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| 1 | Coronary heart disease:Significance of liver X receptor α genomics显示文摘Crosstalk between lipid peroxidation and inflammation is known to be a pathognomonic feature for the development of coronary heart disease(CHD).In this regard ligand activated liver X receptor(LXR)-α has emerged as a key molecular switch by its inherent ability to modulate an array of genes involved in these two fundamental cellular processes.In addition,LXR-α has also been found to play a role in hepatic lipogenesis and innate immunity.Although several lines of evidence in experimental model systems have established the atheroprotective nature of LXR-α,human subjects have been reported to possess a paradoxical situation in which increased blood cellular LXR-α gene expression is always accompanied by increased coronary occlusion.This apparent paradox was resolved recently by the finding that CHD patients possess a deregulated LXR-α transcriptome due to impaired ligand-receptor interaction.This blood cellular mutated LXR-α gene ex- pression correlated specifically with the extent of coro- nary occlusion and hence need is felt to devise new synthetic ligands that could restore the function of this mutated LXR-αprotein in order to modulate genes involved in reverse cholesterol transport and suppression of the inflammatory response leading to the effective treatment of CHD. | Vivek Priy Dave Deepak Kaul | 2010 | World Journal of Cardiology2010，2，6： | 3 |
| 2 | Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones显示文摘 | James A. DiSario Martin L. Freeman David J. Bjorkman Padraic MacMathuna Bret T. Petersen Philip E. Jaffe Thomas G. Morales Lee J. Hixson Stuart Sherman Glen A. Lehman M. Mazen Jamal Firas H. Al-Kawas Mukul Khandelwal Joseph P. Moore Gregory A. Derfus Priy | 2004 | Gastroenterology2004，，： | 2 |
| 3 | Competition and Mergers among Nonprofits显示文摘 | PRII ti FER J | 2010 | Journal of Competition Law2010，7，1： | 1 |
| 4 | The clinical spectrum of intracerebral hematoma, hemorrhagic infarct, non- hemorrhagic infarct, and non-lesional venous stroke in patients with cerebral sinus-venous thrombosis显示文摘 | Kumral E Polat F Uzunk?prii C etc | 2012 | European journal of neurology: the official journal of the European Federation of Neurological Societies2012，19，4： | 1 |
| 5 | Preparation of gold catalysts for glu- cose oxidation by incipient wetness 显示文摘 | Baatz C Prii~e U | 2007 | Journal of Cata- lysis2007，249，： | 1 |
| 6 | Klotho: an antiaging protein involved in mineral and vitamin D metabolism显示文摘 | TORRES P U PRII D MOLINA-BLITRY V | 2007 | Kidney Int2007，71，8： | 1 |
| 7 | Evaluation and management of fungal infections in immunocompromised pationts 显示文摘 | Venkatesam A Priy A Perfect R | 2005 | Dermatologic Therapy2005，18，1： | 1 |
| 8 | Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones显示文摘 | James A. DiSario Martin L. Freeman David J. Bjorkman Padraic MacMathuna Bret T. Petersen Philip E. Jaffe Thomas G. Morales Lee J. Hixson Stuart Sherman Glen A. Lehman M. Mazen Jamal Firas H. Al-Kawas Mukul Khandelwal Joseph P. Moore Gregory A. Derfus Priy | 2004 | Gastroenterology2004，，5： | 1 |
| 9 | Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones显示文摘 | James A. DiSario Martin L. Freeman David J. Bjorkman Padraic MacMathuna Bret T. Petersen Philip E. Jaffe Thomas G. Morales Lee J. Hixson Stuart Sherman Glen A. Lehman M. Mazen Jamal Firas H. Al-Kawas Mukul Khandelwal Joseph P. Moore Gregory A. Derfus Priy | 2004 | Gastroenterology2004，，5： | 1 |
| 10 | Heart and Brain:A neutro-genomic link显示文摘The philosophy of heart and brain are very ancient in our literature where the things good for the heart are not suggested good for the brain and vice-versa.Modern medicine is characterized by a high degree of specialization and the heart-brain connection that could be targeted to treat these complex cardiovascular/brain disorders.The idea that adverse diet/genome interactions can cause disease is not new.In the recent era the science of nutritional genomics have increased our understanding of diet-health-gene interactions and have provided a number of benefits for individuals,groups and societies.Since dietary chemicals are regularly ingested and participate indirectly and directly in regulating gene expression,it follows that a subset of genes regulated by diet must be involved in disease initiation,progression,and severity.In this regards Liver X Receptor(LXR)-a,a key transcription factors,associated with the several chronic pathological situation including coronary heart disease and neurodegenerative diseases have recently been found to be regulated by the dietary components.The crucial findings at molecular biology unit,Post Graduate Institute of Medical Education and Research(PGIMER),Chandigarh,INDIA have not only forced us to explore nutritional genomics as a holistic systems approach to understand the relationship between diet and health,but also to look into the disease preventing and health promoting foods that match our lifestyles,cultures and genetics.After all,we are what we eat. | Vivek Priy Dave Deepak Kaul | 2013 | World Journal of Biological Chemistry2013，4，2： | 0 |
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