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| 1 | Pancreatic cancer stroma:understanding biology leads to new therapeutic strategies显示文摘Pancreatic ductal adenocarcinoma(PDA)is among the deadliest cancers in the United States and in the world.Late diagnosis,early metastasis and lack of effective therapy are among the reasons why only 6%of patients diagnosed with PDA survive past 5 years.Despite development of targeted therapy against other cancers,little progression has been made in the treatment of PDA.Therefore,there is an urgent need for the development of new treatments.However,in order to proceed with treatments,the complicated biology of PDA needs to be understood first.Interestingly,majority of the tumor volume is not made of malignant epithelial cells but of stroma.In recent years,it has become evident that there is an important interaction between the stromal compartment and the less prevalent malignant cells,leading to cancer progression.The stroma not only serves as a growth promoting source of signals but it is also a physical barrier to drug delivery.Understanding the tumor-stroma signaling leading to development of desmoplastic reaction and tumor progression can lead to the development of therapies to decrease stromal activity and improve drug delivery.In this review,we focus on how the current understanding of biology of the pancreatic tumor microenvironment can be translated into the development of targeted therapy. | Agnieszka Anna Rucki Lei Zheng | 2014 | World Journal of Gastroenterology2014，20，9： | 13 |
| 2 | PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors显示文摘 | Kevin C. Soares Agnieszka A. Rucki Annie A. Wu Kelly Olino Qian Xiao Yi Chai Anthony Wamwea Elaine Bigelow Eric Lutz Linda Liu Sheng Yao Robert A. Anders Daniel Laheru Christopher L. Wolfgang Barish H. Edil Richard D. Schulick Elizabeth M. Jaffee Lei Zhen | 2015 | Journal of Immunotherapy2015，，1： | 2 |
| 3 | A high-performance W-band uniplanar subharmonic mixer 显示文摘 | Raman S Rucky F Rebeiz G M | 1997 | IEEE Transactions on Microwave Theory and Techniques1997，45，6： | 1 |
| 4 | Validation of QSAR models for legislative purposes 显示文摘 | Rucki M Tichy M | 2009 | Interdiscip Toxico12009，2，3： | 1 |
| 5 | PD-1/PD-L1 blockade together with v~teeine therapy facilitates effector T-cell infiltration into pancreatic tumors显示文摘 | Soares KC Rucki AA Wu AA | 2015 | J Immunother2015，38，1： | 1 |
| 6 | Air gauges as a part of the dimensional inspection systems显示文摘 | Rucki Miroslaw Barisic Branimir Varga Gyula | 2010 | Measurement2010，43，1： | 1 |
| 7 | Field analysis and electrical models of multi-electrode impedance sensors 显示文摘 | Szczepanik Z Rucki Z | 2007 | Sensors and Actuators A : Physical2007，133，1： | 1 |
| 8 | The possibili- ty of employing a calculable four-electrode conductance :ell to substitute for the secondary standards of electro- 显示文摘 | MORON Z RUCKI Z SZCZEPANIK Z | 1997 | IEEE Transactions on Instrumen- tation and Measurement1997，46，6： | 1 |
| 9 | Analysis of digitizing and tradional measuring system at surface measurement of lids 显示文摘 | Branimir B Rucki M Car Z | 2008 | Key Engineering Materials2008，，： | 1 |
| 10 | Novel glutathionedependent thiopurine prodrugs:evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice显示文摘 | GUNNARSDOTTIR S RUCKI M ELFARRA A A | 2002 | J Pharmacol Exp Ther2002，301，1： | 1 |
| 11 | TOWARDS FFT-BASED DIRECT NUMERICAL SIMULATIONS OF TURBULENT FLOWS ON A GPU显示文摘The accurate simulation of turbulence and the implementation of corresponding turbulence models are both critical to the understanding of the complex physics behind turbulent flows in a variety of science and engineering applications.Despite the tremendous increase in the computing power of central processing units(CPUs),direct numerical simulation of highly turbulent flows is still not feasible due to the need for resolving the smallest length scale,and today’s CPUs cannot keep pace with demand.The recent development of graphics processing units(GPU)has led to the general improvement in the performance of various algorithms.This study investigates the applicability of GPU technology in the context of fast-Fourier transform(FFT)-based pseudo-spectral methods for DNS of turbulent flows for the Taylor–Green vortex problem.They are implemented on a single GPU and a speedup of unto 31x is obtained in comparison to a single CPU. | CATHERINE RUCKI ABHILASH J.CHANDY | 2014 | International Journal of Modeling, Simulation, and Scientific Computing2014，5，1： | 0 |
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