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| 1 | Navigated liver surgery:State of the art and future perspectives显示文摘Background:In recent years,the development of digital imaging technology has had a significant influence in liver surgery.The ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital imaging.The combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases.Results:Fifty-one pertinent articles were retrieved and included.The different types of digital imaging technologies and the real-time navigated liver surgery were estimated and compared.Conclusions:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of fluorescence.Furthermore,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor margins.In liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s liver and models of the recipient’s hilar anatomy can contribute further to improving the results.In particular,pediatric LDLT abdominal cavity models can help to manage the largest challenge of this procedure,namely large-for-size syndrome. | Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis Ernest Hidalgo Nicola de’Angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 6 |
| 2 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Recurrence and survival following microwave, radiofrequency ablation, and hepatic resection of colorectal liver metastases: A systematic review and network meta-analysis显示文摘Background: Gold standard for colorectal liver metastases(CRLM) remains hepatic resection(HR). However, patients with severe comorbidities, unresectable or deep-situated resectable CRLM are candidates for ablation. The aim of the study was to compare recurrence rate and survival benefit of the microwave ablation(MWA), radiofrequency ablation(RFA) and HR by conducting the first network meta-analysis. Data sources: Systematic search of the literature was conducted in the electronic databases. Both updated traditional and network meta-analyses were conducted and the results were compared between them. Results: HR cohort demonstrated significantly less local recurrence rate and better 3-and 5-year diseasefree(DFS) and overall survival(OS) compared to MWA and RFA cohorts. HR cohort included significantly younger patients and with significantly lower preoperative carcinoembryonic antigen(CEA) by 10.28 ng/m L compared to RFA cohort. Subgroup analysis of local recurrence and OS of solitary and ≤3 cm CRLMs did not demonstrate any discrepancies when compared with the whole sample. Conclusions: For resectable CRLM the treatment of choice still remains HR. MWA and RFA can be used as a single or adjunct treatment in patients with unresectable CRLM and/or prohibitive comorbidities. | Paschalis Gavriilidis Keith J Roberts Nicola de’Angelis Luca Aldrighetti Robert P Sutcliffe | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，4： | 4 |
| 4 | Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?显示文摘 | Emily C. Bellavance Kimberly M. Lumpkins Gilles Mentha Hugo P. Marques Lorenzo Capussotti Carlo Pulitano Pietro Majno Paulo Mira Laura Rubbia-Brandt Alessandro Ferrero Luca Aldrighetti Steven Cunningham Nadia Russolillo Benjamin Philosophe Eduardo Barroso | 2008 | Journal of Gastrointestinal Surgery2008，，10： | 2 |
| 5 | A Risk Model to Predict 90-Day Mortality among Patients Undergoing Hepatic Resection显示文摘 | Omar Hyder Carlo Pulitano Amin Firoozmand Rebecca Dodson Christopher L. Wolfgang Michael A. Choti Luca Aldrighetti Timothy M. Pawlik | 2013 | Journal of the American College of Surgeons2013，，6： | 2 |
| 6 | Hilar Cholangiocarcinoma: Preoperative Liver Optimization with Multidisciplinary Approach. Toward a Better Outcome显示文摘 | Francesca Ratti Federica Cipriani Fabio Ferla Marco Catena Michele Paganelli Luca A. M. Aldrighetti | 2013 | World Journal of Surgery2013，，6： | 2 |
| 7 | PREOPERATIVE METHYLPREDNISOLONE ADMINISTRATION MAINTAINS COAGULATION HOMEOSTASIS IN PATIENTS UNDERGOING LIVER RESECTION: IMPORTANCE OF INFLAMMATORY CYTOKINE MODULATION显示文摘 | Carlo Pulitanò Luca Aldrighetti Marcella Arru Renato Finazzi Marco Catena Eleonora Guzzetti Laura Soldini Laura Comotti Gianfranco Ferla | 2007 | Shock2007，，4： | 1 |
| 8 | Sequential intra‐arterial therapy and portal vein embolization is feasible and safe in patients with advanced hepatic malignancies显示文摘 | Peter D. Peng Omar Hyder Mark Bloomston Hugo Marques Celia Corona‐Villalobos Elijah Dixon Carlo Pulitano Kenzo Hirose Richard D. Schulick Eduardo Barroso Luca Aldrighetti Michael Choti Feng Shen Ihab Kamel Jean‐Francois H. Geschwind Timothy M. Pawlik | 2012 | HPB2012，，8： | 1 |
| 9 | Effect of donor age and sex on the outcome of liver transplantation显示文摘 | Ignazio Roberto Marino Howard R. Doyle Luca Aldrighetti Cataldo Doria John McMichael Timothy Gayowski John J. Fung Andreas G. Tzakis Thomas E. Starzl | 1995 | Hepatology1995，，6： | 1 |
| 10 | Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer显示文摘 | Marcella Arru Luca Aldrighetti Renato Castoldi Saverio Di Palo Elena Orsenigo Marco Stella Carlo Pulitanò Francesca Gavazzi Gianfranco Ferla Valerio Di Carlo Carlo Staudacher | 2008 | World Journal of Surgery2008，，1： | 1 |
| 11 | Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer显示文摘 | Marcella Arru Luca Aldrighetti Renato Castoldi Saverio Di Palo Elena Orsenigo Marco Stella Carlo Pulitanò Francesca Gavazzi Gianfranco Ferla Valerio Di Carlo Carlo Staudacher | 2008 | World Journal of Surgery2008，，1： | 1 |
| 12 | LESS technique for liver resection: the progress of the mini-invasive approach: A single-centre experience显示文摘 | Federica Cipriani Marco Catena Francesca Ratti Michele Paganelli Fabio Ferla Luca Aldrighetti | 2012 | Minimally Invasive Therapy & Allied Technologies2012，，1： | 1 |
| 13 | Laparoendoscopic single site (LESS) surgery for left-lateral hepatic sectionectomy as an alternative to traditional laparoscopy: case-matched analysis from a single center显示文摘 | Luca Aldrighetti Francesca Ratti Marco Catena Carlo Pulitanò Fabio Ferla Federica Cipriani Gianfranco Ferla | 2012 | Surgical Endoscopy2012，，： | 1 |
| 14 | Surgical Management of Patients with Synchronous Colorectal Liver Metastasis: A Multi-Center International Analysis显示文摘 | Skye C. Mayo Carlo Pulitano Hugo Marques Christopher L. Wolfgang Wassila de Saussure Michael A. Choti Isabelle Gindrat Luca Aldrighetti Eduardo Barrosso Gilles Mentha Timothy M. Pawlik | 2012 | Journal of the American College of Surgeons2012，，： | 1 |
| 15 | Rates and Patterns of Recurrence Following Curative Intent Surgery for Colorectal Liver Metastasis: An International Multi-Institutional Analysis of 1669 Patients显示文摘 | Mechteld C. de Jong Carlo Pulitano Dario Ribero Jennifer Strub Gilles Mentha Richard D. Schulick Michael A. Choti Luca Aldrighetti Lorenzo Capussotti Timothy M. Pawlik | 2009 | Annals of Surgery2009，，3： | 1 |
| 16 | Does Hepatic Pedicle Clamping Affect Disease-Free Survival Following Liver Resection for Colorectal Metastases?显示文摘 | Felice Giuliante Francesco Ardito Carlo Pulitanò Maria Vellone Ivo Giovannini Luca Aldrighetti Gianfranco Ferla Gennaro Nuzzo | 2010 | Annals of Surgery2010，，6： | 1 |
| 17 | A Prospective Evaluation of Laparoscopic Versus Open Left Lateral Hepatic Sectionectomy显示文摘 | Luca Aldrighetti Carlo Pulitanò Marco Catena Marcella Arru Eleonora Guzzetti Massimiliano Casati Laura Comotti Gianfranco Ferla | 2008 | Journal of Gastrointestinal Surgery2008，，3： | 1 |
| 18 | Conditional Survival after Surgical Resection of Colorectal Liver Metastasis: An International Multi-Institutional Analysis of 949 Patients显示文摘 | Hari Nathan Mechteld C. de Jong Carlo Pulitano Dario Ribero Jennifer Strub Gilles Mentha Jean-Fran?ois Gigot Richard D. Schulick Michael A. Choti Luca Aldrighetti Lorenzo Capussotti Timothy M. Pawlik | 2010 | Journal of the American College of Surgeons2010，，5： | 1 |
| 19 | A Prospective Evaluation of Laparoscopic Versus Open Left Lateral Hepatic Sectionectomy显示文摘 | Luca Aldrighetti Carlo Pulitanò Marco Catena Marcella Arru Eleonora Guzzetti Massimiliano Casati Laura Comotti Gianfranco Ferla | 2008 | Journal of Gastrointestinal Surgery2008，，： | 1 |
| 20 | Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer显示文摘 | Marcella Arru Luca Aldrighetti Renato Castoldi Saverio Di Palo Elena Orsenigo Marco Stella Carlo Pulitanò Francesca Gavazzi Gianfranco Ferla Valerio Di Carlo Carlo Staudacher | 2008 | World Journal of Surgery2008，，1： | 1 |
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