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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization显示文摘血管肉瘤是有差的预后的肝的一个稀罕的主要的恶意的瘤。这里,我们与被紧急情况对待的一个破裂的肝的血管肉瘤报导一个病人的一个案例指导导管的 embolization,由左边的偏身出汗列在后面。 | Christine Leowardi Yura Hormann UIf Hinz Moritz N Wente Peter Hallscheidt Christa Flechtenmacher Markus W Büchler Helmut Friess Matthias HM Schwarzbach | 2006 | World Journal of Gastroenterology2006，12，5： | 4 |
| 3 | 胰腺癌细胞株对氟尿嘧啶存在固有不敏感性显示文摘目的 研究胰腺癌细胞株是否对氟尿嘧啶 ( 5 - FU )具有固有或获得性不敏感。方法 用 SRB方法检测5 - FU对胰腺癌细胞株 As PC- 1、Capan- 1、Mia- Pa Ca- 2、Panc- 1和 T3 M4的毒性作用。结果 5 - FU对所有胰腺癌细胞株的 IC50 都很高 ,其中 Mia- Pa Ca- 2和 Panc- 1细胞株对 5 - FU最不敏感 ( IC50 =12 ,13 nmol/ L )。即使是在 5 - FU最敏感的 Capan- 1细胞株 ,其 IC50 仍相当高 ( 473 pm ol/ L)。这些细胞株对 5 - FU的 IC50 甚至高出其临床常用剂量给药时血浆药物浓度的 1~ 5 6倍。结论 大多数胰腺癌细胞株对 5 - FU固有不敏感 ,这些发现也许能作为临床上 5 - | 刘胜利 Helmut Friess Jorg Kleeff Markus W Bchler | 2002 | 中国药科大学学报2002，33，6： | 3 |
| 4 | The Neurotrophic Factor Artemin Promotes Pancreatic Cancer Invasion显示文摘 | Güralp O. Ceyhan Nathalia A. Giese Mert Erkan Annika G. Kerscher Moritz N. Wente Thomas Giese Markus W. Büchler Helmut Friess | 2006 | Annals of Surgery2006，，2： | 3 |
| 5 | Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases显示文摘 | J?rg Kleeff Markus K. Diener Kaspar Z?graggen Ulf Hinz Markus Wagner Jeannine Bachmann J?rg Zehetner Michael W. Müller Helmut Friess Markus W. Büchler | 2007 | Annals of Surgery2007，，4： | 3 |
| 6 | Autoimmune pancreatitis associated with a large pancreatic pseudocyst显示文摘Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, but often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal bile duct requiring repeated stent-ing. Because of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: < 37.0 U/L), the patient underwent explorative laparotomy and pylorus preserving partial pancreaticoduodenectomy. Histology revealed surprisingly AIP with an inflammatory pseudocyst. In conclusion, cyst fluid analysis of tumor markers and cyst fluid cytology lack high accuracy to clearly differentiate cystic pancreatic lesions. Although AIP is rarely associated with pseudocysts, the disease has to be considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures. | Thilo Welsch Jrg Kleeff Irene Esposito Markus W Büchler Helmut Friess | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 7 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 8 | Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma显示文摘 | Shailesh V. Shrikhande MD J?rg Kleeff MD Carolin Reiser MD Jürgen Weitz MD Ulf Hinz MSc Irene Esposito MD Jan Schmidt MD Helmut Friess MD Markus W. Büchler MD | 2007 | Annals of Surgical Oncology2007，，1： | 2 |
| 9 | A strategy for optimizing quality and quantity of DNA extracted from soil显示文摘 | Helmut Bürgmann Manuel Pesaro Franco Widmer Josef Zeyer | 2001 | Journal of Microbiological Methods2001，，1： | 2 |
| 10 | Ecological footprint time series of Austria, the Philippines, and South Korea for 1961–1999: comparing the conventional approach to an ‘actual land area’ approach显示文摘 | Mathis Wackernagel Chad Monfreda Karl-Heinz Erb Helmut Haberl Niels B Schulz | 2003 | Land Use Policy2003，，3： | 2 |
| 11 | Yes-associated protein (YAP65) in relation to Smad7 expression in humanpancreatic ductal adenocarcinoma显示文摘 | Junchao Guo J?rg Kleeff Yupei Zhao Junsheng Li Thomas Giese Irene Esposito Markus Büchler Murray Korc Helmut Friess | 2006 | International Journal of Molecular Medicine2006，，5： | 2 |
| 12 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 13 | The cause of land use and land cover change: moving beyond the myths显示文摘 | Eric F L Turner B L Helmut J G | 2001 | Global Environmental Change2001，11，4： | 1 |
| 14 | PAULRAJ:blind channel identification and equalization in OFDM-Based multiantenna systems显示文摘 | HELMUT B ROBERT W HEATH JR etal | 2002 | IEEE Transactions on Signal Processing2002，50，1： | 1 |
| 15 | How to do a safe pancreatic anastomosis显示文摘 | Kaspar Z'graggen Waldemar Uhl Helmut Friess Markus W. Büchler | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，6： | 1 |
| 16 | Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma显示文摘 | Helmut W Frieder B Ulrike R | 2006 | Ann Surg2006，244，2： | 1 |
| 17 | Differential expression of chemokines in normal pancreas and in chronic pancreatitis显示文摘 | Leslie Saurer Peter Reber Thomas Schaffner Markus W. Büchler Caroline Buri Andreas Kappeler Alfred Walz Helmut Friess Christoph Mueller | 2000 | Gastroenterology2000，，2： | 1 |
| 18 | Portal Vein Resection for Advanced Pancreatic Head Cancer显示文摘 | Jürgen Weitz Peter Kienle Jan Schmidt Helmut Friess Markus W. Büchler | 2007 | Journal of the American College of Surgeons2007，，4： | 1 |
| 19 | 5-Lipoxygenase and Leukotriene B 4 Receptor Are Expressed in Human Pancreatic Cancers But Not in Pancreatic Ducts in Normal Tissue显示文摘 | René Hennig Xian-Zhong Ding Wei-Gang Tong Matthias B. Schneider Jens Standop Helmut Friess Markus W. Büchler Parviz M. Pour Thomas E. Adrian | 2002 | The American Journal of Pathology2002，，2： | 1 |
| 20 | Progress report: A randomized multicenter European stydy comparing adjuvant radiotherapy, 6 Mo chemotherapy, and combination therapy vs No-adjuvant treatment in resectable pancreatic cancer (ESPAC-1)显示文摘 | John P. Neoptolemos Pat Baker Hans Beger Karl Link Paolo Pederzoli Claudio Bassi Christos Dervenis Helmut Friess Markus Büchler | 1997 | International Journal of Pancreatology1997，，2： | 1 |
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