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| 1 | Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke显示文摘Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the brain.In this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their functions.The currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these treatments.Memantine is an approved drug for the treatment of Alzheimer's disease.Memantine is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate receptor.Memantine has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical trials.The present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients. | Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.López-Valdés | 2021 | Neural Regeneration Research2021，16，3： | 8 |
| 2 | Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes显示文摘AIM To assess the relationship of brain-derived neurotrophic factor(BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS The study included 40 patients with diabetes mellitus type 2(DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy(HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment.RESULTS The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2(43.78 ± 9.05 vs 31.55 ± 10.24, P = 0.005). There were no differences between patients in HD(11.39 ± 8.87 vs 11.11 ± 10.64 P = 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment(1564 ± 1335 vs 664 ± 484 P = 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences(P < 0.001).CONCLUSION Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD. | Blanca Murillo Ortíz Joel Ramírez Emiliano Edna Ramos-Rodríguez Sandra Martínez-Garza Hilda Macías-Cervantes Sergio Solorio-Meza Texar Alfonso Pereyra-Nobara | 2016 | World Journal of Diabetes2016，7，20： | 7 |
| 3 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 4 | Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models in vivo显示文摘Acute and chronic colitis affect a huge proportion of the population world-wide.The etiology of colitis cases can be manifold,and diet can significantly affect onset and outcome of colitis.While many forms of acute colitis are easily treatable,chronic forms of colitis such as ulcerative colitis and Crohn’s disease(summarized as inflammatory bowel diseases)are multifactorial with poorly understood pathogenesis.Inflammatory bowel diseases are characterized by exacerbated immune responses causing epithelial dysfunction and bacterial translocation.There is no cure and therapies aim at reducing inflammation and restoring intestinal barrier function.Unfortunately,most drugs can have severe side effects.Changes in diet and inclusion of nutritional supplements have been extensively studied in cell culture and animal models,and some supplements have shown promising results in clinical studies.Most of these nutritional supplements including vitamins,fatty acids and phytochemicals reduce oxidative stress and inflammation and have shown beneficial effects during experimental colitis in rodents induced by dextran sulphate sodium or 2,4,6-trinitrobenzene sulfonic acid,which remain the gold standard in pre-clinical colitis research.Here,we summarize the mechanisms through which such nutritional supplements contribute to epithelial barrier stabilization. | Hilda Vargas-Robles Karla Fabiola Castro-Ochoa Alí Francisco Citalán-Madrid Michael Schnoor | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 5 | 在培养基和食料中添加铅和镉对轮虫种群动态的影响(英文)显示文摘由于工业活动的影响 ,墨西哥水体环境中的重金属浓度在上升。浮游动物 ,尤其是轮虫类 ,由于对环境变化十分敏感而且是淡水中的常见组成部分 ,因此被广泛用于生态毒理试验以确定水质标准。在不同的胁迫途径下 (如通过培养基或食料 ) ,重金属的毒性是不同的。在本研究中 ,通过在轮虫Brachionusrubens的培养基和食料中添加重金属这两种途径 ,我们评估了镉和铅的效应。对于这两种重金属 ,均采用将轮虫置于含 0 5×10 6个 /ml绿藻的培养基中或每天喂食经 5倍于LC50 值的金属处理 (1,2和 4h)的绿藻。对于在培养基中添加镉 ,使用了三个毒性水平 (0 1,0 2和 0 4mg/L) ,铅的浓度分别为 0 0 0 5 ,0 0 10和 0 0 15mg/L。基于LC50的数据 ,B .rubens对铅的敏感性要比镉高 2 4倍。镉浓度为 0 4mg/L时 ,培养基中加入镉造成B .rubens的生长趋缓。而喂食经不同时间处理的绿藻后 ,轮虫的密度随着食料在重金属中处理时间的延长而减小。培养基中或食料中添加铅时 ,轮虫种群生长的的趋势与在镉处理下的情况类似。随着培养基中重金属浓度的增加 ,每天种群增长率 (r值 )会减小。在培养基和食料处理两种不同途径下 ,r值会在 0 33(对照 )到 0 0 2d-1(经重金属处理 ) | S.S.S.SARMA Hilda Fabiola NU'EZ-CRUZ S. NANDINI | 2005 | 动物学报2005，51，1： | 3 |
| 6 | The Malaysian cataract surgery registry:incidence and risk factors of postoperative infectious endophthalmitis over a 7-year period显示文摘AIM:To report the incidence,risk factors and visual outcomes for postoperative endophthalmitis(POE)based on 7-year data from the Malaysian Ministry of Health Cataract Surgery Registry(MOH CSR).METHODS:Data was collected from the web-based MOH CSR.All consecutive cataract surgery patients from 1st June 2008 to 31st December 2014 were identified.Exclusion criteria were traumatic cataract or previous ocular surgery.Demographic data,ocular co-morbidities,intraoperative details and postoperative visual acuity(VA)at final ophthalmological follow-up were noted.All eyes were taken for analysis.Subjects with POE were compared against subjects with no POE for risk factor assessment using multiple logistic regressions.RESULTS:A total of 163 503 subjects were screened.The incidence of POE was 0.08%(131/163 503).Demographic POE risk factors included male gender(OR:2.121,95%CI:1.464-3.015)and renal disease(OR:2.867,95%CI:1.503-5.467).POE risk increased with secondary causes of cataract(OR:3.562,95%CI:1.740-7.288),uveitis(OR:11.663,95%CI:4.292-31.693)and diabetic retinopathy(OR:1.720,95%CI:1.078-2.744).Intraoperative factors reducing POE were shorter surgical time(OR:2.114,95%CI:1.473-3.032),topical or intracameral anaesthesia(OR:1.823,95%CI:1.278-2.602),posterior chamber intraocular lens(PCIOL;OR:4.992,95%CI:2.689-9.266)and foldable IOL(OR:2.276,95%CI:1.498-3.457).POE risk increased with posterior capsule rupture(OR:3.773,95%CI:1.915-7.432)and vitreous loss(OR:3.907,95%CI:1.720-8.873).Postoperative VA of 6/12 or better was achieved in 15.27%(20/131)subjects with POE.CONCLUSION:This study concurs with other studies regarding POE risk factors.Further strengthening of MOH CSR data collection process will enable deeper analysis and optimization of POE treatment. | Yong Zheng Wai Fiona Lee Min Chew Mohamad Aziz Salowi Chai Liang Ang Yong Yuin Chong Tassha Hilda Adnan Pik-Pin Goh | 2018 | International Journal of Ophthalmology(English edition)2018，11，10： | 3 |
| 7 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 8 | Role of TNFSF15 in the intestinal inflammatory response显示文摘Gastrointestinal diseases, specifically Crohn's disease, ulcerative colitis, diverticular disease, and primary biliary cirrhosis are all characterized by complicated inflammation of the digestive tract. Their pathology is multifactorial, and risk factors encompass both genetic and environmental factors. Recent advances in the genetic component of inflammatory bowel diseases(IBDs) have revealed that the tumor necrosis factor superfamily member 15(TNFSF15) contains a number of risk alleles associated not only with IBD but also with other diseases such as diverticular disease and primary biliary cirrhosis. These risk alleles in TNFSF15 and the altered expression of its gene product can serve as the common ground between these disorders by explaining at least some of the underlying processes that lead to a dysregulated immune response and subsequent chronic inflammation. Here, we aim to outline how the TNFSF15 gene is involved in the proliferation and cell fate of different populations of T cells and subsequently in the control of both pro-and anti-inflammatory cytokines. Furthermore, we summarize what is currently known of TNFSF15 control region variants, how they are associated with each mentioned disease, and how these variants can explain the autoimmune pathology of said diseases through altered TNFSF15 expression. | Tanya Kadiyska Ivan Tourtourikov Ana-Maria Popmihaylova Hilda Kadian Ani Chavoushian | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，4： | 2 |
| 9 | 早餐的省略和在墨西哥的胃的癌症的风险显示文摘 <Abstract>AIM: To investigate factors associated with gastric cancer (GC) in the Mexican population using a validated questionnaire. METHODS: We designed and validated in Spanish a Questionnaire to Find Factors Associated with Diseases of the Digestive Tract using GC as a model. A crosssectional study using 49 subjects, with confirmed histopathological GC diagnosis, and 162 individuals without GC participated. Odds ratio and 95% CIs were estimated in univariate and multivariate analysis adjusted for possible confounding factors. In order to match agegroups, a multivariate sub-analysis was performed in subjects ≥ 39 years of age and in females and males separately. RESULTS: In the univariate analysis, we found an association between GC and education to primary level or below, low socioeconomic status, the use of dental prostheses, omission of breakfast, consumption of very hot food and drink, addition of salt to prepared foods, consumption of salt-preserved foods and the pattern of alcohol consumption. We found protection against GC associated with the use of mouthwash, food refrigeration and regular consumption of fruit and vegetables. In the multivariate sub-analysis with subjects of ≥ 39 years, the omission of breakfast was identified as a risk factor for GC. CONCLUSION: Our study suggests an association between the omission of breakfast and the failure to refrigerate food with GC in the Mexican population. | Monserrat Verdalet-Olmedo Clara Luz Sampieri Jaime Morales-Romero Hilda Montero-L de Guevara lvaro Manuel Machorro-Castao Kenneth León-Córdoba | 2012 | World Journal of Gastrointestinal Oncology2012，4，11： | 2 |
| 10 | Five-Year Subjective and Objective Results of Laparoscopic and Conventional Nissen Fundoplication: A Randomized Trial显示文摘 | Werner A. Draaisma Hilda G. Rijnhart-de Jong Ivo A. M. J. Broeders Andre J. P. M. Smout Edgar J. B. Furnee Hein G. Gooszen | 2006 | Annals of Surgery2006，，1： | 2 |
| 11 | The rs3761548 polymorphism of FOXP3 is a protective genetic factor against allergic rhinitis in the Hungarian female population显示文摘 | Eszter Fodor Edina Garaczi Hilda Polyánka Andrea Koreck Lajos Kemény Márta Széll | 2011 | Human Immunology2011，，10： | 1 |
| 12 | Under- standing Teacher Education Reform 显示文摘 | Borko Hilda Liston Dan Whitcomb Jennifer A | 2007 | Journal of Teacher Education2007，58，： | 1 |
| 13 | NCLB and Scientifically-Based Research: Opportunities Lost and Found 显示文摘 | Borko Hilda Liston Dan Whitcomb Jennifer A | 2007 | Journal of Teacher Education2007，58，： | 1 |
| 14 | Stranger than Fiction: Arthur Levine' s Educating School Teach- ers-the Basis for a Proposal 显示文摘 | Borko Hilda Liston Dan Whitcomb Jennifer A | 2007 | Journal of Teacher Edu- cation2007，58，： | 1 |
| 15 | Sex hormones originating from different livestock production systems: fate and potential disrupting activity in the environment显示文摘 | Iris G Lange Andreas Daxenberger Bettina Schiffer Hilda Witters Dolores Ibarreta Heinrich H.D Meyer | 2002 | Analytica Chimica Acta2002，，1： | 1 |
| 16 | Congenital cysts of the iris stroma显示文摘 | Hilda C Earl P Don H | 1993 | Am J Ophthalmol1993，116，： | 1 |
| 17 | Apples and Fishes: The Debate over Dispositions in Teacher Edu- cation 显示文摘 | Borko Hilda Liston Dan Whitcomb Jennifer A | 2007 | Journal of Teacher Education2007，58，： | 1 |
| 18 | Impact of salt stress on seed germination indices of five wheat eultivars 显示文摘 | HOMA M FATEMEH M K HILDA B | 2013 | Annals of Biological Research2013，4，6： | 1 |
| 19 | Free and forced vibrations of a simply supported rectangular plate partially embedded in an elastic foundation 显示文摘 | Daniel A Hilda L Patricio A A L | 1989 | Applied Acoustics1989，28，4： | 1 |
| 20 | Slructure and species distribution in Coringa mangrove forest, Godavari Delta, Andhra Pradesh India显示文摘 | Azariah Jayapaul Azariah Hilda Gunasekaran S and Selvam V | 1992 | Hydrobiologia1992，247，： | 1 |
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