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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | 一种基于时延估计的双辅助声源阵形校准方法显示文摘布放柔性水平阵列时,各阵元的相对位置很难精确知道,为了解决这一问题,提出了一种阵形校准方法。首先布设两个成一定张角的校准声源,利用它们估计各阵元信号的时延关系,利用声源和接收阵的GPS位置,确定各阵元的相对位置。得到的位置估计是无偏估计,给出了位置估计标准差的数值模拟结果,得出了两校准声源的最佳角度关系。利用2001年亚洲海国际实验的数据对该方法进行了验证,用校准后的阵形得到的测量声源方位角和实际角度一致,实测的阵增益也和理论值相符合。理论及实验分析结果表明,该方法能够准确定出各阵元的相对位置。 | 汪俊 吴立新 Jim Lynch Arthur Newhall | 2007 | 声学学报2007，32，2： | 14 |
| 3 | Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells显示文摘RapidmitogenactivatedproteinkinaseactivationbytransforminggrowthfactorαinwoundedratintestinalepithelialcelsMichaelGkee,Michi... | Michael Gke, Michiyuki Kanai, Kathryn Lynch Devaney, and Daniel K. Podolsky Gastrointestinal Unit, Department of Medicine, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massa | 1998 | World Journal of Gastroenterology1998，4，3： | 14 |
| 4 | 武隆喀斯特及其地壳抬升性质解读显示文摘在特定的地质结构及峡谷水文网分布条件下,武隆喀斯特以独立发育的诸多包气带喀斯特系统为主要特征,而且不同喀斯特系统间的结构与形态组成差异甚大。喀斯特系统的分析可解读相适应的地壳运动性质是:自新近纪末期以来,地壳运动只有上升没有下降过程;前80~100万年为持续上升,即几乎没有相对稳定的经历;继后是间歇性抬升与相对稳定,似以后者占优;分布于深切峡谷相对高度150~300m间的大型成层性洞穴,主要发育于中更新世;晚更新世以来的上升与相对稳定彼此平分秋色。 | 朱学稳 陈伟海 Erin Lynch | 2007 | 中国岩溶2007，26，2： | 11 |
| 5 | Grinding process within vertical roller mills: experiment and simulation显示文摘Based on screening analysis, laser size analysis, grindability and rigidity tests of samples collected on line from a cement and a power plant, a simulation of the grinding process in vertical roller mills was carried out. The simulation calculation used a breakage function, B. The results indicate that the breakage function, B, and the selection function, S, in the form of a matrix, can be used to express the probability of the material breaking during the grinding process. This allows the size distribution of the product to be numerically estimated. The simulation results also show that the simulated size distribution curves fit the actual experimental product curves quite well. The model provides a good starting point for simulation of the grinding process. Further research is needed to determine the proper breakage function and the matrix value of the selection function. | WANG Jian-huai CHEN Qing-ru KUANG Ya-li LYNCH A j ZHUO Jin-wu | 2009 | Mining Science and Technology2009，19，1： | 11 |
| 6 | 机构知识库在美国的发展显示文摘1背景
2005年初,网络信息联盟(http://gffzz97eb856eb985430bhq6co5vbocovp6k6w.ffgz.tsg.suse.edu.cn)对它在美国的学术成员机构进行了有关机构知识库发展现状的问卷调查。在同一时间,联盟为参加名为“为机构知识库构造一个战略性案例”的国际性会议而进行准备,开展了美国国家报告的信息编撰工作,因此,调查工作和信息编撰工作是一起进行的。“为机构知识库构造一个战略性案例”国际会议于2005年5月10-11日在阿姆斯特朗举办,网络信息联盟、英国联合信息系统委员会和荷兰SURF基金会联合主办此次国际会议。共有13个国家参会,他们分别提供了本国机构知识库的部署情况。 | Clifford A. Lynch Joan K. Lippincott 孙茜(编译) | 2005 | 图书情报工作动态2005，，11： | 8 |
| 7 | 13国大学机构知识库发展概况显示文摘1介绍
2005年5月10-11日。CNI、ISC以及SURF基金会举办了名为“创建机构知识库的战略”的研讨会。会议的目的是要广泛了解当前机构知识库在学术机构中的发展,并且对国家政策与战略的形成进行探讨。在会议的准备过程中,组织者就从十三个国家收集了机构知识库建设的有关信息,这3个国家包括澳大利亚、加拿大、美国、十个欧洲国家——比利时、法国、英国、丹麦、挪威、瑞典、芬兰、德国、意大利以及荷兰。 | Gerard van Westrienen Clifford A. Lynch 卢宏娟(译) | 2005 | 图书情报工作动态2005，，11： | 7 |
| 8 | 脊髓损伤后肠道功能障碍显示文摘回顾结肠、直肠动力和排便的基本生理学特征 ,阐述脊髓损伤对排便的影响 ,讨论目前临床上的治疗措施 ,并提出新的治疗和研究方向。 | AC Lynch AA ntony BR Dobbs FA Frizelle 王红星 | 2002 | 中国康复理论与实践2002，8，3： | 7 |
| 9 | Primary squamous cell carcinoma of the rectum: An update and implications for treatment显示文摘AIM: To provide an update on the aetiology, pathogenesis, diagnosis, staging and management of rectal squamous cell carcinoma(SCC).METHODS: A systematic review was conducted according to the preferred reporting items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE was performed with the reference list of selected articles reviewed to ensure all relevant publications were captured. The search strategy was limited to the English language, spanning from 1946 to 2015. A qualitative analysis was undertaken examining patient demographics, clinical presentation, diagnosis, staging, treatment and outcome. The quantitaive analysis was limited to data extracted on treatment and outcomes including radiological, clinical and pathological complete response where available. The narrative and quantitative review were synthesised in concert.RESULTS: The search identified 487 articles in total with 79 included in the qualitative review. The quantitative analysis involved 63 articles, consisting of 43 case reports and 20 case series with a total of 142 individual cases. The underlying pathogenesis of rectal SCC while unclear, continues to be defined, with increasing evidence of a metaplasia-dysplasia-carcinoma sequence and a possible role for human papilloma virus in this progression. The presentation is similar to rectal adenocarcinoma, with a diagnosis confirmed by endoscopic biopsy. Many presumed rectal SCC's are in fact an extension of an anal SCC, and cytokeratin markers are a useful adjunct in this distinction. Staging is most accurately reflected by the tumour-nodemetastasis classification for rectal adenocarcinoma. It involves examining locoregional disease by way of magnetic resonance imaging and/or endorectal ultrasound, with systemic spread excluded by way of computed tomography. Positron emission tomography is integral in the workup to exclude an external siteof primary SCC with metastasis to the rectum. While the optimal treatment remains as yet undefined, recent studies have demonstrated a global shift away from surgery towards definitive chemoradiotherapy as primary treatment. Pooled overall survival was calculated to be 86% in patients managed with chemoradiation compared with 48% for those treated traditionally with surgery. Furthermore, local recurrence and metastatic rates were 25% vs 10% and 30% vs 13% for the chemoradiation vs conventional treatment cohorts.CONCLUSION: The changing paradigm in the treatment of rectal SCC holds great promise for improved outcomes in this rare disease. | Glen R Guerra Cherng H Kong Satish K Warrier Andrew C Lynch Alexander G Heriot Samuel Y Ngan | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 5 |
| 10 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 11 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 12 | Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P <
0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P <
0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P <
0.05 ) , hMLH1 吸烟者(P <
0.1 ) 并且 hMSH2 吸烟者(P <
0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P <
0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P <
0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。 | Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy | 2006 | World Journal of Gastroenterology2006，12，28： | 5 |
| 13 | Malaria: Global progress 2000-2015 and future challenges显示文摘Background:2015 was the target year for malaria goals set by the World Health Assembly and other international institutions to reduce malaria incidence and mortality.A review of progress indicates that malaria programme financing and coverage have been transformed since the beginning of the millennium,and have contributed to substantial reductions in the burden of disease.Findings:Investments in malaria programmes increased by more than 2.5 times between 2005 and 2014 from US$960 million to US$2.5 billion,allowing an expansion in malaria prevention,diagnostic testing and treatment programmes.In 2015 more than half of the population of sub-Saharan Africa slept under insecticide-treated mosquito nets,compared to just 2%in 2000.Increased availability of rapid diagnostic tests and antimalarial medicines has allowed many more people to access timely and appropriate treatment.Malaria incidence rates have decreased by 37%globally and mortality rates by 60%since 2000.It is estimated that 70%of the reductions in numbers of cases in sub-Saharan Africa can be attributed to malaria interventions.Conclusions:Reductions in malaria incidence and mortality rates have been made in every WHO region and almost every country.However,decreases in malaria case incidence and mortality rates were slowest in countries that had the largest numbers of malaria cases and deaths in 2000;reductions in incidence need to be greatly accelerated in these countries to achieve future malaria targets.Progress is made challenging because malaria is concentrated in countries and areas with the least resourced health systems and the least ability to pay for system improvements.Malaria interventions are nevertheless highly cost-effective and have not only led to significant reductions in the incidence of the disease but are estimated to have saved about US$900 million in malaria case management costs to public providers in sub-Saharan Africa between 2000 and 2014.Investments in malaria programmes can not only reduce malaria morbidity and mortality,thereby contributing to the health targets of the Sustainable Development Goals,but they can also transform the well-being and livelihood of some of the poorest communities across the globe. | Richard E.Cibulskis Pedro Alonso John Aponte Maru Aregawi Amy Barrette Laurent Bergeron Cristin A.Fergus Tessa Knox Michael Lynch Edith Patouillard Silvia Schwarte Saira Stewart Ryan Williams | 2016 | Infectious Diseases of Poverty2016，5，1： | 4 |
| 14 | Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure显示文摘 | Rusty L. Montgomery Thomas G. Hullinger Hillary M. Semus Brent A. Dickinson Anita G. Seto Joshua M. Lynch Christianna Stack Paul A. Latimer Eric N. Olson Eva van Rooij | 2011 | Circulation2011，，14： | 4 |
| 15 | 卡泊芬净引起严重可逆性血小板减少显示文摘 | Julia Lynch Annie Wong-Beringer 席瑜钦 | 2005 | 中国处方药2005，4，2： | 4 |
| 16 | Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease显示文摘Bone-produced fibroblast growth factor 23(FGF23)increases in response to inflammation and iron deficiency and contributes to cardiovascular mortality in chronic kidney disease(CKD).Neutrophil gelatinase-associated lipocalin(NGAL or lipocalin 2;LCN2 the murine homolog)is a pro-inflammatory and iron-shuttling molecule that is secreted in response to kidney injury and may promote CKD progression.We investigated bone FGF23 regulation by circulating LCN2.At 23 weeks,Col4a3KO mice showed impaired kidney function,increased levels of kidney and serum LCN2,increased bone and serum FGF23,anemia,and left ventricular hypertrophy(LVH).Deletion of Lcn2 in CKD mice did not improve kidney function or anemia but prevented the development of LVH and improved survival in association with marked reductions in serum FGF23.Lcn2 deletion specifically prevented FGF23 elevations in response to inflammation,but not iron deficiency or phosphate,and administration of LCN2 increased serum FGF23 in healthy and CKD mice by stimulating Fgf23 transcription via activation of cAMP-mediated signaling in bone cells.These results show that kidney-produced LCN2 is an important mediator of increased FGF23 production by bone in response to inflammation and in CKD.LCN2 inhibition might represent a potential therapeutic approach to lower FGF23 and improve outcomes in CKD. | Guillaume Courbon Connor Francis Claire Gerber Samantha Neuburg Xueyan Wang Emily Lynch Tamara Isakova Jodie LBabitt Myles Wolf Aline Martin Valentin David | 2021 | Bone Research2021，9，3： | 4 |
| 17 | Gastrointestinal Microbiome Signatures of Pediatric Patients With Irritable Bowel Syndrome显示文摘 | Delphine M. Saulnier Kevin Riehle Toni–Ann Mistretta Maria–Alejandra Diaz Debasmita Mandal Sabeen Raza Erica M. Weidler Xiang Qin Cristian Coarfa Aleksandar Milosavljevic Joseph F. Petrosino Sarah Highlander Richard Gibbs Susan V. Lynch Robert J. Shulman | 2011 | Gastroenterology2011，，5： | 4 |
| 18 | Colorectal cancer显示文摘 | David Cunningham Wendy Atkin Heinz-Josef Lenz Henry T Lynch Bruce Minsky Bernard Nordlinger Naureen Starling | 2010 | The Lancet2010，，9719： | 3 |
| 19 | New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC显示文摘 | Hans F.A. Vasen Patrice Watson Jukka–Pekka Mecklin Henry T. Lynch | 1999 | Gastroenterology1999，，6： | 3 |
| 20 | Centralized/Distributed Recursive Algorithms for Information Fusiori by Dempster-Shafer Techniques with Applications to Target Identification显示文摘 | Lang Hong Andrew Lynch | 1992 | IEEE Trans on Aerrospace and Electronic System1992，28，4： | 3 |
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