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| 1 | ERCP in acute pancreatitis:What takes place in routine clinical practice?显示文摘AIM:To evaluate the data from a survey carried out in Italy regarding the endoscopic approach to acute pancreatitis in order to obtain a picture of what takes place after the release of an educational project on acute pancreatitis sponsored by the Italian Association for the Study of the Pancreas.METHODS:Of the 1 173 patients enrolled in our survey,the most frequent etiological category was biliary forms(69.3%) and most patients had mild pancreatitis(85.8%).RESULTS:344/1 173(29.3%) underwent endoscopic retrograde cholangiopancreatography(ERCP).The mean interval between the onset of symptoms and ERCP was 6.7 ± 5.0 d;only 89 examinations(25.9%) were performed within 72 h from the onset of symptoms.The main indications for ERCP were suspicion of common bile duct stones(90.3%),jaundice(44.5%),clini cal worsening of acute pancreatitis(14.2%) and cho langitis(6.1%).Biliary and pancreatic ducts were visua lized in 305 patients(88.7%) and in 93 patients(27.0%) respectively.The success rate in obtaining a cholangio gram was statistically higher(P = 0.003) in patients with mild acute pancreatitis(90.6%) than in patients with severe disease(72.2%).Biliary endoscopic sphinc terotomy was performed in 295 of the 305 patients(96.7%) with no difference between mild and severe disease(P = 0.985).ERCP morbidity was 6.1% and mortality was 1.7%;the mortality was due to the complications of acute pancreatitis and not the endoscopic procedure.CONCLUSION:The results of this survey,as with those carried out in other countries,indicate a lack of compliance with the guidelines for the indications for interventional endoscopy. | Armando Gabbrielli Raffaele Pezzilli Generoso Uomo Alessandro Zerbi Luca Frulloni Paolo De Rai Laura Castoldi Guido Costamagna Claudio Bassi Valerio Di Carlo | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，9： | 14 |
| 2 | Intestinal barrier: A gentlemen's agreement between microbiota and immunity显示文摘Our body is colonized by more than a hundred trillion commensals, represented by viruses, bacteria and fungi. This complex interaction has shown that the microbiome system contributes to the host's adaptation to its environment, providing genes and functionality that give flexibility of diet and modulate the immune system in order not to reject these symbionts. In the intestine,specifically, the microbiota helps developing organ structures, participates of the metabolism of nutrients and induces immunity. Certain components of the microbiota have been shown to trigger inflammatory responses, whereas others, anti-inflammatory responses.The diversity and the composition of the microbiota,thus, play a key role in the maintenance of intestinal homeostasis and explain partially the link between intestinal microbiota changes and gut-related disorders in humans. Tight junction proteins are key molecules for determination of the paracellular permeability. In the context of intestinal inflammatory diseases, the intestinal barrier is compromised, and decreased expression and differential distribution of tight junction proteins is observed. It is still unclear what is the nature of the luminal or mucosal factors that affect the tight junctionproteins function, but the modulation of the immune cells found in the intestinal lamina propria is hypothesized as having a role in this modulation. In this review,we provide an overview of the current understanding of the interaction of the gut microbiota with the immune system in the development and maintenance of the intestinal barrier. | Andrea Moro Caricilli Angela Castoldi Niels Olsen Saraiva Cmara | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，1： | 11 |
| 3 | Development of an HPLC–UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients显示文摘A new method using high-performance liquid chromatography coupled with ultra violet detection(HPLC–UV)was developed and validated for the simultaneous quantification of atazanavir,dolutegravir,darunavir,efavirenz,etravirine lopinavir,raltegravir,rilpivirine and tipranavir in human plasma.For the first time we reported here the development and validation of an HPLC–UV assay to quantify the frequently administered 9antiretroviral compounds including dolutegravir and rilpivirine.A simple solid phase extraction procedure was applied to 500 μL aliquots of plasma.The chromatographic separation of the drugs and internal standard(quinoxaline) was achieved with a gradient of acetonitrile and sodium acetate buffer on a C_(18) reverse-phase analytical column with a 25 min analytical run time.Calibration curves were optimised according to the therapeutic range of drug concentrations in patients,and the coefficient of determination(r^2) was higher than0.99 for all analytes.Mean intraday and interday precisions(RSD) for all compounds were less than 15.0%,and the mean accuracy(% deviation from nominal concentration) was also found to be less than 15.0%.Extraction recovery range was between 80% and 120% for all drugs analysed.The solid phase extraction and HPLC–UV method enable a specific,sensitive,and reliable simultaneous determination of nine antiretroviral agents in plasma.Good extraction efficiency and low limit of HPLC–UV quantification make this method suitable for use in clinical trials and therapeutic drug monitoring. | Nitin Charbe Sara Baldelli Valeria Cozzi Simone Castoldi Dario Cattaneo Emilio Clementi | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 4 |
| 4 | Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘 | Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde | 2011 | Hepatology2011，，1： | 3 |
| 5 | Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis显示文摘 | Single B Castoldi AF | 1997 | J Exp Med1997，185，8： | 1 |
| 6 | Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP in preterm babies with respiratory distress syndrome: a randomised control trial 显示文摘 | Lista G Castoldi F Fontana P | 2010 | Arch Dis Child Fetal Neonatal Ed2010，95，2： | 1 |
| 7 | Nasal continuous positive air-way pressure(CPAP) versus bi-level nasal CPAP in preterm babieswith respiratory distress syndrome:a randomised control trial显示文摘 | Lista G Castoldi F Fontana P | 2010 | Arch Dis Child Fetal Neonatal Ed2010，95，2： | 1 |
| 8 | Proposal for the classifica- tion of acute leukemias: European group for the immunological characterization of leukemias显示文摘 | Bene MC Castoldi G Knappe W | 1995 | Leukemia1995，9，10： | 1 |
| 9 | A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)显示文摘 | SCHMIDT S BENES V | 2006 | RNA2006，12，： | 1 |
| 10 | Influence of solfon- ated melamine formaldehyde condensate on the quality of building blocks production by extrusion of cement-clay pastes显示文摘 | Arosio F Castoldi L Ferlazzo N | 2007 | Applied Clay Science2007，35，12： | 1 |
| 11 | Proposals for the immunological classification of acute leukemia显示文摘 | BENE M C CASTOLDI G KNAPP W | 1995 | Leukemia1995，9，： | 1 |
| 12 | ANG II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo显示文摘 | Castoldi G Di Gioia CR Pieruzzi F | 2003 | Am J Physiol Heart Circ Physiol2003，284，2： | 1 |
| 13 | Expression and functional role of urokinase-type plasminogen activator receptor in normal and acute leukemic cells显示文摘 | LANZA F CASTOLDI G L CASTAGNARI B | 1998 | Br J Haematol1998，103，： | 1 |
| 14 | Prolonged ethanol ingestion enhances benzene myelotoxicity and lowers urinary concentrations of benzene metabolite levels in CD - 1 male mice显示文摘 | Giorgio marrubini Anna F Castoldi Teresa Coecini | 2003 | Toxicology Sciences2003，75，： | 1 |
| 15 | Humeral head impression frac- ture in acute posterior shoulder dislocation: new surgical technique 显示文摘 | Assom M Castoldi F Rossi R | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，7： | 1 |
| 16 | Identification of the reaction networks of the NOx storage/reduction in lean NO, trap systems 显示文摘 | Forzatti P Castoldi L Lietti L | 2007 | Stud Surf Sci Catal2007，171，： | 1 |
| 17 | Expression of the miR- 17-92 polyeistron in chronic myeloid leukemia (CML)cD34+ cells显示文摘 | Venturini L Battmer K Castoldi M | 2007 | Blood2007，109，10： | 1 |
| 18 | Volume guarantee versus high-frequency ventilation: lung inflammation in preterm infants 显示文摘 | Lista G Castoldi F Bianchi S | 2008 | Arch Dis Child Fetal Neonatal Ed2008，93，： | 1 |
| 19 | Nasal continuous positive airway pressure (CPAP) versus bi-level nasal CPAP inpreterm babies with respiratory distress syndrome:a randomised control trial显示文摘 | Lista G Castoldi F Fontana P | 2010 | Arch Dis Child Fetal Neonatal Ed2010，95，2： | 1 |
| 20 | Proposals for the immunological classification of acute leukemia显示文摘 | Bene MC Castoldi G Knapp W | 1995 | Leukemia1995，9，： | 1 |
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