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| 1 | Severe acute pancreatitis: Clinical course and management显示文摘Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%. | Hans G Beger Bettina M Rau | 2007 | World Journal of Gastroenterology2007，13，38： | 122 |
| 2 | 急性胰腺炎的外科治疗显示文摘 | Hans Guenther Beger Bettina Rau Rainer Isenmann Jens Mayer 刘斌 吴在德 | 2001 | 中华外科杂志2001，39，4： | 28 |
| 3 | 不同pH值培养液对肝细胞一氧化氮合成的影响显示文摘目的 探讨不同 pH值条件对肝细胞培养时一氧化氮 (NO)产生的影响及对肝细胞的损伤程度。方法 本研究首先将成年健康大鼠经静脉注射灭活有毒棒状杆菌 ,感染 4天后处死动物取肝脏作肝细胞分离并培养 ,2 4h后在培养液中加入L 精氨酸 ,同时将培养液调节成pH7.0、pH7.4及 pH7.8三组 ,又在每一 pH处理组中分出对照组 (CP组 )、大肠杆菌内毒素刺激组 (CP +LPS组 )及单甲基精氨酸抑制组 (CP +LPS +NMA组 ) ,继续培养 2 4h。结果 CP组产生约 10 0 μmol/L的NO ,pH值的改变对其无明显影响。在CP +LPS处理的肝细胞 ,pH7.4及 pH7.8组的值分别为 (2 39.3± 18) μmol/L及(2 2 8.4± 14.7) μmol/L ,显著高于pH7.0组 ((16 3.2± 5 .7) μmol/L ,P <0 .0 1)。加用NMA后 ,一氧化氮的产生明显减少 ,但三组间差异无显著性。加用LPS后肝细胞的损伤加重 ,pH7.0组LDH及ALT值显著高于 pH7.4及pH7.8组。当应用NMA抑制NO生成时 ,培养液中乳酸脱氢酶 (LDH)和丙氨酸转氨酶 (ALT)值显著升高 ,并以酸性组为明显。在CP组肝细胞 ,iNOS的产生量在三种不同 pH处理间无明显差别 ,加用LPS刺激后 ,iNOS的合成明显增加 ,而且酸性或碱性情况下iNOS的合成较 pH7.4时更高。结论 对处于炎症状态的肝细胞 ,酸性环境会抑制一氧化氮合成 。 | 舒志军 韩伏莅 Jung M Beger HG Nuessler AK | 2000 | 中华消化杂志2000，20，1： | 6 |
| 4 | Duodenum-preserving resection of the head of the pancreas in chronic pancreatitis with inflammatory mass in the head显示文摘 | Hans G. Beger M.D. F.A.C.S. Markus Büchler M.D | 1990 | World Journal of Surgery1990，，1： | 3 |
| 5 | Therapeutic Application of Caspase 1/Interleukin-1β-Converting Enzyme Inhibitor Decreases the Death Rate in Severe Acute Experimental Pancreatitis显示文摘 | Adam S. Paszkowski Bettina Rau Jens M. Mayer Peter M?ller Hans G. Beger | 2002 | Annals of Surgery2002，，1： | 2 |
| 6 | Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: High correlation of serum interleukin-18 with pancreatic necrosis and systemic complications显示文摘 | Bettina Rau Katja Baumgart Adam S. Paszkowski Jens M. Mayer Hans G. Beger | 2001 | Critical Care Medicine2001，，8： | 2 |
| 7 | Surgical treatment of infected necrosis显示文摘 | B. Rau W. Uhl M. W. Buchler H. G. Beger | 1997 | World Journal of Surgery1997，，2： | 2 |
| 8 | Prevention of severe change in acute pancreatitis: prediction and prevention显示文摘 | Hans G. Beger Bettina Rau Rainer Isenmann | 2001 | Journal of Hepato - Biliary - Pancreatic Surgery2001，，2： | 2 |
| 9 | Intraarterial Adjuvant Chemotherapy after Pancreaticoduodenectomy for Pancreatic Cancer: Significant Reduction in Occurrence of Liver Metastasis显示文摘 | Hans G. Beger Frank Gansauge Markus W. Büchler Karl Heinz Link | 1999 | World Journal of Surgery1999，，9： | 2 |
| 10 | Duodenum preserving head resection in chronic pancreatitis changes the natural course of the disease:a single-center 26-year experience显示文摘 | Beger HG Schlosser W Friess HM | 1999 | Ann Surg1999，230，4： | 1 |
| 11 | Treatment of pancreatic cancer:challenge of the facts显示文摘 | Beger HG Rau B Gansauge F | 2003 | World J Surg2003，27，10： | 1 |
| 12 | Necrosectomy and postoperative local larvae in mercerizing pancreatitis显示文摘 | Beger HG | 1988 | Br J Surg1988，75，3： | 1 |
| 13 | Necrosectomy and postoperative local lavage in patients with necrotizing pancreatitis: results of a prospective clinical trial 显示文摘 | Buchler M Bittner R | 1988 | World J Surg1988，2，： | 1 |
| 14 | Metabolic activation of the tu- morigenic pyrrolizidine alkaloid, monocmtaline, leading to DNA adduct formation in vivo显示文摘 | Wang Y P Yan J Beger R | 2005 | Cancer Lett2005，226，： | 1 |
| 15 | Natural course of acute pancreatitis显示文摘 | Beger HG Mayer J | 1997 | World J Surg1997，21，： | 1 |
| 16 | Duodenum-preserving head resection in chronic pancreatitis changes the natural course of t hd disease:a single-center 26-year experience 显示文摘 | Beger HG Schlosser W Friess HM | 1999 | Ann Surg1999，230，： | 1 |
| 17 | Early severe acute pancreatitis : characteristics of a new subgroup 显示文摘 | Isenmann R Rau B Beger HG | 2001 | Pancreas2001，22，3： | 1 |
| 18 | Natural course of acute pancreatitis显示文摘 | H. G. Beger B. Rau J. Mayer U. Pralle | 1997 | World Journal of Surgery1997，，2： | 1 |
| 19 | ComparisonofCA72-4 CA19-9 and CEA in the diagnosis and monitoring of gastric cancer显示文摘 | Safi F Kohns V Beger HG | 1995 | Intibiol markers1995，10，2： | 1 |
| 20 | Use of ^13CNMR spectrometric data to produce a predictive model of estrogen receptor binding activity 显示文摘 | Beger R D Freeman J P Lay Jr J O | 2001 | J Chem Inf Comput Sci2001，41，1： | 1 |
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