|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome显示文摘BACKGROUND Polycystic ovary disease(PCOS)may be a risk factor for nonalcoholic fatty liver disease(NAFLD)due to common pathogenetic pathways,including insulin resistance and obesity.Both PCOS and NAFLD are more severe in South Asian women.Data on NAFLD in South Asian women with PCOS are lacking.AIM To investigate prevalence and predictors of NAFLD and liver fibrosis in PCOS patients from South Asia.METHODS We conducted an observational routine screening program by means of transient elastography(TE)with associated controlled attenuation parameter(CAP).NAFLD was defined as CAP≥288 decibels per meter.Significant liver fibrosis(stage 2 and higher out of 4)was defined as TE measurement≥8.0 kilopascals.Elevated alanine aminotransferase(ALT)was defined as ALT>24 IU/L,as per upper limit of normal reported in South Asian women.Biochemical hyperandrogenism was defined as free androgen index>5.Predictors of NAFLD were determined by logistic regression analysis.RESULTS 101 PCOS patients(mean age 36.3 years)with no significant alcohol intake or viral hepatitis were included.Prevalence of NAFLD and significant liver fibrosis was 39.6% and 6.9%,respectively.Elevated ALT was observed in 40%and 11.5%of patients with and without NAFLD,respectively.After adjusting for duration of PCOS and insulin resistance measured by homeostasis model for assessment of insulin resistance,independent predictors of NAFLD were higher body mass index[adjusted odds ratio(aOR)1.30,95% confidence interval(CI):1.13-1.52],hyperandrogenism(aOR:5.32,95%CI:1.56-18.17)and elevated ALT(aOR:3.54,95%CI:1.10-11.47).Lifetime cardiovascular risk was higher in patients with NAFLD compared to those without NAFLD(0.31±0.11 vs 0.26±0.13).CONCLUSION Despite their young age,NAFLD diagnosed by TE with CAP is a frequent comorbidity in South Asian women with PCOS and is strongly associated with higher body mass index and hyperandrogenism.Non-invasive screening strategies could help early diagnosis and initiation of interventions,including counselling on weight loss,cardiovascular risk stratification and linkage to hepatology care where appropriate. | Mohamed Shengir Srinivasan Krishnamurthy Peter Ghali Marc Deschenes Philip Wong Tianyan Chen Giada Sebastiani | 2020 | World Journal of Gastroenterology2020，26，44： | 11 |
| 2 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 3 | 酒精室间隔消融术与肥厚型心肌病显示文摘大多数的肥厚型心肌病患者左心症状是由于流出道梗阻所致,内科治疗能缓解其症状。少数患者内科治疗后,仍有症状,传统上,这些患者可接受室间隔切除术缓解流出道梗阻。由于手术仅限于几个有经验的中心,药物难治性的患者多采用经皮消融疗法解除梗阻、缓解症状。 | Carey Kimmelstiel Barath Krishnamurthy Andrew Weintraub Navin Kapur | 2009 | 中华心血管病杂志2009，37，12： | 8 |
| 4 | Effect of process parameters on microstructural and mechanical properties of Ti.SS 304L explosive cladding显示文摘The present work pertains to the study of microstructure and mechanical properties of explosively cladded commercially pure titanium(cpTi) with austenitic stainless steel(SS 304L) subjected to varied process parameters, viz., loading ratios(mass of explosive or mass of flyer plate) and preset angles. The microstructural study reveals the transformation from straight to wavy interface while increasing loading ratios. Vickers hardness increases with loading ratios, and the maximum hardness is witnessed in the closer proximity of collision interface. Ram tensile and shear strength of explosive claddings are higher than that of parent plates. While the base plate fails in impact test, the flyer plate is deformed, indicating good impact strength. Increased mass of claddings, due to oxide formation, is witnessed in corrosion tests, which confirms the superiority of explosive claddings in corrosive environment. Triaxial weldability window, an analytical estimation for Ti-SS 304L explosive claddings, is developed and correlated. | Saravanan Somasundaram Raghukandan Krishnamurthy Hokamoto Kazuyuki | 2017 | Journal of Central South University2017，24，6： | 7 |
| 5 | Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro显示文摘Objective:To assesse the inhibitor) effect of alcoholic extract of two Indian medicinal plants namely Ceasalpinia digyna Rottler and.Alangium lamarckii Thwaits on aldose reductase(AR) of rat lens.Methods:Rats lens were enucleated through posterior approach and their homogenate was prepared and centrifuged to obtain a clear supernatant for the determination of AR activity and protein content.Results:The alcoholic extract of Ceasalpirda digyna and Alangium lamarckii had a potent inhibitory effect on the lens AR enzyme.The IC50 values of alcoholic extract of the selected plants were calculated and were(46.29±11.17) and(106.00±5.11)μg/mL,respectively. Quercetin was used as a positive control and its IC50 value was(2.95±1.53)μg/mL.Conclusions:Thus,it is concluded that alcoholic extracts of the selected plant exhibit significant inhibitory effects on AR in the rat lens in vitro. | Rajesh Kumar Dinesh Kumar Patel Damiki Laloo Krishnamurthy Sairam Siva Hemalatha | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 6 | Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial显示文摘 | S. L. Samson P. Sathyanarayana M. Jogi E. V. Gonzalez A. Gutierrez R. Krishnamurthy R. Muthupillai L. Chan M. Bajaj | 2011 | Diabetologia2011，，12： | 3 |
| 7 | Salivary gland disorders:A comprehensive review显示文摘Salivary glands are complex in nature. They could be either tubulo acinar, merocrine or exocrine glands secreting mainly saliva. Salivary gland is one of the main soft tissue structures in the maxillofacial area. Saliva is a clear, slightly acidic muco serous fluid that coats the teeth, mucosa and thereby helps to create and maintain a healthy environment in the oral cavity. Salivary glands may be affected by a number of diseases: local and systemic and the prevalence of salivary gland diseases depend on various etiological factors. The glands may be infected byviral, bacterial, rarely fungal or its ductal obstruction which may cause painful swelling or obstruction, affecting their functions. The salivary gland may also be affected by a various benign and malignant tumours. This review article briefly describes about the various salivary gland disorders, diagnostic techniques and their management including the recent advances and the future perspective. | Shashikala Krishnamurthy Subash Beloor Vasudeva Sandhya Vijayasarathy | 2015 | World Journal of Stomatology2015，4，2： | 3 |
| 8 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 9 | Gas solid techniques for preparation of pure lanthanum hexaboride显示文摘The processes reported for the preparation of lanthanum hexaboride (LaB6) from lanthanum oxide involve the use of carbon either elemental or in the form of boron carbide or elemental boron itself as reducing agents, fused salts at high temperatures or reactions which require the product boride to be leached out. Each of these techniques either increases the process costs and/or increases chances of contamination in fi-nal product. Pure LaB6 can best be prepared by a reaction which produces a gaseous byproduct. In the present study, such a reaction was successfully used to yield pure lanthanum hexaboride. The process involved mixing of anhydrous lanthanum chloride with aluminium and boron and heating the charges under dynamic argon flow. Lanthanum chloride is known to be highly hygroscopic; hence the process using improperly dehydrated LaCl3 led to the formation of lanthanum oxychloride which does not convert to LaB6 under conditions wherein LaCl3 converts. Not only the formation of AlCl3 but also its continuous removal from the reaction zone is necessary for the success of the process. | Mukherjee A. Gulnar A.K. Sahoo D.K. Krishnamurthy N. | 2012 | Rare Metals2012，31，3： | 2 |
| 10 | Studies on inverter-fed five-phase induction motor drive 显示文摘 | Pavithran K N Parimelalagan R Krishnamurthy M R | 1988 | IEEE Power Elec1988，3，2： | 2 |
| 11 | Fingerprint of black teas from India: identification of the regio-specific characteristics显示文摘 | B.B Borse L Jagan Mohan Rao S Nagalakshmi N Krishnamurthy | 2002 | Food Chemistry2002，，4： | 2 |
| 12 | Making middleboxes someone else’s problem显示文摘 | Justine Sherry Shaddi Hasan Colin Scott Arvind Krishnamurthy Sylvia Ratnasamy Vyas Sekar | 2012 | ACM SIGCOMM Computer Communication Review2012，，： | 2 |
| 13 | Expedited extraction of xylan from corncob by power ultrasound显示文摘Some lignocellulosic biomass like corncob contains a large amount of xylan,a valuable material for applications in food,chemical and pharmaceutical industries.Conventional extraction of xylan is a time consuming process,requiring 12 to 24 hours to complete.In this study,the efficacy of power ultrasound for reducing the extraction time and increasing the xylan yield was investigated.Two acoustic energy densities(0.18 W/mL and 0.45 W/mL)of the power ultrasound were applied to corncob for 10,20,30,and 60 min.The treated samples were steamed at 110,118 and 121℃for 30 min.At 0.45 W/mL acoustic energy density and 121℃steaming temperature,ultrasonic treatment was able to extract 39%of xylan in 43 min.In contrast,the conventional treatment was able to extract only 34%of xylan in 24 h.Power ultrasound assisted extraction reduced the processing time by 97%in addition to yield increase by 14.7%.Power ultrasound can be a potential technology for enhanced xylan extraction from corncob to result in significant processing time savings. | Wade Yang Vishnu K.Ajapur Kathiravan Krishnamurthy Hao Feng Ruijin Yang Taha M.Rababah | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 2 |
| 14 | Performance analysis of a dynamic programming track before detection algorithm显示文摘 | Johnston L A Krishnamurthy V | 2002 | IEEE Trans on Aerospace and Electronic Systems2002，38，1： | 2 |
| 15 | Investigating the Relationship Between the Content of Online Word of Mouth, Advertising, and Brand Performance显示文摘 | Shyam Gopinath Jacquelyn S. Thomas Lakshman Krishnamurthi | 2014 | Marketing Science2014，，2： | 2 |
| 16 | Pullout Simulation of Postinstalled Chemically Bonded Anchors显示文摘 | Michael McVay Ronald A. Cook Kailash Krishnamurthy | 1996 | Journal of Structural Engineering1996，，9： | 2 |
| 17 | Determination of sulfonylurea herbicides by capillary electroehromatography 显示文摘 | BASAVAIAH K KRISHNAMURTHY G | 1999 | Anal Sci1999，15，： | 1 |
| 18 | Bubbles and capital flow volatility: Causes and risk management 显示文摘 | Caballero R J Krishnamurthy A | 2006 | Journal of Monetary Economics2006，53，1： | 1 |
| 19 | Change management for collaborative engineering显示文摘 | Law K H | 1995 | Computing in Civil Engineering1995，2，： | 1 |
| 20 | Regional Study for Mapping the Natural Resources Prospect & Problem Zones Using Remote Sensing and GIS显示文摘 | J Krishnamurthy | 2005 | Geocarto International2005，20，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员