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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | FAIR Convergence Matrix:Optimizing the Reuse of Existing FAIR-Related Resources显示文摘The FAIR principles articulate the behaviors expected from digital artifacts that are Findable,Accessible,Interoperable and Reusable by machines and by people.Although by now widely accepted,the FAIR Principles by design do not explicitly consider actual implementation choices enabling FAIR behaviors.As different communities have their own,often well-established implementation preferences and priorities for data reuse,coordinating a broadly accepted,widely used FAIR implementation approach remains a global challenge.In an effort to accelerate broad community convergence on FAIR implementation options,the GO FAIR community has launched the development of the FAIR Convergence Matrix.The Matrix is a platform that compiles for any community of practice,an inventory of their self-declared FAIR implementation choices and challenges.The Convergence Matrix is itself a FAIR resource,openly available,and encourages voluntary participation by any self-identified community of practice(not only the GO FAIR Implementation Networks).Based on patterns of use and reuse of existing resources,the Convergence Matrix supports the transparent derivation of strategies that optimally coordinate convergence on standards and technologies in the emerging Internet of FAIR Data and Services. | Hana Pergl Sustkova Kristina Maria Hettne Peter Wittenburg Annika Jacobsen Tobias Kuhn Robert Pergl Jan Slifka Peter McQuilton Barbara Magagna Susanna-Assunta Sansone Markus Stocker Melanie Imming Larry Lannom Mark Musen Erik Schultes | 2020 | Data Intelligence2020，2，1： | 4 |
| 3 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 4 | The changing automotive environment: high-temperature electronics 显示文摘 | Johnson R W Evans J L Jacobsen Peter | 2004 | IEEE transactions on electronics packaging manufacturing2004，27，3： | 1 |
| 5 | Feasibility and safety of endoscopic full-thickness esophageal wall resection and defect closure: a prospective long-term survival animal study显示文摘 | Annette Fritscher-Ravens Tamzin Cuming Bjorn Jacobsen Frauke Seehusen Amir Ghanbari Erich Kahle Axel von Herbay Peter Koehler Peter Milla | 2009 | Gastrointestinal Endoscopy2009，，7： | 1 |
| 6 | Cleavage of desmin by cysteine proteases: Calpains and cathepsin B显示文摘 | Caroline Pascale Baron Susanne Jacobsen Peter Patrick Purslow | 2004 | Meat Science2004，，68： | 1 |
| 7 | Degenerative Lumbar Spondylolisthesis: An Epidemiological Perspective: The Copenhagen Osteoarthritis Study显示文摘 | Steffen Jacobsen Stig Sonne-Holm Hans Rovsing Henrik Monrad Peter Gebuhr | 2007 | Spine2007，，1： | 1 |
| 8 | Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study显示文摘OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 years.In addition,one-year all-cause mortality and AF relapse were compared.METHODS&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide registries.Patients aged 65−74 years served as the reference group for patients≥75 years.Relapse of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within follow-up.The composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age. | Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi | 2021 | Journal of Geriatric Cardiology2021，18，11： | 1 |
| 9 | High prevalence of IgA class anti-neutrophil cytoplasmic antibodies (ANCA) is associated with increased risk of bacterial infection in patients with cirrhosis显示文摘 | Maria Papp Nora Sipeki Zsuzsanna Vitalis Tamas Tornai Istvan Altorjay Istvan Tornai Miklos Udvardy Kai Fechner Silvia Jacobsen Bianca Teegen Andrea Sumegi Gabor Veres Peter Laszlo Lakatos Janos Kappelmayer Peter Antal-Szalmas | 2013 | Journal of Hepatology2013，，： | 1 |
| 10 | Renoprotective effects of adding angiotensin Ⅱ receptor blocker to maximal recommended doses of ACE inhibitor in diabetic nephropathy: a randomized double-blind crossover trial 显示文摘 | Kasper Rossing Peter Jacobsen Lotte Pietraszek | 2003 | Diabetes Care2003，26，8： | 1 |
| 11 | Incisionless revision of post-Roux-en- Y bypass stomal and pouch dilation: multicenter registry results显示文摘 | Santiago Horgan Garth Jacobsen G. Derek Weiss John S. Oldham Peter M. Denk Frank Borao Steven Gorcey Brad Watkins John Mobley Kari Thompson Adam Spivack Dave Voellinger Chris Thompson Lee Swanstrom Paresh Shah Greg Haber Matthew Brengman Gregory Schroder | 2010 | Surgery for Obesity and Related Diseases2010，，3： | 1 |
| 12 | Functional characterization of Narc 1, a novel proteinase related to proteinase K显示文摘 | Saule Naureckiene Linh Ma Kodangattil Sreekumar Urmila Purandare C Frederick Lo Ying Huang Lillian W Chiang Jill M Grenier Bradley A Ozenberger J Steven Jacobsen Jeffrey D Kennedy Peter S DiStefano Andrew Wood Brendan Bingham | 2003 | Archives of Biochemistry and Biophysics2003，，1： | 1 |
| 13 | Evaluation of antidotes for poisoning by organophosphorus pesticides显示文摘 | Dag Jacobsen Tim J Meredith Peter Eyer Andrew J Heath David A Ligtenstein Tim C Marrs Ladislaus Szinicz J Allister Vale and John A Haines | 2000 | Emergency Medicine2000，，12： | 1 |
| 14 | Nitrogen transformations in microenvironments of river beds and riparian zones显示文摘 | Niels Peter Revsbech Jacob Peter Jacobsen Lars Peter Nielsen | 2005 | Ecological Engineering2005，，5： | 1 |
| 15 | Strained silicon as a new electro-optic material 显示文摘 | Rune S Jacobsen Karin N Andersen Peter I Borel | 2006 | Nature2006，441，： | 1 |
| 16 | Nitrogen transformations in microenvironments of river beds and riparian zones显示文摘 | Niels Peter Revsbech Jacob Peter Jacobsen Lars Peter Nielsen | 2005 | Ecological Engineering2005，24，5： | 1 |
| 17 | Clinical dentin hypersensitivity:understanding the causes and prescribing a treatment 显示文摘 | Peter L Jacobsen Gretchen B | 2001 | J Dent Prac2001，2，1： | 1 |
| 18 | Single versus dual blockade of the renin - angiotensin system ( angiotensin - converting enzyme inhibitors and/or angiotensin Ⅱ receptor blockers) in diabetic nephropathy 显示文摘 | Jacobsen Peter Rossing | 2004 | Current Opinion in Nephrology & Hypertension2004，13，3： | 1 |
| 19 | The inheritance and chromosomal localization of AFLP markers in a non-inbred potato offspring显示文摘 | Herman J. Eck Jeroen Rouppe Voort Jan Draaistra Peter Zandvoort Ellen Enckevort Bart Segers Johan Peleman Evert Jacobsen Johannes Helder Jaap Bakker | 1995 | Molecular Breeding1995，，4： | 1 |
| 20 | 25‐Hydroxyvitamin D and symptomatic ischemic stroke: An Original Study and Meta‐Analysis显示文摘 | Peter Br?ndum‐Jacobsen B?rge G. Nordestgaard Peter Schnohr Marianne Benn | 2012 | Ann Neurol2012，，： | 1 |
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