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| 1 | PCSK9 inhibitors: A new era of lipid lowering therapy显示文摘Hyperlipidemia is a well-established risk factor for developing cardiovascular disease(CVD). The recent American College of Cardiology and American Heart Association guidelines on lipid management emphasize treatment of individuals at increased risk for developing CVD events with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors(statins) at doses proven to reduce CVD events. However, there are limited options for patients who are either intolerant to statin therapy, develop CVD despite being on maximally tolerated statin therapy, or have severe hypercholesterolemia. Recently the Food and Drug Administration approved two novel medications for low-density lipoprotein(LDL)-cholesterol reduction: Evolocumab and Alirocumab. These agents target and inactivate proprotein convertase subtilsinkexin type 9(PCSK9), a hepatic protease that attaches and internalizes LDL receptors into lysosomes hence promoting their destruction. By preventing LDL receptor destruction, LDL-C levels can be lowered 50%-60% above that achieved by statin therapy alone. This review explores PCSK-9 biology and the mechanisms available to alter it; clinical trials targeting PCSK9 activity, and the current state of clinically available inhibitors of PCSK9. | Rahul Chaudhary Jalaj Garg Neeraj Shah Andrew Sumner | 2017 | World Journal of Cardiology2017，9，2： | 23 |
| 2 | Characterization of the Formation of Branched Short-Chain Fatty Acid:CoAs for Bitter Acid Biosynthesis in Hop Glandular Trichomes显示文摘痛苦的酸,作为啤酒香料并且为他们的多样的生物活动为他们的使用知道,主要 formedin 跳跃(Humulus lupulus ) 腺的毛状体。分叉的短链的 acyl-CoAs (例如 isobutyryl-CoA, isovaleryl-CoA 和 2-methylbutyryl-CoA ) , derivedfrom 分支链氨基酸(BCAA ) 的降级,为痛苦的 acidsin 的生合成的必要积木跳跃。然而,很少关于部件被需要生产并且维持分叉的 short-chainacyl-CoAs 的水池在的被知道跳跃毛状体。这里,我们在场 CoA ligases 和 thioesterases 是在痛苦的酸生合成的 likelyinvolved 的证据的几根线。蛋白质有的 Recombinant HlCCL2 ( carboxyl CoA ligase )为象底层酸的 isovaleric 的高特定的活动( K 猫 /K m = 4100 s 1 M 1),而 recombinant HlCCL4 明确地利用了 isobutyric 酸( K 猫 /K m = 1800 s 1 M 1)并且 2-methylbutyric 酸( K 猫 /K m = 6900 s 1 M 1)作为底层。两 HlCCLs 跳跃 valerophenone synthase (HlVPS ) ,在腺的毛状体强烈被表示并且对细胞质局部性。有在酵母的 HlVPS 的 HlCCL2 和 HlCCL4 的合作表示导致了 acylphloroglucinols (为痛苦的酸生合成的直接先锋) 的重要生产, whichfurther 在 vivo 证实了这二 HlCCLs 的生物化学的功能。在线粒体催化 CCL 的反向的反应的 thioesterase 的功能的鉴定,和 thecomprehensive,基因的分析包含了 BCAA 分解代谢,支持了 cytosolic CoA ligases 在腺的毛状体为 linkingBCAA 降级和痛苦的酸生合成被要求的想法。进化和另外的可能的生理的 rolesof 分叉短链的丰满的酸: 在 planta 的 CoA ligases 也是 discussed.Key 词: | Haiyang Xu Fengxia Zhang Baoxiu Liu David V. Huhman Lloyd W. Sumner Richard A. Dixon Guodong Wang | 2013 | Molecular Plant2013，6，4： | 9 |
| 3 | 微网中储能系统的能量管控方法显示文摘微网利用光伏、风机等可再生能源发电(renewable energy source of electricity,RES-E)并与能量存储系统配合向本地负荷供电,可以减小能量传输损耗以及大电网扰动的影响。然而,微网中的可再生能源分布式电源出力与负荷逆向分布,如何利用储能元件实现能源就地高效利用、避免大量过剩功率入网是当前微网发展重点之一。针对这一问题,该文提出一种可变阈值的自动适应控制方法,采用自适应智能技术控制储能元件的即时充放电功率,提高电能分配效率,实现对于负荷的'削峰填谷'。文中利用现场测得的RES数据对提出的方法进行验证,结果表明与传统利用固定阈值和需要精确预测的方法相比提出的方法在不需要RES和负荷预测数据的情况下,可以更有效减小负荷峰值,得到更加平滑的负荷曲线,同时最大程度地利用本地RES能源。 | 贾科 陈奕汝 毕天姝 Mark SUMNER | 2016 | 中国电机工程学报2016，36，10： | 7 |
| 4 | A case study of multi-seam coal mine entry stability analysis with strength reduction method显示文摘In this paper,the advantage of using numerical models with the strength reduction method(SRM) to evaluate entry stability in complex multiple-seam conditions is demonstrated.A coal mine under variable topography from the Central Appalachian region is used as a case study.At this mine,unexpected roof conditions were encountered during development below previously mined panels.Stress mapping and observation of ground conditions were used to quantify the success of entry support systems in three room-and-pillar panels.Numerical model analyses were initially conducted to estimate the stresses induced by the multiple-seam mining at the locations of the affected entries.The SRM was used to quantify the stability factor of the supported roof of the entries at selected locations.The SRM-calculated stability factors were compared with observations made during the site visits,and the results demonstrate that the SRM adequately identifies the unexpected roof conditions in this complex case.It is concluded that the SRM can be used to effectively evaluate the likely success of roof supports and the stability condition of entries in coal mines. | Tulu Ihsan Berk Esterhuizen Gabriel S. Klemetti Ted Murphy Michael M. Sumner James Sloan Michael | 2016 | International Journal of Mining Science and Technology2016，26，2： | 5 |
| 5 | Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease 显示文摘 | Sumner MD Elliott ME Weidne G | 2005 | Am J Cardiol2005，96，15： | 3 |
| 6 | 高性能水泥助磨剂在减排上的作用显示文摘一、水泥工业的减排途径目前知道的减排方式主要是降低产量或转移生产到别的国家,另外就是通过一系列技术改造来使用煤的替代燃料,降低熟料在水泥中使用比例等。这其中,使用高掺合料的复合和配制水泥是世界水泥行业减排的主要手段之一(见图1)。 | 陈斌 Mike Sumner Franco Gianetti | 2008 | 中国水泥2008，，7： | 3 |
| 7 | PI_3激酶参与AT_1受体介导Ang II调节SHR脑神经元电活动的信号转导显示文摘目的 探索AT1受体介导AngII调节SHR和WKY鼠脑神经元电活动的信号转导机制。 方法 原代培养SHR和WKY新生鼠脑干和下丘脑神经元 ,用全细胞膜片钳以电流箝方式记录神经元的放电活动 ,观察AngII及各种信号分子抑制剂对脑神经元放电频率的影响。结果 AngⅡ (10 0nmol·L-1)可使WKY新生鼠脑神经元的放电频率从 (0 .4 4± 0 .0 8)Hz增加到 (1.39± 0 .16 )Hz。这种效应在SHR鼠更加显著。由AngⅡ引起的这两种鼠脑神经元放电频率的增加均可被AT1受体拮抗剂Losartan完全消除。使用PKC抑制剂calphostinC和钙调蛋白激酶II抑制剂KN 93能完全阻断AngⅡ对WKY鼠脑神经元的作用 ,但对SHR鼠脑神经元的放电频率仅阻抑约 5 0 %。磷脂酰肌醇 3(PI3 )激酶抑制剂LY2 94 0 0 2 (10 μmol·L-1)对SHR鼠脑神经元的放电频率可产生部分阻断作用 ,但对WKY鼠脑神经元无明显影响。结论 AngII增加SHR和WKY鼠脑神经元放电频率的作用均由AT1受体介导。PI3 | 杜剑青 孙成文 唐敬师 Colin Sumners Mohan K Raizada | 2003 | 西安交通大学学报(医学版)2003，24，6： | 2 |
| 8 | Alfalfa response to lime, phos phorus, potassium, magnesium, and molybdenum on acid ultisols 显示文摘 | Walworth J L Sumner M E | 1990 | Fertilizer Research1990，24，3： | 1 |
| 9 | Utility of Penman- Monteith, Priestley Taylor, reference evapotranspiration, and pan evaporation methods to estimate pasture evapotranspiration显示文摘 | David M Sumner Jennifer M Jacobs | 2005 | Journal of Hydrology2005，308，14： | 1 |
| 10 | Cu+- and Cu2x-sensitive PEBBLE fluorescent nanosensors u- sing DsRed as the recognition element 显示文摘 | Sumner J P Westerberg N M Stoddard A K | 2006 | Sens Actuators B2006，113，： | 1 |
| 11 | Serotonin trans- porter (SERF) mRNA and binding site densities in male rat brain affected by sex steroids 显示文摘 | McQueen J K Wilson H Sumner B E | 1999 | Brain Res Mol Brain Res1999，63，2： | 1 |
| 12 | Utility of Penman-Monteith,Priest-ley-Taylor,reference evapotranspiration and pan evaporation methods to estimate pasture evapotranspiration 显示文摘 | Sumner D M Jacobs J M | 2005 | Journal of Hydrology2005，308，14： | 1 |
| 13 | A simple, spreadsheet-based, food safetyrisk assessment tool 显示文摘 | Ross T Sumner J | 2002 | J Food Microbiol2002，77，12： | 1 |
| 14 | Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice显示文摘 | S C Sumner T R Fennell T A Moore | 1999 | Chem Res Toxicol1999，12，： | 1 |
| 15 | Cation and Nitrogen Contents of Organic Matter Determine Its Soil Liming Potential显示文摘 | POCKNEE S SUMNER M E | 1997 | Soil Science Society of America Journal1997，61，1： | 1 |
| 16 | Toe blood pressure:A valuable adjunct to ankle pressure measurement for assessing peripheral arterial disease显示文摘 | Ramsey DE Manke DA Sumner DS | 1983 | J Cardiovasc Surg1983，24，1： | 1 |
| 17 | Dominant-negatice transcrption factor AP-2 augments SB-2 melanoma tumor growth in vivo显示文摘 | GERSHENWALD J E SUMNER W CALDERONE T | 2001 | Oncogene2001，20，26： | 1 |
| 18 | Stability of fumonisins in thermally processed corn products显示文摘 | Castelo MM Sumner SS Bullerman LB | 1998 | J-Food-Prot1998，61，8： | 1 |
| 19 | The distribution of genes onchromosomes: a cytological approach显示文摘 | Sumner AT de la Torre J Stuppia L | 1993 | J Mol Evol1993，37，2： | 1 |
| 20 | The spectrum of neuropathy in diabetes and impaired glucose tolerance 显示文摘 | Sumner C J Sheth S Griffin JW | 2003 | Neurology2003，60，1： | 1 |
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