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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Adherence to combination therapy enhances sustained response in genotype-1–infected patients with chronic hepatitis C显示文摘 | John G. McHutchison Michael Manns Keyur Patel Thierry Poynard Karen L. Lindsay Christian Trepo Jules Dienstag William M. Lee Carmen Mak Jean–Jacques Garaud Janice K. Albrecht | 2002 | Gastroenterology2002，，4： | 2 |
| 3 | Role of growth factors and thrombopoietic agents in the treatment of chronic hepatitis C显示文摘 | Hans L. Tillmann Keyur Patel John G. McHutchison | 2009 | Current Gastroenterology Reports2009，，1： | 1 |
| 4 | Clinical Validation of a Next-Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-Related Genes显示文摘 | Rajesh R. Singh Keyur P. Patel Mark J. Routbort Neelima Reddy Bedia Barkoh Brian Handal Rashmi Kanagal-Shamanna Wesley O. Greaves L. Jeffrey Medeiros Kenneth Aldape Rajyalakshmi Luthra | 2013 | The Journal of Molecular Diagnostics2013，，： | 1 |
| 5 | Antifibrotic Therapies: Will We Ever Get There?显示文摘 | Alexander James Thompson Keyur Patel | 2010 | Current Gastroenterology Reports2010，，1： | 1 |
| 6 | Evaluation of a panel of non-invasive serum markers to differentiate mild from moderate-to-advanced liver fibrosis in chronic hepatitis C patients显示文摘 | Keyur Patel Stuart C. Gordon Ira Jacobson Christophe Hézode Esther Oh Katie M. Smith Jean-Michel Pawlotsky John G. McHutchison | 2004 | Journal of Hepatology2004，，6： | 1 |
| 7 | 慢性丙型肝炎病毒感染的诊断和治疗显示文摘在未来10~20年中,与丙肝病毒感染相关的肝病并发症将增加.需要贯彻预防策略,减少高危人群中人与人之间的传播,通过抗病毒治疗,可能维持病毒清除状态,预防疾病进展,目前的最佳治疗方法是,根据基因型和病毒学反应,应用聚乙二醇干扰素α和利巴韦林治疗24~48周,针对丙肝病毒感染的新型特异性靶向抗病毒治疗正在临床研制中. | Keyur Patel Andrew J Muir John G McHutchison 张静(译) 林三仁(校) | 2006 | 英国医学杂志中文版2006，9，4： | 1 |
| 8 | Pleiotropy and allelic heterogeneity in the TOMM40 - APOE genomic region related to clinical and metabolic features of hepatitis C infection显示文摘 | Ornit Chiba-Falek Colton Linnertz John Guyton Stephen D. Gardner Allen D. Roses Jeanette J. McCarthy Keyur Patel | 2012 | Human Genetics2012，，12： | 1 |
| 9 | A Polymorphism Near IL28B Is Associated With Spontaneous Clearance of Acute Hepatitis C Virus and Jaundice显示文摘 | Hans L. Tillmann Alex J. Thompson Keyur Patel Manfred Wiese Hannelore Tenckhoff Hans D. Nischalke Yuliya Lokhnygina Ulrike Kullig Uwe G?bel Emanuela Capka Johannes Wiegand Ingolf Schiefke Wolfgang Güthoff Kurt Grüngreiff Ingrid K?nig Ulrich Spengler Jeane | 2010 | Gastroenterology2010，，5： | 1 |
| 10 | Using Capsule Endoscopy to Identify GI Tract Lesions in Cirrhotic Patients With Portal Hypertension and Chronic Anemia显示文摘 | Karen R. Canlas Brian M. Dobozi Sauyu Lin Alastair D. Smith Don C. Rockey Andrew J. Muir Naurang M. Agrawal Martin H. Poleski Keyur Patel John G. McHutchison | 2008 | Journal of Clinical Gastroenterology2008，，7： | 1 |
| 11 | Su1550 Diagnostic Yield of EUS-FNA for Upper GI Tract Subepithelial Lesions-Results of a Multicenter Study显示文摘 | Pamela Reyes Fauze Maluf-Filho Ricardo T. Schulz Livia M. Rodriguez Jimenez Leonardo Sosa Wallia J. Wever Keyur Patel Carlos Micames | 2013 | Gastrointestinal Endoscopy2013，，5： | 1 |
| 12 | Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C显示文摘 | Hans L. Tillmann Keyur Patel Andrew J. Muir Cynthia D. Guy Josephine H. Li Xiang Qian Lao Alexander Thompson Paul J. Clark Stephen D. Gardner John G. McHutchison Jeanette J. McCarthy | 2011 | Journal of Hepatology2011，，6： | 1 |
| 13 | Steatosis Is an Independent Predictor of Relapse Following Rapid Virologic Response in Patients With HCV Genotype 3显示文摘 | Samir R. Shah Keyur Patel Patrick Marcellin Graham R. Foster Michael Manns Shyam Kottilil Letha Healey Erik Pulkstenis G. Mani Subramanian John G. McHutchison Mark S. Sulkowski Stefan Zeuzem David R. Nelson | 2011 | Clinical Gastroenterology and Hepatology2011，，8： | 1 |
| 14 | Diagnosis and treatment of chronic hepatitis C infection 显示文摘 | Keyur Patel Andrew J Muir John G McHutchison | 2006 | BMJ2006，332，： | 1 |
| 15 | Polybrominated diphenyl ether levels in foodstuffs collected from three locations from the United States显示文摘 | Arnold Schecter Justin Colacino Keyur Patel Kurunthachalam Kannan Se Hun Yun Darrah Haffner T. Robert Harris Linda Birnbaum | 2009 | Toxicology and Applied Pharmacology2009，，2： | 1 |
| 16 | Adherence to combination therapy enhances sustained response in genotype-1–infected patients with chronic hepatitis C显示文摘 | John G. McHutchison Michael Manns Keyur Patel Thierry Poynard Karen L. Lindsay Christian Trepo Jules Dienstag William M. Lee Carmen Mak Jean–Jacques Garaud Janice K. Albrecht | 2002 | Gastroenterology2002，，4： | 1 |
| 17 | Adherence to combination therapy enhances sustained response in genotype-1–infected patients with chronic hepatitis C显示文摘 | John G. McHutchison Michael Manns Keyur Patel Thierry Poynard Karen L. Lindsay Christian Trepo Jules Dienstag William M. Lee Carmen Mak Jean–Jacques Garaud Janice K. Albrecht | 2002 | Gastroenterology2002，，4： | 1 |
| 18 | 显示文摘 | Keyur P Somani Sujata S Kansata Natvar K Patel | 2003 | International Journal of Adhesion and Adhesives2003，23，4： | 1 |
| 19 | HLA class I allelic diversity and progression of fibrosis in patients with chronic hepatitis C显示文摘 | Keyur Patel Suzanne Norris Lauralynn Lebeck Anne Feng Michael Clare Stephen Pianko Bernard Portmann Lawrence M. Blatt James Koziol Andrew Conrad John G. McHutchison | 2006 | Hepatology2006，，2： | 1 |
| 20 | Replicated Association Between an IL28B Gene Variant and a Sustained Response to Pegylated Interferon and Ribavirin显示文摘 | Jeanette J. McCarthy Josephine H. Li Alexander Thompson Sunil Suchindran Xiang Qian Lao Keyur Patel Hans L. Tillmann Andrew J. Muir John G. McHutchison | 2010 | Gastroenterology2010，，7： | 1 |
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