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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis显示文摘Crohn's disease and ulcerative colitis evolve with a relapsing and remitting course.Determination of inflammatory state is crucial for the assessment of disease activity and for tailoring therapy.However,no simple diagnostic test for monitoring intestinal inflammation is available.Noninvasive markers give only indirect assessments of disease activity.Histopathological or endoscopical examinations accurately assess inflammatory activity,but they are invasive,time consuming and expensive and therefore are unsuitable for routine use.Imaging procedures are not applicable for ulcerative colitis.The usefulness of ultrasound and Doppler imag-ing in assessing disease activity is still a matter of discussion for Crohn's disease,and an increased interest in computed tomography enterograph (CTE) has been seen,mainly because it can delineate the extent and severity of bowel wall inflammation,besides detecting extraluminal findings.Until now,the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than CTE.Due to this,clinical activity indices are still commonly used for both diseases. | Eduardo Garcia Vilela Henrique Osvaldo da Gama Torres Fabiana Paiva Martins Maria de Lourdes de Abreu Ferrari Marcella Menezes Andrade Aloísio Sales da Cunha | 2012 | World Journal of Gastroenterology2012，18，9： | 23 |
| 3 | Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives显示文摘Hypervigilance and symptoms anticipation,visceral hypersensitivity and gastroduodenal sensorimotor abnormalities account for the varied clinical presentation of functional dyspepsia(FD)patients.Many patients recognize meals as the main triggering factor;thus,dietary manipulations often represent the first-line management strategy in this cohort of patients.Nonetheless,scarce quality evidence has been produced regarding the relationship between specific foods and/or macronutrients and the onset of FD symptoms,resulting in nonstandardized nutritional approaches.Most dietary advises are indeed empirical and often lead to exclusion diets,reinforcing in patients the perception of“being intolerant”to food and self-perpetuating some of the very mechanisms underlying dyspepsia physiopathology(i.e.,hypervigilance and symptom anticipation).Clinicians are often uncertain regarding the contribution of specific foods to dyspepsia physiopathology and dedicated professionals(i.e.,dietitians)are only available in tertiary referral settings.This in turn,can result in nutritionally unbalanced diets and could even encourage restrictive eating behaviors in severe dyspepsia.In this review,we aim at evaluating the relationship between dietary habits,macronutrients and specific foods in determining FD symptoms.We will provide an overview of the evidence-based nutritional approach that should be pursued in these patients,providing clinicians with a valuable tool in standardizing nutritional advises and discouraging patients from engaging into indiscriminate food exclusions. | Marcella Pesce Martina Cargiolli Sara Cassarano Barbara Polese Barbara De Conno Laura Aurino Nicola Mancino Giovanni Sarnelli | 2020 | World Journal of Gastroenterology2020，26，5： | 14 |
| 4 | The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture显示文摘Osteoporotic fractures are a major public health problem worldwide, but incidence varies greatly across racial groups and geographic regions. Recent work suggests that the incidence of osteoporotic fracture is rising among Asian populations. Studies comparing areal bone mineral density and fracture across races generally indicate lower bone mineral density in Asian individuals including the Chinese, but this does not reflect their relatively low risk of non-vertebral fractures. In contrast, the Chinese have relatively high vertebral fracture rates similar to that of Caucasians. The paradoxically low risk for some types of fractures among the Chinese despite their low areal bone mineral density has been elucidated in part by recent advances in skeletal imaging.New techniques for assessing bone quality non-invasively demonstrate that the Chinese compensate for smaller bone size by differences in hip geometry and microstructural skeletal organization. Studies evaluating factors influencing racial differences in bone remodeling, as well as bone acquisition and loss, may further elucidate racial variation in bone microstructure. Advances in understanding the microstructure of the Chinese skeleton have not only helped to explain the epidemiology of fracture in the Chinese, but may also provide insight into the epidemiology of fracture in other races as well. | Elaine Cong Marcella D Walker | 2014 | Bone Research2014，2，2： | 13 |
| 5 | A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA显示文摘 | Marcella Cesana Davide Cacchiarelli Ivano Legnini Tiziana Santini Olga Sthandier Mauro Chinappi Anna Tramontano Irene Bozzoni | 2011 | Cell2011，，4： | 4 |
| 6 | Eosinophilic esophagitis: From pathophysiology to treatment显示文摘Eosinophilic esophagitis(Eo E) is a chronic immune disease, characterized by a dense eosinophilic infiltrate in the esophagus, leading to bolus impaction and refluxlike symptoms. Traditionally considered a pediatric disease, the number of adult patients with Eo E is continuously increasing, with a relatively higher incidence in western countries. Dysphagia and food impaction represent the main symptoms complained by patients, but gastroesophageal reflux-like symptoms may also be present. Esophageal biopsies are mandatory for the diagnosis of Eo E, though clinical manifestations and proton pump inhibitors responsiveness must be taken into consideration. The higher prevalence of Eo E in patients suffering from atopic diseases suggests a common background with allergy, however both the etiology and pathophysiology are not completely understood. Elimination diets are considered the firstline therapy in children, but this approach appears less effective in adults patients, who often require steroids; despite medical treatments, Eo E is complicated in some cases by esophageal stricture and stenosis, that require additional endoscopic treatments. This review summarizes the evidence on Eo E pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments. | Alessandra D’Alessandro Dario Esposito Marcella Pesce Rosario Cuomo Giovanni Domenico De Palma Giovanni Sarnelli | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 4 |
| 7 | 对上面的胃肠的道的活动性混乱的基因贡献显示文摘 Motility disorders of the upper gastrointestinal tract encompass a wide range of different diseases. Esophageal achalasia and functional dyspepsia are representative disorders of impaired motility of the esophagus and stomach, respectively. In spite of their variable prevalence, what both diseases have in common is poor knowledge of their etiology and pathophysiology. There is some evidence showing that there is a genetic predisposition towards these diseases, especially for achalasia. Many authors have investigated the possible genes involved, stressing the autoimmune or the neurological hypothesis, but there is very little data available. Similarly, studies supporting a post-infective etiology, based on an altered immune response in susceptible individuals, need to be validated. Further association studies can help to explain this complex picture and find new therapeutic targets. The aim of this review is to summarize current knowledge of genetics in motility disorders of the upper gastrointestinal tract, addressing how genetics contributes to the development of achalasia and functional dyspepsia respectively. | Giovanni Sarnelli Alessandra D’Alessandro Marcella Pesce Ilaria Palumbo Rosario Cuomo | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，4： | 3 |
| 8 | Intracameral lidocaine as supplement to classic topical anesthesia for relieving ocular pain in cataract surgery显示文摘AIM: To evaluate safety, efficacy, and patient adherence of intracameral lidocaine as supplement of classic topical anesthetic drops in cataract surgery.METHODS: A prospective and controlled trial including a large cohort of 1650 individuals suffering with bilateral cataract not complicated, in program by phacoemulsification surgery, were randomly assigned to 2 different groups for the type of anesthesia received, 0.4% oxybuprocaine hydrochloride(INN) drops, and INN drops associated to intracameral 1% lidocaine hydrochloride monohydrate. At the end of surgery, tables were assigned to each patient indicating the degree of pain(0-3) felt during the operation.RESULTS: Thirty-two percent of patients in group 1 declared to have not felt any pain against the 77% of patients in group 2. Fifty-nine percent of patients in group 1 complained about only a slight discomfort against 20% of group 2 patients. Only a small percentage of patients in group 1(5%) admitted severe pain, while no patient in group 2 admitted severe pain. Four patients of group 2 reported an episode of transient amaurosis, lasting several hours after surgery.CONCLUSION: Intracameral administration of lidocaine is a simple and secure method able to increase the analgesia during the cataract surgery, eliminating the discomfort and increasing also the cooperation of the patients during the steps of manipulation. | Marcella Nebbioso Maria Luisa Livani Valentina Santamaria Aloisa Librando Massimiliano Sepe | 2018 | International Journal of Ophthalmology(English edition)2018，11，12： | 3 |
| 9 | Senescence and p130/Rb12: a new beginning to the end显示文摘 | Francesco P Fiorentinot Catherine E Symonds Marcella Macaluso Antonio Giordano | 2009 | Cell Research2009，19，9： | 3 |
| 10 | Yield Response to Deficit Irrigation and Partial Root-Zone Drying in Processing Tomato (Lycopersicon esculentum Mill,)显示文摘 | Eugenio Nardella Marcella Michela Giuliani Giuseppe Gatta Antonio De Caro | 2012 | Journal of Agricultural Science and Technology(A)2012，2，2： | 3 |
| 11 | An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR显示文摘 | Marcella Martignoni Ruben de Kanter Pietro Grossi Axel Mahnke Grazia Saturno Mario Monshouwer | 2004 | Chemico-Biological Interactions2004，，1： | 2 |
| 12 | 涡流检测技术用于储罐涂层的检测显示文摘涂层已广泛应用于金属基体的防腐保护。在过去的几十年中,防腐涂层体系广泛应用于恶劣环境条件下的工业设备防护,特别是在石油和天然气工业设备中得到了广泛的应用,常用于储罐、管道、热交换器和结构部件的腐蚀防护。 | Marcella Grosso Clava J Pacheco Monica P Arenas 王志强(摘译) | 2019 | 现代涂料与涂装2019，22，1： | 2 |
| 13 | Nitrogen immobilization in paddy soils as affected by redox conditions and rice straw incorporation显示文摘 | Daniel Said-Pullicino Maria Alexandra Cucu Marcella Sodano Jago Jonathan Birk Bruno Glaser Luisella Celi | 2014 | Geoderma2014，，： | 2 |
| 14 | Vitamin E Treatment in Pediatric Obesity-Related Liver Disease: A Randomized Study显示文摘 | Pietro Vajro Claudia Mandato Adriana Franzese Edmondo Ciccimarra Stefania Lucariello Marcella Savoia Grazia Capuano Fiorella Migliaro | 2004 | Journal of Pediatric Gastroenterology and Nutrition2004，，1： | 2 |
| 15 | Results, Outcome Predictors, and Complications after Stapled Transanal Rectal Resection for Obstructed Defecation显示文摘 | Giuseppe Gagliardi M.D. Mario Pescatori M.D. F.R.C.S. E.B.S.Q. Donato F. Altomare M.D. Gian Andrea Binda M.D. Corrado Bottini M.D. Giuseppe Dodi M.D. Vincenzino Filingeri M.D. Giovanni Milito M.D. Marcella Rinaldi M.D. Giovanni Romano M.D. Liana Spazzaf | 2008 | Diseases of the Colon & Rectum2008，，2： | 2 |
| 16 | Nutrient profiling schemes: overview and comparative analysis显示文摘 | Marcella Garsetti Jan Vries Maurice Smith Amélie Amosse Nathalie Rolf-Pedersen | 2007 | European Journal of Nutrition2007，，2： | 2 |
| 17 | Water oxidation electrocatalysis with iron oxide nanoparticles prepared via laser ablation显示文摘Iron oxide nanoparticles(FeO_x NPs, 5–30 nm size) prepared via laser ablation in liquid were supported onto Indium Tin Oxide conductive glass slides by magnetophoretic deposition(MD) technique. The resulting Fe O x@ITO electrodes are characterized by a low amount of iron coverage of 16–50 nmol/cm^2,and show electrocatalytic activity towards water oxidation in neutral phosphate buffer pH 7 with 0.58 V overpotential and quantitative Faradaic efficiency towards oxygen production. XPS analysis on the oxygen region of the FeO_x films reveals a substantial hydration of the surface after catalysis, recognized as a crucial step to access reactivity. | Erica Pizzolato Stefano Scaramuzza Francesco Carraro Alessia Sartori Stefano Agnoli Vincenzo Amendola Marcella Bonchio Andrea Sartorel | 2016 | Journal of Energy Chemistry2016，25，2： | 2 |
| 18 | Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis显示文摘 | Tsung-Cheng Chang Erik A. Wentzel Oliver A. Kent Kalyani Ramachandran Michael Mullendore Kwang Hyuck Lee Georg Feldmann Munekazu Yamakuchi Marcella Ferlito Charles J. Lowenstein Dan E. Arking Michael A. Beer Anirban Maitra Joshua T. Mendell | 2007 | Molecular Cell2007，，： | 2 |
| 19 | Relationship between MRI pertusion and clinical severity in multiple sclerosis显示文摘Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging(MRI)techniques.Furthermore,MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes,physical disability,and cognitive impairment.However,a review focused on these aspects is still missing.Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings.Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners,with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients.However,only 3T scanners showed a statistically significant distinction.Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found.However,the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances. | Maria Marcella Laganà Laura Pelizzari Francesca Baglio | 2020 | Neural Regeneration Research2020，15，4： | 2 |
| 20 | Thiol-peptide level and proteomic changes in response to cadmium toxicity in Oryza sativa L. roots显示文摘 | Roberta Aina Massimo Labra Pietro Fumagalli Candida Vannini Milena Marsoni Ulisse Cucchi Marcella Bracale Sergio Sgorbati Sandra Citterio | 2006 | Environmental and Experimental Botany2006，，3： | 2 |
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