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| 1 | 预防性回肠造口在直肠癌超低位前切除术中的应用价值显示文摘目的探讨预防性回肠造口降低直肠癌超低位前切除术后吻合口瘘发生率的临床价值。方法回顾性分析8年间行直肠癌超低位前切除术98例患者的临床资料。比较实施预防性回肠造口组(A)45例和未实施组(B)53例两组间吻合口瘘发生率的差异。结果A组仅1例发生吻合口瘘(2.2%);B组11例发生吻合口瘘(20.8%)(P(0.05)。结论有选择的预防性回肠造口,可有效降低直肠癌超低位前切除术后吻合口瘘的发生率。 | 阎玉矿 Helmut Friess Jrg Kleeff | 2007 | 中国普通外科杂志2007，16，4： | 20 |
| 2 | 胰腺的癌症病人的反应评估追随者 neoadjuvant 治疗显示文摘 Pancreatic ductal adenocarcinoma(PDAC) is one of the most aggressive human neoplastic entities,with a very poor prognosis characterized by a high mortality rate and short survival.This is due both to its aggressive biological behaviour and the high incidence of locally advanced stages at the time of the initial diagnosis.The limits of resectability and the role of neoadjuvant(radio) chemotherapy for PDAC management are still unclear.A recently published article by Kats et al compared the radiological,surgical and histopathological results of 129 patients with borderline resectable tumors undergoing neoadjuvant treatment followed by surgery.Although post-neoadjuvant treatment imaging implied a low response rate,a high rate of complete resections was achieved.This seems to confirm that,though radiology has made a significant progress in defining locally advanced PDAC,there is place for further improvement.In particular,the differentiation between radiotherapy-induced scarring/fibrosis and cancer-associated desmoplasia remains a clinical/radiological challenge.Though selection of patients with occult systemic disease is possible with neoadjuvant treatment,downstaging does not seem to occur frequently.Thus,development of novel,more aggressive(radio) chemotherapy regimens is required to improve prognosis of patients with locally unresectable but not systemically micro-metastasized tumors. | Chiara Tosolini Christoph W Michalski Jrg Kleeff | 2013 | World Journal of Gastrointestinal Surgery2013，5，2： | 7 |
| 3 | Update on surgical treatment of pancreatic neuroendocrine neoplasms显示文摘Pancreatic neuroendocrine neoplasms(PNENs) are rare and account for only 2%-4% of all pancreatic neoplasms. All PNENs are potential(neurendocrine tumors PNETs) or overt(neuroendocrine carcinomas PNECs) malignant,but a subset of PNETs is low-risk. Even in case of low-risk PNETs surgical resection is frequently required to treat hormone-related symptoms and to obtain an appropriate pathological diagnosis. Low-risk PNETs in the body and the tail are ideal for minimallyinvasive approaches which should be tailored to the individual patient. Generally,surgeons must aim for parenchyma sparing in these cases. In high-risk and malignant PNENs,indications for tumor resection are much wider than for pancreatic adenocarcinoma,in many cases due to the relatively benign tumor biology. Thus,patients with locally advanced and metastatic PNETs may benefit from extensive resection. In experienced hands,even multi-organ resections are accomplished with acceptable perioperative morbidity and mortality rates and are associated with excellent long term survival. However,poorly differentiated neoplasms with high proliferation rates are associated with a dismal prognosis and may frequently only be treated with chemotherapy. The evidence on surgical treatment of PNENs stems from reviews of mostly singlecenter series and some analyses of nation-wide tumor registries. No randomized trial has been performed to compare surgical and non-surgical therapies in potentially resectable PNEN. Though such a trial would principally be desirable,ethical considerations and the heterogeneity of PNENs preclude realization of such a study. In the current review,we summarize recent advances in the surgical treatment of PNENs. | Jan G D’Haese Chiara Tosolini Güralp O Ceyhan Bo Kong Irene Esposito Christoph W Michalski J?rg Kleeff | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 4 | P物质及其受体在胰腺癌细胞中的表达显示文摘目的 了解P物质(SP)、神经激肽-1受体(NK-1R)及中性肽链内切酶(NEP)在胰腺癌细胞中表达。方法应用实时定量逆转录-聚合酶链反应(RQ-RT-PCR)技术,检测正常胰腺、胰腺癌组织和7株胰腺癌细胞中前速激肽原A(PPT-A)、NK-1R和NEP的mRNA表达,应用Westernblot检测NK-1R和NEP的蛋白水平。结果正常胰腺组织PPT-A的mRNA表达水平为0.430 0±0.464 7,胰腺癌组织中为1.790 0±1.833 1(P<0.05);正常胰腺NK-1R的mRNA表达水平为0.088 2±0.086 8,胰腺癌组织中为2.154 5±2.103 1(P<0.01);正常胰腺组织NEP的mRNA表达水平为3.234 7±6.301 0,胰腺癌为8.606 9±8.703 2(P>0.05)。Western Blot结果发现,胰腺癌组织中NK-1R蛋白也过度表达,而NEP的蛋白水平未相应上调。结论 胰腺癌组织中SP和NK-1R都明显上调,而SP的降解酶——NEP未相应上调,这表明胰腺癌组织中SP的产生与灭活的平衡被打破,产生过多的SP,发挥过度的生物学效应。 | 石欣 裴斐 高乃荣 Friess Helmut Kleeff Jorg Buchler Markus | 2003 | 中华实验外科杂志2003，20，2： | 4 |
| 5 | Surgical approaches for resection of pancreatic cancer: an overview显示文摘Objective: To overview the different surgical approach-es for the resection of pancreatic cancer and our expe-rience with these techniques.Methods: Surgical procedures including the Whipple re-section, pylorus-preserving resection, total and subto-tal panreatectomies, regional pancreatectomy and theextended lymph node resection were discussed.Results: Studies have shown that no operation seems toproduce significantly improved results in terms of sur-vival, mortality and resection rates compared to thestandard Whipple resection and pylorus-preservingduodenopancreatectomy.Conclusion: Despite the progress in the surgical treat-ment of pancreatic cancer, the overall prognosis afterresection remains unsatisfied. Surgery is likely to beoptional for the treatment of pancreatic cancer. | Helmut Friess Jrg Kleeff Markus W Buchler | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，1： | 3 |
| 6 | 胰腺癌细胞株对氟尿嘧啶存在固有不敏感性显示文摘目的 研究胰腺癌细胞株是否对氟尿嘧啶 ( 5 - FU )具有固有或获得性不敏感。方法 用 SRB方法检测5 - FU对胰腺癌细胞株 As PC- 1、Capan- 1、Mia- Pa Ca- 2、Panc- 1和 T3 M4的毒性作用。结果 5 - FU对所有胰腺癌细胞株的 IC50 都很高 ,其中 Mia- Pa Ca- 2和 Panc- 1细胞株对 5 - FU最不敏感 ( IC50 =12 ,13 nmol/ L )。即使是在 5 - FU最敏感的 Capan- 1细胞株 ,其 IC50 仍相当高 ( 473 pm ol/ L)。这些细胞株对 5 - FU的 IC50 甚至高出其临床常用剂量给药时血浆药物浓度的 1~ 5 6倍。结论 大多数胰腺癌细胞株对 5 - FU固有不敏感 ,这些发现也许能作为临床上 5 - | 刘胜利 Helmut Friess Jorg Kleeff Markus W Bchler | 2002 | 中国药科大学学报2002，33，6： | 3 |
| 7 | Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases显示文摘 | J?rg Kleeff Markus K. Diener Kaspar Z?graggen Ulf Hinz Markus Wagner Jeannine Bachmann J?rg Zehetner Michael W. Müller Helmut Friess Markus W. Büchler | 2007 | Annals of Surgery2007，，4： | 3 |
| 8 | 胰腺癌细胞对5氟脲嘧啶和健择的获得性耐药机制的研究显示文摘目的探讨胰腺癌细胞对 5氟脲嘧啶 (5 FU)和健择产生获得性耐药的机制。方法用磺酰罗丹明B蛋白染色法检测细胞毒性作用 ,根据药物剂量与细胞生存的关系计算 5 0 %抑制浓度(IC50 ) ;用RNA酶保护分析和Westernblot法来检测Bcl xL和mcl 1的表达水平。结果 5 FU和健择对 3株胰腺癌细胞均产生了细胞毒性作用。 5 FU长期作用后 ,Capan 1细胞IC50 上升了 2 1倍 (P <0 0 5 ) ;健择长期作用后 ,Capan 1细胞IC50 上升了 1 8倍 (P <0 0 5 ) ;而Mia Paca 2细胞在 5 FU和健择作用前后IC50 明显降低 (P <0 0 5 )。产生获得性耐药细胞的Bcl xL 和mcl 1的表达均上调。结论胰腺癌细胞对 5 FU相对耐药 ,而对健择较为敏感。化疗药物长期作用后 ,抑凋亡基因Bcl xL和mcl 1的表达上调 ,胰腺癌细胞产生了获得性耐药。 | 石欣 高乃荣 霍明东 胡浩霖 Friess Helmut Kleeff Jorg Buchler Markus | 2003 | 中华普通外科杂志2003，18，1： | 3 |
| 9 | Autoimmune pancreatitis associated with a large pancreatic pseudocyst显示文摘Pancreatic cystic lesions comprise various entities with different histopathological characteristics and their dif-ferential diagnosis is often a challenge for clinicians. Autoimmune pancreatitis (AIP) is usually not considered in the differential diagnosis of cystic lesions, but often mimics the morphological aspects of pancreatic neo-plasm. We report the case of a 64-year-old male patient with a cystic pancreatic head lesion (diameter 5 cm) and stenosis of the distal bile duct requiring repeated stent-ing. Because of the clinical presentation together with moderate elevation of serum CA19-9 and massive eleva-tion of cyst fluid CA19-9 (122.695 U/L; normal range: < 37.0 U/L), the patient underwent explorative laparotomy and pylorus preserving partial pancreaticoduodenectomy. Histology revealed surprisingly AIP with an inflammatory pseudocyst. In conclusion, cyst fluid analysis of tumor markers and cyst fluid cytology lack high accuracy to clearly differentiate cystic pancreatic lesions. Although AIP is rarely associated with pseudocysts, the disease has to be considered in the differential diagnosis of cys-tic pancreatic lesions. Early examination of serum IgG, IgG4 and auto-antibodies might save these patients from unnecessary endoscopical and surgical procedures. | Thilo Welsch Jrg Kleeff Irene Esposito Markus W Büchler Helmut Friess | 2006 | World Journal of Gastroenterology2006，12，36： | 2 |
| 10 | Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma显示文摘 | Shailesh V. Shrikhande MD J?rg Kleeff MD Carolin Reiser MD Jürgen Weitz MD Ulf Hinz MSc Irene Esposito MD Jan Schmidt MD Helmut Friess MD Markus W. Büchler MD | 2007 | Annals of Surgical Oncology2007，，1： | 2 |
| 11 | Fast Track—Different Implications in Pancreatic Surgery显示文摘 | P. O. Berberat H. Ingold A. Gulbinas J. Kleeff M. W. Müller C. Gutt M. Weigand H. Friess M. W. Büchler | 2007 | Journal of Gastrointestinal Surgery2007，，： | 2 |
| 12 | 软骨寡聚基质蛋白在慢性胰腺炎损伤中退变腺泡细胞内的表达显示文摘目的 研究正常胰腺、慢性胰腺炎与胰腺癌组织中软骨寡聚基质蛋白 (cartilageoligomericmatrixprotein ,COMP)mRNA和蛋白表达水平的差异 ,揭示COMP在慢性胰腺炎样损伤中的意义。 方法 采用Northern印迹法、Western印迹法、原位杂交法与免疫组化方法对 14例慢性胰腺炎、14例胰腺癌及 15例正常胰腺组织进行分析。 结果 在慢性胰腺炎组织中和胰腺癌组织中类似慢性胰腺炎损伤的退变腺泡细胞胞浆内 ,存在高水平的COMPmRNA信号与免疫反应 ;而在胰腺癌细胞、正常胰腺组织的导管细胞与胰岛细胞的胞浆内 ,COMPmRNA信号与免疫反应微弱或缺如。结论 COMP在慢性胰腺炎及胰腺癌中类似慢性胰腺炎损伤的退变腺泡细胞内高表达 ,可能与慢性胰腺炎中腺泡细胞功能异常有关。 | 廖泉 赵玉沛 Jorg Kleeff 肖毅 Arthur Zimmermann Markus W.Buchler Helmut Friess | 2003 | 中华外科杂志2003，41，5： | 2 |
| 13 | Yes-associated protein (YAP65) in relation to Smad7 expression in humanpancreatic ductal adenocarcinoma显示文摘 | Junchao Guo J?rg Kleeff Yupei Zhao Junsheng Li Thomas Giese Irene Esposito Markus Büchler Murray Korc Helmut Friess | 2006 | International Journal of Molecular Medicine2006，，5： | 2 |
| 14 | Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma显示文摘 | Mert Erkan Carolin Reiser-Erkan Christoph W. Michalski Stefanie Deucker Danguole Sauliunaite Sylvia Streit Irene Esposito Helmut Friess J?rg Kleeff | 2009 | Neoplasia2009，，： | 2 |
| 15 | Id-1 and Id-2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis 显示文摘 | Kleeff J Wildi S | 1999 | Am J Pathol1999，155，3： | 1 |
| 16 | Most pancreatic cancer resections are R1 resections 显示文摘 | Esposito I Kleeff J Bergmann F | 2008 | Ann Surg Oncol2008，15，6： | 1 |
| 17 | Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer显示文摘 | Michalski CW Kleeff J Wente MN | | 0，，03： | 1 |
| 18 | The helix-loop-helix protein Id2 is over expressed in human pancreatic cancer显示文摘 | Kleeff J Ishiwata T Friess H | 1998 | Cancer Res1998，58，17： | 1 |
| 19 | Expression analysis of MAC30in human pancreatic cancer and tumors of the gastro-intestinal tract显示文摘 | Kayed H Kleeff J Ding J | 2004 | Histol Histopathol2004，19，4： | 1 |
| 20 | Most pancreatic cancer resections are R1 resections 显示文摘 | Esposito I Kleeff J Bergmann F | 2008 | Ann Surg Oncol2008，15，6： | 1 |
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