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| 1 | Hepatocellular adenoma: An update显示文摘Hepatocellular adenomas(HCA) are rare benign liver tumors.Recent technological advancements have helped in the early identification of such lesions.However,precise diagnosis of hepatocellular incidentalomas remains challenging.Studies at the molecular level have provided new insights into the genetics and pathophysiology of these lesions.These in turn have raised questions over their existing management modalities.However,the rarity of the tumor still restricts the quality of evidence available for current recommendations and guidelines.This article provides a comprehensive review on the etiology,molecular biology,pathophysiology,clinical manifestations,and complications associated with HCA.It also elaborates on the genetic advancements,existing diagnostic tools and current guidelines for management for such lesions. | Adarsh Vijay Ahmed Elaffandi Hatem Khalaf | 2015 | World Journal of Hepatology2015，7，25： | 12 |
| 2 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 3 | Palliative surgical bypass for unresectable periampullary carcinoma显示文摘BACKGROUND:Around 60%to 80%of patients with periampullary carcinoma are unresectable either due to distant metastasis or local vascular invasion.With the advancement of endoscopic interventional procedures,the role of surgical bypass has diminished.However,surgical bypass is still appropriate in patients with unresectable disease discovered at the time of surgery.This study was conducted to assess the results of palliative surgical bypass for patients with unresectable periampullary carcinoma at our hospital,a tertiary referral center of Northern India. METHOD:The study group comprised 204 patients who had undergone surgical bypass for advanced periampullary carcinoma over the last 15 years. RESULTS:Between January 1990 and December 2004,204 patients(128 males,76 females)consisting of 179 patients with carcinoma of head of the pancreas,14 patients with ampullary carcinoma,8 patients with lower end cholangiocarcinoma and 3 patients with duodenal carcinoma underwent surgical bypass.Their average age was 51 years (range 20-78 years).Both biliary and gastric bypasses were done in 158(77.45%),biliary bypass alone in 37(18.13%) and gastric bypass alone in 9(4.32%).Biliary bypass was done by Roux-en-Y hepaticojejunostomy,and gastric bypass by retrocolic gastrojejunostomy.The overall postoperative mortality and morbidity were 0.98%and 26.9%,respectively The patients who died had undergone previously endoscopic intervention.Complications included wound infection in 12.25%of the patients,bile leak in 5.12%,delayed gastric emptying in 5.38%,ascitic leak from drains in 8.8%,and upper gastrointestinal bleeding in 1.96%.The incidences of wound infection and bile leak both were significantly higher in patients who had had preoperative biliary stenting None of the patients who had undergone Roux-en-Y hepati cojejunostomy+retrocolic gastrojejunostomy required any intervention later in their life.CONCLUSIONS:Surgical bypass is a safe procedure with negligible mortality and minimal morbidity.It has not lost its relevance and is an appropriate treatment in patients deemed unresectable on peroperative assessment. | Shivendra Singh Ajay Kumar Sachdev Adarsh Chaudhary Anil Kumar Agarwal | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 3 |
| 4 | Outcome and determinants of mortality in 269 patients with combination anti‐tuberculosis drug‐induced liver injury显示文摘 | Harshad Devarbhavi Rajvir Singh Mallikarjun Patil Keyur Sheth Channagiri Krishnamurthy Adarsh Girisha Balaraju | 2012 | J Gastroenterol Hepatol2012，，1： | 1 |
| 5 | Complete temporal characterization of a single photon显示文摘Precise information about the temporal mode of optical states is crucial for optimizing their interaction efficiency between themselves and/or with matter in various quantum communication devices.Here we propose and experimentally demonstrate a method of determining both the real and imaginary components of a single photon’s temporal density matrix by measuring the autocorrelation function of the photocurrent from a balanced homodyne detector at multiple local oscillator frequencies.We test our method on single photons heralded from biphotons generated via four-wave mixing in an atomic vapor and obtain excellent agreement with theoretical predictions for several settings. | Zhongzhong Qin Adarsh S Prasad Travis Brannan Andrew MacRae A Lezama AI Lvovsky | 2015 | Light(Science & Applications)2015，4，1： | 1 |
| 6 | Retroperitcmeal liposarcoma, Acomprehensive review显示文摘 | Adarsh V Lakshmi R | 2015 | Am J Clin Oncol2015，38，2： | 1 |
| 7 | Role of eoenzyme Qlo ( CQlo ) in cardiac disease, hyper- tension and Meniere-like syndrome 显示文摘 | Adarsh Kumar a Harharpreet Kaur Pushpa Devi | 2009 | Pharmacology & Therapeutics2009，124，： | 1 |
| 8 | Cross-Sectional study of internalised stigma and medication adherence in patients with obsessive compulsive disorder显示文摘Background Patients suffering from psychiatric disorders tend to stigmatise themselves which had been linked to poor adherence to treatment.Aims The aim of the present study was to study internalised stigma and medication adherence and to assess the relationship between them in patients with obsessive compulsive disorder(0CD).Methods A cross-sectional study was conducted on 112 patients diagnosed with 0CD who were attending the Out-patient's department at Department of Psychiatry of a tertiary care hospital in North India.Internalised stigma and current medication adherence were assessed with Internalized Stigma of Mental Illness Scale(ISMI)and Medication Adherence Rating Scale,respectively.Yale-Brown Obsessive Compulsive Scale was used to assess the current severity of OCD symptoms.Sociodemographic and clinical details were also obtained from the patients by using a semistructured sociodemographic proforma.Results Most of the patients reported moderate level of internalised stigma with a mean ISMI score of 77.98(10.82).Most of the patients were compliant while 41.96%reported poor medication adherence.Internalised stigma was negatively correlated with the current medication adherence.Current severity of OCD symptoms also showed a significant positive correlation with internalised stigma and a significant negative correlation with medication adherence.Conclusion High levels of internalised stigma were associated with lower adherence to treatment which suggests that internalised stigma may be a very important factor influencing medication adherence in patients with OCD. | Eram Ansari Sudha Mishra Adarsh Tripathi Sujita Kumar Kar Pronob Kumar Dalai | 2020 | General Psychiatry2020，33，2： | 1 |
| 9 | Extinction-sedimentation inversion technique for measuring size distribution of artificial fogs显示文摘 | Adarsh Deepak Vaughan O H | 1978 | Applied Optics1978，17，3： | 1 |
| 10 | Dissipation of imidacloprid in Orthodox tea and its transfer from made tea to infusion显示文摘 | Monika Gupta Anupam Sharma Adarsh Shanker | 2008 | Food Chemistry2008，106，1： | 1 |
| 11 | Modeling parametric uncertainty in optimal open channel design using FORM-PGSL coupled approach显示文摘 | Adarsh S | 2012 | Stoch Environ Res Risk Assess2012，26，5： | 1 |
| 12 | Complications after Frey’s procedure for chronic pancreatitis显示文摘 | Adarsh Chaudhary Sanjay S. Negi Shakeel Masood Mahesh Thombare | 2004 | The American Journal of Surgery2004，，3： | 1 |
| 13 | 显示文摘 | Siddhardha R S Sai Kumar V Lakshman Kaniyoor Adarsh | 2014 | Spectrochimica Acta Part A: Molecular and Biomolec- ular Spectroscopy2014，133，： | 1 |
| 14 | Fast,accurate,and transferable many-body interatomic potentials by symbolic regression显示文摘The length and time scales of atomistic simulations are limited by the computational cost of the methods used to predict material properties.In recent years there has been great progress in the use of machine-learning algorithms to develop fast and accurate interatomic potential models,but it remains a challenge to develop models that generalize well and are fast enough to be used at extreme time and length scales.To address this challenge,we have developed a machine-learning algorithm based on symbolic regression in the form of genetic programming that is capable of discovering accurate,computationally efficient many-body potential models.The key to our approach is to explore a hypothesis space of models based on fundamental physical principles and select models within this hypothesis space based on their accuracy,speed,and simplicity.The focus on simplicity reduces the risk of overfitting the training data and increases the chances of discovering a model that generalizes well.Our algorithm was validated by rediscovering an exact Lennard-Jones potential and a Sutton-Chen embedded-atom method potential from training data generated using these models.By using training data generated from density functional theory calculations,we found potential models for elemental copper that are simple,as fast as embedded-atom models,and capable of accurately predicting properties outside of their training set.Our approach requires relatively small sets of training data,making it possible to generate training data using highly accurate methods at a reasonable computational cost.We present our approach,the forms of the discovered models,and assessments of their transferability,accuracy and speed. | Alberto Hernandez Adarsh Balasubramanian Fenglin Yuan Simon A.M.Mason Tim Mueller | 2019 | npj Computational Materials2019，，1： | 1 |
| 15 | Surgery for Chronic Pancreatitis显示文摘 | Azhar Perwaiz Amanjeet Singh Adarsh Chaudhary | 2012 | Indian Journal of Surgery2012，，： | 1 |
| 16 | Electrical and magnetic properties of La1-xBix MnO3显示文摘 | Adarsh S Masafumi C | 2005 | Journal of magnetism and magnetic materials2005，，290291： | 1 |
| 17 | Extinction-sedimentation inversion technique for measuring size distribution of artificial fogs 显示文摘 | Adarsh Deepak and O H Vaughan | 1978 | APPLIED OPTICS1978，3，： | 1 |
| 18 | Quadrant based incremental planning for mobile robots显示文摘Path planning of a mobile robot in the presence of multiple moving obstacles is found to be a complicated problem.A planning algorithm capable of negotiating both static and moving obstacles in an unpredictable(on-line)environment is proposed.The proposed incremental algorithm plans the path by considering the quadrants in which the current positions of obstacles as well as target are situated.Also,the governing equations for the shortest path are derived.The proposed mathematical model describes the motion(satisfying constraints of the mobile robot)along a collision-free path.Further,the algorithm is applicable to dynamic environments with fixed or moving targets.Simulation results show the effectiveness of the proposed algorithm.Comparison of results with the improved artificial potential field(iAPF)algorithm shows that the proposed algorithm yields shorter path length with less computation time. | P.Raja M.Abhilash K.Ravi Shankar Alameluvari Adarsh | 2014 | Journal of Central South University2014，21，5： | 1 |
| 19 | Post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘Acute pancreatitis remains the most common complication of endoscopic retrograde cholangiopancreatography(ERCP).It is reported to occur in 2–10%of unselected patient samples and up to 40%of high-risk patients.The purpose of this article is to review the evidence behind the known risk factors for post-ERCP pancreatitis,as well as the technical and medical approaches developed to prevent it.There have been many advances in identifying the causes of this condition.Based on this knowledge,a variety of preventive strategies have been developed and studied.The approach to prevention begins with careful patient selection and performing ERCP for specific indications,while considering alternative diagnostic modalities when appropriate.Patients should also be classified by high-risk factors such as young age,female sex,suspected sphincter of Oddi dysfunction,a history of post-ERCP pancreatitis,and normal serum bilirubin,all of which have been identified in numerous research studies.The pathways of injury that are believed to cause post-ERCP pancreatitis eventually lead to the common endpoint of inflammation,and these individual steps can be targeted for preventive therapies through procedural techniques and medical management.This includes the use of a guide wire for cannulation,minimizing the number of cannulation attempts,avoiding contrast injections or trauma to the pancreatic duct,and placement of a temporary pancreatic duct stent in high-risk patients.Administration of rectal non-steroidal anti-inflammatory agents(NSAIDs)in high-risk patients is the proven pharmacological measure for prevention of post-ERCP pancreatitis.The evidence for or against numerous other attempted therapies is still unclear,and ongoing investigation is required. | Adarsh M.Thaker Jeffrey D.Mosko Tyler M.Berzin | 2015 | Gastroenterology Report2015，3，1： | 1 |
| 20 | Dissipation of imidacloprid in Orthodox tea and its transfer from made tea to infusion显示文摘 | Monika Gupta Anupam Sharma Adarsh Shanker | 2007 | Food Chemistry2007，，1： | 1 |
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