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| 1 | Contrast-enhanced ultrasound Liver Imaging Reporting and Data System:Lights and shadows in hepatocellular carcinoma and cholangiocellular carcinoma diagnosis显示文摘BACKGROUND Contrast-enhanced ultrasound(CEUS)is considered a secondary examination compared to computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of hepatocellular carcinoma(HCC),due to the risk of misdiagnosing intrahepatic cholangiocarcinoma(ICC).The introduction of CEUS Liver Imaging Reporting and Data System(CEUS LI-RADS)might overcome this limitation.Even though data from the literature seems promising,its reliability in real-life context has not been well-established yet.AIM To test the accuracy of CEUS LI-RADS for correctly diagnosing HCC and ICC in cirrhosis.METHODS CEUS LI-RADS class was retrospectively assigned to 511 nodules identified in 269 patients suffering from liver cirrhosis.The diagnostic standard for all nodules was either biopsy(102 nodules)or CT/MRI(409 nodules).Common diagnostic accuracy indexes such as sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)were assessed for the following associations:CEUS LR-5 and HCC;CEUS LR-4 and 5 merged class and HCC;CEUS LR-M and ICC;and CEUS LR-3 and malignancy.The frequency of malignant lesions in CEUS LR-3 subgroups with different CEUS patterns was also determined.Inter-rater agreement for CEUS LI-RADS class assignment and for major CEUS pattern identification was evaluated.RESULTS CEUS LR-5 predicted HCC with a 67.6%sensitivity,97.7%specificity,and 99.3%PPV(P<0.001).The merging of LR-4 and 5 offered an improved 93.9%sensitivity in HCC diagnosis with a 94.3%specificity and 98.8%PPV(P<0.001).CEUS LR-M predicted ICC with a 91.3%sensitivity,96.7%specificity,and 99.6%NPV(P<0.001).CEUS LR-3 predominantly included benign lesions(only 28.8%of malignancies).In this class,the hypo-hypo pattern showed a much higher rate of malignant lesions(73.3%)than the iso-iso pattern(2.6%).Inter-rater agreement between internal raters for CEUS-LR class assignment was almost perfect(n=511,k=0.94,P<0.001),while the agreement among raters from separate centres was substantial(n=50,k=0.67,P<0.001).Agreement was stronger for arterial phase hyperenhancement(internal k=0.86,P<2.7×10-214;external k=0.8,P<0.001)than washout(internal k=0.79,P<1.6×10-202;external k=0.71,P<0.001).CONCLUSION CEUS LI-RADS is effective but can be improved by merging LR-4 and 5 to diagnose HCC and by splitting LR-3 into two subgroups to differentiate iso-iso nodules from other patterns. | Gianpaolo Vidili Marco Arru Giuliana Solinas Diego Francesco Calvisi Pierluigi Meloni Assunta Sauchella Davide Turilli Claudio Fabio Antonio Cossu Giordano Madeddu Sergio Babudieri Maria Assunta Zocco Giovanni Iannetti Enza Di Lembo Alessandro Palmerio Delitala Roberto Manetti | 2022 | World Journal of Gastroenterology2022，28，27： | 3 |
| 2 | Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic colorectal cancer显示文摘 | Arru M | | 0，，01： | 1 |
| 3 | Plastic optical fibers:An introduction to their technological process and applications显示文摘 | Zubia J Arrue J | 2001 | Optical Fiber Technoloav2001，2，7： | 1 |
| 4 | Prospective randomized comparison of laparoscopic versus open adrenalectomy for sporadic pheochromocytoma显示文摘 | TIBERIO G A BAIOCCHI G L ARRU L | 2008 | Surg Endosc2008，22，6： | 1 |
| 5 | Long-term survival of encapsulated GDNF secreting cells implanted within the striatum of parkinsonized rats显示文摘 | Grandoso L Ponce S Manuel I Arrue A Ruiz-Ortega J A Ulibarri I | 2007 | Int J Pharm2007，343，12： | 1 |
| 6 | Techniques for reducing false alarms in infrared forest-fire automatic detection systems 显示文摘 | OLLERO A ARRUE B C MARTINEZ J R | 1999 | Control Engineering Practice1999，7，： | 1 |
| 7 | Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic eoloreetal cancer显示文摘 | Arru M Aldrighetti L Castoldi R | 2008 | World J Surg2008，32，1： | 1 |
| 8 | Prospective randomized comparison of laparoscopic versus open adrenalectomy for sporadic pheochromocytoma显示文摘 | Tiberio GA Baiocchi GL Arru L | 2008 | Surg Endosc2008，22，6： | 1 |
| 9 | Isolate-specific QTLs of resistance to leaf stripe (Pyrenophora graminea ) in the Steptoe Morex spring barley cross显示文摘 | Arru L Franeia E Peeehioni N | 2003 | Theor Appl Genet2003，106，： | 1 |
| 10 | Genomic regions determining resistance to leaf stripe (Pyrenophora graminea ) in barley显示文摘 | Arru L Nicks R E Lindhout P | 2002 | Genome2002，45，： | 1 |
| 11 | Cavernous hemangioma of orbit:MR imaging显示文摘 | Thorn-Kany M Arrue P Delisle MB | 1999 | J Neuroradiol1999，26，2： | 1 |
| 12 | Sugar effects on early seedling development in Arabidopsis显示文摘 | Sara Rognoni Sheng Teng Laura Arru Sjef C. M. Smeekens Pierdomenico Perata | 2007 | Plant Growth Regulation2007，，3： | 1 |
| 13 | Biocontrol by yeasts of blue mold of citrus fruits and the mode of action of an isolate of Pichia guilliermondii显示文摘 | Arras G de-Cicco V Arru S | 1998 | Journal of Horticultural Science and Biotechnology1998，73，： | 1 |
| 14 | A new TDR waveform analysis approach for soil moisture profiling using a single probe显示文摘 | Moret D Arrue J L Lopez M V | 2006 | Journal of Hydrology2006，321，14： | 1 |
| 15 | Tillage and cropping intensification effects on soil aggregation: Temporal dynamics and controlling factors under semiarid conditions显示文摘 | ALVARO F J ARRUE J L GRACIA R | 2008 | Geoderma2008，145，： | 1 |
| 16 | GABA and homovanillic acidin the plasma of Schizophrenic and bipolar I patients 显示文摘 | Arrue A Davila R Zumarraga M | 2010 | NeurochemRes2010，35，2： | 1 |
| 17 | PREOPERATIVE METHYLPREDNISOLONE ADMINISTRATION MAINTAINS COAGULATION HOMEOSTASIS IN PATIENTS UNDERGOING LIVER RESECTION: IMPORTANCE OF INFLAMMATORY CYTOKINE MODULATION显示文摘 | Carlo Pulitanò Luca Aldrighetti Marcella Arru Renato Finazzi Marco Catena Eleonora Guzzetti Laura Soldini Laura Comotti Gianfranco Ferla | 2007 | Shock2007，，4： | 1 |
| 18 | Role of hepatic resection in the treatment of hepatolithiasis显示文摘 | Aldrighetti L Arru M Caterini R | 2001 | Panminerva Med2001，43，2： | 1 |
| 19 | Water balance simulation of a dryland soil during fallow under conventional and conservation tillage in semiarid Aragon, Northeast Spain显示文摘 | Moret D Braud I Arrue J L | 2007 | Soil and Tillage Research2007，92，12： | 1 |
| 20 | Growth, yield and water use efficiency of water barley in response to conservation tillage in a semi-arid region of Spain显示文摘 | Lopez M V Arrue J L | 1997 | Soil & Tillage Research1997，44，： | 1 |
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