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| 1 | Right ventricular septal pacing: Safety and efficacy in a long term follow up显示文摘AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing(< 20%)(NO pacing);(3) 33 patients with high percentage(> 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects. | Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino Emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino | 2015 | World Journal of Cardiology2015，7，8： | 5 |
| 2 | Intravascular contrast agents in diagnostic applications: Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents显示文摘在药,在病理和正常区域之间的辨别是很重要的,并且在大多数情况中,如此的辨别被新奇成像技术使可能。众多的形式被开发了在心血管的疾病或在 angiogenic 和 vasculogenic 过程期间设想组织 vascularization。这里,我们在 vasculature 成像报导最近的进展,提供在为对容器疾病的预示的评价的生物医学的诊断和潜在的未来策略的当前的非侵略的途径的概述,例如动脉瘤和导致心肌的梗塞的冠的动脉吸藏。有几个对比代理人(CA ) 对可得到在疾病的早阶段改进特定的纸巾的可见性,允许快速的治疗。然而, CA 被众多的限制也妨碍,包括从直到空隙的空间,毒性,和低敏感的血容器的快速的散开。从血容器的溢出导致图象的快速的损失。如果对比媒介能充分被限制到脉管的空间,高分辨率的结构、功能的脉管的成像能被获得。许多科学家贡献了新材料或新搬运人系统。例如,红血房间(RBC ) 的使用作为 CA 交货系统看起来提供一种可伸缩的选择给允许足够的脉管的成像的当前的过程。当 biomimetic CA 搬运人,和这种技术应该临床上被验证,从发行量的 CA 的识别和移动能被使用 RBC 阻止或推迟。 | Antonella Antonelli Carla Sfara Mauro Magnani | 2017 | Nano Research2017，10，3： | 5 |
| 3 | Reporting rotator cuff tears on magnetic resonance arthrography using the Snyder's arthroscopic classification显示文摘AIM To determine diagnostic performance of magnetic resonance arthrography(MRA) in evaluating rotator cuff tears(RCTs) using Snyder's classification for reporting.METHODS One hundred and twenty-six patients(64 males, 62 females; median age 55 years) underwent shoulder MRA and arthroscopy, which represented our reference standard. Surgical arthroscopic reports were reviewed and the reported Snyder's classification was recorded. MRA examinations were evaluated by two independent radiologists(14 and 5 years' experience) using Snyder's classification system, blinded to arthroscopy. Agreement between arthroscopy and MRA on partial-and fullthickness tears was calculated, first regardless of their extent. Then, analysis took into account also the extent of the tear. Interobserver agreement was also calculated the quadratically-weighted Cohen kappa statistics.RESULTS On arthroscopy, 71/126 patients(56%) had a fullthickness RCT. The remaining 55/126 patients(44%) had a partial-thickness RCT. Regardless of tear extent, out of 71 patients with arthroscopically-confirmed fullthickness RCTs, 66(93%) were correctly scored by both readers. All 55 patients with arthroscopic diagnosis of partial-thickness RCT were correctly assigned as having a partial-thickness RCT at MRA by both readers. Interobserver reproducibility analysis showed total agreement between the two readers in distinguishing partial-thickness from full-thickness RCTs, regardless of tear extent(k = 1.000). With regard to tear extent, in patients in whom a complete tear was correctly diagnosed, correct tear extent was detected in 61/66 cases(92%); in the remaining 5/66 cases(8%), tear extent was underestimated. Agreement was k = 0.955. Interobserver agreement was total(k = 1.000).CONCLUSION MRA shows high diagnostic accuracy and reproducibility in evaluating RCTs using the Snyder's classification for reporting. Snyder's classification may be adopted for routine reporting of MRA. | Alberto Aliprandi Carmelo Messina Paolo Arrigoni Michele Bandirali Giovanni Di Leo Stefano Longo Sandro Magnani Chiara Mattiuz Filippo Randelli Silvana Sdao Francesco Sardanelli Luca Maria Sconfienza Pietro Randelli | 2017 | World Journal of Radiology2017，9，3： | 3 |
| 4 | Targeting of acute myeloid leukaemia by cytokine‐induced killer cells redirected with a novel CD 123‐specific chimeric antigen receptor显示文摘 | Sarah Tettamanti Virna Marin Irene Pizzitola Chiara F. Magnani Greta M. P. Giordano Attianese Elisabetta Cribioli Francesca Maltese Stefania Galimberti Angel F. Lopez Andrea Biondi Dominique Bonnet Ettore Biagi | 2013 | Br J Haematol2013，，3： | 3 |
| 5 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 6 | A new platform for Real-Time PCR detection of Salmonella spp., Listeria monocytogenes and Escherichia coli O157 in milk显示文摘 | Enrica Omiccioli Giulia Amagliani Giorgio Brandi Mauro Magnani | 2009 | Food Microbiology2009，，6： | 2 |
| 7 | 经活检证实心肌炎患者的存活情况:一项关于组织病理学、临床和血流动力学预测因素的长期回顾性分析显示文摘Objective: We hypothesized that histopathology predicts survival without cardiac transplantation in patients with biopsy- proven myocarditis. Background: The role of endomyocardial biopsy in diagnosing myocarditis remains controversial. Histopathology has been integrated with clinical and hemodynamic features to predict prognosis. However, the influence of histopathology on survival >5 years has not been explored. Methods: We retrospectively identified 112 consecutive patients with histopathologic confirmation of myocarditis. We examined these patients’ clinical presentation, hemodynamic assessment, hospital course, and treatment. We selected 14 variables that might influence survival without cardiac transplantation. Results: A total of 62(55% ) of 112 patients had lymphocytic myocarditis; 88(79% ) and 63(56% ) were alive without cardiac transplantation at 1 and 5 years, respectively. Median follow- up was a mean 95.5 months and median 74.5 months. Among the 55 with complete data of the 14 candidate predictor variables, age, sex, and clinical presentation with congestive heart failure and ventricular(ventricular tachycardia or fibrillation) or atrial arrhythmias(atrial fibrillation or flutter) did not predict the study end point of death or need for transplantation. In univariate analysis, pulmonary capillary wedge pressure ≥ 15 mm Hg significantly predicted the study end point. In multivariate analysis, pulmonary capillary wedge pressure ≥ 15 mm Hg and histopathology of lymphocytic, granulomatous, or giant cell myocarditis each significantly predicted mortality or transplant(P=.047, P=.013, and P=.054, respectively) on cumulative survival without cardiac transplantation. Conclusions: Histopathology predicts long- term survival in patients with myocarditis. Clinical presentation, including presentation with congestive heart failure, ventricular tachycardia/ ventricular fibrillation, or atrial fibrillation/atrial flutter, does not predict survival without transplantation. Endomyocardial biopsy can play a role in predicting transplant- free survival in patients with myocarditis. | Magnani J.W. Suk Danik H.J. Dec Jr. G.W. DiSalvo T.G. 高登峰 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，6： | 2 |
| 8 | The contribution of voxel-based morphometry in staging patients with mild cognitive im- pairment显示文摘 | Bozzali M Filippi M Magnani G | 2006 | Neurology2006，67，： | 1 |
| 9 | 显示文摘 | Magnani A Albanese A Lamponi S | 1996 | Thrombosis Research1996，81，： | 1 |
| 10 | Chromism and luminescence in regioregular poly(3-dodecylthiophene)显示文摘 | Rumbles G Samuel I D W Magnani L | 1996 | Synthetic Metals1996，76，： | 1 |
| 11 | FDG/PET and spiral CT image fusion for medistinal lymph node assessment of non-small cell lung cancer patients显示文摘 | Magnani P Carretta A Rizzo G | 1999 | Cardiovasc Surg (Torino)1999，40，5： | 1 |
| 12 | Myocarditis:Current trends in diagnosis and treatment显示文摘 | Jared W Magnani G William D | 2006 | Circulation2006，113，6： | 1 |
| 13 | Increased arterial stiffness in nonalcoholic fatty liver disease: the Cardio-GOOSE study显示文摘 | Paolo Salvi Raffaele Ruffini Davide Agnoletti Elena Magnani Gabriele Pagliarani Giulia Comandini Antonino Praticò Claudio Borghi Athanase Benetos Paolo Pazzi | 2010 | Journal of Hypertension2010，，8： | 1 |
| 14 | The discovery,biology and drug development of sialyl Lea and sialyl Lex 显示文摘 | Magnani JL | 2004 | Arch Biochem Biophys2004，426，2： | 1 |
| 15 | Analysis of a failed alumina THR ball head 显示文摘 | Labanti M Magnani G | 1999 | Biomaterials1999，20，18： | 1 |
| 16 | 显示文摘 | Barbucci R Lamponi S Magnani A | 1998 | Biomaterials1998，19，： | 1 |
| 17 | Paclitaxel and docetaxel resistance: molecular mechanisms and development of new generation taxanes显示文摘 | Galletti E Magnani M Renzulli M L | 2007 | Chem Med Chem2007，2，7： | 1 |
| 18 | Mandibular distraction in neonates:indications,technique,results显示文摘 | Sesenna E Magri AS Magnani C | | 0，，： | 1 |
| 19 | Preparation and charac- terization of biotinylated red blood cells 显示文摘 | Magnani ML Chiarantini U Mancini U | 1994 | Appl Biochem Bio- technol1994，20，3： | 1 |
| 20 | Resazurin detection of energy metabolism changes in serum-starved PC12 cells and of neuroprotective agent effect显示文摘 | Magnani E Bettini E | 2000 | Brain Res Brain Res Protoc2000，5，： | 1 |
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