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| 1 | Therapeutic potential of snake venom in cancer therapy:current perspectives显示文摘Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer.Snake venom toxins coutributed significantly to the treatment of many medical conditions.There are many published studies describing and elucidating the anti-cancer potential of snake venom.Cancer therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different species.Some of these proteins or peptides and enzymes from snake venom when isolated and evaluated may bind specifically to cancer cell membranes,affecting the migration and proliferation of these cells.Some of substances found in the snake venom present a great potential as anti-tumor agent.In this review,we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity. | Vivek Kumar Vyas Keyur Brahmbhatt Hardik Bhatt Utsav Parmar | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 5 |
| 2 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 3 | Turn-on fluorescence probe for selective detection of Hg(Ⅱ)by calixpyrrole hydrazide reduced silver nanoparticle: Application to real water sample显示文摘A simple and quick method for the synthesis of water dispersible stable silver nanoparticles has been developed. Calix[4]pyrrole octahydrazide(CPOH), has been successfully used as a reducing as well as stabilizing agent for the synthesis of silver nanoparticles. CPOH-AgNps have been duly characterized by SPR, PSA, TEM and EDX-ray. The ability of CPOH-AgNps as selective and sensitive sensor for various ions(Pb(Ⅱ), Cd(Ⅱ), Mn(Ⅱ), Fe(Ⅲ), Ni(Ⅱ), Zn(Ⅱ), Hg(Ⅱ), Co(Ⅱ), Cu(Ⅱ)) by colorimetry and spectrofluorimetry has been explored. CPOH-AgNps were found to be selective only for Hg(Ⅱ) ions. Nanomolar concentration of Hg(Ⅱ) ions can also be determined by spectrofluorimetry by increase in fluorescence intensity. Linear range of detection of Hg(Ⅱ) ions in water was found to be from 1 nmol/L to 1 μmol/L. The method has been successfully applied for determination of Hg(Ⅱ) ions in ground water and industrial effluent waste water samples. | Keyur D. Bhatt Disha J. Vyas Bharat A. Makwana Savan M. Darjee Vinod K. Jain Hemangini Shah | 2016 | Chinese Chemical Letters2016，27，5： | 2 |
| 4 | Adherence to combination therapy enhances sustained response in genotype-1–infected patients with chronic hepatitis C显示文摘 | John G. McHutchison Michael Manns Keyur Patel Thierry Poynard Karen L. Lindsay Christian Trepo Jules Dienstag William M. Lee Carmen Mak Jean–Jacques Garaud Janice K. Albrecht | 2002 | Gastroenterology2002，，4： | 2 |
| 5 | Solid phase extraction, preconcetraction and sequential separation of U ( VI ), Th ( IV ),La(III) and Ce(III) by Octa-O-met hoxy resorcin arene based Amberlite XAD -4 chelating resin 显示文摘 | Keyur D Bhatt Disha J Vyas Hrishikesh S Gupte | 2014 | World Journal of Analy-tical Chemistry2014，2，： | 1 |
| 6 | Outcome and determinants of mortality in 269 patients with combination anti‐tuberculosis drug‐induced liver injury显示文摘 | Harshad Devarbhavi Rajvir Singh Mallikarjun Patil Keyur Sheth Channagiri Krishnamurthy Adarsh Girisha Balaraju | 2012 | J Gastroenterol Hepatol2012，，1： | 1 |
| 7 | Phosphodiesterase Inhibitors, Congestive Heart Failure, and Sudden Death: Time for Re‐Evaluation显示文摘 | Amit Varma Keyur B. Shah Michael L. Hess | 2012 | Congestive Heart Failure2012，，： | 1 |
| 8 | Role of growth factors and thrombopoietic agents in the treatment of chronic hepatitis C显示文摘 | Hans L. Tillmann Keyur Patel John G. McHutchison | 2009 | Current Gastroenterology Reports2009，，1： | 1 |
| 9 | Clinical Validation of a Next-Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-Related Genes显示文摘 | Rajesh R. Singh Keyur P. Patel Mark J. Routbort Neelima Reddy Bedia Barkoh Brian Handal Rashmi Kanagal-Shamanna Wesley O. Greaves L. Jeffrey Medeiros Kenneth Aldape Rajyalakshmi Luthra | 2013 | The Journal of Molecular Diagnostics2013，，： | 1 |
| 10 | Antifibrotic Therapies: Will We Ever Get There?显示文摘 | Alexander James Thompson Keyur Patel | 2010 | Current Gastroenterology Reports2010，，1： | 1 |
| 11 | Evaluation of a panel of non-invasive serum markers to differentiate mild from moderate-to-advanced liver fibrosis in chronic hepatitis C patients显示文摘 | Keyur Patel Stuart C. Gordon Ira Jacobson Christophe Hézode Esther Oh Katie M. Smith Jean-Michel Pawlotsky John G. McHutchison | 2004 | Journal of Hepatology2004，，6： | 1 |
| 12 | 慢性丙型肝炎病毒感染的诊断和治疗显示文摘在未来10~20年中,与丙肝病毒感染相关的肝病并发症将增加.需要贯彻预防策略,减少高危人群中人与人之间的传播,通过抗病毒治疗,可能维持病毒清除状态,预防疾病进展,目前的最佳治疗方法是,根据基因型和病毒学反应,应用聚乙二醇干扰素α和利巴韦林治疗24~48周,针对丙肝病毒感染的新型特异性靶向抗病毒治疗正在临床研制中. | Keyur Patel Andrew J Muir John G McHutchison 张静(译) 林三仁(校) | 2006 | 英国医学杂志中文版2006，9，4： | 1 |
| 13 | HIV and tuberculosis: Partners in crime显示文摘 | Janak Maniar Ratnakar Kamath Sundhiya Mandalia Keyur Shah Alok Maniar | 2006 | Indian Journal of Dermatology, Venereology, and Leprology2006，，4： | 1 |
| 14 | Isolated TuberculousEpididymo–Orchitis:A Rare and Instructive Case Report显示文摘 | Dr Keyur NS Dr Kaushal DS Dr Jainam KS | 2012 | Seajcrr2012，1，3： | 1 |
| 15 | Exercise improvement and plasma biomarker changes with intravenous treprostinil therapy for pulmonary arterial hypertension: A placebo-controlled trial显示文摘 | Jagdish Hiremath Sadagopa Thanikachalam Keyur Parikh Somasundaram Shanmugasundaram Sudhakar Bangera Leland Shapiro Gregory B. Pott Cindy L. Vnencak-Jones Carl Arneson Michael Wade R. James White | 2010 | Journal of Heart and Lung Transplantation2010，，： | 1 |
| 16 | Pleiotropy and allelic heterogeneity in the TOMM40 - APOE genomic region related to clinical and metabolic features of hepatitis C infection显示文摘 | Ornit Chiba-Falek Colton Linnertz John Guyton Stephen D. Gardner Allen D. Roses Jeanette J. McCarthy Keyur Patel | 2012 | Human Genetics2012，，12： | 1 |
| 17 | A Polymorphism Near IL28B Is Associated With Spontaneous Clearance of Acute Hepatitis C Virus and Jaundice显示文摘 | Hans L. Tillmann Alex J. Thompson Keyur Patel Manfred Wiese Hannelore Tenckhoff Hans D. Nischalke Yuliya Lokhnygina Ulrike Kullig Uwe G?bel Emanuela Capka Johannes Wiegand Ingolf Schiefke Wolfgang Güthoff Kurt Grüngreiff Ingrid K?nig Ulrich Spengler Jeane | 2010 | Gastroenterology2010，，5： | 1 |
| 18 | A PDMS micro proton exchange membrane fuel cell by conventional and non-conventional microfabrication techniques 显示文摘 | Keyur Shah Shin W C Besser R S | 2004 | Sensors and Actuators B: Chemical2004，97，23： | 1 |
| 19 | Using Capsule Endoscopy to Identify GI Tract Lesions in Cirrhotic Patients With Portal Hypertension and Chronic Anemia显示文摘 | Karen R. Canlas Brian M. Dobozi Sauyu Lin Alastair D. Smith Don C. Rockey Andrew J. Muir Naurang M. Agrawal Martin H. Poleski Keyur Patel John G. McHutchison | 2008 | Journal of Clinical Gastroenterology2008，，7： | 1 |
| 20 | Classification Techniques For Geometric Data Perturbation in Multiplicative Data Perturbation显示文摘 | Keyur D Shruti Y | 2014 | International Journal of Engineering Development and Research2014，2，2： | 1 |
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