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| 1 | Alterations of glutathione S-transferase and matrix metalloproteinase-9 expressions are early events in esophageal carcinogenesis显示文摘AIM: To investigate the role of glutathione S-transferase (GST) and matrix metalloproteinase-9 (MMP-9) expres-sions in the development and progression of reflux es-ophagitis-Barrett’s metaplasia-dysplasia-adenocarcinoma sequence in the esophagus.METHODS: GST and MMP-9 expressions were analyzed in 51 paraffin-embedded tissue samples by immunohisto-chemistry including patients with reflux esophagitis (n = 7), Barrett’s metaplasia (n = 14), Barrett and esophagi-tis (n = 8), Barrett and dysplasia (n = 7), esophageal adenocarcinoma (n = 8) and a control group without any histological changes (n = 7). Immunostaining was determined semiquantitatively. Statistical analysis with one-way ANOVA, LSD test and correlation analysis were performed. P value of < 0.05 was considered significant.RESULTS: GST expression was significantly higher while MMP-9 expression was significantly lower in control group compared to Barrett’s metaplasia and the other groups. No major changes were observed between Bar-rett, esophagitis, and Barrett and concomitant esophagi-tis. Barrett and concomitant dysplasia, and adenocarci-noma revealed a significant lower expression of GST and higher levels of MMP-9 compared to all other groups. Adenocarcinoma showed almost no expression of GST and significantly higher levels of MMP-9 than Barrett and concomitant dysplasia. Alterations of GST and MMP-9 were inversely correlated (r = - 0.82).CONCLUSION: Decreased GST and increased ex-pression of MMP-9 in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence as compared to normal tissue suggest their association with esophageal tumorigenesis. Loss of GST and gain of MMP-9 in Barrett with dyspla-sia compared to non-dysplastic metaplasia indicate that these alterations may be early events in carcinogenesis. Quantification of these parameters in Barrett’s esopha-gus might be useful to identify patients at higher risk for progression to cancer. | Laszlo Herszenyi Istvan Hritz Istvan Pregun Ferenc Sipos Mark Juhasz Bela Molnar Zsolt Tulassay | 2007 | World Journal of Gastroenterology2007，13，5： | 37 |
| 2 | Utility of serological markers in inflammatory bowel diseases: Gadget or magic?显示文摘为煽动性的肠疾病(IBD ) 的血清学标记的面板很快正在膨胀。尽管 anti-Saccharomyces 啤酒抗体(ASCA ) 和不正常的仙子细胞质的抗体(P-ANCA ) 仍然是的原子反 neutrophil 广泛地调查的大多数,试验性的数据的增加的数量在对各种各样的微生物引起的抗原指导的最新发现的抗体上是可得到的。对在当前的 IBD 诊断算法的各种各样的抗体的评价的角色由于他们的有限敏感经常是可疑的。相反,有疾病行为和显型的血清学标记的协会正在变得逐渐地生长得很好。越来越多的观察证实有 Crohn 在高乳头 ers 表示多重血清学标记的疾病的病人是更可能的有复杂的小肠疾病(例如苛评或穿孔) 并且没有,或与抗体的低乳头 ers,比那些在为外科的更高的风险。基于血清学反应创造同质的疾病亚群可以帮助开发更多的标准化治疗学的途径并且可以在 IBD 的 pathomechanism 的更好的理解帮助。进一步未来的临床的研究被需要在 IBD 建立 serologic 的临床的角色。 | Maria Papp Gary L Norman Istvan Altorjay Peter Laszlo Lakatos | 2007 | World Journal of Gastroenterology2007，13，14： | 24 |
| 3 | Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors:Pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take'toll'?显示文摘煽动性的肠疾病(IBD ) 的致病仅仅部分被理解。各种各样环境并且主人(例如基因 -- ,上皮 -- ,有免疫力、非有免疫力) 因素被包含。它是有可能的基因异质的多因素的复合基因疾病。一些基因自己与 IBD 被联系,当其它增加 ulcerative (UC ) 或 Crohn 的疾病(CD ) 的风险或与疾病地点或行为被联系时。这评论在 IBD 的遗传探讨最近的进展。文章在在微生物引起、基因的因素之间的串音上讨论当前的信息(例如 NOD2/CARD15, SLC22A46A5 和 DLG5 ) 。在理解 IBD 和罐头的致病在最近的年帮助获得的基因数据为治疗学的干预识别很多个潜在的目标。以后,遗传可以更精确地帮助在 IBD 诊断并且预言疾病路线。 | Peter Laszlo Lakatos Simon Fischer Janos Papp Laszlo Lakatos Istvan Gal | 2006 | World Journal of Gastroenterology2006，12，12： | 18 |
| 4 | Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001显示文摘AIM:An investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to 2001.METHODS: Both hospital and outpatient records were collected and reviewed comprehensively. The majority of patients were followed up regularly.RESULTS:The population of the province was decreased from 386000 to 376000 during the period. Five hundred sixty new cases of ulcerative colitis (UC), 212 of Crohn's disease (CD), and 40 of indeterminate colitis (IC) were diagnosed. The incidence rates increased from 1.66 to 11.01 cases per 100 000 persons for UC, from 0.41 to 4.68 for CD and from 0.26 to 0.74 for IC. The prevalence rate at the end of 2001 was 142.6 for UC and 52.9 cases per 100 000 persons for CD. The peak onset age in UC patients was between 30 and 40 years, in CD between 20 and 30 years. A family history of IBD was present in 3.4% in UC and 9.9% in CD patients.Smoking increased the risk for CD (OR=1.94) while it decreased the risk for UC (OR=0.25). Twelve colorectal carcinomas were observed in this cohort, the cumulative colorectal cancer risk after 10 years in UC was 2%, after 20 years 8.8%, after 30 years 13.3%.CONCLUSION:The incidence and prevalence rates of IBD have increased steadily in Veszprem Province, now equivalent to that in Western European countries. Rapid increase in incidence rates supports a probable role for environmental factors. The rate of colorectal cancers in IBD is similar to that observed in Western countries. | Laszlo Lakatos Gabor Mester Zsuzsanna Erdelyi Mihaly Balogh Istvan Szipocs Gyorgy Kamaras Peter Laszlo Lakatos | 2004 | World Journal of Gastroenterology2004，10，3： | 17 |
| 5 | Socio-cognitive Approach to Pragmatics显示文摘Communication is not as smooth a process as current pragmatic theories depict it.In Rapaport's words 'We almost always fail .Yet we almost always nearly succeed: This is the paradox of communication(Rapaport,2003:402).' This paper claims that there is a need for an approach that is able to explain this 'bumpy road' by analyzing both the positive and negative features of the communicative process.The paper presents a socio-cognitive approach(SCA) to pragmatics that takes into account both the societal and individual factors including cooperation and egocentrism that,as claimed here,are not antagonistic phenomena in interaction.This approach is considered an alternative to current theories of pragmatics that do not give an adequate account of what really happens in the communicative process.They consider communication an idealistic,cooperation-based,context-dependent process in which speakers are supposed to carefully construct their utterances for the hearer taking into account all contextual factors and hearers do their best to figure out the intentions of the speakers.This approach relies mainly on the positive features of communication including cooperation,rapport and politeness while almost completely ignores the untidy,trial-and-error nature of communication and the importance of prior contexts captured in the individual use of linguistic units.The overemphasis on cooperative,societal,contextual factors has led to disregard individual factors such as egocentrism and salience that are as important contributors to the communicative process as cooperation,context and rapport.The socio-cognitive approach is presented as a theoretical framework to incorporate and reconcile two seemingly antagonistic sides of the communicative process and explain the dynamic interplay of prior and actual situational contexts. | Istvan Kecskes | 2010 | 外国语2010，33，5： | 16 |
| 6 | About Bilingual Pragmatic Competence显示文摘双语语用能力是双语研究中较少关注的议题。本文主要探讨成年双语者习得的语言及其相关社会-文化如何影响原有的语用知识与能力。作者假定双语者已具备一种由母语主导的语用能力,该能力可根据习得语言的社会-文化要求作出调整。母语语用能力发展与第二语言语用能力发展两者之间存在根本性差异,前者主要受制于社会-文化环境,后者则主要取决于个人的意愿和喜好。母语的语言发展过程与相关社会-文化的积累过程齐头并进,是一种潜意识、自动化、本能的过程,该过程主要依赖于社会-文化环境的性质及其直接接触,个人意愿对于社会技能和知识的获取影响有限。双语语用能力的发展过程则迥然不同,其主要特点是双语者可调控自己对二语的相关社会-文化范式和规约的接受程度。个人可根据自我调控、意识和意愿去调整现有的技能和行为模式,并选择性地获取某些社会技能,从而影响二语语用能力的发展过程。 | Istvan Kecskes | 2014 | 现代外语2014，37，1： | 15 |
| 7 | Presepsin teardown- pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis显示文摘AIM To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHODS Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein(CRP) and procalcitonin(PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality.RESULTS Present 34.7 of patients had bacterial infection. Presepsin levels were significantly higher in patients with infection than without(median, 1002 pg/m L vs 477 pg/m L, P < 0.001), increasing with the severity of infection [organ failure(OF): Yes vs No, 2358 pg/m L vs 710 pg/m L, P < 0.001]. Diagnostic accuracy of presepsin for severe infections was similar to PCT and superior to CRP(AUC-ROC: 0.85, 0.85 and 0.66, respectively, P = NS for presepsin vs PCT and P < 0.01 for presepsin vs CRP). At the optimal cut-off value of presepsin > 1206 pg/m L sensitivity, specificity, positive predictive values and negative predictive values were as follows: 87.5%, 74.5%, 61.8% and 92.7%. The accuracy of presepsin, however, decreased in advanced stage of the disease or in the presence of renal failure, most probably because of the significantly elevated presepsin levels in non-infected patients. 28-d mortality rate was higher among patients with > 1277 pg/m L compared to those with ≤ 1277 pg/m L(46.9% vs 11.6%, P < 0.001). In a binary logistic regression analysis, however, only PCT(OR = 1.81, 95%CI: 1.09-3.01, P = 0.022) but neither presepsin nor CRP were independent risk factor for 28-d mortality after adjusting with MELD score and leukocyte count.CONCLUSION Presepsin is a valuable new biomarker for defining severe infections in cirrhosis, proving same efficacy as PCT. However, it is not a useful marker of short-term mortality. | Maria Papp Tamas Tornai Zsuzsanna Vitalis Istvan Tornai David Tornai Tamas Dinya Andrea Sumegi Peter Antal-Szalmas | 2016 | World Journal of Gastroenterology2016，22，41： | 9 |
| 8 | Genetic changes of p53,K-ras,and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary显示文摘AIM: To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary.METHODS: We examined 42 cases of gallbladder carcinoma: 22 Japanese and 20 Hungarian cases. p53 mutations at exons 5 to 8 and K-ras mutations at codon 12 were tested by direct sequencing. Microsatellite instability was determined from fluorescent dye-labeled PCR amplifications of five-microsatellite markers (BAT-25, BAT-26, D2S123, D5S346, and D17S250).RESULTS: Mutations of p53 were detected in 11 of 22 Japanese cases and 6 of 18 Hungarian cases (11/22 vs 6/18, P = 0.348). Transition at CpG sites was found in none of 11 Japanese cases and 2 of 6 Hungarian cases; the difference was marginally significant (0/11 vs 2/6, P = 0.110). K-ras mutations were detected in only one of the Hungarian cases. Eight of 19 (42.1%) Japanese cases were MSI-high (presence of novel peaks in more than one of the five loci analyzed), whereas only 1 of 15 (6.7%) Hungarian cases was MSI-high (P = 0.047).CONCLUSION: It appears that the p53 mutations and MSI differ in patients with gallbladder carcinoma between two distinct high-incidence areas. Geographic variation might exist in the process of gallbladder carcinogenesis. | Masayuki Nagahashi Yoichi Ajioka Istvan Lang Zoltan Szentirmay Miklos Kasler Hiroto Nakadaira Naoyuki Yokoyama Gen Watanabe Ken Nishikura Toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama Masaharu Yamamoto | 2008 | World Journal of Gastroenterology2008，14，1： | 9 |
| 9 | Contextual Meaning and Word Meaning显示文摘The paper has three goals: 1) Explain the role of context and word in meaning construction and comprehension. 2) Present a model that can explain meaning generated by both monolingual and multilingual meaning construction systems. 3) Discuss how the model can be applied to explain major issues in pragmatics. Pragmatics is understood here in a narrow sense as defined by Sperber & Noveck: “...pragmatics is the study of how linguistic properties and contextual factors interact in the interpretation of utterances” (Sperber & Noveck 2004∶1). It is argued that world knowledge is available to interlocutors in two forms: as encapsulated in lexical items based on prior encounters and experience (conventionalized cognitive context), and as provided by the actual situational context framed by the situation in which the interaction takes place. Meaning formally expressed in the linguistic interactional context is created on-the-spot, and is the result of the interaction of the two sides of world knowledge and the actual situational context. The paper makes three claims∶ First, supremacy of context is not unconditional in language processing. Second, salient meaning rather than literal meaning of lexical units plays a central role in comprehension. Third, intercultural communication differs from intracultural communication in the conceptual content of conventionalized cognitive contexts rather than in communicative means. | Istvan Kecskes | 2006 | 外国语2006，29，5： | 8 |
| 10 | Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression显示文摘AIM: To study the effect of proton pump inhibitor (PPI)treatment on patients with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal growth factor receptor (EGFR) expression.METHODS: After informed consent was obtained, gastric biopsies of the antrum were taken from patients with reflux oesophagitis prior to and after 6 mo of 20 mg omeprazole (n = 14) or 40 mg esomeprazole (n = 12) therapy.Patients did not take any other medications known to affect the gastric mucosa. All patients were Helicobacter pylori negative as confirmed by rapid urease test and histology,respectively. Cell proliferation, apoptosis, EGFR, and p53expression were measured by immunohistochemical techniques. At least 600 glandular epithelial cells were encountered and results were expressed as percentage of total cells counted. Was considered statistically significant.RESULTS: Although there was a trend towards increase of cell proliferation and EGFR expression both in omeprazole and esomeprazole treated group, the difference was not statistically significant. Neither apoptosis nor p53 expression was affected.CONCLUSION: Long-term PPI treatment does not significantly increase gastric epithelial cell proliferation and EGFR expression and has no effect on apoptosis and p53 expression. | Istvan Hritz Laszlo Herszenyi Bela Molnar Zsolt Tulassay Laszlo Pronai | 2005 | World Journal of Gastroenterology2005，11，30： | 7 |
| 11 | 改性γ-聚谷氨酸去除重金属Pb^(2+)性能研究显示文摘研究了不同改性水平的γ-聚谷氨酸(以下简写为γ-PGA)吸附去除水体中重金属离子Pb2+的性能影响。研究结果表明,交联改性后的γ-PGA与未改性的γ-PGA相比,具有更好的Pb2+吸附性能,在将改性γ-PGA加入到含有Pb2+的水体中并均匀混合之后,随着交联度的提高,改性γ-PGA吸附Pb2+的性能逐渐增加,但在吸附最终结束时,不同改性的γ-PGA对Pb2+吸附去除率均在99%以上。在吸附去除Pb2+影响因素分析中发现Pb2+初始质量浓度和溶液pH对不同改性的γ-PGA吸附去除Pb2+性能的影响较大。随着Pb2+质量浓度的增加,不同改性水平γ-PGA对Pb2+的去除率均略有一定程度的下降。当溶液的pH控制在中性或者偏碱性时,25%改性γ-PGA对Pb2+的去除率能够保持在99%以上,当pH降至4.5和3时,Pb2+去除率分别降为90.76%和78.46%。 | 史伟 任蓉 Hajdu Istvan Janos Borbely | 2012 | 水处理技术2012，38，8： | 6 |
| 12 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 13 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 14 | 中国大豆花叶病抗源和抗性鉴别寄主的鉴定与评价显示文摘收集大豆抗大豆花叶病(SMV)抗源和鉴别寄主40份,通过接种Cho和Goodm an划分的抗大豆花叶病毒株系SMV G1-G7,了解这些材料对该株系的抗性反应。同时比较了其中部分材料对中国学者划分的SMV Sc1-Sc17株系的抗性反应。结果感病材料无论对SMV G1-G7株系,还是SMV Sc1-Sc17株系均表现感病;但是,齐黄1、科丰1、早18和8101等对SMV G1-G7株系均表现抗病的材料,对SMV Sc1-Sc17株系却表现出部分抗病;而另外一些材料,如:诱变30、徐豆1、文丰5、铁6915、齐黄10和Harosoy等对SMV G1-G7株系的抗性反应却与北美的鉴别寄主相同。结果表明:无论是对SMV G1-G7株系,还是对SMV Sc1-Sc17株系,抗病材料的抗性遗传基础是相似的;中国一些大豆花叶病毒株系的致病力强于国外的株系。因此,结合国外的SMV株系鉴定系统,创建一套统一的SMV株系鉴定系统是可行的。 | 廖林 Rajcan Istvan 陈鹏印 Buss Gleen Tolin Sue 杨振宇 董志敏 王曙明 | 2010 | 大豆科学2010，29，6： | 5 |
| 15 | 施肥量剧减会造成作物大幅度减产吗?显示文摘利用匈牙利Balaton潮流域200多个农场田块1981-2002年的作物产量、施肥量和土壤养分历史资料,分析施肥量和作物产量的关系,探讨施肥量剧减对作物产量的影响。结果表明,该区在经历上世纪80年代末社会经济变革之后,几种作物施肥量剧烈下降,其中氮肥降低了25-30%,而磷钾肥降低了80%以上;但这种剧烈降低并没有引起作物大幅度 减产,小麦产量变化不大,其他作物产量降低幅度不到10%,也远远低于肥料降低幅度;同时,土壤有效磷钾含量也有下降;并且,化肥用量的下降也对Balaton潮水质量改善有一定贡献。该区的经验对我国改变目前这种过量施肥的局面,减少土壤养分过量积累、调整化肥发展等均有一定借鉴作用。 | 马文奇 Sisak Istvan | 2008 | 生态环境2008，17，3： | 4 |
| 16 | 改性γ-聚谷氨酸络合重金属离子性能显示文摘研究了不同控制条件(温度、Pb2+浓度、pH)对交联改性γ-聚合谷氨酸(γ-PGA)吸附重金属离子所形成的絮凝颗粒性质的影响,对于治理水中重金属污染的相关研究有一定参考价值。实验表明,C-L-γ-PGA絮凝吸附Pb2+的最佳温度段在30℃附近。随着交联度的增加,不同的Pb2+浓度影响絮凝颗粒的大小,当处于较低浓度时,静电引力成为影响絮凝颗粒粒径最主要的因素,当Pb2+浓度增加到一定程度时,重金属的吸附量成为絮凝颗粒的粒径的决定因素。溶液pH达到7附近时,能够形成粒径最大的絮凝颗粒,并出现了最大的Pb2+去除率。C-L-γ-PGA对其他重金属离子也有类似的吸附絮凝作用,且絮凝吸附强弱顺序为Cu2+>Cr3+>Pb2+>Hg2+。吸附絮凝颗粒的粒径反映了重金属被吸附之后分离的难易程度,因此研究不同条件对絮凝颗粒粒径的影响对重金属离子的吸附和去除有重要意义。 | 史伟 陈晨 康小华 Hajdu Istvan Janos borely | 2012 | 环境工程学报2012，6，8： | 4 |
| 17 | Discrimination and Quantification of True Biological Signals in Metabolomics Analysis Based on Liquid Chromatography-Mass Spectrometry显示文摘 | Duan, Lixin Molnar, Istvan Snyder, John Hugh Shen, Guo-an Qi, Xiaoquan | 2016 | Molecular Plant2016，9，8： | 3 |
| 18 | Promising Perspectives of Low Carbohydrate Diet in Cancer Adjuvant Therapy显示文摘Low carbohydrate diet(LCD)and nutrition is a very popular topic in the nutritional scientific literature.Main reason is that it is an old established therapy in intractable epilepsy and there are plenty of positive preclinical and sporadic clinical results in other disorders,including certain cancers.The problem is that a)the metabolic background of this therapy is not elucidated enough,b)animal studies and human experiences are sometimes divergent,c)there are negative human results and d)the clinical studies are not comparable because of the wide variety of study design and conclusion regarding the indication,the composition of diet and duration of treatment can not be drawn.This publication reviews the current situation and gives some hints to the solution. | Istvan G Telessy | 2020 | Journal of Nutritional Oncology2020，5，2： | 3 |
| 19 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 20 | Local color and morphological image feature based vegetation identification and its application to human environment street view vegetation mapping, or how green is our county?显示文摘Measuring the amount of vegetation in a given area on a large scale has long been accomplished using satellite and aerial imaging systems.These methods have been very reliable in measuring vegetation coverage accurately at the top of the canopy,but their capabilities are limited when it comes to identifying green vegetation located beneath the canopy cover.Measuring the amount of urban and suburban vegetation along a street network that is partially beneath the canopy has recently been introduced with the use of Google Street View(GSV)images,made accessible by the Google Street View Image API.Analyzing green vegetation through the use of GSV images can provide a comprehensive representation of the amount of green vegetation found within geographical regions of higher population density,and it facilitates an analysis performed at the street-level.In this paper we propose a fine-tuned color based image filtering and segmentation technique and we use it to define and map an urban green environment index.We deployed this image processing method and,using GSV images as a high-resolution GIS data source,we computed and mapped the green index of Milwaukee County,a 3,082 km^(2) urban/suburban county in Wisconsin.This approach generates a high-resolution street-level vegetation estimate that may prove valuable in urban planning and management,as well as for researchers investigating the correlation between environmental factors and human health outcomes. | Istvan G.Lauko Adam Honts Jacob Beihoff Scott Rupprecht | 2020 | Geo-Spatial Information Science2020，23，3： | 3 |
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