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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Metal-dielectric-metal plasmonic waveguide devices for manipulating light at the nanoscale显示文摘We review some of the recent advances in the development of subwavelength plasmonic devices for manipulatinglight at the nanoscale,drawing examples from our own work in metal-dielectric-metal (MDM)plasmonic waveguide devices.We introduce bends,splitters,and mode converters for MDM waveguideswith no additional loss.We also demonstrate that optical gain provides a mechanism for on/off switchingin MDM plasmonic waveguides.Highly efficient compact couplers between dielectric waveguides andMDM waveguides are also introduced. | Georgios Veronis Zongfu Yu Sukru Ekin Kocaba David A. B. Miller Mark L. Brongersma Shanhui Fan | 2009 | Chinese Optics Letters2009，7，4： | 7 |
| 3 | Comparison of intraperitoneal and intratesticular ozone therapy for the treatment of testicular ischemia-reperfusion injury in rats显示文摘我们在一个试验性的老鼠模型把 intratesticular 臭氧治疗的功效与 intraperitoneal 臭氧治疗作比较。为这个目的, 24 只老鼠加 intratesticular 臭氧(O 信息技术) 包括假冒操作, torsion/detorsion,加 intraperitoneal 臭氧(O-IP ) 的 torsion/detorsion,和 torsion/detorsion 被划分成四个组。O-IP 臭氧组收到了臭氧的 4 mg kg −1 intraperitoneal 注射,并且 O 信息技术组 epididymally 收到了一样的注射。在在 detorsion 以后的 4 h,老鼠被牺牲, orchiectomy 材料组织病理学说地被估计。在到 Sertoli 房间的生精的小管和损坏的精子发生组织病理学说地用 Johnsen 得分系统在睾丸被评估。我 -- 在睾丸织物的 NOS 和电子 NOS 活动也被评估。Torsion-detorsion 引起了一个减少的 Johnsen 分数并且增加了 spermatogonial 和 Sertoli 房间的 apoptosis。阻止的臭氧注射在 Johnsen 分数和 i 增加 -- NOS 水平。O-IP 组的电子 NOS 水平比 O-IP 组,和 i 的显著地低 --O 信息技术组的 NOS 水平比 O-IP 组的显著地低。本地臭氧治疗是比在改进 IRI 相关的阴囊的扭转的全身的臭氧治疗更有效的。我们的学习是第一证明臭氧治疗的 intratesticular 实现的功效比 intraperitoneal 臭氧治疗的高。 | Fatih Mete Huseyin Tarhan Orcun Celik Ilker Akarken Kamil Vural Rahmi Gokhan Ekin Isil Aydemir Yusuf Ozlem Ilbey | 2017 | Asian Journal of Andrology2017，19，1： | 5 |
| 4 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 5 | Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells显示文摘 | Güralp O. Ceyhan Ihsan Ekin Demir Burak Altintas Ulrich Rauch Gerald Thiel Michael W. Müller Nathalia A. Giese Helmut Friess Karl-Herbert Sch?fer | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 2 |
| 6 | Zero emissions of oil in water from offshore oil and gas installations: economic and environmental implications显示文摘 | Paul Ekins Robin Vanner James Firebrace | 2006 | Journal of Cleaner Production2006，，13： | 2 |
| 7 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 8 | AnempiricalinVestigationoftheTurkishconsumer’sacceptanceofInternetbankingservice显示文摘 | PolatogluVN EkinS | 2001 | TheInternationalJournalofBankMarketing2001，19，45： | 1 |
| 9 | Further characterization of the expression in liver and catalytic activity of CYP 26B显示文摘 | Ekins S VandenBranden M Ring BJ | 1998 | J Pharmacol Exp Ther1998，266，： | 1 |
| 10 | Binding of thyrotropin to receptors in fat tissue显示文摘 | Gill DL Marshall NJ Ekins RP | 1978 | Mol Cell Endocrinol1978，10，1： | 1 |
| 11 | More sensitive Immunoassay显示文摘 | Ekins RP | 1990 | Nature1990，284，： | 1 |
| 12 | Treatment options in painful chronic pancreatitis: a systematic review显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Elke Tieftrunk Helmut Friess | 2014 | HPB2014，，6： | 1 |
| 13 | Identifying critical natural capital: conclusions about critical natural eapital显示文摘 | Ekins P | 2003 | Ecolngieal Economics2003，44，： | 1 |
| 14 | Using a choice experiment to account for preference heterogeneity in wetland attributes: The case of Cheimaditida wetland in Greece 显示文摘 | Ekin Birol Katia Karousakis Phoebe Koundouri | 2006 | Ecological Economics2006，60，： | 1 |
| 15 | Iron acquisition by Acti- nobacillus suis Identification and characterization of transfer-rin receptor proteins and encoding genes显示文摘 | Bahrami F Ekins A Niven D F | 2003 | Vet Microbiol2003，94，： | 1 |
| 16 | Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites 显示文摘 | Ekins S de Groot M J Jones JP | 2001 | Drug Metab Dispos2001，29，： | 1 |
| 17 | Synthesis and characterization of novel hydroxyalkyl carbamate and dihydroxyalkyl carbamate terminated poly (dimethylsiloxane) oligomers and their block copolymers with poly (Ecarproactone) 显示文摘 | Ekin A Webster D C | 2006 | Macromolecules2006，39，： | 1 |
| 18 | A pharmacophore for humanPregnane X Receptor ligands显示文摘 | Ekins S Erickson JA | 2002 | Drug Metab Dis-pos2002，30，1： | 1 |
| 19 | Eco-innovation for Environmental Sustainability:Concepts,Progress and Policies显示文摘 | Ekins P | 2010 | Int Econ Econ Policy2010，，7： | 1 |
| 20 | Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrume P450 active sitcs显示文摘 | Ekins S De Groot M J Jones J P | 2001 | Drug Mctab Dispos2001，29，： | 1 |
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