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| 1 | 转染病毒白细胞介素10基因对同种小鼠心脏移植生存的影响显示文摘目的了解病毒白细胞介素10(vIL10)基因对同种小鼠移植心脏的影响。方法用小鼠干细胞病毒(MSCVneo)逆转录病毒表达系统和vIL10cDNA构建MSCVneovIL10重组体,在体外转导CBA(H2K)小鼠的造血干细胞,输入经致死量照射(900rad)的同基因CBA(H2K)小鼠体内,8周后以vIL10表达阳性的CBA(H2K)小鼠(12只,实验组)作为受体,C57BL/6(H2b)小鼠为供体,进行同种腹部异位心脏移植,以未处理、移植无病毒转染的造血干细胞(HSCs)、移植空MSCVneo转染的HSCs鼠(均为10只)为对照组。在移植后第8天,每组受体动物各杀死5只,取出移植心脏行组织病理学、CD+4与CD+8T淋巴细胞浸润(免疫荧光抗体法)检查,IL2、IL4、IL6、小鼠IL10(mIL10)、γ干扰素(IFNγ)、诱导型一氧化氮合酶(iNOS)、B71、B72mRNA表达的测定[逆转录聚合酶链反应(RTPCR)法],余下的动物观察移植心脏存活时间。结果(1)实验组移植心脏存活时间(800±333)d,其他对照组分别为(104±10),(116±11)与(112±17)d(P<001);(2)实验组心肌炎性细胞浸润稀少、心肌结构完整、无明显血管炎,急性排斥反应Ⅰ级,而其他对照组则出现严重的炎性细胞浸润、心肌灶性坏死、心内膜炎、血管炎和心肌出血,急性排斥反应均为Ⅲ级;(3)实验组移植物内IL2、IFNγ、B71、和B72和iNOS的mRNA表达明显下调。 | 杨定华 吴孟超 彭民浩 Andreas Tzakis | 2005 | 中华外科杂志2005，43，2： | 4 |
| 2 | Liver transplantation for severe hepatic trauma:Experience from a single center显示文摘Liver transplantation has been reported in the literature as an extreme intervention in cases of severe and complicated hepatic trauma.The main indications for liver transplant in such cases were uncontrollable bleeding and postoperative hepatic insufficiency.We here describe four cases of orthotopic liver transplantation after penetrating or blunt liver trauma.The indications were liver failure,extended liver necrosis,liver gangrene and multiple episodes of gastrointestinal bleeding related to portal hypertension,respectively.One patient died due to postoperative cerebral edema.The other three patients recovered well and remain on immunosuppression.Liver transplantation should be considered as a saving procedure in severe hepatic trauma,when all other treatment modalities fail. | Spiros G Delis Andreas Bakoyiannis Gennaro Selvaggi Debbie Weppler David Levi Andreas G Tzakis | 2009 | World Journal of Gastroenterology2009，15，13： | 3 |
| 3 | Intestinal transplantation with or without other abdom inal organs : nutr itional and dietary management of 50 patients显示文摘 | Nour B Reyes A Tzakis S etal | 1994 | Transplant Proc1994，26，3： | 1 |
| 4 | Upper-abdominal exentemtion in transplantation for extensive malignancies of the upper abdomen-an update 显示文摘 | Tzakis AG Todo S Madariaga J | 1991 | Transplantation1991，51，3： | 1 |
| 5 | Intestinal and multivisceral transplantation in children 显示文摘 | Kato T Tzakis AG Selvaggi G | 2006 | Ann Surg2006，243，6： | 1 |
| 6 | Use of the abdominal rectus fascia as a nonvascularized allograft for abdominal wall closure after liver, intestinal, and multivisceral transplantation 显示文摘 | Gondolesi G Selvaggi G Tzakis A | 2009 | Transplantation2009，87，12： | 1 |
| 7 | Managing liver transplantation during the COVID-19 pandemic:A survey among transplant centers in the Southeast United States显示文摘BACKGROUND The coronavirus disease-2019(COVID-19)pandemic has had a profound worldwide impact.Indeed,it has led to a vast decrease in organ transplantation,including liver transplants(LT).There is little data regarding adjustments made by LT centers as a response to the COVID-19 pandemic.AIM To assess the experience of LT centers in the United States during the pandemic.METHODS We performed an observational survey study from May 11,2020 to June 5,2020.We sent out a 13 question survey to 15 LT centers across the southeastern United States.RESULTS Eleven LT centers responded to the survey.We found that(11/11)100%of transplant centers made adjustments because of the COVID-19 pandemic.At least 50%of transplant centers had at least one transplant recipient infected with COVID-19.To adjust,greater than 50%of centers performed fewer LT,100%of patients were tested for COVID-19,and most centers implemented a virtual platform.CONCLUSION The COVID-19 pandemic greatly affected liver transplantation in the southeastern United States.It was evident that a concerted effort was made by LT centers to protect their patients and employees from COVID-19 but also to continue the lifesaving procedure of LT in this sick patient population.Further studies are needed to assess how LT centers around the world managed the pandemic in order to learn strategies to continue life-saving procedures in this patient population. | Adalberto Jose Gonzalez Nikhil Kapila Emmanuel Thomas Antonio Pinna Andreas Tzakis Xaralambos Bobby Zervos | 2021 | World Journal of Hepatology2021，13，12： | 1 |
| 8 | Intrahepatic Biliary Strictures without Hepatic Artery Thrombosis after Liver Transplantation: An Analysis of 1,113 Liver Transplantations at a Single Center显示文摘 | Noboru Nakamura Seigo Nishida Guy R. Neff Anil Vaidya David M. Levi Tomoaki Kato Phillip Ruiz Andreas G. Tzakis Juan R. Madariaga | 2005 | Transplantation2005，，4： | 1 |
| 9 | Current status of transplantation of the small intestine 显示文摘 | Ruiz P Kato T Tzakis A | 2007 | Transplantation2007，83，1： | 1 |
| 10 | Clinical presentation of hepatic artery thrombosis after liver transplantation in the cyclosporine era显示文摘 | Tzakis AG Gordon RD Shaw BW | 1985 | Transplantation1985，40，6： | 1 |
| 11 | Successful living related liver transplantation in an adult with fulminant hepatic failure显示文摘 | Kato T Nery JR Morcos J J Gyamfi AR Ruiz P Molina EG Tzakis AG | | 0，，： | 1 |
| 12 | Small bowel transplantation: technical advances/updates 显示文摘 | Selvaggi G Tzakis AG | 2009 | Curr Opin Organ Transplant2009，14，3： | 1 |
| 13 | Transplantation of the abdominal wall显示文摘 | Levi DM Tzakis ACT Kato T | 2003 | Lancet2003，361，9376： | 1 |
| 14 | FK506 for the treatment of resistant liver involvement in chronic graft-versus-host disease:a pilot study显示文摘 | Fung JJ Tzakis A Przepiorka D | 1990 | Blood1990，76，： | 1 |
| 15 | Orthotopic liver transplantation with preservation of the inferior v ena cava显示文摘 | Tzakis A Todo S Starzl TE | 1989 | Ann Surg1989，210，5： | 1 |
| 16 | Intestinal transplantation with or without other abdominal organs: nutritional and dietary management of 50 patients 显示文摘 | Nour B Reyes J Tzakis A | 1994 | Transplant Proc1994，26，3： | 1 |
| 17 | Orthotopic liver transplantation with preservation of the inferior vena cava显示文摘 | Tzakis AG Todos Starzl TE | 1989 | Ann Surg1989，210，： | 1 |
| 18 | Complications of venous reconstruction in human orthotopic liver transplantation显示文摘 | Lerut J Tzakis AG Bron K | 1987 | Ann Surg1987，205，4： | 1 |
| 19 | Assessment of five-year experience with abdominal organ cluster transplantation显示文摘 | Alessiani M Tzakis A Todo S | 1995 | J Am Coll Surg1995，180，： | 1 |
| 20 | Small bowel transplantation: current progress and clinical application 显示文摘 | Frezza EE Tzakis A Fung J J | 1996 | Hepatogastroenterology1996，43，8： | 1 |
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