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| 1 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 2 | Third Universal Definition of Myocardial Infarction显示文摘 | Kristian Thygesen Joseph S. Alpert Allan S. Jaffe Maarten L. Simoons Bernard R. Chaitman Harvey D. White | 2012 | Journal of the American College of Cardiology2012，，16： | 8 |
| 3 | Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma显示文摘 | Lei Zheng Jing Xue Elizabeth M. Jaffee Aida Habtezion | 2013 | Gastroenterology2013，，6： | 4 |
| 4 | Synergistic Effects of A1896, T1653 and T1762/A1764 Mutations in Genotype C2 Hepatitis B Virus on Development of Hepatocellular Carcinoma显示文摘 | H. Lyu D. Lee Y.‐H. Chung J. A. Kim J.‐H. Lee Y.‐J. Jin W. Park P. Mathews E. Jaffee L. Zheng E. Yu Y. J. Lee | 2012 | J Viral Hepat2012，，3： | 3 |
| 5 | EUS-FNA is superior to ERCP-based tissue sampling in suspected malignant biliary obstruction: Results of a prospective, single-blinded, comparative study显示文摘 | Frank Weilert Yasser M. Bhat Kenneth F. Binmoeller Steve Kane Ian M. Jaffee Richard E. Shaw Rees Cameron Yusuke Hashimoto Janak N. Shah | 2013 | Gastrointestinal Endoscopy2013，，： | 2 |
| 6 | The U.S. patent system in transition: policy innovation and the innovation process显示文摘 | Adam B Jaffe | 2000 | Research Policy2000，，4： | 2 |
| 7 | RHO GTPASES: Biochemistry and Biology显示文摘 | Aron B. Jaffe Alan Hall | 2005 | Annual Review of Cell and Developmental Biology2005，，： | 2 |
| 8 | Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration显示文摘 | Daniel F. Martin Maureen G. Maguire Stuart L. Fine Gui-shuang Ying Glenn J. Jaffe Juan E. Grunwald Cynthia Toth Maryann Redford Frederick L. Ferris | 2012 | Ophthalmology2012，，7： | 2 |
| 9 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 10 | Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones显示文摘 | James A. DiSario Martin L. Freeman David J. Bjorkman Padraic MacMathuna Bret T. Petersen Philip E. Jaffe Thomas G. Morales Lee J. Hixson Stuart Sherman Glen A. Lehman M. Mazen Jamal Firas H. Al-Kawas Mukul Khandelwal Joseph P. Moore Gregory A. Derfus Priy | 2004 | Gastroenterology2004，，： | 2 |
| 11 | Depression as a Risk Factor for Poor Prognosis Among Patients With Acute Coronary Syndrome: Systematic Review and Recommendations: A Scientific Statement From the American Heart Association显示文摘 | Judith H. Lichtman Erika S. Froelicher James A. Blumenthal Robert M. Carney Lynn V. Doering Nancy Frasure-Smith Kenneth E. Freedland Allan S. Jaffe Erica C. Leifheit-Limson David S. Sheps Viola Vaccarino Lawson Wulsin | 2014 | Circulation2014，，12： | 2 |
| 12 | PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors显示文摘 | Kevin C. Soares Agnieszka A. Rucki Annie A. Wu Kelly Olino Qian Xiao Yi Chai Anthony Wamwea Elaine Bigelow Eric Lutz Linda Liu Sheng Yao Robert A. Anders Daniel Laheru Christopher L. Wolfgang Barish H. Edil Richard D. Schulick Elizabeth M. Jaffee Lei Zhen | 2015 | Journal of Immunotherapy2015，，1： | 2 |
| 13 | The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997显示文摘 | Harris Jaffe Diebold Flandrin Muller‐Hermelink Vardiman Lister Bloomfield | 2001 | Histopathology2001，，1： | 2 |
| 14 | Knowledge spillovers and patent citations: Evidence from a survey of innovators显示文摘 | Jaffe Adam B Manuel Trajtenberg and Michael S Fogarty | 2000 | Industrial Technology and Productivity2000，90，2： | 1 |
| 15 | Hartree-Fock study of phase changes in ZnO at high pressure显示文摘 | Jaffe J E Hess A C | | 0，，： | 1 |
| 16 | Evaluation of a delivery system providing long-term release of cyclosporine显示文摘 | Pearson PA Jaffe GJ Martin DF | | 0，，： | 1 |
| 17 | Laparoscopic myomectomy for hemoperitoneum from a uterine leiomyoma with concomitant tubal abortion:a case report显示文摘 | Davison JZ Bennett TA Jaffe IM | | 0，，9： | 1 |
| 18 | Light-induced expression of a MYB gene regulates anthocyanin biosynthesis in red apples显示文摘 | Takos AM Jaffe FW Jacob SR | | 0，，03： | 1 |
| 19 | A Theory and Test of Credit Rationing显示文摘 | Jaffee M Modigliani F | 1969 | The American Economic Review1969，59，5： | 1 |
| 20 | Geographic localization of knowledge spillovers as evidenced by patent citations显示文摘 | Manuel T Rebecca H | 1993 | Quarterly Journal of Economics1993，108，3： | 1 |
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