|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver steatosis correlates with iron overload but not with HFE gene mutations in chronic hepatitis C显示文摘BACKGROUND: Liver steatosis and iron overload, which are frequently observed in chronic hepatitis C (CHC), may contribute to the progression of liver injury. This study aimed to evaluate the correlation between liver steatosis and iron overload in Polish patients with CHC compared to non- alcoholic fatty liver disease (NAFLD) and HFE-hereditary hemochromatosis (HH) patients. METHODS: A total of 191 CHC patients were compared with 67 NAFLD and 21 HH patients. Liver function tests, serum markers of iron metabolism, cholesterol and triglycerides were assayed. The inflammatory activity, fibrosis, iron deposits and steatosis stages were assessed in liver specimens. HFE gene polymorphisms were investigated by PCR-RFLP. RESULTS: Liver steatosis was associated with obesity and diabetes mellitus. This disease was confirmed in 76/174 (44%) CHC patients, most of whom were infected with genotype 1. The average grade of steatosis was higher in NAFLD patients. CHC patients had significantly higher iron concentrations and transferrin saturations than NAFLD patients. Compared with CHC patients, HH patients had higher values of serum iron parameters and more intensive hepatocyte iron deposits without differences in the prevalence and intensity of liver steatosis. In the CHC group, lipids accumulation in hepatocytes was significantly associated with the presence of serummarkers of iron overload. No correlation between the HFE gene polymorphism and liver steatosis in CHC patients was found. CONCLUSIONS: Liver steatosis was diagnosed in nearly half of CHC patients, most of whom were infected with genotype 1. The intensity of steatosis was lower in CHC patients than that in NAFLD patients because of a less frequent diagnosis of metabolic syndrome. Only in CHC patients were biochemical markers of iron accumulation positively correlated with liver steatosis; these findings were independent of HFE gene mutations. | Katarzyna Sikorska Piotr Stalke Tomasz Romanowski Robert Rzepko Krzysztof Piotr Bielawski | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 2 |
| 2 | Iron overload and HFE gene mutations in Polish patients with liver cirrhosis显示文摘BACKGROUND:Increased liver iron stores may contribute to the progression of liver injury and fibrosis,and are associated with a higher risk of hepatocellular carcinoma development.Pre-transplant symptoms of iron overload in patients with liver cirrhosis are associated with higher risk of infectious and malignant complications in liver transplant recipients.HFE gene mutations may be involved in the pathogenesis of liver iron overload and influence the progression of chronic liver diseases of different origins.This study was designed to determine the prevalence of iron overload in relation to HFE gene mutations among Polish patients with liver cirrhosis.METHODS:Sixty-one patients with liver cirrhosis included in the study were compared with a control group of 42 consecutive patients subjected to liver biopsy because of chronic liver diseases.Liver function tests and serum iron markers were assessed in both groups.All patients were screened for HFE mutations (C282Y,H63D,S65C).Thirty-six of 61 patients from the study group and all controls had liver biopsy performed with semiquantitative assessment of iron deposits in hepatocytes.RESULTS:The biochemical markers of iron overload and iron deposits in the liver were detected with a higher frequency (70% and 47% respectively) in patients with liver cirrhosis.There were no differences in the prevalence of all HFE mutations in both groups.In patients with a diagnosis of hepatocellular carcinoma,no significant associations with iron disorders and HFE gene mutations were found.CONCLUSIONS:Iron disorders were detected in patients with liver cirrhosis frequently but without significant association with HFE gene mutations.Only the homozygous C282Y mutation seems to occur more frequently in the selected population of patients with liver cirrhosis.As elevated biochemical iron indices accompanied liver iron deposits more frequently in liver cirrhosis compared to controls with chronic liver disease,there is a need for more extensive studies searching for the possible influence of non-HFE iron homeostasis regulators and their modulation on the course of chronic liver disease and liver cirrhosis. | Katarzyna Sikorska Piotr Stalke Tomasz Romanowski Ewa Izycka-Swieszewska Krzysztof Piotr Bielawski | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 2 |
| 3 | Contrast-enhanced,ultrafast 3D pulmonary MR angiography in a single breath-hold:initial assessment of imaging performance显示文摘 | Steiner P McKinnon GC Romanowski B | 1997 | J Magn Reson Imaging1997，7，1： | 1 |
| 4 | The ABCs of SPFs:anintroduction of sun protection products 显示文摘 | SCHUELLER R ROMANOWSKI P | 1999 | Cosmetics & Toiletries1999，114，9： | 1 |
| 5 | Minimally invasive unicendylar arthroplasty:eight year followp显示文摘 | Romanowski MR Repicci JA | 2002 | J Knee Surg2002，15，1： | 1 |
| 6 | Efficacy and safety of famciclovir for treating mucocutaneous herpes simplex infection in HIV-infected individuals, collaborative famciclovir HIV study group 显示文摘 | Romanowski B Aoki FY Martel A Y | 2000 | AIDS2000，14，9： | 1 |
| 7 | Crystal structure of the Streptococcus pneumoniae phosphomeval- onate kinase, a member of the GHMP kinase superfami- ly 显示文摘 | Romanowski M J Bonanno J B Burley S K | 2002 | Proteins2002，47，4： | 1 |
| 8 | Human cathelicidin (LL-37),a multifunctional peptide,is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity显示文摘 | Gordon YJ Huang LC Romanowski EG | | 0，，： | 1 |
| 9 | Benzalkonium chloride enhances the antibacterial efficacy of gatifloxaein in an experimental rabbit model of intrastromal keratitis显示文摘 | Romanowski EG Mah FS Kowalski RP | 2008 | J OculPharmacolTher2008，24，4： | 1 |
| 10 | A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs显示文摘 | Gordon YJ Romanowski EG McDermott AM | 2005 | Curt Eye Res2005，30，7： | 1 |
| 11 | Adsorption of plasmid DNA to mineral surfaces and protection against Dnase-1 显示文摘 | Romanowski G Lorenz M G Wackernagel W | 1991 | Appl Environ Microb1991，57，4： | 1 |
| 12 | Areview of antimierobial peptides and their therapeutic poten-tial as anti-infective drugs显示文摘 | GORDON Y J ROMANOWSKI E G MCKERMOTT A M | 2005 | Curr Eye Res2005，30，7： | 1 |
| 13 | Conditining agents for hair and skin 显示文摘 | Randy Schueller Petty Romanowski | 1995 | Cosmetics & Toiletries1995，110，8： | 1 |
| 14 | Syphilis:review with emphsis on clinical epidemiologic, and some biologic features 显示文摘 | Singh AE Romanowski B | 1999 | Clin Micmbiol Rev1999，12，2： | 1 |
| 15 | Monoclonal antibody prophylaxis against the in vivo toxicity of ricin in mice显示文摘 | Chanh TC Romanowski MJ Hewetson JF | 1993 | Immunol Invest1993，22，1： | 1 |
| 16 | Review with emphasis on clinical, epidemiologic, and some biologic features显示文摘 | Singh A E Romanowski B Syphilis M | 1999 | Clin Microbiol Rev1999，12，14： | 1 |
| 17 | Anatomic single-bundle anterior cruciate ligament reconstruction 显示文摘 | Van Eck CF Romanowski JR Fu FH | 2009 | Arthroscopy2009，25，9： | 1 |
| 18 | The effect of immunization of pigs with Ascaris suum cuticle components on the development of resistance to parenteral migration during a challenge infection显示文摘 | Hill DE Fetterer RH Romanowski RD | 1994 | Vet Immunol Immunopathol1994，42，： | 1 |
| 19 | Lead and cadmium in relation to body weight and mortality of the house sparrow Passer domesticus and tree sparrow Passer montanus 显示文摘 | Pinowski J J Romanowski M Barkowska K Sawicka-Kapusta P Kaminski and A G Kruszewicz | 1993 | Acta Orithologica (Warsaw)1993，，： | 1 |
| 20 | BV Blue test for diagnosis of bacterial vaginosis显示文摘 | Myziuk L Romanowski B Johnson SC | 2003 | J Clin Microbiol2003，41，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员