with CBD stone extraction with12 mm or more dilation balloons after ES.ESLBD is at least as effective as ES,and reduces the need for additional mechanical lithotripsy.Adverse events rates are not statistically different after ESLBD compared to ES for pancreatitis,bleeding and perforation.However,particular attention should be paid in patients with CBD strictures,which is identified as a risk factor of perforation.ESLBD is slightly cost-effective compared to ES.A small sphincterotomy is usually performed,and may reduce bleeding rates compared to full sphincterotomy.Dilation is performed with 12-20 mm enteral balloons.Optimal inflation time is yet to be determined.The procedure can be performed safely even in patients with peri-ampullary diverticula and surgically altered anatomy.ESLBD is effective and safe in the removal of large CBD stones,however,small sphincterotomy might be preferred and CBD strictures should be considered as a relative contraindication. | Olivier Rouquette Gilles Bommelaer Armo Abergel Laurent Poincloux | 2014 | World Journal of Gastroenterology2014，20，24： | 17 |
| 11 | CONCEPTUAL INTEGRATION显示文摘 | Gilles Fauconnier | 2003 | 外国语2003，26，2： | 16 |
| 12 | Endoscopic and histologic characteristics of serrated lesions显示文摘In recent years , a second pathway for colonic carcinogenesis , distinct from the adenomatous pathway, has been explored. This is referred to as serrated pathway and includes three types of polyp,characterised by a serrated appearance of the crypts:hyperplastic polyps(HP),sessile serrated adenomas(SSA)or lesions,and traditional serrated adenomas.Each lesion has its own genetic,as well as macroscopic and microscopic morphological features.Because of their flat aspect,their detection is easier with chromoendoscopy(carmin indigo or narrow-band imaging).However,as we show in this review,the distinction between SSA and HP is quite difficult.It is now recommended to resect in one piece as it is possible the serrated polyps with a control in a delay depending on the presence or not of dysplasia.These different types of lesion are described in detail in the present review in general population,in polyposis and in inflammatory bowel diseases patients.This review highlights the need to improve characterization and understanding of this way of colorectal cancerogenesis. | Driffa Moussata Gilles Boschetti Marion Chauvenet Karine Stroeymeyt Stéphane Nancey Franoise Berger Thierry Lecomte Bernard Flourié | 2015 | World Journal of Gastroenterology2015，21，10： | 14 |
| 13 | Targeted therapies in breast cancer:New challenges to fight against resistance显示文摘Breast cancer is the most common type of cancer found in women and today represents a significant challenge to public health. With the latest breakthroughs in molecular biology and immunotherapy, very specific targeted therapies have been tailored to the specific pathophysiology of different types of breast cancers. These recent developments have contributed to a more efficient and specific treatment protocol in breast cancer patients. However, the main challenge to be further investigated still remains the emergence of therapeutic resistance mechanisms, which develop soon after the onset of therapy and need urgent attention and further elucidation. What are the recent emerging molecular resistance mechanisms in breast cancer targeted therapy and what are the best strategies to apply in order to circumvent this important obstacle? The main scope of this review is to provide a thorough update of recent developments in the field and discuss future prospects for preventing resistance mechanisms in the quest to increase overall survival of patients suffering from the disease. | Viviana Masoud Gilles Pagès | 2017 | World Journal of Clinical Oncology2017，8，2： | 13 |
| 14 | 长期秸秆还田显著降低褐土底层有机碳储量显示文摘【目的】秸秆还田作为一种有效的培肥方式,对土壤固碳效果显著,但对于深层土壤有机碳的影响还存在不确定性。分析不同秸秆还田方式下褐土剖面土壤有机碳(SOC)储量变化,为褐土区秸秆还田措施优化和固碳减排等提供科学依据。【方法】长期秸秆还田试验开始于1992年,采用裂区设计,主区为化肥春季和秋季施用,副区为4个秸秆还田处理:秸秆不还田(CK)、秸秆覆盖还田(SM)、秸秆粉碎后直接还田(SC)和秸秆过腹还田(CM)。在2013年春玉米收获后采集0—100 cm土层土壤样品,分析不同秸秆还田方式下SOC和土壤养分含量。【结果】在春季和秋季施肥下,与CK相比,CM、SM和SC处理表层(0—20 cm)SOC含量显著提高,而SM和SC处理40—60和80—100 cm SOC含量显著降低。同时,与CK处理相比各处理SOC储量变化量在处理间存在显著差异。在春季和秋季施肥下,与CK相比,SM、SC和CM处理表层SOC储量平均分别增加2.32、5.42和12.60 t/hm^(2),且CM处理显著高于SM和SC处理;而在底层(40—100 cm)平均分别降低3.98、6.99和3.76 t/hm^(2);0—100 cm,CM处理SOC储量增加9.62 t/hm^(2),而SM和SC处理平均分别降低1.81和5.36 t/hm^(2)。冗余分析结果表明,有机碳输入和土壤养分对表层碳储量变化的总解释率为90.10%,而对下层(20—100 cm)的总解释率仅为31.80%。其中,影响表层碳储量变化的主要因子是有效磷(解释率为80.10%),而下层则是全氮(25.28%)。【结论】在施用化肥基础上,长期秸秆还田促进表层碳累积,但底层氮素供应不足引起碳耗竭。总体上,秸秆过腹还田是褐土区农田培肥和增产的最优秸秆还田方式。 | 徐虎 蔡岸冬 周怀平 Colinet Gilles 张文菊 徐明岗 | 2021 | 植物营养与肥料学报2021，27，5： | 13 |
| 15 | 柑橘大实蝇成虫的翅载和额外负载能力显示文摘对柑橘大实蝇Bactrocera(Tetradacus)minax(Enderlein)的有效管理受阻于对其成虫运动行为的较少的认识。通过测定其成虫翅载能力和忍受额外负载重量的能力,从而确定其成虫所携带不同的额外负载的电子标签重量对其正常起飞的影响程度,为制作合适的昆虫谐波雷达的电子标签提供技术参数。其雌雄成虫的翅载能力并没有随着成虫个体重量增加而降低,也没有因为性别不同而存在差异。成虫经过正常取食和饥饿(只喂清水)变化处理,其成虫平均净载重量约为11mg。来自网室成虫忍受额外负载试验结果表明,成虫额外负载7.3mg重量或为占其自身体重大约23%重量对于其向上起飞行为有较少或没有直接的影响。结果进一步表明,在确定昆虫谐波雷达技术跟踪其成虫携带的电子标签适合性时,选择的电子标签的重量不能超过7.3mg。 | 黄秀琴 李正跃 李传仁 Gilles BOITEAU 桂连友 | 2012 | 昆虫学报2012，55，5： | 10 |
| 16 | 有机-无机杂化核壳型乳胶粒的制备及其粒径控制显示文摘以苯乙烯乳液聚合合成种子, 再在种子外生成苯乙烯与甲基丙烯酸 3 三甲氧基硅丙酯 (MPS) 的共聚物,利用MPS中硅氧烷基的水解 缩合反应, 形成交联的壳, 得到有机 无机杂化型核壳乳胶粒. 然后用溶剂将聚苯乙烯模板溶解, 可得到空心微胶囊. 通过透射电镜 (TEM) 和动态光散射粒径仪 (DLS) 观测乳胶粒及微胶囊的形态. 并研究了乳化剂种类、介质 pH值、MPS用量和加入方式对粒径、粒子数和体系稳定性的影响. 发现非离子型乳化剂、酸性或碱性介质、MPS用量过多均促进乳胶粒子数减少, 减弱了乳液稳定性. 而采取连续滴加MPS的方法则可提高乳液的稳定性, 且粒径可控. | 倪克钒 单国荣 翁志学 Elodie BourgeatLami Gilles Fevotte | 2005 | 化工学报2005，56，2： | 10 |
| 17 | 常规脂蛋白检测和载脂蛋白在心血管病预测中的比较显示文摘总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。 | Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark PB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，27，7： | 10 |
| 18 | Management of hepatocellular adenoma: Solitary-uncomplicated, multiple and ruptured tumors显示文摘AIM: While hepatocellular adenomas (Has) have often been studied as a unique entity, we aimed to better define current management of the various forms of Has.METHODS: Twenty-five consecutive patients operated for solitary-uncomplicated (9), multiple (6), and ruptured (10)Has were reviewed according to management strategies and outcomes.RESULTS: All solitary-uncomplicated Has (ranged 2.2-14 cm in size) were removed. Out of 25 Has, 2 (8%) included foci of carcinoma. In the multiple HA group, previously undiagnosed tumors were identified during surgery in 5/6cases. In three cases with multiple spread HA, several lesions had to be left unresected. They remained unmodified after 4-, 6-, and 6-year radiological follow-up. Patients with ruptured HA (ranged 1.7-10 cm in size) were initially managed with hemodynamic support and angiography,allowing the embolization of actively bleeding tumors in two patients. All ruptured tumors were subsequently removed 5.5 d (range 4-70 d) after admission. CONCLUSION: Tumors suspected of HA, regardless of the size, should be resected, because of high chances of rupture causing bleeding, and/or containing malignant foci.Although it is desirable to remove all lesions of multiple HA, this may not be possible in some patients, for whom long-term radiological follow-up is advised. Ruptured HA can be managed by hemodynamic support and angiography,allowing scheduled surgery. | Christian Toso Pietro Majno Axel Andres Laura Rubbia-Brandt Thierry Berney Leo Buhler Philippe Morel Gilles Mentha | 2005 | World Journal of Gastroenterology2005，11，36： | 9 |
| 19 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 20 | Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis显示文摘BACKGROUND Rectosigmoid endometriosis is an underdiagnosed disease responsible for abdominal pain, transit disorders and rectal bleeding. Two surgical approaches,rectosigmoid bowel resection(segmental or patch) or intramuscular layer dissection(shaving), are available.AIM To assess whether the lesion features observed via preoperative rectosigmoid endoscopic ultrasonography(RS-EUS) might predict the need for bowel resection.METHODS This multicentric retrospective study was conducted on patients with rectosigmoid endometriosis who underwent a curative surgical procedure,evaluated by RS-EUS performed by two trained operators, between January 2012 and March 2018. A univariate statistical analysis was performed on nodules' RSEUS features(thickness, width, infiltration of the submucosae, presence of a bump into the digestive lumen and presence of multiple rectosigmoid localizations). A multivariate logistic regression was then performed on the significant results.RESULTS Of the 367 patients, 73 patients with rectosigmoid endometriosis were evaluated by RS-EUS and underwent rectosigmoid surgery. After the univariate analysis was completed, thickness, width and infiltration of the submucosae were identified as potential predictive factors for bowel resection. In a multivariate logistic regression model, only thickness appeared to be a significant [odds ratio(OR) = 1.49, 95% confidence interval(CI): 1.04-2.12, P = 0.028] predictive factor for bowel resection. Receiver operating characteristic analysis performed showed that a thickness over 5.20 mm might be used as cut-off with a sensitivity of 76%, a specificity of 81%, and an area under carve = 0.82. The cut-off values for 100%sensitivity and 100% specificity were 0.90 mm and 10.00 mm, respectively. A trend concerning width to predict the need for resection was also observed(OR1.12, 95%CI: 1.00-1.26, P = 0.054)CONCLUSION The presence of a rectosigmoid nodule of endometriosis greater than 5.20 mm thick on RS-EUS might predict the need for bowel resection. | Victor Desplats René-Louis Vitte Joseph du Cheyron Gilles Roseau Arnaud Fauconnier Frédérick Moryoussef | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
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