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| 1 | Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients显示文摘AIM: To analyze the correlation between cytokineinduced killer (CIK) cells adoptive immunotherapy and cancer-related death in gastric cancer patients. METHODS: One hundred and fifty-six gastric cancer patients after operation at the Third Affiliated Hospital of Soochow University were enrolled in this study. Their clinical data including demographic characteristics, operation time, tumor size, pathological type and staging, tumor metastasis, outcome of chemotherapy or CIK cells adoptive immunotherapy, survival time or time of death were collected with a standard structured questionnaire. Kaplan-Meier method was used to estimate the median survival time, and the 2- and 5- year survival rates. Hazard risk (HR) and 95% confidence interval (95% CI) of CIK cells adoptive immunotherapy for gastric cancer were calculated using the two-stage time-dependent covariates Cox model. RESULTS: The survival time of gastric cancer patients was longer after CIK cells adoptive immunotherapy than after chemotherapy (χ 2 = 10.907, P = 0.001). The median survival time of gastric cancer patients was also longer after CIK cells adoptive immunotherapy than after chemotherapy (49 mo vs 27 mo, P < 0.05). The 2- and 5-year survival rates of gastric cancer patients were significantly higher after CIK cells adoptive immunotherapy than after chemotherapy (73.5% vs 52.6%, 40.4% vs 23.9%, P < 0.05). A significant difference was observed in the survival curve for patients who received CIK cells adoptive immunotherapy (0, 1-10, 11-25, and over 25 frequencies) (χ 2 = 14.534, P = 0.002). The frequencies of CIK cells adoptive immunotherapy were significantly related with the decreasing risk of death in gastric cancer patients after adjustment for sex and age of the patients, tumor stage and relapse (HR = 0.54, 95% CI: 0.36-0.80) when the first stage Cox model was used to define the subjects who remained alive beyond 36 mo as survivors. However, no correlation was observed between the frequencies of death in CIK cells adoptive immunotherapy and the risk of gastric cancer patients (HR = 1.09, 95% CI: 0.63-0.89) when the second stage Cox model was used to define the subjects who survived for more than 36 mo as survivors. CONCLUSION: The survival time of the gastric cancer patients treated with chemotherapy combined with CIK cells adoptive immunotherapy is significantly longer than that of the patients treated with chemotherapy alone and increasing the frequency of CIK cells adoptive immunotherapy seems to benefit patients more. | Jing-Ting Jiang, Chang-Ping Wu, Lu-Jun Chen, Xiao Zheng, Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Yi-Bei Zhu, Jing Sun, Xue-Guang Zhang, Key Laboratory of Stem Cell of Jiangsu Province, Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University, Suzhou 215123, Jiangsu Province, China Yue-Ping Shen, Wen-Xiang Wei, Department of Medicine, Soochow University, Suzhou 215123, Jiangsu Province, China Bin-Feng Lu, Department of Immunology, University of Pitts- burgh School of Medicine, Pittsburgh, PA 15261, United States | 2010 | World Journal of Gastroenterology2010，16，48： | 82 |
| 2 | Numerical Simulation on Climate Effects of Freezing-Thawing Processes Using CCM3显示文摘A parameterization of soil freezing-thawing physics for use in the land-surface model of the National Center for Atmospheric Research(NCAR) Community Climate Model(CCM3) is developed and evaluated.The new parameterization scheme has improved the representation of physical processes in the existing land surface model.Numerical simulations using CCM3 with improved land-surface processes and with the original land-surface processes are compared against the NCEP reanalysis.It is found that the CCM3 version using the improved land surface model shows significant improvements in simulating precipitation in China during the summer season,the general circulation over East Asia,and wind fields over the Tibet Plateau.For the summer season,the improved model was able to better simulate the Indian summer monsoon components,including the mean northerly wind in the upper troposphere and mean southerly wind in the lower troposphere. | Chenghai Wang1,2*,Guodong Cheng3,Aijun Deng4,Wenjie Dong5 1.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 2.State Key Laboratory of Cryosphere Sciences,Cold and Arid Regions Environmental and Engineering Research Insti-tute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 3.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 4.Department of Meteorology,The Pennsylvania State University,University Park,PA 16802 5.State Key Laboratory of Earth Surface Processes and Ecology Resource,Beijing Normal University,Beijing 100875,China Chenghai Wang1,2*,Guodong Cheng3,Aijun Deng4,Wenjie Dong5 1.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 2.State Key Laboratory of Cryosphere Sciences,Cold and Arid Regions Environmental and Engineering Research Insti-tute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 3.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research In-stitute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China 4.Department of Meteorology,The Pennsylvania State University,University Park,PA 16802 5.State Key Laboratory of Earth Surface Processes and Ecology Resource,Beijing Normal University,Beijing 100875,China | 2008 | Research in Cold and Arid Regions2008，，1： | 44 |
| 3 | 利妥昔单抗治疗重度ANCA相关性血管炎与常规免疫抑制剂疗效相同显示文摘新英格兰医学杂志2013年8月发表了美国学者的研究结果,18个月的单疗程利妥昔单抗治疗重度抗中性粒细胞胞浆抗体(antineutrophilcytoplasmicantibody,ANCA)相关性血管炎,与常规免疫抑制剂环磷酰胺联合硫唑嘌呤的疗效相同。 | Specks U Merkel PA Seo P 王建中 | 2013 | 中华肾病研究电子杂志2013，2，5： | 33 |
| 4 | Signal transduction mediated by Bid,a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways显示文摘Two major apoptosis pathways have been defined in mammalian cells, the Fas/TNF-R1 death receptor pathway and the mitochondria pathway. The Bcl-2 family proteins consist of both anti-apoptosis and pro- apoptosis members that regulate apoptosis, mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events. However, death signals mediated by Fas/TNF-R1 receptors can usually activate caspases directly, bypassing the need for mitochondria and escaping the regulation by Bcl-2 family proteins. Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated Bid is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of a number of human diseases. | YIN XIAO-MING (Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA) | 2000 | Cell Research2000，10，3： | 25 |
| 5 | A Study on Solid/Melt Interfaces and the Formation of<100> Texture in Solidified FCC Metals显示文摘The (100) texture of solidified fcc metals, caused by the preferential (100) dendrite growth, could be closeIy related to solid/melt interfaces which behave differently along different crystallographic orientation. The stability and roughness of {111} and {100} solid/melt interfaces of fcc metals were investigated using a modified Temkin multi-layer model. It is demonstrated that {100}crystal/melt interface is more unstable and rougher than {111} interface. The effect of the stability of crystal/melt interface on the (100) texture formation in solidified fcc metals has been analysed and discussed. | D.Y.Li(Dept. of Mater. Sci & Eng., The Pennsylvania State University, University Park, PA 16802, USA )B.Debray and J.A.Szpunar(Dept. of Metall. Eng., McGill University, 3450 Uuiversity Street, Molitreal, PQ, Canada H3A 2A7) | 1997 | Journal of Materials Science & Technology1997，13，6： | 20 |
| 6 | 用三氧化铬-硫酸溶剂对黑色页岩铼-锇定年方法初探显示文摘讨论了铼-锇同位素稀释法测定黑色页岩年龄的溶样方式,比较了王水和不同温度下CrO3-H2SO4的Carius管溶样技术,通过改进流程将铼空白控制在10pg之内,并结合高灵敏度的电感耦合等离子体质谱分析手段,初步研究建立了一种用CrO3-H2SO4溶剂准确测定黑色页岩年龄的方法。 | 刘华 屈文俊 王英滨 任静 杜安道 Jan Paava 孙文静 | 2008 | 岩矿测试2008，27，4： | 17 |
| 7 | 环形可调液体阻尼器对扭转振动控制的试验研究显示文摘本文对环形可调液体阻尼器控制扭转振动作了振动台试验,获得了一些数据和结论。试验结果表明,环形可调液体阻尼器是1种十分有效并有实用前景的扭转振动控制装置。 | 梁枢果 Hitc.,PA | 1996 | 特种结构1996，13，3： | 12 |
| 8 | Detection of soluble TRAIL in HBV infected patients and its clinical implications显示文摘AIM: To detect the expression of soluble TRAIL (TNF-related apoptosis inducing ligand, TRAIL) in the peripheral blood of HBV infected patients and try to elucidate whether the expression level of sTRAIL have any correlativity with the clinical staging, the expression level of HBV markers and the degree of liver damage.METHODS: 52 cases of HBV infected patients were investigated, induding 8 HBV carriers, 30 chronic hepatitis B, 11 drrhotics and 3 HBV infection related hepatocellular carcinoma. Expression of soluble TRAIL and markers of the hepatitis B were mearsured by enzyme-linked immunosorbent assay.RESULTS: The expression level of sTRAIL in the peripheral blood of the HBV infected patients was significantly higher than that of healthy controls (1378.35±540.23 pg/ml vs 613.75±175.80 pg/ml, P<0.001). In the group of chronic hepatitis, the expression level of sTRAIL was coincident with the status of the disease and was significantly correlated with the level of ALT. In the group of cirrhosis and liver cancer, its expression level was significantly higher than that of the healthy persons and HBV carriers, but lower than that of the hepatitis B patients; meanwhile, the expression of siRAIL did not have any correlativity with the functional indexes of the liver. CONCLUSION: The soluble TRAIL in the HBV infected people may participate in the liver damage. Our results indicated that the expression level of soluble TRAIL may reflect the ravage of liver caused by host immune reaction to a certain degree. | Li-Hui Han Wen-Sheng Sun Chun-Hong Ma Li-Ning Zhang Su-Xia Liu Qiu Zhang Li-Fen Gao,Institute of Immunology,Medical College of Shandong University,Jinan 250012,Shandong Province,China You-Hai Chen,Institute for Human Gene Therapy,University of Pennsylvania,Philadelphia PA 19104,USA | 2002 | World Journal of Gastroenterology2002，8，6： | 12 |
| 9 | 不良事件报道规范:随机试验报道统一标准的增补显示文摘1996年,世界几家著名医学期刊的编辑和有关方面的专家发表了<随机试验报道的统一标准>(CONSORT,Consolidated Standards of Reproting Trials).2001年,他们对该标准进行了修订.由于许多证据显示,随机对照试验中有关干预措施的损害或不良事件的报道有待进一步改善和提高,他们通过检索证据、开会讨论、拟写初稿、分别评价和完成文稿等方式,在CONSORT标准2001修订版的框架内进行了增补,形成了一份不良事件报道的循证性标准.这份标准约有13个页码,主要包括建议-解释和附录-范例两大部分.以下是这份标准的部分术语、所有建议及其具体要求和报道中常见不足的摘译. | John PA 傅鹰 | 2005 | 药物流行病学杂志2005，14，3： | 10 |
| 10 | Feasibility of semi-solid die casting of ADC12 aluminum alloy显示文摘The feasibility of semi-solid die casting of ADC12 aluminum alloy was studied.The effects of plunger speed, gate thickness, and solid fraction of the slurry on the defects were determined.The defects investigated are gas and shrinkage porosity.In the experiments, semi-solid slurry was prepared by the gas-induced semi-solid (GISS) technique.Then, the slurry was transferred to the shot sleeve and injected into the die.The die and shot sleeve temperatures were kept at 180 °C and 250 °C, respectively.The results show that the samples produced by the GISS die casting give little porosity, no blister and uniform microstructure.From all the results, it can be concluded that the GISS process is feasible to apply in the ADC12 aluminum die casting process.In addition, the GISS process can give improved properties such as decreased porosity and increased microstructure uniformity. | S.JANUDOM T.RATTANOCHAIKUL R.BURA PA S.WISUTMETHANGOON J.WANNASIN | 2010 | Transactions of Nonferrous Metals Society of China2010，20，9： | 9 |
| 11 | 围术期大剂量阿托伐他汀疗法能够减少心脏手术后的急性肾损伤吗?显示文摘他汀类药物能够影响急性肾损伤(AKI)的几个环节。为了验证假说:围术期短期大剂量阿托伐他汀能够减少心脏手术后发生AKI,美国学者从2009年11月到2014年10月在范德比尔特大学医学中心进行了成人心脏手术患者的双盲、安慰剂对照的随机临床试验。 | Billings FT 4th Hendricks PA Schildcrout JS 王建中 | 2016 | 中华肾病研究电子杂志2016，5，1： | 9 |
| 12 | 细小种植体在剩余牙槽嵴吸收的无牙颌患者的成功率显示文摘目的:在剩余牙槽嵴吸收的无牙下颌上进行修复治疗,目前对临床医生仍然是一个巨大的挑战。尽管对此类病例种植体支持的义齿有很好的稳定性和实用性,开展治疗往往仍存在问题。问题不仅限于此类病例往往存在义齿承托区过窄的困难,而且老年病人往往无法接受采用进一步手术来改善牙槽嵴条件。 | Morneburg TR Prschel PA 王鹏 | 2008 | 口腔颌面外科杂志2008，18，5： | 8 |
| 13 | Kato法和孵化法检查日本血吸虫病的效果比较及其评价显示文摘粪便孵化法为诊断日本血吸虫病的常规方法。Kato法为晚近发展的另一病原学检查技术,在肠道寄生虫病的诊断中已经广泛应用,但在血吸虫病诊断中尚未作为常规推广使用。为比较上述两法对血吸虫病的检出效果及其成本和现场应用价值,我们对一血吸虫病重型疫区居民进行了检查,并对检查费用进行了核算和比较。 材料和方法 1 粪便检查 受检对象为鄱阳湖矶山岛439例居民。收集一次粪便。孵化法采用1送1检。 | 向景雍 苗林宝 唐建益 肖汉华 袁建华 姜唯声 曾小军 吴福东 吴观陵 PA Peters | 1993 | 中国血吸虫病防治杂志1993，5，2： | 8 |
| 14 | 血液和脑脊液中伏立康唑、泊沙康唑和伊曲康唑浓度检测显示文摘近年来抗真菌治疗的药物浓度监测日益受到临床重视。为更好了解三唑类抗真菌药物在体内可达到的浓度,作者对德克萨斯大学真菌参考实验室于2001年1月至2013年3月测定的伏立康唑、泊沙康唑和伊曲康唑的血液和脑脊液内浓度进行评估。伏立康唑和泊沙康唑浓度的测定采用HPLC法,伊曲康唑测定采用UPLC/MS或生物测定法。 | Nathan PA Gennethel JP Sheryl AD 何高丽 张菁 | 2014 | 中国感染与化疗杂志2014，14，4： | 7 |
| 15 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 16 | Multi-detector computed tomography evaluation of tracheobronchial anomaly in pediatric patients with left pulmonary artery sling显示文摘The left pulmonary artery sling (LPAS) is a rare vascular anomaly causing respiratory distress in which the left pulmonary artery arises from the posterior aspect of the right pulmonary artery,courses posteriorly to the right of the bronchus and passes between the trachea and oesophagus to reach the hilum of the left lung.The LPAS is frequently associated with tracheobronchial tree anomalies and congenital cardiac defects.Proper assessment of the tracheobronchial and cardiovascular anomaly is essential in LPAS for planning management of the patient.Currently,the most important prognostic factor is considered to be an associated tracheobronchial tree anomaly.1 The purpose of this study was to demonstrate the role of multi-detector computed tomography (MDCT) for diagnosing LPAS and assessing the anatomical relationship with tracheobronchial tree anomaly. | HU Xi-hong PA Mi-er SHEN Quan-li HUANG Guo-ying | 2013 | Chinese Medical Journal2013，，14： | 7 |
| 17 | Characterization of a novel coronavirus associated with severe acute respiratory syndrome显示文摘 | Rota PA Oberste MS Monroe SS | | 0，，： | 6 |
| 18 | 血管畸形与血管瘤:神经束的存在是诊断血管畸形的一个线索显示文摘 | Adegboyega PA Qiu S 黄文斌(摘译) 陈洁宇(摘译) 周晓军(审校) | 2005 | 临床与实验病理学杂志2005，21，5： | 5 |
| 19 | Hepatitis A vaccine associated with autoimmune hepatitis显示文摘为了描述可能的复发的的自体免疫的肝炎的一个盒子,对肝炎与种痘联系了一个病毒(HAV ) 。文学的一份病案报告和评论与肝炎 A 和另外的亲肝病毒联合有关自体免疫的肝炎被写。此后不久使福尔马林失去活性的肝炎的管理一支疫苗,最近从 uncharacterized 恢复了的一个人但是自我限制的 hepatitic 病,经历了严重恶化(著名计算机生产厂商 1687 U/L, INR 1.4 ) 。反原子的抗体是可检测的,并且肝活体检视与自体免疫的肝炎兼容。观察作为自体免疫的肝炎的一个扳机支持 HAV 的角色。在肝炎的上下文对肝的蛋白质在助手 T 房间活动和抗体表示学习感染被总结,并且关于病毒的肝炎和汽车免疫的另外的形式的分子的模仿的概念是简短探索了。 | PA Berry G Smith-Laing | 2007 | World Journal of Gastroenterology2007，13，15： | 5 |
| 20 | Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species显示文摘Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian colobines.Despite several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly understood.Phayre’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and controversial.Thus,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of T.phayrei,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two holotypes.Phylogenetic analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the T.pileatus group branched first,followed by the T.francoisi group,and the T.cristatus and T.obscurus groups most recently.The four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within T.phayrei,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two taxa.Following the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the T.phayrei subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three taxa.Overall,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of T.phayrei but the entire Trachypithecus genus as well. | Christian Roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg | 2020 | Zoological Research2020，41，6： | 5 |
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