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| 1 | Improvement of gastric emptying by enhanced recovery after pancreaticoduodenectomy显示文摘BACKGROUND: Enhanced recovery after surgery(ERAS) has improved postoperative outcomes particularly in colorectal surgery. This study aimed to assess compliance with an ERAS protocol and evaluate its effect on postoperative outcomes in patients undergoing pancreaticoduodenectomy. METHODS: Fifty patients who had received conventional peri operative management from 2005 to 2009(conventional group)were compared with 75 patients who had received perioperative care with an ERAS protocol(fast-track group) from 2010 to2014. Mortality, complications, readmissions and length of hospital stay were evaluated and compared in the groups.RESULTS: Compliance with each element of the ERAS pro tocol ranged from 74.7% to 100%. Uneventful patients had a significant higher adherence to the ERAS protocol(87.5% vs40.7%; P<0.001). There were no significant differences in de mographics and perioperative characteristics between the two groups. Patients in the fast-track group had a shorter time to remove the nasogastric tube, start liquid diet and solid food pass flatus and stools, and remove drains. No difference was found in mortality, relaparotomy, readmission rates and over all morbidity. However, delayed gastric emptying and length of hospital stay were significantly reduced in the fast-track group. The independent effect of the ERAS protocol in reduc ing delayed gastric emptying and length of hospital stay was confirmed by multivariate analysis.CONCLUSION: ERAS pathway was feasible and safe in improving gastric emptying, yielding an earlier postoperative recovery, and reducing the length of hospital stay. | Efstratios Zouros Theodoros Liakakos Anastasios Machairas Paulos Patapis Christos Agalianos Christos Dervenis | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 16 |
| 2 | Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy:A review of the literature and critical reappraisal of the implicated pathomechanism显示文摘Pylorus-preserving pancreaticoduodenectomy (PPPD) is nowadays considered the treatment of choice for periampullary tumors, namely carcinoma of the head, neck, or uncinate process of the pancreas, the ampulla of Vater, distal common bile duct or carcinoma of the peri-Vaterian duodenum. Delayed gastric emptying (DGE) comprises one of the most troublesome complications of this procedure. A search of the literature using Pubmed/Medline was performed to identify clinical trials examining the incidence rate of DGE following standard Whipple pancreaticoduodenectomy (PD) vs PPPD. Additionally we performed a thorough in-depth analysis of the implicated pathomechanism underlying the occurrence of DGE after PPPD. In contrast to early studies, the majority of recently performed clinical trials demonstrated no significant association between the occurrence of DGE with either PD or PPPD. PD and PPPD procedures are equally effective operations regarding the postoperative occurrence of DGE. Further randomized trials are required to investigate the effi cacy of a recently reported (but not yet tested in large- scale studies) modifi cation, that is, PPPD with antecolic duodenojejunostomy. | Kosmas I Paraskevas Costas Avgerinos Costas Manes Dimitris Lytras Christos Dervenis | 2006 | World Journal of Gastroenterology2006，12，37： | 16 |
| 3 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005，，1： | 9 |
| 4 | Selection criteria for liver resection in patients with hepatocellular carcinoma and chronic liver disease显示文摘Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with an annual occurrence of one million new cases. An etiologic association between HBV infection and the development of HCC has been established with a relative risk 200-fold greater than in non-infected individuals. Hepatitis C virus is also proving an important predisposing factor for this malignancy with an incidence rate of 7% at 5 years and 14% at 10 years. The prognosis depends on tumor stage and degree of liver function, which affect the tolerance to invasive treatments. Although surgical resection is generally accepted as the treatment of choice for HCC, new treatment strategies, such as local ablative therapies, transarterial embolization and liver transplantation, have been developed nowadays. With increasing detection of small HCCs from screening programs for cirrhotic patients, it is foreseen that locoregional therapy will play an important role in the near future. | Spiros G Delis Christos Dervenis | 2008 | World Journal of Gastroenterology2008，14，22： | 7 |
| 5 | Current role of bloodless liver resection显示文摘Liver resections are demanding operations which can have life threatening complications although they are performed by experienced liver surgeons. Recently new technologies are applied in the field of liver surgery, having one goal: safer and easier liver operations. The aim of this article is to address the issue of bloodless liver resection using radiofrequency energy. Radionics, Cool-tipTM System and Tissue Link are some of the devices which are using radiofrequency energy. All information included in this article, refers to these devices in which we have personal experience in our unit of liver surgery. These devices take advantage of its unique combination of radiofrequency current and internal electrode cooling to perform sealing of the small vessels and biliary radicals. Dissection is also feasible with the cool-tip probe. For the purposes of this study patient sex, age, type of disease and type of surgical procedure in association with the duration of parenchymal transection, blood loss, length of hospital stay, morbidity and mortality were analyzed. Cool-tip RF device may provide a unique, simple and rather safe method of bloodless liver resections if used properly. It is indicated mostly in cirrhotic patients with challenging hepatectomies (segment Ⅷ, central resections). The total operative time is eliminated and the average blood loss is significantly decreased. It is important to note that this technique should not be applied near the hilum or the vena cava to avoid damage of these structures. | Spiros G Delis Juan Madariaga A Bakoyiannis Ch Dervenis | 2007 | World Journal of Gastroenterology2007，13，6： | 7 |
| 6 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005，，1： | 6 |
| 7 | Surgical resection of a solitary liver metastasis from nasopharyngeal carcinoma: a case report显示文摘BACKGROUND: Nasopharyngeal carcinoma (NPC) has a propensity to develop distant metastases at a high rate and with poor prognosis. Metastatic sites are usually multifocal and involve bones, lungs, liver and distant lymph nodes. Management of metastatic disease is essentially palliative and is based on chemotherapy. METHODS: A 50-year-old man with a solitary liver metastasis from a newly diagnosed NPC was treated by segmentectomy. Prior to surgery, neoadjuvant chemo therapy followed by concurrent chemoradiotherapy was administered. RESULTS: Complete remission of the primary disease was achieved, although the size of the hepatic lesion was increased. After resection of the liver metastasis, no signs of local or distant recurrence was noted during the 6-month follow up. CONCLUSION: Although surgical treatment has a limited role in metastatic NPC, there are rare cases of localized disease with a reasonable outcome after resection. | Spiros Delis Ioannis Biliatis Antonia Bourli Nikolaos Kapranos Christos Dervenis | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 4 |
| 8 | Rare cystic liver lesions: A diagnostic and managing challenge显示文摘Cystic formations within the liver are a frequent finding among populations.Besides the common cystic lesions,like simple liver cysts,rare cystic liver lesions like cystadenocarcinoma should also be considered in the differential diagnosis.Thorough knowledge of each entity’s nature and course are key elements to successful treatment.Detailed search in PubMed,Cochrane Database,and international published literature regarding rare cystic liver lesions was carried out.In our research are included not only primary rare lesions like cystadenoma,hydatid cyst,and polycystic liver disease,but also secondary ones like metastasis from gastrointestinal stromal tumors lesions.Up-to date knowledge regarding diagnosis and management of rare cystic liver lesions is provided.A diagnostic and therapeutic algorithm is also proposed.The need for a multidisciplinary approach by a team including radiologists and surgeons familiar with liver cystic entities,diagnostic tools,and treatment modalities is stressed.Patients with cystic liver lesions must be carefully evaluated by a multidisciplinary team,in order to receive the most appropriate treatment,since many cystic liver lesions have a malignant potential and evolution. | Andreas Bakoyiannis Spiros Delis Charina Triantopoulou Christos Dervenis | 2013 | World Journal of Gastroenterology2013，19，43： | 4 |
| 9 | Molecular aspects of carcinogenesis in pancreatic cancer显示文摘BACKGROUND:Pancreatic cancer(PCa)is one of the most aggressive human solid tumors,with rapid growth and metastatic spread as well as resistance to chemotherapeutic drugs,leading rapidly to virtually incurable disease.Over the last 20 years,however,significant advances have been made in our understanding of the molecular biology of PCa,with a focus on the cytogenetic abnormalities in PCa cell growth and differentiation. DATA SOURCES:A MEDLINE search and manual cross- referencing were utilized to identify published data for PCa molecular biology studies between 1986 and 2008, with emphasis on genetic alterations and developmental oncology. RESULTS:Activation of oncogenes,deregulation of tumor suppressor and genome maintenance genes,upregulation of growth factors/growth factor receptor signaling cascade systems,and alterations in cytokine expression,have been reported to play important roles in the process of pancreatic carcinogenesis.Alterations in the K-ras proto- oncogene and the p16INK4a,p53,FHIT,and DPC4 tumor suppressor genes occur in a high percentage of tumors. Furthermore,a variety of growth factors are expressed at increased levels.In addition,PCa often exhibits alterations in growth inhibitory pathways and evades apoptosis through p53 mutations and aberrant expression of apoptosis-regulating genes,such as members of the Bcl family.Additional pathways in the development of an aggressive phenotype,local infiltration and metastasis are still under ongoing genetic research.The present paper reviews recent studies on the pathogenesis of PCa,and includes a brief reference to alterations reported for other types of pancreatic tumor. CONCLUSIONS:Advances in molecular genetics and biology have improved our perception of the pathogenesis of PCa.However,further studies are needed to better understand the fundamental changes that occur in PCa,thus leading to better diagnostic and therapeutic management. | Alexandros Koliopanos Constantinos Avgerinos Constantina Paraskeva Zisis Touloumis Dionisisa Kelgiorgi Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 4 |
| 10 | Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)显示文摘 | Moritz N. Wente Claudio Bassi Christos Dervenis Abe Fingerhut Dirk J. Gouma Jakob R. Izbicki John P. Neoptolemos Robert T. Padbury Michael G. Sarr L. William Traverso Charles J. Yeo Markus W. Büchler | 2007 | Surgery2007，，5： | 4 |
| 11 | Diagnosis, objective assessment of severity, and management of acute pancreatitis显示文摘 | C. Dervenis C. D. Johnson C. Bassi E. Bradley C. W. Imrie M. J. McMahon I. Modlin | 1999 | International Journal of Pancreatology1999，，3： | 4 |
| 12 | Radical resection of pancreatic cancer显示文摘BACKGROUND: Pancreatic adenocarcinoma (PCa) is a disease with dismal prognosis, and the only possibility of cure, albeit small, is based on the combination of complete resection with negative histopathological margins (R0 resection) with adjuvant treatment. Therefore, a lot of effort has been made during the last decade to assess the role of extensive surgery in both local recurrence and survival of patients with PCa. DATA SOURCES: Medline search and manual cross- referencing were utilized to identify published evidence- based data for PCa surgery between 1973 and 2006, with emphasis to feasibility, efficacy, long-term survival, disease free survival, recurrence rates, pain relief and quality of life. RESULTS: Extended surgery is safe and feasible in high volume surgical centers with comparable short-term results. Organ preserving surgery is a main goal because of quality of life reasons and is performed whenever possible from the tumor extent. Concerning long-term survival major vein resection does not adversely affect outcome. To date, there are no changes in long-term survival attributed to the extended lymph node dissection. However, there is a benefit in locoregional control with fewer local recurrences and extended lymphadenectomy allows better staging for the disease. CONCLUSIONS: Extended PCa surgery is safe and feasible despite the inconclusive results in patient's survival benefit. In the future, appropriately powered randomized trials of standard vs. extended resections may show improved outcomes for PCa patients. | Alexander Koliopanos C Avgerinos Athanasios Farfaras C Manes Christos Dervenis | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 4 |
| 13 | The New Revised Classification of Acute Pancreatitis 2012显示文摘 | Michael G. Sarr Peter A. Banks Thomas L. Bollen Christos Dervenis Hein G. Gooszen Colin D. Johnson Gregory G. Tsiotos Santhi Swaroop Vege | 2013 | Surgical Clinics of North America2013，，3： | 3 |
| 14 | Postpancreatectomy hemorrhage (PPH)–An International Study Group of Pancreatic Surgery (ISGPS) definition显示文摘 | Moritz N. Wente Johannes A. Veit Claudio Bassi Christos Dervenis Abe Fingerhut Dirk J. Gouma Jakob R. Izbicki John P. Neoptolemos Robert T. Padbury Michael G. Sarr Charles J. Yeo Markus W. Büchler | 2007 | Surgery2007，，1： | 2 |
| 15 | Ventral colporectopexy for overt rectal prolapse and obstructed defaecation syndrome: a systematic review显示文摘 | N. Gouvas P. A. Georgiou C. Agalianos E. Tan P. Tekkis C. Dervenis E. Xynos | 2015 | Colorectal Dis2015，，2： | 2 |
| 16 | Hatzitheoklitos bacterial translocation and its prevention in acute pancreatitis 显示文摘 | Dervenis C Smailis D | 2003 | J Hepatobiliary Pancreat Surg2003，10，6： | 1 |
| 17 | Postoperative pancreatic fistula:an international study group(ISGPF) definition显示文摘 | Bassi C Dervenis C Butturini G | 2005 | Surg2005，138，1： | 1 |
| 18 | Postoperative pancreatic fistula:an international study group (ISGPF) definition显示文摘 | Bassi C Dervenis C Butturini G | 2005 | Surgery2005，138，1： | 1 |
| 19 | Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery ( ISGPS ) 显示文摘 | Wente MN Bassi C Dervenis C | 2007 | Surgery2007，142，5： | 1 |
| 20 | Postoperative pancreatic fistula:an international study group(1SGPF) defini- tion 显示文摘 | BASSI C DERVENIS C BURUFINI G | 2005 | Surge y2005，138，1： | 1 |
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