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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus显示文摘 | Alexander J. Thompson Andrew J. Muir Mark S. Sulkowski Dongliang Ge Jacques Fellay Kevin V. Shianna Thomas Urban Nezam H. Afdhal Ira M. Jacobson Rafael Esteban Fred Poordad Eric J. Lawitz Jonathan McCone Mitchell L. Shiffman Greg W. Galler William M. Lee | 2010 | Gastroenterology2010，，1： | 7 |
| 3 | A Generic Workflow for the Data FAIRification Process显示文摘The FAIR guiding principles aim to enhance the Findability,Accessibility,Interoperability and Reusability of digital resources such as data,for both humans and machines.The process of making data FAIR(“FAIRification”)can be described in multiple steps.In this paper,we describe a generic step-by-step FAIRification workflow to be performed in a multidisciplinary team guided by FAIR data stewards.The FAIRification workflow should be applicable to any type of data and has been developed and used for“Bring Your Own Data”(BYOD)workshops,as well as for the FAIRification of e.g.,rare diseases resources.The steps are:1)identify the FAIRification objective,2)analyze data,3)analyze metadata,4)define semantic model for data(4a)and metadata(4b),5)make data(5a)and metadata(5b)linkable,6)host FAIR data,and 7)assess FAIR data.For each step we describe how the data are processed,what expertise is required,which procedures and tools can be used,and which FAIR principles they relate to. | Annika Jacobsen Rajaram Kaliyaperumal Luiz Olavo Bonino da Silva Santos Barend Mons Erik Schultes Marco Roos Mark Thompson | 2020 | Data Intelligence2020，2，1： | 5 |
| 4 | The“A”of FAIR-As Open as Possible,as Closed as Necessary显示文摘In order to provide responsible access to health data by reconciling benefits of data sharing with privacy rights and ethical and regulatory requirements,Findable,Accessible,Interoperable and Reusable(FAIR)metadata should be developed.According to the H2020 Program Guidelines on FAIR Data,data should be'as open as possible and as closed as necessary','open'in order to foster the reusability and to accelerate research,but at the same time they should be'closed'to safeguard the privacy of the subjects.Additional provisions on the protection of natural persons with regard to the processing of personal data have been endorsed by the European General Data Protection Regulation(GDPR),Reg(EU)2016/679,that came into force in May 2018.This work aims to solve accessibility problems related to the protection of personal data in the digital era and to achieve a responsible access to and responsible use of health data.We strongly suggest associating each data set with FAIR metadata describing both the type of data collected and the accessibility conditions by considering data protection obligations and ethical and regulatory requirements.Finally,an existing FAIR infrastructure component has been used as an example to explain how FAIR metadata could facilitate data sharing while ensuring protection of individuals. | Annalisa Landi Mark Thompson Viviana Giannuzzi Fedele Bonifazi Ignasi Labastida Luiz Olavo Bonino da Silva Santos Marco Roos | 2020 | Data Intelligence2020，2，1： | 4 |
| 5 | New charge-carrier blocking materials for high efficiency OLEDs显示文摘 | Vadim I. Adamovich Steven R. Cordero Peter I. Djurovich Arnold Tamayo Mark E. Thompson Brian W. D’Andrade Stephen R. Forrest | 2003 | Organic Electronics2003，，2： | 2 |
| 6 | Regula- tion of leaf and fruit growth in plants growing in drying soil: ex ploitation of the plants' chemical signalling system and hydraulic architecture to increase the efficiency of water use in agriculture 显示文摘 | William J Davies Mark A Bacon D Stuart Thompson | 2000 | Journal of Experimental Botany2000，51，350： | 1 |
| 7 | An empirical analysis of the impact of patent protection on Economic Growth:an Ex- tension显示文摘 | Mark A Thompson Francis W.R | | 0，，01： | 1 |
| 8 | Direct and combined revascularization in pediatric moyamoya disease显示文摘 | Golby A J Marks MP Thompson RC | 1999 | Neurosurgery1999，45，： | 1 |
| 9 | Self- adapting Bottom Hole Assembly Vibration Suppression 显示文摘 | Mark Hutchinson Dan Burgess Fred Thompson | 2013 | Society of Petroleum Engineers2013，，9： | 1 |
| 10 | Reduction of solar keratosis by regular sunsereen use 显示文摘 | Thompson SC Jolley D Marks R | 1993 | N Engl J Med1993，329，16： | 1 |
| 11 | Prediction of flutter of turbine blades in a transonic annular cascade显示文摘 | BEAN Ivan Mc HOURIGAN Kerry THOMPSON Mark | 2005 | Journal of Fluids Engineering2005，127，6： | 1 |
| 12 | Long-term results of convex epiphyseodesis for congenital seoliosis显示文摘 | Marks DS Sayampanathan SR Thompson AG | 1995 | Eur Spine J1995，4，5： | 1 |
| 13 | Boceprevir versus placebo with pegylated interferon alfa-2b and ribavirin for treatment of hepatitis C virus genotype 1 in patients with HIV: a randomised, double-blind, controlled phase 2 trial显示文摘 | Mark Sulkowski Stanislas Pol Josep Mallolas Hugo Fainboim Curtis Cooper Jihad Slim Antonio Rivero Carmen Mak Seth Thompson Anita YM Howe Larissa Wenning Peter Sklar Janice Wahl Wayne Greaves | 2013 | The Lancet Infectious Diseases2013，，7： | 1 |
| 14 | Placing knowledge management in context显示文摘 | THOMPSON Mark P A WALSHAM G | 2004 | The Journal of Management Studies2004，41，5： | 1 |
| 15 | Analysis of Quantitative Trait Loci for Blood Pressure on Rat Chromosomes 2 and 13: Age-Related Differences in Effect显示文摘 | Nilesh J. Samani Dominique Gauguier Madeleine Vincent Michael A. Kaiser Marie-Therese Bihoreau David Lodwick Robert Wallis Valerie Parent Phillip Kimber Fraser Rattray John R. Thompson Jean Sassard Mark Lathrop | 1996 | Hypertension1996，，： | 1 |
| 16 | Convex spinal epiphys-iodesis in the management of progressive infantile idiopathic scoliosis显示文摘 | Marks DS Iqbal MJ Thompson AG | 1996 | Spine(Phila Pa 1976)1996，21，16： | 1 |
| 17 | Convex spinal epiphy siodesis in the management of progressive infantile idiopathic scoliosis显示文摘 | Marks DS Iqbal MJ Thompson AG | 1996 | Spine1996，21，16： | 1 |
| 18 | An em- pirical analysis of the impact of patent protection on eco- nomic growth:an extensio显示文摘 | MARK A THOMPSON FRANCIS W RUSHING | 1999 | Journal of Economic Devel- opment1999，24，1： | 1 |
| 19 | Long- term results of combined anterior and posterior convex epiphysiodesis for congenital scoliosis due to hemivertebrae显示文摘 | Thompson AG Marks DS Sayampanathan SR | 1995 | Spine1995，20，12： | 1 |
| 20 | Does the addition of a fundoplication improve outcomes for patients undergoing laparoscopic Heller’s cardiomyotomy?显示文摘 | Damian Mayo Ewen A. Griffiths Omar A. Khan Mark A. Szymankiewicz Christian W. Wakefield Sarah K. Thompson | 2012 | International Journal of Surgery2012，，6： | 1 |
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