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| 1 | Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction显示文摘AIM To comprehensively evaluate mitochondrial(dys) function in preclinical models of nonalcoholic steatohepatitis(NASH).METHODS We utilized two readily available mouse models of nonalcoholic fatty liver disease(NAFLD) with or without progressive fibrosis: Lep^(ob)/Lep^(ob)(ob/ob) and FATZO mice on high trans-fat, high fructose and high cholesterol(AMLN) diet. Presence of NASH was assessed using immunohistochemical and pathological techniques, and gene expression profiling. Morphological features of mitochondria were assessed via transmission electron microscopy and immunofluorescence, and function was assessed by measuring oxidative capacity in primary hepatocytes, and respiratory control and proton leak in isolated mitochondria. Oxidative stress was measured by assessing activity and/or expression levels of Nrf1, Sod1, Sod2, catalase and 8-OHdG. RESULTS When challenged with AMLN diet for 12 wk, ob/ob and FATZO mice developed steatohepatitis in the presence of obesity and hyperinsulinemia. NASH development was associated with hepatic mitochondrial abnormalities, similar to those previously observed in humans, including mitochondrial accumulation and increased proton leak. AMLN diet also resulted in increased numbers of fragmented mitochondria in both strains of mice. Despite similar mitochondrial phenotypes, we found that ob/ob mice developed more advanced hepatic fibrosis. Activity of superoxide dismutase(SOD) was increased in ob/ob AMLN mice, whereas FATZO mice displayed increased catalase activity, irrespective of diet. Furthermore, 8-OHd G, a marker of oxidative DNA damage, was significantly increased in ob/ob AMLN mice compared to FATZO AMLN mice. Therefore, antioxidant capacity reflected as the ratio of catalase:SOD activity was similar between FATZO and C57 BL6 J control mice, but significantly perturbed in ob/ob mice. CONCLUSION Oxidative stress, and/or the capacity to compensate for increased oxidative stress, in the setting of mitochondrial dysfunction, is a key factor for development of hepatic injury and fibrosis in these mouse models. | Michelle L Boland Stephanie Oldham Brandon B Boland Sarah Will Jean-Martin Lapointe Silvia Guionaud Christopher J Rhodes James L Trevaskis | 2018 | World Journal of Gastroenterology2018，24，16： | 7 |
| 2 | IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines显示文摘 | Jochen Schmitz Alexander Owyang Elizabeth Oldham Yaoli Song Erin Murphy Terril K. McClanahan Gerard Zurawski Mehrdad Moshrefi Jinzhong Qin Xiaoxia Li Daniel M. Gorman J. Fernando Bazan Robert A. Kastelein | 2005 | Immunity2005，，5： | 6 |
| 3 | Paraspinal strength and electromyographic fatigue in patients with sub-acute back pain and controls:Reliability,clinical applicability and between-group differences显示文摘BACKGROUND Paraspinal muscle strength and fatigue are considered important in low back pain(LBP)prevention and rehabilitation.High reliability of paraspinal strength and electromyographic(EMG)-fatigue parameters has not been universally reported.Moreover,the discriminative validity of these parameters requires further exploration,under the threat of potentially poor reliability of the methods examined.AIM To investigate the reliability and discriminative validity of paraspinal strength and EMG-related fatigue in subjects with recurrent LBP and healthy participants.METHODS Test-retest measurements were performed in 26 healthy and 66 LBP volunteers,for reliability.Paraspinal isometric maximal and mean strength were determined with a maximum voluntary isometric contraction(MVIC)protocol,performed in a custom-made device.For the fatigue test,participants performed a 60% MIVC level continuous isometric contraction of the paraspinals,in conjunction with EMG analysis from 4 muscle sites of the lumbar spine.Initial median frequency(IMF),the median frequency slope(MFslope),as well as the root mean square(RMS)slope EMG parameters were used as fatigue measures.Data were analysed with repeated measures ANOVA for test-retest differences.For reliability,the intraclass correlation coefficient(ICC3,1),standard error of the measurement(SEM)and the smallest detectable difference(SDD)were reported.Group-related differences for fatigue measures were analysed with a Multivariate Analysis of Covariance,with age,weight and strength as covariates.RESULTS Isometric strength presented statistically significant between-day differences(P<0.01),however these did not exceed 10%(healthy:7.2%/LBP-patients:9.7%)and ICC reliability values were excellent,yet test-retest error was increased for the patient group(healthy:ICC3,1:0.92-0.96,SEM:5.72-5.94 Hz,SDD:18.51%-18.57%/LBP-patients:ICC3,1:0.91-0.96,SEM:6.49-6.96,SDD:30.75%-31.61%).For the frequency data,IMF reliability was excellent(healthy:ICC3,1:0.91-0.94,SEM:3.45-7.27 Hz,SDD:9.56%-20.14%/patients:ICC3,1:0.90-0.94,SEM:6.41-7.59 Hz,SDD:17.75%-21.02%)and of MF raw and normalised slopes was good(healthy:ICC3,1:0.78-0.82,SEM:4.93-6.02 Hz,SDD:13.66-16.67%/LBP-patients:ICC3,1:0.83-0.85,SEM:6.75-7.47 Hz,SDD:18.69%-20.69%).However,the reliability for RMS data presented unacceptably high SDD values and were not considered further.For discriminative validity,less MVIC and less steep MFslopes were registered for the patient group(P<0.01).CONCLUSION Reliability and discriminative ability of paraspinal strength and EMG-related frequency parameters were demonstrated in healthy participants and patients with LBP. | George A Koumantakis Jacqueline A Oldham | 2021 | World Journal of Orthopedics2021，12，11： | 5 |
| 4 | IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines显示文摘 | Jochen Schmitz Alexander Owyang Elizabeth Oldham Yaoli Song Erin Murphy Terril K. McClanahan Gerard Zurawski Mehrdad Moshrefi Jinzhong Qin Xiaoxia Li Daniel M. Gorman J. Fernando Bazan Robert A. Kastelein | 2005 | Immunity2005，，5： | 3 |
| 5 | Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry 显示文摘 | Oldham P B McCarroll M E McGown L B | 1993 | Anal Chem1993，72，12： | 2 |
| 6 | Void fill techniques for stabilizing roof conditions during longwall recovery显示文摘It has been proven that longwall faces can be moved safely and efficiently. However,abutment pressures and poor ground control conditions can halt operations and be hazardous to coal miners. Recently at a mine in Southwestern Pennsylvania,roof material collapsed above shields that created two large voids and caused major challenges for shield recovery. A unique,engineering solution was developed that utilized a modified concrete material to fill the voids,creating stability in the affected area. The many phases of this project included the construction phase,void pumping,cutting out,and bolting of the concrete material. This project eliminated the hazards associated with bolting the recovery face and removing shields in adverse conditions,making it possible for the mine operator to safely complete the longwall move. | Oldham Robin Dickerson Craig Mc Henry Rusty | 2016 | International Journal of Mining Science and Technology2016，26，1： | 2 |
| 7 | Mechanical properties of a biodegradable bone regeneration scaffold显示文摘 | Porter B D Oldham J B He S L | 2000 | J Biomech Eng2000，122，3： | 2 |
| 8 | Myostatin regulation during skeletal muscle regeneration显示文摘 | Kirk S Oldham J Kambadur R | 2000 | Cell Physiol2000，184，3： | 2 |
| 9 | Evaluation of a 2D diode array for IMRT quality assurance显示文摘 | Daniel Létourneau Misbah Gulam Di Yan Mark Oldham John W. Wong | 2003 | Radiotherapy and Oncology2003，，2： | 2 |
| 10 | Validity of the personality diagnostic questionnaire revision: a replication in an outpatient sample显示文摘 | Hyler SE Skodd AE Oldham JM | 1992 | Comprehensive Psychiatry1992，33，2： | 1 |
| 11 | Open butch urethropexy has a low rate of preoperative complications 显示文摘 | Kenton K Oldham L Brubaker L | 2002 | Obstet Gynecol2002，187，： | 1 |
| 12 | IL-33,an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 13 | Validity of the Personality Diagnostic Questionnaire - Revision : A Replication in an Outpatient Sample显示文摘 | Hyler S E Skodd AE Oldham JM | 1992 | Comprehensive Psychiatry1992，33，2： | 1 |
| 14 | Living with lethal PIP3levels:viability of flies lacking PTEN restored by a pH domain muta - tion in AKT/PKB 显示文摘 | Stocker H Andjelkovic M Oldham S | 2002 | Science2002，1295，5562： | 1 |
| 15 | Open Burch urethropexy has a low rate of perioperative complications显示文摘 | Kenton K Oldham L Brubaker L | 2002 | Am J Obstet Gynecol2002，187，： | 1 |
| 16 | IL-33,an intedeukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 17 | Particulate Matter in Polluted Air May Increase Biomarkers of Inflammation in Mouse Brain显示文摘 | A. Campbell M. Oldham A. Becaria S.C. Bondy D. Meacher C. Sioutas C. Misra L.B. Mendez M. Kleinman | 2004 | Neurotoxicology2004，，1： | 1 |
| 18 | Cummings, rewarding crea- tivity: When does it really matter? 显示文摘 | BAER M OLDHAM G R | 2003 | Leadership Qua- terly2003，14，45： | 1 |
| 19 | IL-33, an interleukin-1-likecytokine that signals via the IL-1 receptor-related protein ST2 andinduces T helper type 2-associated cytokines显示文摘 | Schmitz J Owyang A Oldham E | 2005 | Immunity2005，23，5： | 1 |
| 20 | Comparison between halothane and sevoflurane for adult vital capacity induction 显示文摘 | HALL JE OLDHAM TA STEWART JIM | 1997 | British Journal of Anaesthesla1997，79，3： | 1 |
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