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| 1 | Adhesive small bowel adhesions obstruction: Evolutions in diagnosis, management and prevention显示文摘Intra-abdominal adhesions following abdominal surgery represent a major unsolved problem. They are the first cause of small bowel obstruction. Diagnosis is based on clinical evaluation, water-soluble contrast followthrough and computed tomography scan. For patients presenting no signs of strangulation, peritonitis or severe intestinal impairment there is good evidence to support non-operative management. Open surgery is the preferred method for the surgical treatment of adhesive small bowel obstruction, in case of suspected strangulation or after failed conservative management, but laparoscopy is gaining widespread acceptance especially in selected group of patients. 'Good' surgical technique and anti-adhesive barriers are the main current concepts of adhesion prevention. We discuss current knowledge in modern diagnosis and evolving strategies for management and prevention that are leading to stratified care for patients. | Fausto Catena Salomone Di Saverio Federico Coccolini Luca Ansaloni Belinda De Simone Massimo Sartelli Harry Van Goor | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 28 |
| 2 | Advanced gastric cancer:what we know and what we stillhave to learn显示文摘Gastric cancer is a common neoplastic disease and, more precisely, is the third leading cause of cancer death in the world, with differences amongst geographic areas. The definition of advanced gastric cancer is still debated. Different stadiating systems lead to slightly different stadiation of the disease, thus leading to variations between the single countries in the treatment and outcomes. In the present review all the possibilities of treatment for advanced gastric cancer have been analyzed. Surgery, the cornerstone of treatment for advanced gastric cancer, is analyzed first, followed by an investigation of the different forms and drugs of chemotherapy and radiotherapy. New frontiers in treatment suggest the growing consideration for intraperitoneal administration of chemotherapeutics and combination of traditional drugs with new ones. Moreover, the necessity to prevent the relapse of the disease leads to the consideration of administering intraperitoneal chemotherapy earlier in the therapeutical algorithm. | Federico Coccolini Giulia Montori Marco Ceresoli Simona Cima Maria Carla Valli Gabriela E Nita Arianna Heyer Fausto Catena Luca Ansaloni | 2016 | World Journal of Gastroenterology2016，22，3： | 25 |
| 3 | Advances in laparoscopy for acute care surgery and trauma显示文摘The greatest advantages of laparoscopy when compared to open surgery include the faster recovery times, shorter hospital stays, decreased postoperative pain, earlier return to work and resumption of normal daily activity as well as cosmetic benefits. Laparoscopy today is considered the gold standard of care in the treatment of cholecystitis and appendicitis worldwide. Laparoscopy has even been adopted in colorectal surgery with good results. The technological improvements in this surgical field along with the development of modern techniques and the acquisition of specific laparoscopic skills have allowed for its utilization in operations with fully intracorporeal anastomoses. Further progress in laparoscopy has included single-incision laparoscopic surgery and natural orifice trans-luminal endoscopic surgery. Nevertheless, laparoscopy for emergency surgery is still considered challenging and is usually not recommended due to the lack of adequate experience in this area. The technical difficulties of operating in the presence of diffuse peritonitis or large purulent collections and diffuse adhesions are also given as reasons. However, the potential advantages of laparoscopy, both in terms of diagnosis and therapy, are clear. Major advantages may be observed in cases with diffuse peritonitis secondary to perforated peptic ulcers,for example, where laparoscopy allows the confirmation of the diagnosis, the identification of the position of the ulcer and a laparoscopic repair with effective peritoneal washout. Laparoscopy has also revolutionized the approach to complicated diverticulitis even when intestinal perforation is present. Many other emergency conditions can be effectively managed laparoscopically, including trauma in select hemodynamically-stable patients. We have therefore reviewed the most recent scientific literature on advances in laparoscopy for acute care surgery and trauma in order to demonstrate the current indications and outcomes associated with a laparoscopic approach to the treatment of the most common emergency surgical conditions. | Matteo Mandrioli Kenji Inaba Alice Piccinini Andrea Biscardi Massimo Sartelli Ferdinando Agresta Fausto Catena Roberto Cirocchi Elio Jovine Gregorio Tugnoli Salomone Di Saverio | 2016 | World Journal of Gastroenterology2016，22，2： | 11 |
| 4 | Peritoneal carcinomatosis显示文摘Several gastrointestinal and gynecological malignancies have the potential to disseminate and grow in the peritoneal cavity.The occurrence of peritoneal carcinomatosis(PC)has been shown to significantly decrease overall survival in patients with liver and/or extraperitoneal metastases from gastrointestinal cancer.During the last three decades,the understanding of the biology and pathways of dissemination of tumors with intraperitoneal spread,and the understanding of the protective function of the peritoneal barrier against tumoral seeding,has prompted the concept that PC is a loco-regional disease:in absence of other systemic metastases,multimodal approaches combining aggressive cytoreductive surgery,intraperitoneal hyperthermic chemotherapy and systemic chemotherapy have been proposed and are actually considered promising methods to improve loco-regional control of the disease,and ultimately to increase survival.The aim of this review article is to present the evidence on treatment of PC in different tumors,in order to provide patients with a proper surgical and multidisciplinary treatment focused on optimal control of their locoregional disease. | Federico Coccolini Federico Gheza Marco Lotti Salvatore Virzì Domenico Iusco Claudio Ghermandi Rita Melotti Gianluca Baiocchi Stefano Maria Giulini Luca Ansaloni Fausto Catena | 2013 | World Journal of Gastroenterology2013，19，41： | 9 |
| 5 | Esophagogastric junction gastrointestinal stromal tumor:Resection vs enucleation显示文摘Esophageal gastrointestinal stromal tumors(GISTs) are extremely uncommon,representing approximately 5% of GISTs with the majority of esophageal GISTs occurring at the esophagogastric junction(EGJ).The treatment options available for these GISTs are fairly controversial.Many different options are nowadays at our disposal.From surgery to the target therapies we have the possibility to treat the majority of GISTs,including those which are defined as unresectable.The EGJ GISTs represent a stimulating challenge for the surgeon.The anatomical location increases the possibility of postoperative complications.As the role of negative margins in GIST surgery is still controversial and the eff icacy of target therapy has been demonstrated,why not treat EGJ GISTs with enucleation and,where indicated,adjuvant target therapy? | Federico Coccolini Fausto Catena Luca Ansaloni Daniel Lazzareschi Antonio Daniele Pinna | 2010 | World Journal of Gastroenterology2010，16，35： | 7 |
| 6 | Antimicrobial management of intra-abdominal infections:Literature's guidelines显示文摘Antimicrobial management of severe intra-abdominal infections (IAIs) involves a delicate balance of optimizing empirical therapy,which has been shown to improve clinical outcomes,while simultaneously reducing unnecessary antimicrobial use.Two sets of guidelines for the management of intra-abdominal infections were recently published.In 2010,the Surgical Infection Society and the Infectious Diseases Society of America (SIS-IDSA) created guidelines for the diagnosis and management of complicated IAIs.The new SIS-IDSA guidelines replace those previously published in 2002 and 2003.The World Society of Emergency Surgery (WSES) guidelines represent additional contributions,made by specialists worldwide,to the debate regarding proper antimicrobial drug methodology.These guidelines represent the conclusions of the consensus conference held in Bologna,Italy,in July 2010 during the first congress of the WSES. | Massimo Sartelli Fausto Catena Federico Coccolini Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，9： | 7 |
| 7 | Early changes of graft function,cytokines and superoxide dismutase serum levels after donor liver denervation and Kupffer cell depletion in a rat-to-rat liver transplantation model显示文摘BACKGROUND:Hepatic reperfusion injury may cause acute inflammatory damage,producing significant organ dysfunction,and is an important problem in liver transplantation.This experiment aimed to study early changes of hepatic function after donor liver denervation and Kupffer cell depletion in rat-to-rat liver transplantation and to evaluate the effect of pre-treatment on liver reperfusion injury.METHODS:Donor rats were divided into four groups:control group;group G was pre-treated with gadolinium chloride(G),an inhibitor of Kupffer cells;group H with hexamethonium(H),a sympathetic ganglionic blocking agent;and group HG,with combined H and G pre-treatment.Under the same conditions,serum alanine aminotransferase(ALT),arterial ketone body ratio(AKBR),tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and superoxide dismutase(SOD)of recipient rats were assessed at 4,8,16 and 24 hours after liver transplantation.Histological studies of the grafts were compared.RESULTS:HG pre-treatment significantly decreased ALT,TNF-α,and IL-6 levels,increased AKBR and SOD levels,and demonstrated less pathological damage at 8,16 and 24 hours compared with the control group.Similar trends were also found in the other groups(G and H).However,the differences among them were not significant at 4 post-operative hours.CONCLUSIONS:Donor denervation and Kupffer cell depletion had preventive effect on liver reperfusion injury.HG pre-treatment is a feasible and reproducible method to protect grafts from reperfusion injury. | Catena Marco Ferla Gianfranco | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 7 |
| 8 | Laparoscopic management of intra-abdominal infections:Systematic review of the literature显示文摘AIM: To investigate the role of laparoscopy in diagnosis and treatment of intra abdominal infections.METHODS: A systematic review of the literature was performed including studies where intra abdominal infections were treated laparoscopically.RESULTS: Early laparoscopic approaches have become the standard surgical technique for treating acute cholecystitis. The laparoscopic appendectomy has been demonstrated to be superior to open surgery in acute appendicitis. In the event of diverticulitis, laparoscopic resections have proven to be safe and effective procedures for experienced laparoscopic surgeons and may be performed without adversely affecting morbidity and mortality rates. However laparoscopic resection has not been accepted by the medical community as the primary treatment of choice. In high-risk patients, laparoscopic approach may be used for exploration or peritoneal lavage and drainage. The successful laparoscopic repair of perforated peptic ulcers for experienced surgeons, is demonstrated to be safe and effective. Regarding small bowel perforations, comparative studies contrasting open and laparoscopic surgeries have not yet been conducted. Successful laparoscopic resections addressing iatrogenic colonic perforation have been reported despite a lack of literature-based evidence supporting such procedures. In post-operative infections, laparoscopic approaches may be useful in preventing diagnostic delay and controllingthe source.CONCLUSION: Laparoscopy has a good diagnostic accuracy and enables to better identify the causative pathology; laparoscopy may be recommended for the treatment of many intra-abdominal infections. | Federico Coccolini Cristian Tranà Massimo Sartelli Fausto Catena Salomone Di Saverio Roberto Manfredi Giulia Montori Marco Ceresoli Chiara Falcone Luca Ansaloni | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 5 |
| 9 | Early renal failure as a cardiovascular disease:Focus on lipoprotein(a) and prothrombotic state显示文摘Patients with renal failure are at increased risk of cardiovascular events even at the earliest stages of disease.In addition to many classic cardiovascular risk factors,many conditions that are commonly identified as emerging risk factors might contribute to occurrence of cardiovascular disease.Changes in circulating levels of many of these emerging risk factors have been demonstrated in patients with early stages of renal failure caused by different types of renal disease and have been associated with detection of cardiovascular complications.However,for most of these factors evidence of benefits of correction on cardiovascular outcome is missing.In this article,we comment on the role of lipoprotein(a) and prothrombotic factors as potential contributors to cardiovascular events in patients with early renal failure. | Cristiana Catena Gian Luca Colussi Francesca Nait Francesca Pezzutto Flavia Martinis Leonardo A Sechi | 2015 | World Journal of Nephrology2015，4，3： | 4 |
| 10 | Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study显示文摘BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected patients.However,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well established.AIM To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with DAAs.METHODS Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern Italy.The study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be confounders.RESULTS The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persists in patients with advanced liver disease or with complications,such as mixed cryoglobulinemia or renal failure. | Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo | 2019 | World Journal of Gastroenterology2019，25，40： | 4 |
| 11 | Gastrointestinal stromal tumor and mitosis,pay attention显示文摘The difference between stages Ⅰ and Ⅲ of gastric gastrointestinal stromal tumor depends principally on the number of mitosis.According with TNM classification,the presence in the tumor of high mitotic rate determines the upgrading.Many studies exposed different count techniques in evaluating the number of mitosis.An international standardized method to assess mitotic rate is needed. | Federico Coccolini Fausto Catena Luca Ansaloni Antonio Daniele Pinna | 2012 | World Journal of Gastroenterology2012，18，6： | 2 |
| 12 | Are capecitabine and oxaliplatin (XELOX) suitable treatments for progressing low-grade and high-grade neuroendocrine tumours?显示文摘 | Emilio Bajetta Laura Catena Giuseppe Procopio Sara Dosso Ettore Bichisao Leonardo Ferrari Antonia Martinetti Marco Platania Elena Verzoni Barbara Formisano Roberto Bajetta | 2007 | Cancer Chemotherapy and Pharmacology2007，，： | 2 |
| 13 | The Treatment of Peritoneal Carcinomatosis in Advanced Gastric Cancer: State of the Art显示文摘 | Giulia Montori Federico Coccolini Marco Ceresoli Fausto Catena Nicola Colaianni Eugenio Poletti Luca Ansaloni George H. Sakorafas | 2014 | International Journal of Surgical Oncology2014，，： | 2 |
| 14 | 高血压患者同型半胱氨酸水平升高与代谢综合征和心血管事件相关显示文摘高同型半胱氨酸(homocysteine,Hcy)血症和代谢综合征(metabolic syndrome,MS)是明确的心血管危险因素,常与高血压相关。然而血浆Hcy与MS、胰岛素抵抗相关性存在争议,且在高血压患者中的研究较少。该研究探讨高血压患者Hcy与MS和心脑血管事件的相关性。 | Catena C Colussi G Nait F Capobianco F Sechi LA 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，1： | 2 |
| 15 | Colorectal stenting as a bridge to surgery reduces morbidity and mortality in left-sided malignant obstruction: a predictive risk score-based comparative study显示文摘 | Vincenzo Cennamo Carmelo Luigiano Gianpiero Manes Rocco Maurizio Zagari Luca Ansaloni Carlo Fabbri Liza Ceroni Fausto Catena Antonio Daniele Pinna Lorenzo Fuccio Alessandro Mussetto Tino Casetti Federico Coccolini Nicola D’Imperio Franco Bazzoli | 2012 | Digestive and Liver Disease2012，，6： | 2 |
| 16 | Hilar Cholangiocarcinoma: Preoperative Liver Optimization with Multidisciplinary Approach. Toward a Better Outcome显示文摘 | Francesca Ratti Federica Cipriani Fabio Ferla Marco Catena Michele Paganelli Luca A. M. Aldrighetti | 2013 | World Journal of Surgery2013，，6： | 2 |
| 17 | Lichtenstein repair of inguinal hernia with Surgisis inguinal hernia matrix soft-tissue graft in immunodepressed patients显示文摘 | Catena F Ansaloni L Leone A | 2005 | Hernia2005，9，1： | 1 |
| 18 | Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients 显示文摘 | Colussi G Catena C Lapenna R | 2007 | Diabetes Care2007，30，9： | 1 |
| 19 | Plasma aldosterone and left ventricular diastolic function in treatment-nave patients with hypertension:tissue-Doppler imaging study显示文摘 | Catena C Verheyen N Pilz S | 2015 | Hypertension2015，65，6： | 1 |
| 20 | Insulin sensitivity in patients with primary aldosteronism : A follow - up study 显示文摘 | Catena C Lapenna R Baroselli S | 2006 | J Clin Endocri- nol Metab2006，91，9： | 1 |
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