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| 1 | 锡林河流域地表水水化学主离子特征及控制因素显示文摘通过对2006~2008年锡林河主要径流期内13个河水断面239个水样以及同期地下水和大气降水主离子水化学进行分析,结合锡林河流域的气象和水文资料,利用Piper三线图和Gibbs图分析了锡林河河水的水化学特征及主离子组成变化特征.结果表明,锡林河河水TDS变化范围在136.7~376.5mg·L^-1之间,平均245.1mg·L^-1,为低矿化度河水;河水中主要阳离子以Ca2+为主,阴离子以HCO3^-为主,河水的水化学类型从HCO3-—Ca2+过渡到HCO3--Ca2+·Mg2+;河水主离子平均浓度年内、年际变化均不大,年内变化表现在5月主离子浓度高于其他月,年际变化表现为主离子在2007年的平均浓度均较小;空间上,Ca2+、Na+、Mg2+、K+、Cl^-和HCO3^-的浓度呈现沿程逐渐增加的趋势,SO4^2-的浓度变化呈先增加后减小的趋势;河水中主离子浓度值介于大气降水和地下水之间,并且十分接近地下水浓度,说明地表水同时受大气降水和地下水补给并主要依靠地下水补给;Gibbs图显示河水离子组成主要与流域内的岩石风化有关,流域有一定量的蒸发岩存在,但蒸发岩对水化学的贡献弱于碳酸盐岩. | 唐玺雯 吴锦奎 薛丽洋 张明泉 Frauke Barthold Lutz Breuer Hans-Georg Frede | 2014 | 环境科学2014，35，1： | 61 |
| 2 | 跨国机构与地方共同作用下的城市全球化——德国波恩的案例研究显示文摘城市是一个动态发展系统,外生和内生的行动者通过互动促进城市发展。跨国机构作为重要的外生行动者,在一些城市的全球化发展过程中产生了重要的作用。案例城市波恩正是在联邦、州和地方政府的权力和政策安排下,创造了跨国行动者嵌入的制度环境和背景,以联合国机构为主的众多跨国机构通过与政府、企业和居民,以及非人类行动者在建立国际合作的共同诉求下积极转译,产生互动效应,为城市建构了稳固而'无缝'的行动者网络。行动者的不同目的和行为方式在塑造网络的同时,也重新建构了城市空间,空间成为检验网络构建是否成熟的一种重要的表现方式。波恩的城市空间实现了从外交政治功能向国际合作功能的转型;形成以联合国机构为轴心,其他机构点状辐射的轴辐式空间集聚;同时,由于资源、信息和所处地位的不同,波恩不同行动者在网络节点之间产生不均等的权力空间。行动者不断的排斥、冲突、协商和融合的过程,促进了城市空间功能不断完善,也致使以跨国机构为核心的行动者网络逐步成熟。通过引入行动者网络理论(ANT),本研究把跨国机构作为重要行动者与城市全球化发展相结合,更深入地解析了城市全球化过程中多重行动者的互动过程。 | 梅琳 薛德升 Frauke KRAAS | 2014 | 地理学报2014，69，2： | 11 |
| 3 | 珠江三角洲世界工厂的非正规职业中介及其作用——以广东省东莞市塘厦镇为例显示文摘国内外现有研究认为,农民工的求职渠道非常单一,主要依赖社会关系网络。本文选取典型的珠江三角洲世界工厂所在地——广东省东莞市塘厦镇为案例,对非正规职业中介机构进行了深入调查研究。发现非正规中介机构在农民工的求职过程中发挥着重要作用,帮助农民工实现灵活、即时的就业,其存在是在我国转型期市场改革不断深入的背景下,企业/工厂的用工需求、农民工的求职需要、中介机构的逐利目的和地方政府的宽容态度共同作用的结果。非正规职业中介机构是市场动力作用下的新型农民工非正规求职渠道,是原有的社会关系网络求职渠道的延伸。研究表明,在现阶段中国城市化过程中,非正规的动力在解决农民工求职乃至城市化过程中具有重要的作用。 | 薛德升 林婷 KRAAS Frauke KILLIAN Pamela | 2010 | 地理研究2010，29，10： | 11 |
| 4 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 5 | Placebo responses in patients with gastrointestinal disorders显示文摘Over the last several years there has been a growing interest in placebo, not only as an inert control in clinical trials, but also in the placebo effect as a group effect as well as a reaction in individual subjects. Methodological factors such as regression to the mean and natural history of the disease play a role in the evaluation of a possible placebo effect. In this report, we discuss several factors including Pavlovian conditioning, beliefs outcome, expectations, and other factors as potential mediators of the placebo response. Placebo effects are common in gastrointestinal diseases and there seems to be no clear difference between placebo effects in functional gastrointestinal diseases (functional dyspepsia and irritable bowel syndrome) and organic gastrointestinal disease (duodenal ulcer and inflammatory bowel disease). | Frauke Musial Sibylle Klosterhalfen Paul Enck | 2007 | World Journal of Gastroenterology2007，13，25： | 7 |
| 6 | Menopause in German and Chinese Women——An Analysis of Symptoms,TCM-diagnosis and Hormone Status显示文摘目的将在上海(中国) 调查经绝期相关的症状,繁体中文药(TCM ) 诊断和绝经女人,在 Essen (德国) 的女人和其它的二件可比较的城市的样品的荷尔蒙地位。受不了经绝期症候群的方法病人在德国(35 个题目) 从 Duisburg-Essen 的大学的 TCM 门诊病人诊所被招募,从 Shuguang,医院在中国(35 个题目) 结盟了到繁体中文药的上海大学。为跟踪绝经症状的 Kupperman 索引被使用。完全的 TCM 诊断被一样的调查者在中国以及在德国执行。睾丸激素和雌激素血样品从每个女人被收集一次。在那里的结果是在 Kupperman 索引的特定的症状的有效差量,例如在德国绝经女人的蚁走感和消沉的更高的流行;而中国绝经女人从眩晕,头疼和同等感觉症状更显著地受苦了。有关 TCM 诊断,沈(肾)-yang 缺乏与中国女人的 5.71 % 相对照在 51.43% 德国女人被诊断;德国女人的 17.14 % 作为与中国女人的 74.29 % 相比有 Shen-yin 缺乏被诊断。德国女人与中国女人(P⩽0.0005 ) 相比为睾丸激素显示出显著地更低的吝啬的荷尔蒙层次。结论德国、中国的绝经女人不显示出不同流行,但是有绝经症状的不同模式。从一个 TCM 观点,而中国女人从 Shen-yin 缺乏症候群承受更多,而且,德国女人从沈阳缺乏承受更多。这些结果被支持由显著地在与中国女人相比的德国女人的睾丸激素的底层,在 TCM,它是 yang 的一个特征缺乏。 | Rampp Thomas Tan Linda ZHANG Lin SUN Zhuo-jun Klose Petra Musial Frauke Dobos Gustav Juergen | 2008 | Chinese Journal of Integrative Medicine2008，14，3： | 3 |
| 7 | Role of soluble factors and three-dimensional culture in in vitro differentiation of intestinal macrophages显示文摘AIM: To examine the factor(s) involved in differentiation of intestinal macrophages (IMACs) using a recently established in vitro model. METHODS: To test whether soluble or membrane bound factors induce IMAC-differentiation, freshly elutriated monocytes (MO) were incubated with conditioned media or cell membranes of intestinal epithelial cells (IEC) or cultured with IEC in transwell systems. To determine the importance of an active migration of MO, three- dimensional aggregates from a 1:1-mixture of MO and IEC were examined by immunohistochemistry and flow cytometry. Apoptosis was examined by caspase-3 Western blots. Extracellular matrix production in differentiation models was compared by immunohistochemistry. RESULTS: IMAC differentiation was observed in a complex three-dimensional co-culture model (multicellular spheroid, MCS) with IEC after migration of MO into the spheroids. By co-culture of MO with conditioned media or membrane preparations of IEC no IMAC differentiation was induced. Co-culture of MO with IEC in transwell- cultures, with the two cell populations separated by a membrane also did not result in intestinal-like differentiation of MO. In contrast to IEC-spheroids with immigrating MO in mixed MCS of IEC and MO only a small subpopulation of MO was able to survive the seven day culture period. CONCLUSION: Intestinal-like differentiation of MO in vitro is only induced in the complex three-dimensional MCS model after immigration of MO indicating a roleof cell-matrix and/or cell-cell interactions during the differentiation of IMACs. | Tanja Spoettl Martin Hausmann Katrin Menzel Heidi Piberger Hans Herfarth Juergen Schoelmerich Frauke Bataille Gerhard Rogler | 2007 | World Journal of Gastroenterology2007，13，7： | 3 |
| 8 | Contrast-enhanced harmonic endoscopic ultrasound is able to discriminate benign submucosal lesions from gastrointestinal stromal tumors显示文摘 | Klaus Kannengiesser Reiner Mahlke Frauke Petersen Anja Peters Matthias Ross Torsten Kucharzik Christian Maaser | 2012 | Scandinavian Journal of Gastroenterology2012，，12： | 3 |
| 9 | 用双色荧光原位杂交技术鉴定血痕性别显示文摘目的 探讨荧光原位杂交技术在血痕性别鉴定中应用及其价值。方法对20例新鲜人血及20例1-2年人血痕的X、Y染色体采用双色荧光探针进行原位杂交分析。结果 人新鲜血,男性X、Y信号检出的完整率为98.8%,其中Y信号的检出率为100%,女性X、X信号检出的完整率为96.5%;1-2年人血痕,男性X、Y信号检出的完整率为88%,其中Y信号的检出率为90%,女性X、X信号检出的完整率为80%;40例血液(痕)性别检测的符合率为100%。结论双色荧光原位杂交技术可以鉴定血痕性别。 | 朱少华 FISCHER FRAUKE | 2004 | 中国法医学杂志2004，19，3： | 3 |
| 10 | Role of discs large homolog 5显示文摘在 2004,在磁盘的基因变化的一个协会大相当或相同的事物 5 (DLG5 ) 有煽动性的肠疾病(IBD ) 的基因在二件大欧洲学习样品被描述。新奇 IBD 危险性基因引发在 CD 和 IBD 上调查它的效果分别地,在 Crohn 疾病的原因论有关发现的起始的协会和它的角色的有效性导致争论调查结果和进行中的讨论的大量的研究的 DLG5 的起始的报告。这评论试图总结知识的当前的状态并且把报导调查结果放在复杂疾病的当前的概念的上下文。这象基因基因和基因环境相互作用一样包括在不同人口之间的统计力量,显型差别和基因异质的方面。 | Frauke Friedrichs Monika Stoll | 2006 | World Journal of Gastroenterology2006，12，23： | 3 |
| 11 | Suitability of common models to estimate hydrology and diffuse water pollution in North-eastern German lowland catchments with intensive agricultural land use显示文摘Various process-based models are extensively being used to analyze and forecast catchment hydrology and water quality. However, it is always important to select the appropriate hydrological and water quality modeling tools to predict and analyze the watershed and also consider their strengths and weaknesses. Different factors such as data availability, hydrological, hydraulic, and water quality processes and their desired level of complexity are crucial for selecting a plausible modeling tool. This review is focused on suitable model selection with a focus on desired hydrological, hydraulic and water quality processes(nitrogen fate and transport in surface, subsurface and groundwater bodies) by keeping in view the typical lowland catchments with intensive agricultural land use,higher groundwater tables, and decreased retention times due to the provision of artificial drainage. In this study, four different physically based, partially and fully distributed integrated water modeling tools, SWAT(soil and water assessment tool), SWIM(soil and water integrated model),HSPF(hydrological simulation program– FORTRAN) and a combination of tools from DHI(MIKE SHE coupled with MIKE 11 and ECO Lab), have been reviewed particularly for the Tollense River catchment located in North-eastern Germany. DHI combined tools and SWAT were more suitable for simulating the desired hydrological processes, but in the case of river hydraulics and water quality, the DHI family of tools has an edge due to their integrated coupling between MIKE SHE, MIKE 11 and ECO Lab. In case of SWAT, it needs to be coupled with another tool to model the hydraulics in the Tollense River as SWAT does not include backwater effects and provision of control structures. However, both SWAT and DHI tools are more data demanding in comparison to SWIM and HSPF. For studying nitrogen fate and transport in unsaturated, saturated, and river zone, HSPF was a better model to simulate the desired nitrogen transformation and transport processes. However, for nitrogen dynamics and transformations in shallow streams, ECO Lab had an edge due its flexibility for inclusion of user-desired water quality parameters and processes. In the case of SWIM, most of the input data and governing equations are similar to SWAT but it does not include water bodies(ponds and lakes), wetlands and drainage systems. In this review, only the processes that were needed to simulate the Tollense River catchment were considered, however the resulted model selection criteria can be generalized to other lowland catchments in Australia, North-western Europe and North America with similar complexity. | Muhammad WASEEM Frauke KACHHOLZ Jens TRANCKNER | 2018 | Frontiers of Agricultural Science and Engineering2018，5，4： | 2 |
| 12 | Postoperative pain after transvaginal cholecystectomy: single-center, double-blind, randomized controlled trial显示文摘 | Dietmar H. Borchert Matthias Federlein Frauke Fritze-Büttner Jens Burghardt Britta Liersch-L?hn Yüksel Atas Verena Müller Oskar Rückbeil Stefan Wagenpfeil Stefan Gr?ber Klaus Gellert | 2014 | Surgical Endoscopy2014，，6： | 2 |
| 13 | Moll energy for rural India显示文摘 | Frauke U René M J Benders | 2009 | Applied Energy2009，86，1： | 1 |
| 14 | Brazilian and African passive margins of the Central Segment of the South Atlantic Ocean: Kinematic constraints显示文摘 | Daniel Aslanian Maryline Moulin Jean-Louis Olivet Patrick Unternehr Luis Matias Fran?ois Bache Marina Rabineau Hervé Nouzé Frauke Klingelheofer Isabelle Contrucci Cinthia Labails | 2008 | Tectonophysics2008，，1： | 1 |
| 15 | Servicescape interior design and consumers’ personality impressions显示文摘 | Ulrich R. Orth Frauke Heinrich Keven Malkewitz | 2012 | Journal of Services Marketing2012，，3： | 1 |
| 16 | The stuttering energy transition in Germany: Wind energy policy and feed- in tariff lock-inOriginal 显示文摘 | Johan Nordensv~ird Frauke Urban | 2015 | Energy Policy2015，82，7： | 1 |
| 17 | Feasibility and safety of endoscopic full-thickness esophageal wall resection and defect closure: a prospective long-term survival animal study显示文摘 | Annette Fritscher-Ravens Tamzin Cuming Bjorn Jacobsen Frauke Seehusen Amir Ghanbari Erich Kahle Axel von Herbay Peter Koehler Peter Milla | 2009 | Gastrointestinal Endoscopy2009，，7： | 1 |
| 18 | Delibera- ting on Low Carbon Development 显示文摘 | Yacob Mulugetta Frauke Urban | 2010 | Energy Policy2010，38，12： | 1 |
| 19 | Instant evaluation of contrast enhanced endoscopic ultrasound helps to differentiate various solid pancreatic lesions in daily routine显示文摘BACKGROUND Contrast enhanced harmonic endoscopic ultrasound(CEH-EUS) is a spreading technique; some studies have shown its value in the diagnosis of pancreatic adenocarcinoma using quantitative analysis.AIM To examine the value of CEH-EUS for differentiating various pancreatic lesions in everyday routine with qualitative and quantitative analysis.METHODS Data of 55 patients with pancreatic lesions who underwent CEH-EUS were analysed retrospectively. Perfusion characteristics were classified by the investigator qualitatively immediately upon investigation, quantitative analysis was performed later on. Samples from fine needle aspiration(EUS-FNA) or surgical specimen served as gold standard.RESULTS CEH-EUS showed 39 hypoenhanced lesions, 3 non-enhanced and 13 hyperenhanced lesions. Concordance of the investigators qualitative classification of peak contrast enhancement with quantitative analysis later on was 100%, while other parameters such as arrival time, time to peak or area under the curve did not show additional value. 34 of 39 hypoenhanced lesions were pancreatic adenocarcinoma; of the hyperenhanced lesions 4 were inflammatory, 3 neuroendocrine carcinomas, 1 lymphoma, 1 insulinoma and 4 metastases(2 of renal cell carcinoma, 2 of lung cancer). Non-enhanced lesions showed up as necroses. Sensitivity for the detection of pancreatic adenocarcinoma was 100%,specificity 87.2% for hypoenhancement alone; in otherwise healthy pancreatic tissue all hypoenhanced lesions were pancreatic adenocarcinoma(sensitivity and specificity 100%, PPV and NPV for adenocarcinoma 100%).CONCLUSION This study again shows the excellent value of CEH-EUS in everyday routine for diagnostics of various focal pancreatic lesions suggesting that qualitatively assessed hypoenhancement is highly predictive for adenocarcinoma. Additional quantitative analysis of perfusion parameters does not add diagnostic yield. In case of the various hyperenhanced pancreatic lesions in our data set, histologic sampling is essential for further treatment. | Klaus Kannengiesser Reiner Mahlke Frauke Petersen Anja Peters Torsten Kucharzik Christian Maaser | 2019 | World Journal of Clinical Cases2019，7，1： | 1 |
| 20 | Energy Consumption and Economic Growth : New insights into the cointegration relationship 显示文摘 | Ansgar Bellke Frauke Dobnik and Christian Dreger | 2011 | Energy Economics2011，，5： | 1 |
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