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| 1 | Type 2 diabetes mellitus:From a metabolic disorder to an inflammatory condition显示文摘Diabetes mellitus is increasing at an alarming rate and has become a global challenge.Insulin resistance intarget tissues and a relative deficiency of insulin secretion from pancreatic β-cells are the major features of type 2 diabetes(T2D).Chronic low-grade inflammation in T2 D has given an impetus to the field of immuno-metabolism linking inflammation to insulin resistance and β-cell dysfunction.Many factors advocate a causal link between metabolic stress and inflammation.Numerous cellular factors trigger inflammatory signalling cascades,and as a result T2 D is at the moment considered an inflammatory disorder triggered by disordered metabolism.Cellular mechanisms like activation of Tolllike receptors,Endoplasmic Reticulum stress,and inflammasome activation are related to the nutrient excess linking pathogenesis and progression of T2 D with inflammation.This paper aims to systematically review the metabolic profile and role of various inflammatory pathways in T2 D by capturing relevant evidence from various sources.The perspectives include suggestions for the development of therapies involving the shift from metabolic stress to homeostasis that would favour insulin sensitivity and survival of pancreatic β-cells in T2 D. | Iqra Hameed Shariq R Masoodi Shahnaz A Mir Mudasar Nabi Khalid Ghazanfar Bashir A Ganai | 2015 | World Journal of Diabetes2015，6，4： | 36 |
| 2 | GRADE指南:Ⅸ.证据质量升级显示文摘证据质量升级的最常见原因是效应量大。当方法学严谨的观察性研究表明风险至少降低或增加2倍时,GRADE建议考虑将证据质量升高1级;当风险至少降低或增加5倍时,考虑将证据质量升高2级。当存在剂量-反应关系,或所有合理的混杂、偏倚会降低明显的治疗效应,或混杂、偏倚使得结果无效为假效应时,系统评价作者和指南制定者也可考虑升高证据质量。其他考虑因素包括起效迅速、潜在的疾病(状态)趋势以及间接证据。 | Gordon H.Guyatt Andrew D.Oxman Shahnaz Sultan Paul Glasziou Elie A.Akl Pablo Alonso-Coello David Atkins Regina Kunz Jan Brozek Victor Montori Roman Jaeschke David Rind Philipp Dahm Joerg Meerpohl Gunn Vist Elise Berliner Susan Norris Yngve Falck-Ytter M.Hassan Murad Holger J.Schünemann 代表GRADE工作组 李幼平 杨晓妍 李玲 王应强 | 2011 | 中国循证医学杂志2011，11，12： | 22 |
| 3 | 千根草甲醇提取物的抗高血糖及镇痛作用(英文)显示文摘目的:本研究旨在证实孟加拉国传统药用植物千根草甲醇提取物的抗高血糖及镇痛作用。方法:实验分为独立的两个部分。在研究千根草甲醇提取物抗高血糖作用的实验中,36只小鼠被分为6组,每组6只,分别给予口服不同剂量的千根草甲醇提取物、降血糖药格列本脲及10 mL/kg 1%Tween 80溶剂,1 h后,予各组小鼠口服2 g/kg葡萄糖,2 h后测取所有小鼠的血糖水平并进行比对。为观察千根草甲醇提取物的镇痛作用,另外42只小鼠被分为7组,每组6只,分别给予各组小鼠口服10 mL/kg 1%Tween 80溶剂、不同剂量千根草甲醇提取物,或200和400 mg/kg镇痛药阿司匹林1 h后,向所有小鼠腹腔内注射10 mL/kg 1%醋酸诱发扭体反应。诱发扭体反应5 min后,每只小鼠观察10 min,记录扭体次数。结果:分别口服50、100、200和400 mg/kg千根草甲醇提取物的4组小鼠与对照组相比血糖水平显著降低(P<0.05)。当小鼠口服400 mg/kg千根草甲醇提取物时,血糖水平下降最多。口服10 mg/kg格列本脲的小鼠血糖水平下降48.6%。与对照组相比,甲醇提取物同样被证实具有显著的镇痛作用(P<0.05)。当服用剂量在400 mg/kg时,小鼠扭体次数抑制率达40.9%,而口服200 mg/kg镇痛药阿司匹林时,小鼠扭体次数抑制率为49.0%。结论:孟加拉国民间草药千根草在治疗糖尿病与疼痛方面有显著作用,其甲醇提取物抗高血糖及镇痛的作用值得进一步研究,以便开发出以此植物为基础的新型化合物与有效药。 | Mohammed Rahmatullah Sumaiyah Kanij Hasan Zulfiquar Ali Shahnaz Rahman Rownak Jahan | 2012 | 中西医结合学报2012，10，2： | 9 |
| 4 | Efficacy and safety of Amla(Phyllanthus emblica L.) in non-erosive reflux disease:a double-blind,randomized,placebo-controlled clinical trial显示文摘Background: Gastroesophageal reflux disease(GERD) is one of the most common gastrointestinal complaints. GERD, caused by the reflux of stomach contents into the esophagus, leads to troublesome symptoms such as heartburn and regurgitation. It is classified into two types: erosive esophagitis,characterized by visible esophageal mucosa erosion in endoscopy, and non-erosive reflux disease(NERD). GERD is a chronic and recurrent disease that impairs the quality of life and imposes socioeconomic and therapeutic burdens to both patients and society.Objective: Due to the failure of the conventional treatments for GERD and to the traditional use of Amla(Phyllanthus emblica L.), in addition to beneficial effects shown in recent studies, we evaluated the safety and efficacy of Amla tablet for improvement of symptoms of patients with NERD.Design, setting, participants and interventions: We designed a double-arm, randomized, double-blind,placebo-controlled clinical trial. Sixty-eight patients who had classic symptoms of GERD(heartburn,regurgitation and epigastralgia) for at least three months before the start of the trial were randomized in two parallel groups. Patients in the Amla group received two 500 mg Amla tablets twice a day, after meals,for 4 weeks. In the control group, patients received placebo tablets similar to the Amla prescription.Main outcome measures: The patients were visited at baseline, and at the end of the 2 nd and 4 th weeks of intervention; their symptoms were measured on a frequency and severity scale for the symptoms of NERD,according to the quality of life in reflux-associated disease questionnaire.Results: Frequencies of heartburn and regurgitation in both groups of the study were significantly reduced after intervention(P < 0.001). Repeated measures logistic regression analysis showed that, in the Amla group, there was a more significant reduction in regurgitation frequency, heartburn frequency, regurgitation severity and heartburn severity during the study period, compared with the placebo group(P < 0.001).Conclusion: This randomized double-blind, placebo-controlled clinical trial demonstrated that Amla could reduce frequencies of heartburn and regurgitation and improve heartburn and regurgitation severity in patients with NERD. | Shahnaz Karkon Varnosfaderani Fataneh Hashem-Dabaghian Gholamreza Amin Mahbubeh Bozorgi Ghazaleh Heydarirad Esmaeil Nazem Mohsen Nasiri Toosi Seyed Hamdollah Mosavat | 2018 | Journal of Integrative Medicine2018，16，2： | 7 |
| 5 | A novel and efficient synthesis of pyrazolo[3,4-d]pyrimidine derivatives and the study of their anti-bacterial activity显示文摘In this work 4-amino-6-aryl-2-phenyl pyrimidine-5-carbonitrile derivatives were synthesized through a one-pot,three-component reaction of an aldehyde,malononitrile and benzamidine hydrochloride,in the presence of magnetic nano Fe_3O_4 particles as a catalyst under solvent-free conditions.3-Amino-6-aryl- 2-phenylpyrazolo[3,4-d]pyrimidine derivatives were prepared through an efficient and environmentally friendly reaction between 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives and hydrazine hydrate and their antibacterial activity has been evaluated. | Shahnaz Rostamizadeh Masoomeh Nojavan Reza Aryan Hamid Sadeghian Mahdieh Davoodnejad | 2013 | Chinese Chemical Letters2013，24，7： | 7 |
| 6 | Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population显示文摘背景丙肝病毒(HCV ) 在全世界组成一个主要公共健康问题,特别在开发象巴基斯坦一样的国家。在这研究,我们估计了在长期的丙肝病人的治疗在这研究由性,年龄,和病毒的 load.Methods 分类的干扰素(INF ) 的结果,有遗传型 3 的 750 个 HCV 积极病人被选择,从哪个 616 完成了全部治疗。他们的个人历史,支持处理的 HCV RNA 和浆液丙氨酸 transaminase (中高音) 是 quantified.Patients 与 INF- 2b 的联合治疗被对待 300 万个单位(三次一个星期) 正 ribavirin (1000-1200mg 每天) 为 24 个星期。在 24 个星期以后,他们的 HCV RNA 和浆液中高音水平是从 616 个病人,的 quantified.Results (63.5%) 391 对治疗学的政体(加 ribavirin 的 INF- 2b ) 作出回应。在应答者之中, 27.1% 是男人, 36.4% 是女人。最好的治疗反应在有 Iow 的病人被观察病毒的负担 8 ?????牴湡睳汥 吗?? | Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza | 2011 | Chinese Medical Journal2011，，9： | 6 |
| 7 | Burden and outcomes for complex perianal fistulas in Crohn's disease:Systematic review显示文摘AIM To systematically review the literature on epidemiology,disease burden, and treatment outcomes for Crohn's disease(CD) patients with complex perianal fistulas.METHODS PubMed, Embase, and Cochrane were searched for relevant articles(published 2000-November 2016) and congress abstracts(published 2011-November 2016).RESULTS Of 535 records reviewed, 62 relevant sources were identified(mostly small observational studies). The cumulative incidence of complex perianal fistulas in CD from two referral-centre studies was 12%-14%(follow-up time, 12 years in one study; not reported in the second study). Complex perianal fistulas result in greatly diminished quality of life; up to 59% of patients are at risk of faecal incontinence. Treatments include combinations of medical and surgical interventions and expanded allogeneic adipose-derived stem cells. High proportions of patients experience lack of or inadequate response to treatment(failure and relapse rates,respectively: medical, 12%-73% and 0%-41%; surgical:0%-100% and 11%.20%; combined medical/surgical:0%-80% and 0%-50%; stem cells: 29%-47% and not reported). Few studies(1 of infliximab; 3 of surgical interventions)have been conducted in treatment-refractory patients, a population with high unmet needs. Limited data exist on the clinical value of anti-tumour necrosis factor-α dose escalation in patients with complex perianal fistulas in CD.CONCLUSION Complex perianal fistulas in CD pose substantial clinical and humanistic burden. There is a need for effective treatments, especially for patients refractory to antitumour necrosis factor-α agents, as evidenced by high failure and relapse rates. | Julian Panes Walter Reinisch Ewa Rupniewska Shahnaz Khan Joan Forns Javaria Mona Khalid Daniela Bojic Haridarshan Patel | 2018 | World Journal of Gastroenterology2018，24，42： | 5 |
| 8 | Sensitivity analysis of the vane length and passage width for a radial type swirler employed in a triple swirler configuration显示文摘The design of axial or radial swirlers typically governs a number of geometrical parameters that are determined by the desired flow field.In the meantime,the number of unknown parameters increases with the number of concentrically mounted swirlers.The available literature is nonetheless limited,and designers are obligated to increase the number of initial assumptions.In this article,three kinds of triple swirlers are employed and simulations are performed to determine the effect of each parameter on the swirler performance.Based on the correlation provided,overlengthening the radial vane length could result in significant changes in the flow field from the jetlike pattern to a wide swirl-jet angle due to the Coanda effect.Passage width should also have the potential to alter the swirl-jet angle and velocity field at the exit of the swirler. | Foad Vashahi Shahnaz Rezaei Reza Alidoost Dafsari Jeekeun Lee | 2019 | Theoretical & Applied Mechanics Letters2019，9，6： | 3 |
| 9 | Silica supported ammonium dihydrogen phosphate(NH_4H_2PO_4/SiO_2):A mild,reusable and highly efficient heterogeneous catalyst for the synthesis of 14-aryl-14-H-dibenzo[a,j]xanthenes显示文摘Silica supported ammonium dihydrogen phosphate(NH_4H_2PO_4/SiO_2) is found to be a recyclable heterogeneous catalyst for a rapid and efficient synthesis of various aryl-14-H-dibenzo[a,j]xanthenes with excellent yields under solvent-free conditions.The present methodology offers several advantages such as excellent yields,simple procedure,short reaction times and milder conditions. | Shahnaz Rostamizadeh Ali Mohammad Amani Gholam Hossein Mahdavinia Nasrin Shadjou | 2009 | Chinese Chemical Letters2009，20，7： | 3 |
| 10 | Silica supported sodium hydrogen sulfate(NaHSO_4/SiO_2):A mild and efficient reusable catalyst for the synthesis of aryl-14-H-dibenzo[a,j]xanthenes under solvent-free conditions显示文摘A simple and efficient procedure for the preparation of aryl-14-H-dibenzo[a,j]xanthenes by a one-pot condensation reaction of 2-naphthol and aryl aldehydes,in the presence of silica supported sodium hydrogen sulfate(NaHSO_4/SiO_2)as a catalyst and in the absence of solvent has been developed.The present method offers several advantages such as excellent yields,short reaction time (10-30 min),mild condition,simple work-up,and the use of a cheap and environmentally friendly catalyst with remarkable reusability. | Shahnaz Rostamizadeh Nasrin Shadjou Ali Mohammad Amani Saeed Balalaie | 2008 | Chinese Chemical Letters2008，19，10： | 3 |
| 11 | Randomized, controlled trial of standard, large-capacity versus jumbo biopsy forceps for polypectomy of small, sessile, colorectal polyps显示文摘 | Peter V. Draganov Myron N. Chang Ahmad Alkhasawneh Lisa R. Dixon John Lieb Baharak Moshiree Steven Polyak Shahnaz Sultan Dennis Collins Amitabh Suman John F. Valentine Mihir S. Wagh Samir L. Habashi Chris E. Forsmark | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 12 | A mild and facile method for one pot synthesis of 2,5-di-substituted 1,3,4-oxadiazoles at room temperature显示文摘2,5-Di-substituted 1,3,4-oxadiazoles 3a-n 从酸一种肺结核特效药 1 的反应作为一个壶过程被综合了,酰卤化物 2 并且在在房间温度的 acetonitrile 的磷 pentoxide。高产量,短反应时间(10 鈥 ? 5 min ) ,温和状况,和容易的病情的检查是这方法论的优点。 | Shahnaz Rostamizadeh Somaye Ghamkhar | 2008 | Chinese Chemical Letters2008，19，6： | 2 |
| 13 | Recovery of prolactin function following spontaneous pregnancy in a woman with Sheehan′s syndrome显示文摘 | Bashir Laway Shahnaz Mir Abdul Zargar | 2013 | Indian Journal of Endocrinology and Metabolism2013，，9： | 1 |
| 14 | Denoising of ECG signals based on noise reduction algorithms in EMD and wavelet domains显示文摘 | Kabir M A Shahnaz C | 2012 | Biomedical Signal Processing and Control2012，7，5： | 1 |
| 15 | Platelet-activating factor (PAF) receptor binding activity of the roots of Enicosanthellum pulchrum显示文摘 | Noraziah Nordin Juriyati Jalil Ibrahim Jantan Shahnaz Murad | 2012 | Pharmaceutical Biology2012，，3： | 1 |
| 16 | Distinguishing healthy from otosclerotic ears:Effect of probe--tone frequency on static admittance显示文摘 | Shahnaz N Polka L | 2002 | Journal of the American Academy of Audiology2002，13，： | 1 |
| 17 | One-pot synthesis of 1,2,4-triazines显示文摘 | Shahnaz Rostamizadeh Kamran Sadeghi | 2002 | Synthetic Communications2002，32，12： | 1 |
| 18 | Identification of the major allergen of Macrobrachium rosenbergii (giant freshwater prawn)显示文摘Objective:To characterize the major allergens of Macrobrachium rosenbergii.(giant freshwater prawn).Methods:Raw and cooked extracts of the giant freshwater prawn were prepared.The IgE reactivity pattern was identified by sodium dodecyl sulfate polyaerylamide gel electrophoresis(SDS-PAGE)and immunoblotting technique with the sera of 20 skin prick test(SPT)positive patients.The major allergen identified was then characterized using the proteomics approach involving a combination of two-dimensional(2-DE)electrophoresis,mass spectrometry and bioinformatics tools.Results:SDS-PAGE of the raw extract showed 23 protein bands(15-250 kDa)but those ranging from 40 to 100 kDa were not found in the cooked extract.From immunoblotting experiments,raw and cooked extracts demonstrated 11 and 5 IgE-binding proteins,respectively,with a molecular mass ranging from 15 to 155 kDa.A heat-resistant 36 kDa protein was identified as the major allergen of both extracts.In addition,a 42 kDa heat-sensitive protein was shown to be a major allergen of the raw extract.The 2-DE gel fractionated the prawn proteins to more than 50 different protein spots.Of these,10 spots showed specific:IgE reactivity with patients'sera.Matrix assisted laser desorption/ionization-lime of flight(MALDI-TOF)analysis led to identification of 2 important allergens,tropomyosin and arginine kinase.Conclusions:It can be concluded that the availability of such allergens would help in component-based diagnosis and therapy of prawn allergies. | Zailatul Hani Mohamad Yadzir Rosmilah Misnan Noormalin Abdullah Faizal Bakhtiar Masita Arip Shahnaz Murad | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 1 |
| 19 | Tissue transglu- taminase antibody levels predict IgA deficiency 显示文摘 | Shahnaz A Maguire G Parker R | 2013 | Arch Dis Child2013，98，11： | 1 |
| 20 | Women and Microcredit:Can a Mantra Deliver Empowerment?显示文摘 | SHAHNAZ A A | 1997 | The Times of India1997，，14： | 1 |
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