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| 1 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | 法国混凝土路面砖(板)透水路面:技术条件显示文摘混凝土路面砖透水路面被越来越多地用于城市区域的雨水管控,但对于这些产品,法国既没有完全执行欧盟标准、也没有制定自己的标准或规范。CERIB—法国混凝土工业研究中心的宗旨是选择适合法国的适用技术,主要是透水性能和力学性能,以及如何确保相关性能的长期性。重点关注的最常用产品有:多孔性自透水混凝土路面砖、宽缝铺装的混凝土路面砖、混凝土植草砖。本文重点研究两个性能:路面透水性和力学性能。介绍透水性试验方法,以及由CERIB开发、用于评价植草砖路面抗压力学性能的试验方法。 | Jennifer FALEYEUX Sophie JACOB 崔玉忠 | 2017 | 建筑砌块与砌块建筑2017，，3： | 2 |
| 3 | Utility of Penman- Monteith, Priestley Taylor, reference evapotranspiration, and pan evaporation methods to estimate pasture evapotranspiration显示文摘 | David M Sumner Jennifer M Jacobs | 2005 | Journal of Hydrology2005，308，14： | 1 |
| 4 | Utility of Penman–Monteith, Priestley–Taylor, reference evapotranspiration, and pan evaporation methods to estimate pasture evapotranspiration显示文摘 | David M. Sumner Jennifer M. Jacobs | 2004 | Journal of Hydrology2004，，1： | 1 |
| 5 | Carbon nanotube based electrochemical sensors for biomolecules 显示文摘 | Jacobs Christopher B Peairs M Jennifer Venton B Jill | 2010 | Analytica Chimica Acta2010，662，2： | 1 |
| 6 | Coumestrol antagonizes neuroendoerine actions of estrogen via the estrogen receptor a 显示文摘 | Dena A Jacob Jennifer L | 2001 | Experimental Biology and Medicine2001，226，： | 1 |
| 7 | Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome显示文摘 | Jason N. Johnson James Jaggers Shuang Li Sean M. O’Brien Jennifer S. Li Jeffrey P. Jacobs Marshall L. Jacobs Karl F. Welke Eric D. Peterson Sara K. Pasquali | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，5： | 1 |
| 8 | 小儿急性中耳炎的顺势疗法:一项随机、安慰剂对照的初步试验显示文摘背景:以前多用抗生素作为急性中耳炎的初始治疗方法,目前这种做法受到了质疑。顺势疗法已经历史性地被用于治疗中耳炎,但迄今尚无在方法学上无懈可击的试验可确定这种疗法具有阳性效果。方法:在美国西雅图一家私立儿童医院中进行了此项随机、双盲、安慰剂对照的试点研究。共有75例年龄在18个月至6岁的儿童被纳入本研究,他们都有36小时内中耳渗液、耳痛和/或发热。患儿接受了个体化的顺势疗法或口服安慰剂,每日3次,共5天(或症状消失,视何种情况首先出现而定)。对转归的衡量包括经过5天、2周和6周治疗后治疗失败的例数。同时也评价了前3天的每日症状评分以及在治疗后第2周和第6周中耳渗液的情况。结果:在治疗5天、2周和6周后顺势疗法组出现治疗失败者较少,与对照组相比,差异分别为11.4%、18.4%和19.9%。但这些差异不具有统计学意义。每日症状评分表明,在以顺势疗法治疗后24小时和64小时,症状有显著减退(P<0.05)。样本容量计算表明,从5天治疗失败率来看,这2组中每组都需要243例患儿才能判定结果是否具有显著意义。结论:这些结果显示,我们并不能排除这样的可能性:与安慰剂相比,顺势疗法治疗儿童急性中耳炎具有阳性效果。但需要更大规模的研究加以验证。 | 顾良军 Jennifer Jacobs 等 | 2001 | 世界医学杂志2001，5，11： | 1 |
| 9 | Genomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7)显示文摘 | Judith Gault Misi Robinson Ralph Berger Carla Drebing Judith Logel Jan Hopkins Ted Moore Suzette Jacobs Jennifer Meriwether Mun Jun Choi Eun Jung Kim Katy Walton Karin Buiting Ashley Davis Charles Breese Robert Freedman Sherry Leonard | 1998 | Genomics1998，，2： | 1 |
| 10 | The formation and growth of intermetallics in composite solder显示文摘 | Yujing Wu Jennifer A. Sees Cyrus Pouraghabagher L. Ann Foster James L. Marshall Elizabeth G. Jacobs Russell F. Pinizzotto | 1993 | Journal of Electronic Materials1993，，7： | 1 |
| 11 | Autoimmune thyroiditis as an indicator of autoimmune sequelae during cancer immunotherapy显示文摘 | Yi-chi M. Kong Jennifer B. Jacob Jeffrey C. Flynn Bruce E. Elliott Wei-Zen Wei | 2009 | Autoimmunity Reviews2009，，1： | 1 |
| 12 | A phase 3, randomized, double-blind, placebo-controlled study of the safety and efficacy of the live, oral adenovirus type 4 and type 7 vaccine, in U.S. military recruits显示文摘 | Robert A. Kuschner Kevin L. Russell Mary Abuja Kristen M. Bauer Dennis J. Faix Howard Hait Jennifer Henrick Michael Jacobs Alan Liss Julia A. Lynch Qi Liu Arthur G. Lyons Mohammad Malik James E. Moon Jeremiah Stubbs Wellington Sun Doug Tang Andrew C. Towl | 2013 | Vaccine2013，，28： | 1 |
| 13 | Data Literacy:Understanding Teachers' Data Using A Context of Accountability and Response to Intervention显示文摘 | Jennifer Jacobs Angela Gregory David Hoppey & Diane Yendol-Hoppey | 2009 | Action in Teacher Education2009，3，3： | 1 |
| 14 | The Rat Genome Database 2013—data, tools and users显示文摘 | Stanley J. F. Laulederkind G. Thomas Hayman Shur-Jen Wang Jennifer R. Smith Timothy F. Lowry Rajni Nigam Victoria Petri Jeff de Pons Melinda R. Dwinell Mary Shimoyama Diane H. Munzenmaier Elizabeth A. Worthey Howard J. Jacob | 2013 | Briefings in Bioinformatics2013，，4： | 1 |
| 15 | Fischer-Tropsch synthesis: Comparisons between Pt and Ag promoted Co/A12 03 catalysts for reducibility, local atomic structure, catalytic activity, and oxidation-reduction (OR) cycle显示文摘 | THANI J JACOBS G MAW P WILSON D S MUTHU K G GAO P BOONYARACH K DAVIS B H JENNIFER L S K YEN C H CRONAUER D C JEREMY K A MARSHALL C L | 2013 | Appl Catal A: Gen2013，，： | 1 |
| 16 | Video as a tool for fostering productive discussions in mathematics professional development显示文摘 | Hilda Borko Jennifer Jacobs Eric Eiteljorg Mary Ellen Pittman | 2006 | Teaching and Teacher Education2006，，2： | 1 |
| 17 | Relations of Biomarkers of Distinct Pathophysiological Pathways and Atrial Fibrillation Incidence in the Community显示文摘 | Renate B. Schnabel Martin G. Larson Jennifer F. Yamamoto Lisa M. Sullivan Michael J. Pencina James B. Meigs Geoffrey H. Tofler Jacob Selhub Paul F. Jacques Philip A. Wolf Jared W. Magnani Patrick T. Ellinor Thomas J. Wang Daniel Levy Ramachandran S. Vasan | 2010 | Circulation2010，，2： | 1 |
| 18 | SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo显示文摘 | Jennifer P. Arbitrario Brian J. Belmont Marc J. Evanchik W. Michael Flanagan Raymond V. Fucini Stig K. Hansen Shannon O. Harris Ahmad Hashash Ute Hoch Jennifer N. Hogan Anthony R. Howlett Jeffrey W. Jacobs Joni W. Lam Sean C. Ritchie Michael J. Romanowski | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 1 |
| 19 | Review: Carbon nanotube based electrochemical sensors for biomolecules显示文摘 | Christopher B Jacobs M Jennifer Peairs B | 2010 | Analytica Chimica Acta2010，662，2： | 1 |
| 20 | Review: Carbon nanotube based electrochemical sensors for biomolecules显示文摘 | Christopher B. Jacobs M. Jennifer Peairs B. Jill Venton | 2010 | Analytica Chimica Acta2010，，2： | 1 |
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