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| 1 | Clinical importance of aspirin and clopidogrel resistance显示文摘Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked 'aspirin and/or clopidogrel resistance', as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel. | Gergely Feher Andrea Feher Gabriella Pusch Katalin Koltai Antal Tibold Beata Gasztonyi Elod Papp Laszlo Szapary Gabor Kesmarky Kalman Toth | 2010 | World Journal of Cardiology2010，2，7： | 36 |
| 2 | 接受治疗的老年高血压患者的血压、抗高血压药物应用、衰弱指标与严重摔伤风险的关系显示文摘一些研究表明,降压药物、低收缩压和舒张压与跌倒风险增加相关。许多老年人表现出衰弱的指征,这可能会增加跌倒的风险。该研究纳入脑卒中地区和种族差异原因(the reasons for geographic and racial differences in stroke,REGARDS)研究中年龄≥65岁的受试者5236例,探索收缩压、舒张压、抗高血压药物类别数量以及衰弱指标与严重跌倒损伤风险的关系, | 刘莉 叶鹏 Bromfield SG Ngameni CA Colantonio LD Bowling CB Shimbo D Reynolds K Safford MM Banach M Toth PP Muntner P | 2017 | 中华高血压杂志2017，25，8： | 19 |
| 3 | Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases显示文摘AIM: To investigate the effect of vitamin D(VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease(IBD) patients. METHODS: A cohort of 220 IBD patients including 141 Crohn's disease(CD) and 79 ulcerative colitis(UC) patients was followed-up at a tertiary IBD center. A subgroup of the cohort(n = 26) took VD supplements for > 3 mo. Health related quality of life was assessed using the short IBD questionnaire(s IBDQ). VD serum concentration and s IBDQ score were assessed between August and October 2012(summer/autumn period) and between February and April 2013(winter/spring period). The mean VD serum concentration and its correlation with disease activity of CD were determined for each season separately. In a subgroup of patients, the effects of VD supplementation on winter VD serum concentration, change in VD serum concentration from summer to winter, and winter s IBDQ score were analyzed.RESULTS: During the summer/autumn and the winter/spring period, 28% and 42% of IBD patients were VD-deficient(< 20 ng/m L), respectively. In the winter/spring period, there was a significant correlation between s IBDQ score and VD serum concentration in UC patients(r = 0.35, P = 0.02), with a trend towards significance in CD patients(r = 0.17, P = 0.06). In the winter/spring period, VD-insufficient patients(< 30 ng/m L) had a significantly lower mean s IBDQ score than VD-sufficient patients; this was true of both UC(48.3 ± 2.3 vs 56.7 ± 3.4, P = 0.04) and CD(55.7 ± 1.25 vs 60.8 ± 2.14, P = 0.04) patients. In all analyzed scenarios(UC/CD, the summer/autumn period and the winter/spring period), health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/m L. Supplementation with a median of 800 IU/d VD day did not influence VD serum concentration or the s IBDQ score.CONCLUSION: VD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period. | Tibor Hlavaty Anna Krajcovicova Tomas Koller Jozef Toth Monika Nevidanska Martin Huorka Juraj Payer | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 4 | Enhanced Photocatalytic Activity of TiO2 Nanofibers and Their Flexible Composite Films: Decomposition of Organic Dyes and Efficient H2 Generation from Ethanol-Water Mixtures显示文摘与磅和 Pd nanoparticles 装饰的 TiO2 nanofibers 在各种各样的 photocatalytic 过程被综合了并且学习。在水里的器官的染料的分解的优秀 photocatalytic 行为,灵活独立纤维素 / 催化剂的表面上的器官的污点的降级合成电影并且在从乙醇用的氢的产生推迟了并且使不能调动催化剂被表明。基于 nanofiber 的 TiO2 材料的表演是在某情况 outperformstheir 的竞争 withand 常规基于 nanoparticle 的对应物。在所有情况中,装饰 Pd 的 TiO2 nanoparticles 和 nanofibers 证明了比他们的基于磅的对应物更有效,它能在在 TiO2 和金属 nanoparticles 之间的接触根据缩放 nano 的 Schottky 接口的形成被解释。形成纤维素 / 催化剂 composites 的可行性提供在大区域的涂层和独立电影利用光催化剂材料的一个新奇方法。 | Ming-Chung Wu Andras Sapi Anna Avila Maria Szabo Jussi Hiltunen Mika Huuhtanen Geza Toth Akos Kukovecz Zoltan Konya Riitta Keiski Wei-Fang Su Heli Jantunen Krisztian Kordas | 2011 | Nano Research2011，4，4： | 7 |
| 5 | Association of comorbidities with increasing severity of peripheral neuropathy in diabetes mellitus显示文摘AIM: To analyze a large population of patients with diabetes and peripheral neuropathy(PN) to determine other meaningful comorbid etiologies for PN.METHODS: Peripheral Neuropathy is a common complication of type 1 and 2 diabetes mellitus;however,other potential causes for PN may be co-existing in patients with diabetes.A prospective cohort study was performed to assess patients with diabetes and PN.We compared patients having PN due solely to diabetes with patients possessing co-existing comorbidities,performing clinical(Toronto Clinical Scoring System and the Utah Early Neuropathy Scale),laboratory and electrophysiological assessments in all patients.RESULTS: Patients with either type 1 or 2 diabetes mellitus and co-existing comorbidities did not have more severe clinical or electrophysiological PN phenotypes overall.However,in patients with type 1 diabetes,presence of a lipid disorder was associated with greater PN severity.In type 2 diabetes patients,both a lipid disorder and cobalamin deficiency were associated with greater PN severity.There was no additive effect upon PN severity with presence of three or more comorbid etiologies.CONCLUSION: The presence of specific,and not general,comorbidities in patients with type 1 or 2 diabetes corresponds with greater PN severity. | Shafna Sachedina Cory Toth | 2013 | World Journal of Diabetes2013，4，4： | 7 |
| 6 | Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study显示文摘AIM To analyze 1-year liver injury burden in inflammatory bowel disease(IBD) patients. METHODS During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase(AT) activities of ALT, AST, ALP and gamma-glutamyl transpeptidase(GGT) were measured at baseline, 3 mo prior to study entry and prospectively every 3 mo for 1 year. Liver injury patterns were predefined as: Grade 1 in ALT 1-3 × upper limit of normal(ULN), grade 2 in ALT > 3 × ULN, hepatocellular injury in ALT > 2 × ULN, cholestatic injury in simultaneous GGT and ALP elevation > ULN.Persisting injury was reported when AT elevations were found on > 1 measurement. Risk factors for the patterns of liver injury were identified among demographic parameters, disease phenotype and IBD treatment in univariate and multivariate analysis. Finally, implications for the change in IBD management were evaluated in cases with persisting hepatocellular or cholestatic injury.RESULTS Two hundred and fifty-one patients were included having 917 ALT and 895 ALP and GGT measurements. Over one year, grade 1 injury was found in 66(26.3%), grade 2 in 5(2%) and hepatocellular injury in 16 patients(6.4%). Persisting hepatocellular injury was found in 4 cases. Cholestasis appeared in 11 cases(4.4%) and persisted throughout the entire study period in 1 case. In multivariate analysis, hepatocellular injury was associated with BMI(OR = 1.13, 1.02-1.26), liver steatosis(OR = 10.61, 2.22-50.7), IBD duration(1.07, 1.00-1.15) and solo infliximab(OR = 4.57, 1.33-15.7). Cholestatic liver injury was associated with prior intestinal resection(OR = 32.7, 3.18-335), higher CRP(OR = 1.04, 1.00-1.08) and solo azathioprine(OR = 10.27, 1.46-72.3). In one case with transient hepatocellular injury azathioprine dose was decreased. In 4 cases with persisting hepatocellular injury, fatty liver or alcohol were most likely causes and IBD treatment was pursued without change. In the case with persisting cholestatic injury, no signs of portal hypertension were identified and treatment with infliximab continued.CONCLUSION Liver injury was frequent, mostly transient and rarely changed management. Infliximab or azathioprine were confirmed as its risk factors indicating the need for regular AT monitoring. | tomas koller martina galambosova simona filakovska michaela kubincova tibor hlavaty jozef toth anna krajcovicova juraj payer | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 7 | Insight into the antifungal mechanism of Neosartorya fischeri antifungal protein显示文摘细丝状的子囊菌纲分泌的小、充满半胱氨酸的、高度稳定的抗真菌的蛋白质为新奇抗真菌的策略的发展有大潜力。然而,他们的实际申请仍然由于他们行动的不充分澄清的模式被限制。这个工作的目的是提供深卓见进 Neosartorya fischeri 的抗真菌的机制抗真菌的蛋白质(NFAP ) ,这个蛋白质组的一个新奇代表。在 NFAP 敏感的曲霉属菌 nidulans 在 NFAP,减少的细胞的新陈代谢, apoptosis 正式就职,在肌动朊分发的变化和在菌丝的尖端的几丁质免职的一短暴露时间以内被观察。NFAP 确实由 endocytosis 显示出既不直接的膜破坏效果也不举起。A 的调查。nidulans 发信号异种表明 NFAP 经由表明导致极的生长的 apoptosis 和抑制的 G 蛋白质激活营地 / 蛋白质 kinase A 小径。相反, NFAP 没在房间墙正直小径,而是小径无关的 mitogen 激活的未知房间墙正直上有任何影响蛋白质 kinase 激活 A 的目标被假定涉及房间死亡正式就职。一起拿, NFAP 从曲霉属菌 giganteus 和毛丛 chrysogenum 与二大多数调查 NFAP 相关的蛋白质相比在它抗真菌的行动的模式显示出类似,而且差别,这被结束。 | Mate Viragh Annamaria Marton Csaba Vizier Liliana Toth Csaba Vagvolgyi Florentine Marx Laszlo Galgoczy | 2015 | Protein & Cell2015，6，7： | 4 |
| 8 | 新型低密度脂蛋白胆固醇评估对全球血脂异常指南中次级靶标非高密度脂蛋白胆固醇和载脂蛋白B应用的影响显示文摘血脂异常指南通常推荐非高密度脂蛋白胆固醇(non-high-density lipoprotein-cholesterol,non-HDL-C)和载脂蛋白B(apolipoprotein B,apoB)作为主要靶点低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的次要靶点。 | Sathiyakumar V Park J Quispe R Elshazly MB Michos ED Banach M Toth PP Whelton SP Blumenthal RS Jones SR Martin SS 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 9 | Pulmonary embolization as primary manifestation of hepatocellular carcinoma with intracardiac penetration: A case report显示文摘Intracardiac manifestation of hepatocellular carcinoma (HCC) is a rare condition and an uncommon finding even at autopsy. Pulmonary tumor embolism as a presenting feature of HCC has been published only twice previously.In our case report, a 63-year-old man presented with high fever and six episodes of recurrent pneumonias during the last half year. Echocardiography was performed, a solid mass was found in the right atrium. Transesophageal echocardiography proved a tumor mass in the inferior vena cava (ⅣC) extending into the right atrium, abdominal ultrasound revealed tumor mass in the ⅣC and a solid tumor in the liver. Combined liver and heart surgery was attempted in order to remove the tumor mass from both the liver and the right atrium. Acute cor pulmonale occurred during tumor removal from the right atrium and the patient expired. In addition to local factors the possibility of embolization should arise in the background of recurrent pneumonia. Occult carcinoma must be included in possible causes of recurrent pulmonary embolism. Searching for primary malignancy should include HCC as frequent cause of hypercoagulability. In case of HCC, echocardiography is suggested because of the possibility of expansion in MC or right atrium and tumor-embolization. | Elod Papp Zsuzsanna Keszthelyi Nagy Karoly Kalmar Lajos Papp Csaba Weninger Tamas Tornoczky Endre Kalman Kalman Toth Tamas Habon | 2005 | World Journal of Gastroenterology2005，11，15： | 4 |
| 10 | Dual mean Minkowski measures of symmetry for convex bodies显示文摘We introduce and study a sequence of geometric invariants for convex bodies in finite-dimensional spaces, which is in a sense dual to the sequence of mean Minkowski measures of symmetry proposed by the second author. It turns out that the sequence introduced in this paper shares many nice properties with the sequence of mean Minkowski measures, such as the sub-arithmeticity and the upper-additivity. More meaningfully, it is shown that this new sequence of geometric invariants, in contrast to the sequence of mean Minkowski measures which provides information on the shapes of lower dimensional sections of a convex body, provides information on the shapes of orthogonal projections of a convex body. The relations of these new invariants to the well-known Minkowski measure of asymmetry and their further applications are discussed as well. | GUO Qi TOTH Gabor | 2016 | Science China Mathematics2016，59，7： | 4 |
| 11 | Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration显示文摘 | Daniel F. Martin Maureen G. Maguire Stuart L. Fine Gui-shuang Ying Glenn J. Jaffe Juan E. Grunwald Cynthia Toth Maryann Redford Frederick L. Ferris | 2012 | Ophthalmology2012，，7： | 3 |
| 12 | Combining extractive heterogeneous-azeotropic distillation and hydrophilic pervaporation for enhanced separation of non-ideal ternary mixtures显示文摘The separation of non-ideal mixtures using distillation can be an extremely complex process and there continues to be a need to further improve these techniques.A new method which combines extractive heterogeneous-azeotropic distillation(EHAD)and hydrophilic pervapora-tion(HPV)for the separation of non-ideal termary mixtures is demonstrated.This improved distillation method combines the benefits of heterogeneous-azeotropic and extractive distillations in one column but no added materials are needed as is usually the case with pervaporation.The separation of water-methanol-ethyl acetate and water-methanol-isopropyl acetate mixtures were investigated to demonstrate the accuracy of the combined EHAD/HPV technique.There is not currently an established treatment strategy for the separation of the second mixtures in the literature.These separation processes were rigorously modelled and optimized using a professional flowsheet.The objective functions were total cost and energy consumption and heat integration was also investigated.The verification of the process modelling was carried out using laboratory-scale measurements.Extractive heterogeneous-distillation combined with methanol dehydration was found to be more efficient than conventional distillation for the separation of these highly non-ideal mixtures. | Eniko Haaz Botond Szilagyi Daniel Fozer Andras Jozsef Toth | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 2 |
| 13 | X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations显示文摘We report lanthanide-based micelles integrating hypericin (Hyp) for X-ray- triggered photodynamic therapy (PDT). The lanthanide luminescence induced by X-ray irradiation excites the photosensitizer, which leads to the generation of singlet oxygen. This versatile approach can be extended to other photosensitizers or other types of liponanoparticles and can allow for magnetic resonance imaging (MRI) guidance. | Slavka Kascakova Alexandre Giuliani Sara Lacerda Agnes Pallier Pascal Mercere eva Toth Matthieu Refregiers | 2015 | Nano Research2015，8，7： | 2 |
| 14 | Subfractions and Subpopulations of HDL: An Update显示文摘 | M. Rizzo J. Otvos D. Nikolic G. Montalto P.P. Toth M. Banach | 2014 | Current Medicinal Chemistry2014，，25： | 2 |
| 15 | Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap显示文摘阴囊的扭转可以导致严肃的局部缺血,并且生存能力取决于扭转的持续时间和 ischemia-reperfusion 的效果。阴囊的解压缩和 tunica vaginalis 拍动应用程序技术被 Kutikov 等在 2008 介绍。我们试图在一个老鼠模型在阴囊的 microcirculation 和 hemorheological 参数上检验这个方法的影响。六只成年老鼠经历了双边的阴囊的探索。睾丸的 Intravaginal 扭转被 720 ° 创造;为 2 h 的双方上的旋转。在 detorsion 以后,正确睾丸经历了 tunica albuginea 切口和 tunica vaginalis 拍动申请。阴囊的 microcirculation 被监视, hematological 参数,红血球 deformability,和聚集是坚定的。大小在扭转前后被执行,直接在 detorsion 以后,在 1 st -2 nd 和 8 th 手术后的白天。在最后采样以后,睾丸被移开为组织学的考试决定他们的体积。microcirculatory 参数表明了睾丸之间的细微差别。睾丸与中间的地区相比提高了的左(nondecompressed ) 的顶端的地区(P <0.05 ) 。在 2 nd 和 8 th 白天,睾丸的 microcirculation 使正常化然而并非同等地。红血球聚集和 deformability 由 8 th 白天。睾丸经历了萎缩和上皮的坏死,但是减压的体积更低(1.07 ±0.08 对 1.25 ±0.31 ) 。组织学地,在上皮的损坏分数在之间没有重要差别减压并且 nondecompressed 睾丸。在结论, 2-h 局部缺血两个都在阴囊的 microcirculation,在体积的减小,在 hemorheological 参数的变化和严肃的上皮的坏死导致了改变在减压并且没有显著差别的 nondecompressed 睾丸。 | Tamas Jozsat Zoltan Klarik Ferenc Kiss Eniko Toth Anita Mester Zoltan Hargitai Yi-Che Changchien Magdalena Fossum Norbert Nemeth | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 16 | Consensus guidelines for the use of bowel preparation prior to colonic diagnostic procedures: colonoscopy and small bowel video capsule endoscopy显示文摘 | Elisabeth Mathus-Vliegen Maria Pellisé Denis Heresbach Wolfgang Fischbach Tricia Dixon Jonathan Belsey Fabrizio Parente Ricardo Rio-Tinto Alistair Brown Ervin Toth Cristiano Crosta Peter Layer Owen Epstein Christian Boustiere | 2013 | Current Medical Research & Opinion2013，，8： | 2 |
| 17 | Disturbed state constitutive modeling based on stress-strain and nondestructive behavior显示文摘 | Desai C S Toth J | 1996 | International Journal of Solids and Structures1996，33，11： | 2 |
| 18 | Hypokalemic myopathy in a patient with gluten-sensitive enteropathy and dermatitis herpetiformis Duhring: A case report显示文摘The case of a 22-year-old patient with symptomatic hypokalemia caused by rhabdomyolysis is presented as a rarely reported complication of gluten-sensitive enteropathy (GSE) and dermatitis herpetiformis Duhring. The patient's myopathy ceased on potassium supplementation and her other complaints resolved while on gluten-free diet.Recovery was otherwise uneventful with a rapid decline in serum CPK level. At the time of her last follow-up a few months later, she was free of symptoms and CPK remained stable. Patients with GSE may present with hypokalemia in association with diarrhea and emesis, and if potassium loss is rapid, rhabdomyolysis may occur. | Zsolt Barta Zsofia Miltenyi Laszlo Toth Arpad Illes | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 19 | Ranibizumab and Bevacizumab for Treatment of Neovascular Age-related Macular Degeneration显示文摘 | Daniel F. Martin Maureen G. Maguire Stuart L. Fine Gui-shuang Ying Glenn J. Jaffe Juan E. Grunwald Cynthia Toth Maryann Redford Frederick L. Ferris | 2012 | Ophthalmology2012，，7： | 2 |
| 20 | The use of ensemble to identify forecasts with small and large uncertainty显示文摘 | Toth Z Zhu Y J Marchok T | 2001 | Wea Forecasting2001，16，8： | 2 |
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