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| 1 | 微米及纳米丝光沸石分子筛上二甲醚羰基化反应的积碳分析显示文摘对比研究了在传统微米尺寸和新结构纳米丝光沸石催化剂上二甲醚羰基化合成乙酸甲酯的反应行为. 结果表明, 通过减小分子筛的尺寸到纳米水平, 可以有效提高反应物和产物到达或者脱离反应活性位的效率, 从而提高了二甲醚的转化率; 更重要的是, 抑制了硬积碳的生成, 使催化剂保持了更高的稳定性. | 薛会福 黄秀敏 Evert Ditzel 展恩胜 马猛 申文杰 | 2013 | 催化学报2013，34，8： | 16 |
| 2 | Ⅰ型干扰素诱导的内在代谢改变是其免疫功能的关键显示文摘随着对Ⅰ型干扰素诱导的复杂宿主反应越来越深刻地了解,科学家们在一些细胞因子相关的疾病治疗方案的研发上取得了新进展。本研究发现,在TLR-9受体激动剂CpGA的刺激下,通过自分泌Ⅰ型干扰素的受体依赖途径,浆细胞样树突状细胞(pDC)可产生Ⅰ型干扰素,后者可诱导细胞代谢发生变化,包括细胞的脂肪酸氧化(FAO)和氧化磷酸化(OXPHOS)水平增加。直接抑制脂肪酸氧化及其相关过程,如脂肪酸合成,可抑制pDC的完全激活。Ⅰ型干扰素也能促进非造血细胞和病毒感染的细胞FAO和OXPHOS的升高。PPARα参与了Ⅰ型干扰素诱导的代谢变化过程。我们的研究提示了FAO、OXPHOS、PPARα可作为潜在的Ⅰ型干扰素效应的下游干预靶点。 | 武多娇 Sanin DE Everts B 卓乐盈 | 2016 | 中国临床医学2016，23，4： | 13 |
| 3 | Report on Childhood Obesity in China (5) Body Weight, Body Dissatisfaction, and Depression Symptoms of Chinese Children Aged 9-10 Years显示文摘Objective To investigate the relationship between body weight, body dissatisfaction and depression symptoms among Chinese children. Methods The fasting body weight and height of the third and fourth grade students (n=3886, aged 9 or 10 years) from 20 schools in Beijing, China, were measured, and the students were asked to choose the figures of body image and to complete the self-reported children’s depression inventory (CDI) questionnaire. Results The CDI Cronbach’s alpha was 0.81. The total CDI score was 9.60±7.50, 13.2% of children (boys 16.7% vs girls 9.5%) were at risk of developing depression symptoms. Overweight girls, but not boys, had significantly higher total CDI score than their normal weight counteparts. Both obese girls and boys showed a higher negative self-esteem score. More than one fifth underweight girls still wanted to be thinner while more than one third obese boys still wanted to be heavier. Children who wanted to be thinner showed slightly higher scores of ineffectiveness and negative self-esteem. After introducing the body dissatisfaction into the model, overweight was still associated with total CDI score among girls and obesity was still associated with negative self-esteem among both boys and girls. Conclusion Overweight girls show a significantly higher depression symptom score than their normal weight counterparts, which maybe partially explained by body dissatisfaction. Obese boys and girls are both more likely to suffer from low self-esteem, which is partially explained by body dissatisfaction. | YAN-PING LI GUAN-SHENG MA EVERT G. SCHOUTEN XIAO-QI HU ZHAO-HUI CUI DONG WANG FRANS J. KOK | 2007 | Biomedical and Environmental Sciences2007，20，1： | 10 |
| 4 | 同源转基因将成为利用野生资源进行作物育种的一种有效手段显示文摘作物育种的一个主要限制因素是各栽培种的遗传基础日趋狭窄,迫切需要从野生种质资源中导入优异等位基因。杂交障碍和连锁累赘降低了常规育种利用这些等位基因的效率。基因组研究的发展使得越来越多的植物基因的克隆成为可能。同源转基因就是将本物种或其近缘野生种克隆的优异等位基因导入到要改良的育种材料中。这不仅可以缩短育种的周期,而且不会有不良性状的连锁累赘。同源转基因和常规育种所要导入的目标基因的来源是相同的,因此育成的品种同样是安全的。如果转基因条例能够将同源转基因品种视同为常规育种品种,同源转基因将会成为人们利用野生资源进行作物改良的一种有效手段。 | 黄三文 杜永臣 屈冬玉 Evert Jacobsen | 2006 | 园艺学报2006，33，6： | 7 |
| 5 | Key factors determining biochar sorption capacity for metal contaminants:a literature synthesis显示文摘The sorption capacity and affinity of biochar for metals are both important attributes that determine biochar’s suitability as a soil amendment for contaminant mitigation,yet few analyses have considered both characteristics simultaneously.We present a systematic review of literature published between 2010 and 2018 to test the hypothesis that sorption capacity and affinity are affected by biochar properties,attributes of the metal contaminant,and experimental conditions,in that order.We used random forest(RF)and multi-objective optimization to analyze data of 559 individual Langmuir adsorption isotherms extracted from 133 studies covering the sorption capacity(C_(max))and affinity(K_(L))of biochar for 17 different metals,elabo-rated from six different feedstock classes,three different types of feedstock pretreatment,and five types of post-pyrolysis treatment.Highest sorption values were obtained for Pb(II),Cr(IV),and Cd(II).The feedstock used was the key determinant influencing biochar’s capacity and affinity to sorb metal contaminants(first and fourth most important variable in RF mod-els for C_(max) and K_(L),respectively)with best results obtained for biochar elaborated from nutrient-dense feedstocks(animal biowaste,sludge,and manure).Biochars that had both high sorption capacity and affinity were the result of a longer dura-tion of pyrolysis;they had lower C and higher N and O content,as well as lower C/N and higher O/C and H/C ratios,higher pore volumes and higher pH.Applying some form of pretreatment was better than none,whereas chemical modification was the best of the post-treatment methods analyzed.This review demonstrates clearly that multiple parameters during the preparation process influence the effectiveness of biochar to immobilize metal contaminants.Future research that focuses on mechanisms and the underlying factors for the correlations observed should allow the development of biochar formulations that are even more effective at immobilizing metal contaminants in soils and sediments. | Evert Thomas Nils Borchard Christian Sarmiento Rachel Atkinson Brenton Ladd | 2020 | Biochar2020，2，2： | 5 |
| 6 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 7 | Interleukin-1βinduces human cementoblasts to support osteoclastogenesis显示文摘Injury of the periodontium followed by inflammatory response often leads to root resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts.Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin(IL)-1β hereupon. Extracted teeth from healthy volunteers were subjected to sequential digestion by type I collagenase and trypsin.The effect of enzymatic digestion on the presence of cells on the root surface was analyzed by histology. Gene expression of primary human cementoblasts(p HCB) was compared with a human cementoblast cell line(HCEM). The p HCBs were analyzed for their expression of IL-1 receptors as well as of receptor activator of nuclear factor kappa-B ligand(RANKL) and osteoprotegerin(OPG). In a co-culture system consisting of osteoclast precursors(blood monocytes) and p HCBs, the formation of osteoclasts and their resorptive activity was assessed by osteo-assay and ivory slices. The cells obtained after a 120 min enzyme digestion expressed the highest level of bone sialoprotein, similar to that of HCEM. This fraction of isolated cells also shared a similar expression pattern of IL-1 receptors(IL1-R1 and IL1-R2). Treatment with IL-1β potently upregulated RANKL expression but not of OPG. p HCBs were shown to induce the formation of functional osteoclasts. This capacity was significantly stimulated by pretreating the p HCBs with IL-1β prior to their co-culture with human blood monocytes. Our study demonstrated that cementoblasts have the capacity to induce osteoclastogenesis, a capacity strongly promoted by IL-1β. These results may explain why osteoclasts can be formed next to the root of teeth. | nam c-n huynh vincent everts prasit pavasant ruchanee s ampornaramveth | 2017 | International Journal of Oral Science2017，9，4： | 5 |
| 8 | Report on Childhood Obesity in China(8):Effects and Sustainability of Physical Activity Intervention on Body Composition of Chinese Youth显示文摘Objectives To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing,China.Methods The study design was one-year cluster randomized controlled trial of physical activity intervention(20 min of daily exercise in the classroom) with an additional year of follow-up among 4 700 students aged 8-11 years at baseline.Results After the one-year intervention,BMI increased by 0.56 kg/m^2(SD 1.15) in the intervention group and by 0.72 kg/m^2(SD 1.20) in the control group,with a mean difference of-0.15 kg/m^2(95%CI:-0.28 to-0.02).BMI z score decreased by-0.05(SD 0.44) in the intervention group,but increased by 0.01(SD 0.46) in the control group,with a mean difference of-0.07(-0.13 to-0.01).After another year of follow up,compared to the control group,children in the intervention group had significantly lower BMI(-0.13,-0.25 to-0.01),BMI z score(-0.05,-0.10 to-0.01),fat mass(-0.27 kg,-0.53 to-0.02) and percent body fat(-0.53,-1.00 to-0.05).The intervention had a more pronounced effect on weight,height,BMI,BMI z score,and body composition among obese children than among normal weight or overweight children.Compared to the control group,the intervention group had a significantly higher percentage of children who maintained or reduced their BMI z score at year 1(P=0.008) and year 2(P=0.04).Conclusions These findings suggest that 20 min of daily moderate to vigorous physical activity during the school year is a feasible and effective way to prevent excessive gain of body weight,BMI,and body fatness in primary school students. | YAN-PING LI XIAO=QI HU EVERT G. SCHOUTEN AI-LING LIU SONG-MING DU LIN-ZHONG LI ZHAO-HuI CUI DONG WANG FRANS J KOK FRANK B HU GUAN-SHENG MA | 2010 | Biomedical and Environmental Sciences2010，23，3： | 5 |
| 9 | 利用阵列感应测井进行储层渗透率评价显示文摘钻井过程中储层受到泥浆侵入影响的程度与储层岩性有着密切关系,其中储层渗透率对侵入深度有着较大影响,因此若可以获知泥浆侵入深度,则有望对储层渗透率进行评估.本文首先建立含泥饼增长的泥浆侵入数值模型,然后建立阵列感应测井数值模型,两者的联合正演模拟显示泥浆侵入对地层的影响可以反映在阵列感应测井响应上,利用阻尼最小二乘法对阵列感应测井响应进行反演可以得到侵入深度.对侵入深度和储层渗透率的关系进行分析发现:在渗透率为1~100mD(1mD=0.987×10^(-3)μm~2)数量级的储层中,渗透率的变化可以在侵入深度上得到反映.以储层和井数据进行二维数值模拟发现:利用阵列感应测井响应反演出来的侵入深度曲线反映了渗透率在地层上的变化趋势,采用解释图版的方法可以对储层各层段的渗透率进行粗略估算. | 周峰 孟庆鑫 胡祥云 Evert Slob 潘和平 马火林 | 2016 | 地球物理学报2016，59，11： | 4 |
| 10 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 11 | 利用比较基因组学定位马铃薯抗晚疫病主效基因R10显示文摘晚疫病是马铃薯第一大病害。马铃薯抗晚疫病基因R10抗谱广、应用价值大,常用于马铃薯抗病杂交育种。R10位点位于马铃薯11号染色体的短臂末端,与已克隆的抗晚疫病基因R3a同属于抗晚疫病主效位点的单倍型。对包含195个基因型的R10基因的分离群体进行了晚疫病菌株接种和遗传分析,确定R10为抗晚疫病菌株89148-9的主效单基因。应用比较基因组学和BSA分析,开发了6个与R10连锁的分子标记,并将R10定位在1001T和C2_At5g59960两个遗传距离为2.6cM分子标记之间。R10位于已克隆的抗晚疫病基因R3a的近端粒区。本研究所获得的遗传图谱为通过图位克隆和比较基因组学克隆R10基因打下基础。 | 徐建飞 王加加 李颖 金黎平 JACOBSEN Evert 黄三文 屈冬玉 | 2007 | 科技导报2007，25，17： | 3 |
| 12 | 马铃薯广谱抗病Rpi-blb1同源基因抗性被进化晚疫病菌株克服显示文摘马铃薯晚疫病广谱抗性基因Rpi-blb1(克隆于Solanum bulbocastanum)及其两个同源抗病基因Rpi-sto1(克隆于Solanum stoloniferum)和Rpi-pta1(克隆于Solanum papita)的抗性可能已被高度进化的晚疫病菌株所克服。为证实此观点,将从荷兰田间和墨西哥野外S.bulbocastanum和S.stoloniferum病株上采集的晚疫病菌株重新接种于具有共同遗传背景(感病栽培品种Desiree)的Rpi-blb1及其同源基因转化体和3个野生种植株上,测试Rpi-blb1及其同源基因的抗性是否已被克服。结果表明,采自墨西哥野外S.stoloniferum的两个菌株Pic99189和Pic99192已经克服了Rpi-blb1及其同源基因的抗性;在野生种植株的测试中,只有S.papita的抗性明显地被菌株Pic99192所克服。同时发现在转基因植株离体叶片接种试验中,高抗晚疫病菌的转化体需要在多个转化体间进行选择。从采自中国4个不同地区晚疫病菌株接种sto1.Desiree转化体的小规模测试中可推断,Rpi-blb1及其同源抗性基因在中国仍具有潜在的应用价值。 | 朱素贤 祝军 李颖 Nijenhuis Maarten Bergervoet Marjan Rietman Hendrik Jacobsen Evert | 2010 | 园艺学报2010，37，2： | 3 |
| 13 | “参阳”方辅助治疗口腔鳞状细胞癌的远期疗效评价显示文摘目的本研究旨在进一步评价综合序列治疗中加用中药“参阳”方对口腔鳞状细胞癌(简称鳞癌)患者的远期疗效。方法本组病例系初发口腔鳞癌患者,共238例。随机分为治疗组(参阳方)与对照组(安慰剂)。剔除术后未服满中药3个月患者17例,术后失访8例,实际研究病例数213例。其中治疗组104例,对照组109例。全组病例均经过5~10a以上随访(随访率为96.44%)。数据用Logrank法进行统计分析。结果“参阳”方组的3、5、8、10a生存率分别较对照组提高8.46%、9.26%、9.04%、8.57%,经统计学处理,P=0.1936,P>0.05,实际数据有延长生存率的趋势。结论术后服中药“参阳”方,有明显提高口腔鳞癌患者生存率的趋向,可作为综合序列治疗的辅助方法之一。 | 林国础 邱蔚六 陆昌语 郭一钦 曹阳 Walter.Guralnick Chung-Cheng.Hsich Thomas Albert Williarm C.Wood Edward Everts | 2003 | 上海口腔医学2003，12，5： | 2 |
| 14 | Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone显示文摘 | Evert V Delaisse J M Korper W | 1998 | J Bone Miner Rec1998，13，： | 1 |
| 15 | The natural history of a novel, systemic, disseminated model of syngeneic mouse B - cell lymphoma显示文摘 | PASSINEAU M J SIEGAL G P EVERTS M | 2005 | Leuk Lymphoma2005，46，11： | 1 |
| 16 | The effect of feeding different sources of crude fiber during pregnancy on the reproductive performance of sows显示文摘 | Everts H | 1991 | Anim prod1991，52，： | 1 |
| 17 | Particle overpassing on fiat granular boundaries 显示文摘 | EVERTS C H | 1973 | Journal of the Waterways Harbors and Coastal Engineering Di- vision1973，99，4： | 1 |
| 18 | Neoadjuvant Chemotherapy in Advanced Penile Carcinoma 显示文摘 | Joost A.P. Leijte J. Martijn Kerst Evert Bais Ninja Antonini Simon Horenblas | 2007 | European Urology2007，，： | 1 |
| 19 | Medical image matching-a review with classification显示文摘 | Van den P Evert Jan D P Viergever M | 1993 | IEEE Engineering in Medicine and Biology1993，12，1： | 1 |
| 20 | Economic burden of physical activity-related injuries in Dutch children aged 10-12显示文摘 | Dorine CM Collard Evert ALM Verhagen Willem van Mechelen | | 0，，： | 1 |
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