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| 1 | An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options显示文摘Since the documented observations of Kanner in1943, there has been great debate about the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known as autism spectrum disorder(ASD).Re?ecting this complicated history, there has been continual re?nement from DSM-III with ‘Infantile Autism' to the current DSM-V diagnosis. The disorder is now widely accepted as a complex, pervasive, heterogeneous condition with multiple etiologies, sub-types, and developmental trajectories. Diagnosis remains based on observation of atypical behaviors, with criteria of persistent de?cits in social communication and restricted and repetitive patterns of behavior. This review provides a broad overview of the history, prevalence, etiology, clinical presentation, and heterogeneity of ASD. Factors contributing to heterogeneity, including genetic variability, comorbidity, and gender are reviewed. We then explore current evidencebased pharmacological and behavioral treatments for ASD and highlight the complexities of conducting clinical trials that evaluate therapeutic ef?cacy in ASD populations.Finally, we discuss the potential of a new wave of research examining objective biomarkers to facilitate the evaluation of sub-typing, diagnosis, and treatment response in ASD. | Anne Masi Marilena M.De Mayo Nicholas Glozier Adam J.Guastella | 2017 | Neuroscience Bulletin2017，33，2： | 33 |
| 2 | 儿童早期发展综合干预策略对改善贫困农村地区0~35月龄儿童养育照护的效果显示文摘目的 分析儿童早期发展综合干预策略对改善贫困地区0~35月龄儿童早期家庭养育照护的效果.方法 儿童早期发展综合干预项目(IECD)于2014年开始在4个贫困县农村地区试点开展,通过多种途径为项目地区0~35月龄儿童及其看护人提供儿童养育照护多维度综合干预.采用人群干预对照设计,评价干预对看护人健康与心理、儿童营养、早期学习、儿童保护和社会保障等方面的改善效果,分别于2013年和2016年开展基线和中期调查,采用双重差分模型估计干预效果,并控制社会人口学特征等混杂因素.结果 基线调查纳入0~35月龄儿童干预组1 468名、对照组1 485名,中期调查分别纳入1 384名和1 361名.干预组通过2年的干预,看护人抑郁患病率下降9.1%[中期34.8% (479/1 377)比基线43.9% (621/1 414)],对照组下降1.6%[34.3% (464/1 353)比35.9%(509/1 419)],双重差分模型控制因素混杂后,结果显示干预组下降幅度较同期对照组高7.0%(P=0.008);6~23月龄儿童辅食添加频次合格的比例上升10.4%[69.0% (532/771)比58.6%(481/821)],对照组上升幅度2.9%[66.4% (469/706)比63.5%(508/800)],双重差分模型控制混杂因素后,干预组上升幅度比对照组高8.2%(P=0.021);干预组儿童遭受暴力管教的比例下降6.2% [49.1% (478/973)比55.3%(554/1 001)],同期对照组上升4.5%[58.4% (560/959)比53.9%(558/1 036)],双重差分模型控制混杂因素后,两组变化幅度相差11.0%(P=0.001);干预组家庭拥有儿童图书≥3本的比例上升12.7%[42.7% (588/1 378)比30.0% (432/1 440)],同期对照组上升幅度4.2%[25.7% (349/1 357)比21.5%(298/1 388)]双重差分模型控制混杂因素后,干预组比对照组幅度高6.1%(P=0.007).结论 多部门合作儿童早期发展综合干预策略可以有效改善看护人心理状况、促进儿童喂养、支持儿童早期学习,并减少暴力管教等不恰当的养育行为,从而为儿童早期健康发展创造良好养育照护环境. | 石慧峰 张敬旭 王晓莉 徐媛媛 董胜利 赵春霞 黄小娜 赵颀 陈学锋 周烨 Mayo O'Sullivan Ron Pouwels Robert W.Scherpbier | 2018 | 中华儿科杂志2018，56，2： | 17 |
| 3 | Vacuum interrupter,high reliability component of distribution switches,circuit breakers and contactors显示文摘The use of vacuum interrupters(VIs)as the current interruption component for switches,circuit breakers,reclosers and contactors operating at distribution voltages has escalated since their introduction in the mid-1950’s.This electrical product has developed a dominating position for switching and protecting distribution circuits.VIs are even being introduced into switching products operating at transmission voltages.Among the reasons for the VI’s popularity are its compactness,its range of application,its low cost,its superb electrical and mechanical life and its ease of application.Its major advantage is its well-established reliability.In this paper we show how this reliability has been achieved by design,by mechanical life testing and by electrical performance testing.We introduce the“sealed for life”concept for the VI’s integrity.We discuss this in terms of what is meant by a practical leak rate for VIs with a life of over 30 years.We show that a simple high voltage withstand test is an easy and effective method for monitoring the long-term vacuum integrity.Finally we evaluate the need for routine inspection of this electrical product when it is used in adverse ambient environments. | SLADE Paul G. MAYO Stephen SMITH R.Kirkland TAYLOR Erik D. | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，3： | 4 |
| 4 | A study of the temporomandibular joint during bruxism显示文摘A finite element model of the temporomandibular joint(TMJ)and the human mandible was fabricated to study the effect of abnormal loading,such as awake and asleep bruxism,on the articular disc.A quasilinear viscoelastic model was used to simulate the behaviour of the disc.The viscoelastic nature of this tissue is shown to be an important factor when sustained(awake bruxism)or cyclic loading(sleep bruxism)is simulated.From the comparison of the two types of bruxism,it was seen that sustained clenching is the most detrimental activity for the TMJ disc,producing an overload that could lead to severe damage of this tissue. | María S Commisso Javier Martínez-Reina Juana Mayo | 2014 | International Journal of Oral Science2014，6，2： | 3 |
| 5 | Incontinence after Radical Prostatectomy: Detrusor or Sphincter Causes显示文摘 | Roberto Chao Michael E. Mayo | 1995 | The Journal of Urology1995，，： | 2 |
| 6 | miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts显示文摘 | Hanno Matthaei Dennis Wylie Maura B. Lloyd Marco Dal Molin Jon Kemppainen Skye C. Mayo Christopher L. Wolfgang Richard D. Schulick Laura Langfield Bernard F. Andruss Alex T. Adai Ralph H. Hruban Anna E. Szafranska-Schwarzbach Anirban Maitra | 2012 | Clinical Cancer Research2012，，17： | 2 |
| 7 | NDE reliability gains from combining eddy-current and ultrasonic testing显示文摘 | Horn D Mayo W R | 2000 | NDT&E International2000，33，： | 2 |
| 8 | Microbiological Survey of the Human Gastric Ecosystem Using Culturing and Pyrosequencing Methods显示文摘 | Susana Delgado Raúl Cabrera-Rubio Alex Mira Adolfo Suárez Baltasar Mayo | 2013 | Microbial Ecology2013，，3： | 2 |
| 9 | Acute Pancreatitis During Pregnancy显示文摘 | Shou–Jiang Tang Edmundo Rodriguez–Frias Sundeep Singh Marlyn J. Mayo Saad F. Jazrawi Jayaprakash Sreenarasimhaiah Luis F. Lara Don C. Rockey | 2010 | Clinical Gastroenterology and Hepatology2010，，1： | 2 |
| 10 | 显示文摘 | Domingues RB Lakeman FD Mayo MS | 1998 | J Clin Microbiol1998，36，8： | 1 |
| 11 | Treatment of neuromyelitis optica with rituximab : retrospective analysis of 25 patients 显示文摘 | Mayo C Rochester M | 2008 | Arch Neurol2008，65，11： | 1 |
| 12 | Computational method to reduce the search space for directed protein evolution显示文摘 | Mayo S L Arnold F H | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 13 | Gene delivery nanoparticles fabricated by supercritical fluid extraction of emulsions 显示文摘 | Mayo AS Ambati BK Kompella UB | 2010 | Int J Pharm2010，387，27： | 1 |
| 14 | NF-κB antiapoptosis: induction of TRAF1, TRAF2, c-IAP1 and c-IAP2 to suppress caspase-8 activation显示文摘 | Wang CY Mayo MW Korneluk RG | 1998 | Science1998，281，： | 1 |
| 15 | Production of polyclonal antibodies against ochratoxin A and its detection in chilies by ELISA显示文摘 | Thirumala - Devi K Mayo MA Roddy G | 2000 | J Agric Food Chem2000，48，10： | 1 |
| 16 | Spatial memory performances of aged rats in the water maze predict levels hippocampal neumgenesis 显示文摘 | Drapeau E Mayo W Aurousseau C | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 17 | A summary of taxonomic changes recently approved by ICTV显示文摘 | Mayo M A | 2002 | Arch Virol2002，147，： | 1 |
| 18 | The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosus显示文摘 | Wang C Mayo NE Fortin PR | 2001 | J Rheumatol2001，28，3： | 1 |
| 19 | Imaging evaluation of developmental hip dysplasia in the young adult显示文摘 | Beltran LS Rosenberg ZS Mayo JD | 2013 | AJR Am J Roentgenol2013，200，5： | 1 |
| 20 | A random- ized trial of two home-based exercise programmes to im- prove functional walking post-stroke显示文摘 | Mayo NE MacKay-Lyons MJ Scott SC | 2013 | Clin Rehabil2013，27，7： | 1 |
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