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| 1 | Navigated liver surgery:State of the art and future perspectives显示文摘Background:In recent years,the development of digital imaging technology has had a significant influence in liver surgery.The ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital imaging.The combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases.Results:Fifty-one pertinent articles were retrieved and included.The different types of digital imaging technologies and the real-time navigated liver surgery were estimated and compared.Conclusions:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of fluorescence.Furthermore,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor margins.In liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s liver and models of the recipient’s hilar anatomy can contribute further to improving the results.In particular,pediatric LDLT abdominal cavity models can help to manage the largest challenge of this procedure,namely large-for-size syndrome. | Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis Ernest Hidalgo Nicola de’Angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，3： | 6 |
| 2 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 3 | Recurrence and survival following microwave, radiofrequency ablation, and hepatic resection of colorectal liver metastases: A systematic review and network meta-analysis显示文摘Background: Gold standard for colorectal liver metastases(CRLM) remains hepatic resection(HR). However, patients with severe comorbidities, unresectable or deep-situated resectable CRLM are candidates for ablation. The aim of the study was to compare recurrence rate and survival benefit of the microwave ablation(MWA), radiofrequency ablation(RFA) and HR by conducting the first network meta-analysis. Data sources: Systematic search of the literature was conducted in the electronic databases. Both updated traditional and network meta-analyses were conducted and the results were compared between them. Results: HR cohort demonstrated significantly less local recurrence rate and better 3-and 5-year diseasefree(DFS) and overall survival(OS) compared to MWA and RFA cohorts. HR cohort included significantly younger patients and with significantly lower preoperative carcinoembryonic antigen(CEA) by 10.28 ng/m L compared to RFA cohort. Subgroup analysis of local recurrence and OS of solitary and ≤3 cm CRLMs did not demonstrate any discrepancies when compared with the whole sample. Conclusions: For resectable CRLM the treatment of choice still remains HR. MWA and RFA can be used as a single or adjunct treatment in patients with unresectable CRLM and/or prohibitive comorbidities. | Paschalis Gavriilidis Keith J Roberts Nicola de’Angelis Luca Aldrighetti Robert P Sutcliffe | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，4： | 4 |
| 4 | Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?显示文摘 | Emily C. Bellavance Kimberly M. Lumpkins Gilles Mentha Hugo P. Marques Lorenzo Capussotti Carlo Pulitano Pietro Majno Paulo Mira Laura Rubbia-Brandt Alessandro Ferrero Luca Aldrighetti Steven Cunningham Nadia Russolillo Benjamin Philosophe Eduardo Barroso | 2008 | Journal of Gastrointestinal Surgery2008，，10： | 2 |
| 5 | A Risk Model to Predict 90-Day Mortality among Patients Undergoing Hepatic Resection显示文摘 | Omar Hyder Carlo Pulitano Amin Firoozmand Rebecca Dodson Christopher L. Wolfgang Michael A. Choti Luca Aldrighetti Timothy M. Pawlik | 2013 | Journal of the American College of Surgeons2013，，6： | 2 |
| 6 | Hilar Cholangiocarcinoma: Preoperative Liver Optimization with Multidisciplinary Approach. Toward a Better Outcome显示文摘 | Francesca Ratti Federica Cipriani Fabio Ferla Marco Catena Michele Paganelli Luca A. M. Aldrighetti | 2013 | World Journal of Surgery2013，，6： | 2 |
| 7 | Laparoscopic liver resections for hepatocellular carcinoma. Is it a feasible option for patients with liver cirrhosis?显示文摘 | R. Santambrogio L. Aldrighetti M. Barabino C. Pulitanò M. Costa M. Montorsi G. Ferla E. Opocher | 2009 | Langenbeck’s Archives of Surgery2009，，2： | 2 |
| 8 | Islet isolation for allotransplantation: variables associated with successful islet yield and graft function显示文摘 | R. Nano B. Clissi R. Melzi G. Calori P. Maffi B. Antonioli S. Marzorati L. Aldrighetti M. Freschi T. Grochowiecki C. Socci A. Secchi V. Carlo E. Bonifacio F. Bertuzzi | 2005 | Diabetologia2005，，5： | 1 |
| 9 | A prospective evaluation of laparoscopic versus open left lateral hepatic sectionectomy 显示文摘 | Aldrighetti L Pulitano C Catena M | 2008 | J Gastrointest Surg2008，12，3： | 1 |
| 10 | Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic eoloreetal cancer显示文摘 | Arru M Aldrighetti L Castoldi R | 2008 | World J Surg2008，32，1： | 1 |
| 11 | Analysis of prognostic factors influencing long-term survival after hepatic resection for me- tastatic colorectal cancer 显示文摘 | Arm M Aldrighetti L Castoldi R | 2008 | World J Surg2008，32，1： | 1 |
| 12 | Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis显示文摘 | de Lalla C Galli G Aldrighetti L | 2004 | J Immunol2004，173，2： | 1 |
| 13 | Laparoscopic hepatic left lateral sectionectomy using the LaparoEndoscopic Single Site approach: evolution of minimally invasive liver surgery 显示文摘 | Aldrighetti L Guzzetti E Ferla G | 2011 | J Hepatobiliary Pancreat Sci2011，18，1： | 1 |
| 14 | Antiangiogenic strategies in breast cancer management 显示文摘 | GIOVANNINI M ALDRIGHETTI D ZUCCINELLI P | 2010 | Crit Rev Oncol Hematol2010，76，1： | 1 |
| 15 | Colorectalliver metastasis in the setting of lymph node metastasis :defining the benefit of surgical resection 显示文摘 | Pulitan6 C Bodingbauer M Aldrighetti L | 2012 | Ann Surg Oncol2012，19，： | 1 |
| 16 | Antiangiogenicstrategies in breast cancer management显示文摘 | Giovannini M Aldrighetti D Zucchinelli P | 2010 | Crit Rev Oncol Hema-tol2010，76，1： | 1 |
| 17 | Reduced severity of liver is-chemia reperfusion injury following hepatic resection in humans is as-sociated with enhanced intrahepatic expression of Th2cytokines显示文摘 | Pulitano C Sitia G Aldrighetti L | 2006 | Hepatol Res2006，36，1： | 1 |
| 18 | Liverresection for colorectal metastases in presence of extrahepaticdisease : results from an international multi-institutional analysis显示文摘 | Pulitanb C Bodingbauer M Aldrighetti L | 2011 | Ann Surg Oncol2011，18，： | 1 |
| 19 | Impact of preoperative ste-roids administration on ischemia-reperfusion injury and systemicresponses in liver surgery: a prospective randomized study显示文摘 | Aldrighetti L Pulitano C Arm M | 2006 | LiverTranspl2006，12，6： | 1 |
| 20 | A prospective evaluation of laparoscopic versus open left lateral hepatic sectionectomy显示文摘 | Aldrighetti L Pulitane C Catena M | 2008 | J Gastrointest Surg2008，12，3： | 1 |
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