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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | Repeated operations for infiltrative low - grade gliomas without intervening therapy.显示文摘OBJECT:Progression of infiltrative low-grade gliomas(LGGs)has been reported previously.The limitations ofsuch studies include diverse histological grading systems,intervening therapy,and the lack of histological confir-mation of malignant tumor progression.The aim of this study was to determine tumor progression in adult patientswith an initial diagnosis of infiltrative LGG who subsequently underwent a repeated operation,but no other inter-vening therapy.The authors examined factors that may be associated with tumor progression. | Schmidt MH Berger MS Lamborn KR Aldape K McDermott MW Prados MD Chang SM | 2003 | 中国神经肿瘤杂志2003，1，2： | 8 |
| 3 | PTEN expression in non-small-cell lung cancer:Evaluating its relation to tumor characteristics,allelic loss,and epigenetic alteration显示文摘 | Marsit CJ Zheng S Aldape K | 2005 | Hum Pathol2005，36，7： | 1 |
| 4 | Immunohistochemical detection of EGFRvⅢ in high malignancy grade astrocytomas and evaluation of prognostic significance显示文摘 | Aldape KD Ballman K Furth A et al | 2004 | J Neuropathol Exp Neurol2004，63，： | 1 |
| 5 | Detection of human cytomegalovirus in different histological types of gliomas 显示文摘 | Scheurer ME Bondy ML Aldape KD | 2008 | Acta Neuropathol2008，116，1： | 1 |
| 6 | Epidemiology and molecular pathology of glioma 显示文摘 | Schwartzbaum JA Fisher JL Aldape KD | 2006 | Nat Clin Pract Neurol2006，2，9： | 1 |
| 7 | Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule- associated protein 1 light chain 3 显示文摘 | Aoki H Kondo Y Aldape K | 2008 | Autophagy2008，4，4： | 1 |
| 8 | Nuclear FABP7 Immunoreactivity is Preferentially Expressed in Infiltrative Glioma and is Associated with Poor Prognosis in EGFR-overexpressing Glioblastoma显示文摘 | Liang Y Bollen A W Aldape K D | 2006 | BMC Cancer2006，6，： | 1 |
| 9 | Activation of Stat3in human melanoma promoter brain metastasis显示文摘 | Xie T X Huang F Aldape K | 2006 | Cancer Res2006，66，6： | 1 |
| 10 | Epidemiology and molecular pathology of glioma显示文摘 | Schwartzbaum JA Fisher JL Aldape KD | | 0，，09： | 1 |
| 11 | Activation of stat3 in human melanoma promotes brain metastasis显示文摘 | Xie TX Huang FJ Aldape KD | 2006 | Cancer Res2006，66，6： | 1 |
| 12 | Nucleotide sequence of a cyclodextrin glucosyhransferase gene, cgtA, from Bacillus licheniformis 显示文摘 | Hill DE Aldape R RozzeH JD | 1990 | Nucleic Acids Res1990，18，： | 1 |
| 13 | Expression of nitric oxide synthase in human central nervous sustem tumors 显示文摘 | Brenman JE Aldape KD | 1995 | Cancer Res1995，55，： | 1 |
| 14 | Expression of nitric oxide synthase in human central nervous system tumors显示文摘 | Cobbs CS Brenman JE Aldape KD | 1995 | CancerRes1995，55，4： | 1 |
| 15 | Epidemiology and molecular pathology of glioma显示文摘 | Schwartzbaum JA Fisher JL Aldape KD | | 0，，09： | 1 |
| 16 | Expression of nitric oxide synthase in human central nervous system tumors显示文摘 | Cobbs CS Brenman JE Aldape KD | | 0，，04： | 1 |
| 17 | Multigene sets for clinical application in glioma 显示文摘 | deGroot JF Sulman EP Aldape KD | 2011 | J Natl Compr CancNetw2011，9，4： | 1 |
| 18 | Clinical Validation of a Next-Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-Related Genes显示文摘 | Rajesh R. Singh Keyur P. Patel Mark J. Routbort Neelima Reddy Bedia Barkoh Brian Handal Rashmi Kanagal-Shamanna Wesley O. Greaves L. Jeffrey Medeiros Kenneth Aldape Rajyalakshmi Luthra | 2013 | The Journal of Molecular Diagnostics2013，，： | 1 |
| 19 | PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism 显示文摘 | Park S T Aldape R A Futer O | 1992 | J Biol Chem1992，267，5： | 1 |
| 20 | Immunohistochemical detection of EGFRv Ⅲ in high malignancy grade astrocytomas and evaluation of prognostic significance显示文摘 | Aldape KD Ballman K Furth A | 2004 | J Neuropathol Exp Neurol2004，63，7： | 1 |
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