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| 1 | 美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准显示文摘背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 | Vladimir Hachinski Costantino Iadecola Ron C.Petersen Monique M.Breteler David L.Nyenhuis Sandra E.Black William J.Powers Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters David M.Holtzman Gary A.Rosenberg Martin Dichgans John R.Marler Gabrielle G.Leblanc 李焰生(译) 俞羚(译) 高枚春(译) 张静芳(译) 熊昕丽(译) 邹静(译) 林岩(译) 潘元美(译) | 2007 | 国际脑血管病杂志2007，15，1： | 63 |
| 2 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 3 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 4 | Final anatomic and visual outcomes appear independent of duration of silicone oil intraocular tamponade in complex retinal detachment surgery显示文摘AIM: To report anatomic and visual outcomes following silicone oil removal in a cohort of patients with complex retinal detachment, to determine association between duration of tamponade and outcomes and to compare patients with oil removed and those with oil in situ in terms of demographic, surgical and visual factors. METHODS: We reported a four years retrospective case series of 143 patients with complex retinal detachments who underwent intraocular silicone oil tamponade. Analysis between anatomic and visual outcomes, baseline demographics, duration of tamponade and number of surgical procedures were carried out using Fisher's exact test and unpaired two-tailed t-test. RESULTS: One hundred and six patients(76.2%) had undergone silicone oil removal at the time of review with 96 patients(90.6%) showing retinal reattachment following oil removal. Duration of tamponade was not associated with final reattachment rate or with a deterioration in best corrected visual acuity(BCVA). Patients with oil removed had a significantly better baseline and final BCVA compared to those under oil tamponade(P=0.0001, <0.0001 respectively). CONCLUSION: Anatomic and visual outcomes in this cohort are in keeping with those reported in the literature. Favorable outcomes were seen with oil removal but duration of oil tamponade does not affect final attachment rate with modern surgical techniques and should be managed on a case by case basis. | Maedbh Rhatigan Elizabeth Mc Elnea Patrick Murtagh Kirk Stephenson Elaine Harris Paul Connell David Keegan | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 7 |
| 5 | Two centuries of April-July temperature change in southeastern China and its influence on grain productivity显示文摘China is a traditional agriculture based country and one main region for crop production is southeastern China where temperature is a dominant climate variable affecting agriculture. Temperature and social disturbances both influence crop production, yet distinguishing their relative impacts is difficult due to a lack of reliable, high-resolution historical climatic records before the very recent period. Here we present the first tree-ring based warm-season temperature reconstruction for southeastern China, a core region of the East Asian monsoon, for the past 227 years. The reconstruction target was April-July mean temperature, and our model explained 60.6% of the observed temperature variance during 1953–2012.Spatial correlation analysis showed that the reconstruction is representative of April-July temperature change over most of eastern China. The reconstructed temperature series agrees well with China-scale(heavily weighted in eastern China) agricultural production index values quite well at decadal timescales.The impacts of social upheavals on food production, such as those in the period 1920–1949, were confirmed after climatic influences were excluded. Our study should help distinguish the influence of social disturbance and warm-season temperature on grain productivity in the core agricultural region of China during the past two centuries. | Jiangfeng Shi Jinbao Li David D.Zhang Jingyun Zheng Shiyuan Shi Quansheng Ge Harry F.Lee Yesi Zhao Jie Zhang Huayu Lu | 2017 | Science Bulletin2017，62，1： | 6 |
| 6 | 红曲对中度血脂升高美国人调节血脂作用的临床研究显示文摘[目的]评价在饮食控制的情况下红曲(RYRCholestin)对美国高血脂人群的降脂作用和安全性。[方法]开放标记,自身对照,多中心临床试验。187名美国高血脂人群入选(血清低密度脂蛋白胆固醇3.50—4.92mmol/L,总胆固醇5.18—7.25mmol/L;男116人,女71人),162入完成试验。在整个试验中受试者遵照美国国家胆固醇教育计划的饮食要求。试验的前4周仅控制饮食,第5周至第12周连续服用8周RYRCholestin(每日2.4g)。[结果]经前4周饮食控制,血清脂质各指标无显著变化。口服RYRCholestin8周后,血清总胆固醇、低密度脂蛋白胆固醇和三酰甘油分别降低16.6%,24.O%和25.2%,高密度脂蛋白胆固醇升高14.3%(P〈0.001)。显效率为79.0%,有效率为97.5%。停服14d(2周)后,血脂各指标回到试验前水平。试验中共发现可能与服用产品相关的、轻度的29项不良反应。[结论]RYRCholestin的耐受性良好,它可降低血清总胆固醇、低密度脂蛋白胆固醇和三酰甘油,升高血清高密度脂蛋白胆固醇。停服2用后受试者的血脂各项指标均恢复到试验前水平。 | 陆继红 Kermit Bonovich Harry Colfer Michael Davidson Carlos A.Dujovne David L.Fried Mitchell Greenspan Ronald P.Karlsberg Stephen P.King Craig F.LaForce Marc Litt J.Robert McGhee 曾润海 朱佳石 谈宁芝 | 2013 | 上海预防医学2013，25，9： | 5 |
| 7 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 8 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 9 | 桡骨远端骨折——磷酸钙骨水泥注射与常规治疗的比较显示文摘最近的一些随机试验表明,新鲜桡骨远端骨折采用Norian骨骼修复系统(SRS),即磷酸钙骨水泥治疗,其临床效果优于常规方法,而且术后疼痛减轻。关于再移位骨折的小型研究发现:采用磷酸钙骨水泥握力和活动度恢复加快,但不同方法间的疼痛没有差异。对再移位骨折还需要进行更大型的研究。 | Suthorn Bavonratanavech Ian Harris David L.Helfet 陈国奋 顾立强 | 2005 | 中华创伤骨科杂志2005，7，4： | 5 |
| 10 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 11 | Downscaling and Disaggregating NAO-conflict Nexus in Pre-industrial Europe显示文摘Recently, the desiccation effect of the North Atlantic Oscillation(NAO) is found to be positively correlated with violent conflict in pre-industrial Europe, with agricultural shrinkage and its subsequent economic shocks to be their causal link. However, it remains unexplored whether the correlation persists if the study period is extended backward in time, a different definition of violent conflict is applied, or the relationship is examined at lower geographic levels. In this study, we based on 835 internal disturbance incidents in Europe during 1049–1800 to conduct long-temporal and multi-scalar examination on the NAO-conflict nexus. ′Time-series′ and ′panel data′ disaggregation approaches, together with Granger Causality, Multiple Regression, and Survival Analyses were applied to verify the nexus quantitatively. Results show that the positive NAO-conflict correlation was significant at the continent and physiographic zone levels. During the positive NAO phases, the annual probability of internal disturbance outbreak increased by 70.0% in the southern Europe and the Mediterranean, a zone most affected by the NAO-induced desiccation effect. Yet, the NAO-conflict correlation was rather inconsistent when it was downscaled to the sub-regional level. Moreover, the NAO-conflict correlation was inflated under the time-series approach, while the panel data approach demonstrated the region-specific nature of the NAO forcing more clearly. The associated implications in examining climate-conflict nexus are discussed. Our findings may be crucial in examining violent conflict in the northwestern Africa, a highly agricultural region affected by the NAO. | Harry Fung LEE ZHANG David Dian PEI Qing FEI Jie | 2016 | Chinese Geographical Science2016，26，5： | 5 |
| 12 | 胫骨平台骨折采用可注射磷酸钙骨水泥治疗显示文摘胫骨平台骨折采用磷酸钙骨水泥治疗后的继发复位丢失率7%~33%。Lysholm评分优良率为57%~81%。两篇小样本量的回顾性群组研究表明:与拱形钢板内固定植骨相比较,使用磷酸钙骨水泥治疗能缩短手术时间。在复位丢失率方面,是否使用磷酸钙骨水泥比植骨更具优势还不确定。这就需要进行大样本量的严格对照研究,来确定骨修复系统(SRS)的安全、有效及是否更优于植骨术。 | lan Harris David L Helfet | 2008 | 中华创伤骨科杂志2008，10，1： | 3 |
| 13 | Quantitative analysis of the impact of droughts and floods on internal wars in China over the last 500 years显示文摘Although many large-N quantitative studies have evidenced the adverse effects of climatic extremes on social stability in China during the historical period, most of them rely on temperature and precipitation as major explanatory variables, while the influence of floods and droughts on social crises is rarely measured. Furthermore, a comparison of the climate-society nexus among different geographic regions and at different temporal scales is missing in those studies. To address this knowledge gap,this study examines quantitatively the influence of floods and droughts on internal wars in three agro-ecological(rice, wheat,and pastoral) regions in China in AD1470–1911. Poisson regression and wavelet transform coherence analyses are applied to allow for the non-linear and non-stationary nature of the climate-war nexus. Results show that floods and droughts are significant in driving internal wars in historical China, but are characterized by strong regional variation. In the rice region, floods trigger internal wars at the inter-annual and multi-decadal time scales. In the wheat region, both floods and droughts cause internal wars at the inter-annual and multi-decadal time scales. In the pastoral region, internal wars are associated with floods only at the multi-decadal time scale. In addition, the multi-decadal coherence between hydro-climatic extremes and internal wars in all three of the agro-ecological regions is only significant in periods in which population density is increasing or the upper limit of regional carrying capacity is being reached. The above results imply that the climate-war nexus is mediated by regional geographic factors such as physical environmental setting and population pressure. Hence, we encourage researchers who study the historical human-climate relationship to boil down data according to geographic regions in the course of statistical analysis and to examine each region individually in follow-up studies. | Harry F.LEE David D.ZHANG PEI Qing JIA Xin Ricci P.H.YUE | 2017 | Science China Earth Sciences2017，60，12： | 3 |
| 14 | Is Ulnar Nerve Transposition Beneficial During Open Reduction Internal Fixation of Distal Humerus Fractures?显示文摘 | Ryan C Chen David J Harris Stephane Leduc Joseph J Borrelli Paul Tornetta William M Ricci | 2010 | Journal of Orthopaedic Trauma2010，，7： | 2 |
| 15 | Ulcerative colitis neoplasia is not associated with common IBD SNPs显示文摘 | Tara M. Connelly Arthur S. Berg Leonard R. Harris David L. Brinton John P. Hegarty Susan M. Deiling David B. Stewart Walter A. Koltun | 2014 | Surgery2014，，： | 2 |
| 16 | Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis显示文摘 | Simon Yona Ki-Wook Kim Yochai Wolf Alexander Mildner Diana Varol Michal Breker Dalit Strauss-Ayali Sergey Viukov Martin Guilliams Alexander Misharin David A. Hume Harris Perlman Bernard Malissen Elazar Zelzer Steffen Jung | 2013 | Immunity2013，，5： | 2 |
| 17 | Capsule Endoscopy in Patients with Implantable Electromedical Devices is Safe显示文摘 | Lucinda A. Harris Stephanie L. Hansel Elizabeth Rajan Komandoor Srivathsan Robert Rea Michael D. Crowell David E. Fleischer Shabana F. Pasha Suryakanth R. Gurudu Russell I. Heigh Arthur D. Shiff Janice K. Post Jonathan A. Leighton Hsu Heng Yen | 2013 | Gastroenterology Research and Practice2013，，： | 2 |
| 18 | Developmental regulation of RI TL-DNA gene expression in roots, shoots and tubers of transformed potato (Solanum tuberosum cv. Desiree)显示文摘 | Gert Ooms David Twell Margreet E. Bossen J. Harry C. Hoge Michael M. Burrell | 1986 | Plant Molecular Biology1986，，5： | 2 |
| 19 | A fast and accurate model for the creation of explosion fragments with improved fragment shape and dimensions显示文摘Explosion models based on Finite Element Analysis(FEA)can be used to simulate how a warhead fragments.However their execution times are extensive.Active protection systems need to make very fast predictions,before a fast attacking weapon hits the target.Fast execution times are also needed in real time simulations where the impact of many different computer models is being assessed.Hence,FEA explosion models are not appropriate for these real-time systems.The research presented in this paper delivers a fast simulation model based on Mott’s equation that calculates the number and weight of fragments created by an explosion.In addition,the size and shape of fragments,unavailable in Mott’s equation,are calculated using photographic evidence and a distribution of a fragment’s length to its width.The model also identifies the origin of fragments on the warhead’s casing.The results are verified against experimental data and a fast execution time is achieved using uncomplicated simulation steps.The developed model then can be made available for real-time simulation and fast computation. | David Felix Ian Colwill Paul Harris | 2022 | Defence Technology(防务技术)2022，18，2： | 2 |
| 20 | National Institute of Neurological Disorders and Stroke–Canadian Stroke Network Vascular Cognitive Impairment Harmonization Standards显示文摘 | Vladimir Hachinski Costantino Iadecola Ron C. Petersen Monique M. Breteler David L. Nyenhuis Sandra E. Black William J. Powers Charles DeCarli Jose G. Merino Raj N. Kalaria Harry V. Vinters David M. Holtzman Gary A. Rosenberg Anders Wallin Martin Dichgans | 2006 | Stroke2006，，9： | 2 |
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