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| 1 | Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) has been recognized as a major health burden.It is the most important cause of chronic liver disease and a major independent cardiovascular risk factor.Lacking a definite treatment for NAFLD,a specific diet and an increase in physical activity represent the most commonly used therapeutic approaches.In this review,major literature data about the use of omega-3 polyunsaturated fatty acids(n-3 PUFAs) as a potential treatment of NAFLD have been described.n-3 PUFAs,besides having a beneficial impact on most of the cardio-metabolic risk factors(hypertension,hyperlipidemia,endothelial dysfunction and atherosclerosis) by regulating gene transcription factors [i.e.,peroxisome proliferator-activated receptor(PPAR),PPAR,sterol regulatory element-binding protein-1,carbohydrate responsive element-binding protein],impacts both lipid metabolism and on insulin sensitivity.In addition to an enhancement of hepatic beta oxidation and a decrease of the endogenous lipid production,n-3 PUFAs are able to determine a significant reduction of the expression of pro-inflammatory molecules(tumor necrosis factor-and interleukin-6) and of oxygen reactive species.Further strengthening the results of the in vitro studies,both animal models and human intervention trials,showed a beneficial effect of n-3 PUFAs on the severity of NAFLD as expressed by laboratory parameters and imaging measurements.Despite available results provided encouraging data about the efficacy of n-3 PUFAs as a treatment of NAFLD in humans,welldesigned randomized controlled trials of adequate size and duration,with histological endpoints,are needed to assess the long-term safety and efficacy of PUFA,as well as other therapies,for the treatment of NAFLD and non-alcoholic steatohepatitis patients.It is worthwhile to consider that n-3 PUFAs cannot be synthesized by the human body and must be derived from exogenous sources(fish oil,flaxseeds,olive oil) which are typical foods of the Mediterranean diet,known for its beneficial effects in preventing obesity,diabetes and,in turn,cardiovascular events.According to these data,it is important to consider that most of the beneficial effects of n-3 PUFAs can also be obtained by an equilibrate nutrition program. | Matteo Nicola Dario Di Minno Anna Russolillo Roberta Lupoli Pasquale Ambrosino Alessandro Di Minno Giovanni Tarantino | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?显示文摘 | Emily C. Bellavance Kimberly M. Lumpkins Gilles Mentha Hugo P. Marques Lorenzo Capussotti Carlo Pulitano Pietro Majno Paulo Mira Laura Rubbia-Brandt Alessandro Ferrero Luca Aldrighetti Steven Cunningham Nadia Russolillo Benjamin Philosophe Eduardo Barroso | 2008 | Journal of Gastrointestinal Surgery2008，，10： | 2 |
| 3 | Safety of Conservative Management of Bile Leakage after Hepatectomy with Biliary Reconstruction显示文摘 | Alessandro Ferrero Nadia Russolillo Luca Viganò Enrico Sgotto Roberto Lo Tesoriere Marco Amisano Lorenzo Capussotti | 2008 | Journal of Gastrointestinal Surgery2008，，12： | 2 |
| 4 | Laparoscopic left lateral hepatic lobectomy: a safer and faster technique显示文摘 | Giulio Belli Corrado Fantini Alberto D’Agostino Andrea Belli Luigi Cioffi Nadia Russolillo | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，2： | 1 |
| 5 | Intraperative detection of disappearing colorectal liver metastases as a predictor of resid- ual disease显示文摘 | Ferro A Langwella S Russolillo N | 2012 | J Gastrointest Surg2012，16，4： | 1 |
| 6 | Routine anterior approach during right hepatectomy, results of a prospective randomised controlled trial 显示文摘 | Capussotti L Ferrero A Russolillo N | 2012 | J Gastrointest Surg2012，16，7： | 1 |
| 7 | Improving the use of direct oral anticoagulants in atrial fibrillation显示文摘 | Di Minno G Russolillo A Gambacorta C | 2013 | Eur J Intern Med2013，24，4： | 1 |
| 8 | Laparoscopic versus open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: short- and middle-term results显示文摘 | G. Belli C. Fantini A. D'Agostino L. Cioffi S. Langella N. Russolillo A. Belli | 2007 | Surgical Endoscopy2007，，11： | 1 |
| 9 | Routine anterior ap- proach during right hepatectomy: results of a prospective rando- raised controlled trim 显示文摘 | Capussotti L Ferrero A Russolillo N | 2012 | J Gastrointest Surg2012，16，7： | 1 |
| 10 | Intraoperative Detection of Disappearing Colorectal Liver Metastases as a Predictor of Residual Disease显示文摘 | Alessandro Ferrero Serena Langella Nadia Russolillo Luca Vigano’ Roberto Lo Tesoriere Lorenzo Capussotti | 2012 | Journal of Gastrointestinal Surgery2012，，4： | 1 |
| 11 | Evolution of Long-Term Outcome of Liver Resection for Colorectal Metastases: Analysis of Actual 5-Year Survival Rates over Two Decades显示文摘 | Luca Viganò MD Nadia Russolillo MD Alessandro Ferrero MD Serena Langella MD Elisa Sperti MD Lorenzo Capussotti MD | 2012 | Annals of Surgical Oncology2012，，6： | 1 |
| 12 | Safety of Conservative Management of Bile Leakage after Hepatectomy with Biliary Reconstruction显示文摘 | Alessandro Ferrero Nadia Russolillo Luca Viganò Enrico Sgotto Roberto Lo Tesoriere Marco Amisano Lorenzo Capussotti | 2008 | Journal of Gastrointestinal Surgery2008，，12： | 1 |
| 13 | Sildenafil therapy for pulmonary hypertension before and after pediatric congenital heart surgery显示文摘 | Palma G Giordano R Russolillo V | 2011 | Tex Heart Inst J2011，38，3： | 1 |
| 14 | White Certificates for Energy Efficiency Improvement with Energy Taxes: A Theoretical Economic Model 显示文摘 | Oikonomou V C Jepma Becchis F Russolillo D | 2008 | Energy Economics2008，30，6： | 1 |
| 15 | Does Pringle Maneuver Affect Survival in Patients with Colorectal Liver Metastases?显示文摘 | Alessandro Ferrero Nadia Russolillo Luca Viganò Roberto Lo Tesoriere Andrea Muratore Lorenzo Capussotti | 2010 | World Journal of Surgery2010，，10： | 1 |
| 16 | Sildenaftl therapy for pulmonary hypertension before and after pediatric congenital heart surgery显示文摘 | Pakna G Giordano R Russolillo V | 2011 | Tex Heart Inst J2011，38，3： | 1 |
| 17 | Anterolateral minitho- racotomies for the radical correction of congenital heart dis- eases显示文摘 | Pahna G Giordano R Russolillo V | 2009 | Tex Heart Inst J2009，36，6： | 1 |
| 18 | Evolution of long-term outcome of liver resection for colorectal metastases :analysis of actual 5-year survival rates over two decades 显示文摘 | Vigano L Russolillo N Ferrero A | 2012 | Ann Surg Oncol2012，19，： | 1 |
| 19 | Sildenafil therapy for pulmonary hypertension before and after pediatric congenital heart surgery 显示文摘 | Palma G Giordano R Russolillo V | 2011 | Tex Heart Inst J2011，38，3： | 1 |
| 20 | Evolution of long-term outcome of liver resection for colorectal metastases: analysis of actual 5-year survival rates over two decades显示文摘 | Viganò L Russolillo N Ferrero A | 2012 | Ann Surg Oncol2012，19，6： | 1 |
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